The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Overcoming the barriers in micellar drug delivery: loading efficiency,in vivo stability, and micelle–cell interaction
Abstract
IMPORTANCE OF THE FIELD: Spontaneously constructed from block copolymers in aqueous media, the polymer micelle has been extensively studied as a potential carrier of poorly water-soluble drugs, but cellular uptake pathways and stability of micelles in blood have not yet been clearly understood. An in-depth insight into the physical and biological behaviors of polymer micelles is necessitated for designing next-generation micelles. AREAS COVERED IN THIS REVIEW: This review suggests possible solutions to improve micellar drug loading capacity, scrutinizes the parameters influencing the micelle stability in blood, and also discusses the fate of micelles in cellular and in vivo environment, respectively. Direct and indirect evidences from the literatures mostly published after 90's were collected, analyzed and summarized. WHAT THE READER WILL GAIN: A critical analysis of micelle's stability in vivo and micelle-cell interaction is provided to highlight the key issues to be addressed to affirm that micelle can properly work as a drug carrier in clinical settings. TAKE HOME MESSAGE: With a clear understanding of its behaviors in biological environment, the polymer micelle is a promising nanocarrier for chemotherapy.
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Citations
Cites
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Self-citationIn vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy
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Cited by
Owen, S. C., Chan, D. P. Y., & Shoichet, M. S. (2012) · Nano Today · doi:10.1016/j.nantod.2012.01.002 · Cited by 911
Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery
Guo, Y., Sun, Q., Wu, F., Dai, Y., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202007356 · Cited by 650
Polymeric micelles as drug delivery vehicles
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Strategies to improve micelle stability for drug delivery
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Polymeric mixed micelles as nanomedicines: Achievements and perspectives
Cagel, M., Tesan, F. C., Bernabeu, E., Salgueiro, M. J., Zubillaga, M. B., Moretton, M. A., & Chiappetta, D. A. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.12.019 · Cited by 417
Metadata
- Authors
- Kim, S., Shi, Y., Kim, J. Y., Park, K., & Cheng, J.-X.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2009-12-18
- Volume
- 7
- Issue
- 1
- Pages
- 49-62
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2055928148
- Cited by
- 549
- References
- 83
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, S., Shi, Y., Kim, J. Y., Park, K., & Cheng, J.-X. (2010). Overcoming the barriers in micellar drug delivery: loading efficiency,in vivo stability, and micelle–cell interaction. Expert Opinion on Drug Delivery. https://doi.org/10.1517/17425240903380446
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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