Differential receptor-mediated drug targeting to the diseased brain
Abstract
The brain is not directly accessible for intravenously administered macro- and most small molecular drugs because of the presence of the blood-brain barrier (BBB). In this respect the BBB functions as a physical and metabolic barrier which is presented by the endothelial cells in brain capillaries. In order to overcome the BBB, therapeutic compounds have been targeted to internalizing receptors at the BBB. In this review we summarize the different approaches that have been described in current literature, including the possible difficulties for clinical application. Particularly, we focus on the possible impact of brain diseases on receptor-mediated transport to the BBB/brain and how this may affect various targeting strategies. Moreover, it is our opinion that a differential drug targeting/delivery approach should be applied to treat central nervous system (CNS) diseases that are related to the BBB alone, and for CNS diseases that are related to both the brain and the BBB.
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Some exchangeable apolipoproteins (ApoA1 and ApoE) can cross the blood-brain barrier via receptor-mediated transcytosis.
“Some of those exchangeable apolipoproteins (ApoA1 and ApoE) can cross the blood-brain barrier (BBB) via receptor-mediated transcytosis18–21”
From Brain-targeted drug delivery by manipulating protein corona functions (2019) · cites this paper as [18]
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Brain-targeted drug delivery by manipulating protein corona functions
Zhang, Z., Guan, J., Jiang, Z., Yang, Y., Liu, J., Hua, W., Mao, Y., Li, C., Lu, W., Qian, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11593-z · Cited by 334 · see citing works
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Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases
Anthony, D. P., Hegde, M., Shetty, S. S., Rafic, T., Mutalik, S., & Rao, B. S. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119326 · Cited by 110 · see citing works
Del Amo, L., Cano, A., Ettcheto, M., Souto, E. B., Espina, M., Camins, A., García, M. L., & Sánchez-López, E. (2021) · Applied Sciences · doi:10.3390/app11094305 · Cited by 67 · see citing works
- Authors
- Rip, J., Schenk, G., & de Boer, A.
- Affiliations
- Leiden University (NL)
- ORCID
- Rip, J
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2009-03
- Volume
- 6
- Issue
- 3
- Pages
- 227-237
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2002719103
- Cited by
- 98
- References
- 3
- Citations by year
- 2025: 5 · 2024: 11 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 9 · 2016: 11 · 2015: 3 · 2014: 4 · 2013: 9 · 2012: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- blood-brain barrier, receptor-mediated drug delivery, brain disorders, central nervous system disorders, blood-brain barrier permeability
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Central Nervous System Agents, Central Nervous System Diseases, Drug Administration Routes, Drug Carriers, Humans, Receptors, Cell Surface
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