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Cited by 613Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

Polymeric micelles as drug delivery vehicles

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Ahmad, Zaheer, Shah, Afzal, Siddiq, Muhammad, Kraatz, Heinz-Bernhard·2014·RSC Adv.
DOI 10.1039/c3ra47370h
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Abstract

Though much progress has been made in drug delivery systems, the design of a suitable carrier for the delivery of hydrophobic drugs is still a major challenge for researchers.

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  • For hydrophobic drugs, the amount loaded strictly depends on the hydrophobic interactions occurring between the drug and the micellar core.

    “Concerning hydrophobic drugs, the amount loaded strictly depends on the hydrophobic interactions occurring between the drug and the micellar core.”

    From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [81]

    Section 3, “Engineering of the micellar core,” says drug encapsulation mainly depends on hydrophobic interactions between the drug and micellar core. It also identifies polar interactions, hydrogen bonding, and aggregation number as factors in loading, so the claim’s “strictly depends” overstates the source. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • The length of the polymer hydrophobic chain, in addition to the type and level of substituents, is pivotal for defining the degree of encapsulation.

    “The length of the polymers hydrophobic chain, in addition to the type and level of substituents, is pivotal for defining the degree of encapsulation [22,81].”

    From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [81]

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  1. P. Couvreur, F. Puisieux and N. Ano, Adv. Drug Delivery Rev., 1995, 10, 141.
  2. D. D. Lasic, Nature, 1996, 380, 561.
  3. M. S. Baboli, G. Favre, P. Canal and G. Soula, Br. J. Cancer, 1993, 68, 319.
  4. R. A. Firestone, Bioconjugate Chem., 1994, 5, 105.
  5. H. S. Choi, W. Liu, P. Misra, E. Tanaka, J. P. Zimmer, B. I. Ipe, M. G. Bawendi and J. V. Frangion, Nat. Biotechnol., 2007, 25, 1165.
  6. H. M. Aliabadi and A. Lavasanifar, Expert Opin. Drug Delivery, 2006, 3, 139.
  7. G. K. Kwon and M. L. Forrest, Drug Dev. Res., 2006, 67, 15.
  8. K. Kataoka, G. S. Kwon, M. Yokoyama, T. Okano and Y. Sakurai, J. Controlled Release, 1993, 24, 119.
  9. S. Kim, Y. Shi, J. Y. Kim, K. Park and J. X. Cheng, Expert Opin. Drug Delivery, 2010, 7, 49.
  10. X. B. Xiong, F. Arash, S. M. Garg and A. Lavasanifar, J. Controlled Release, 2011, 155, 248.
  11. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama and K. Kataoka, Nat. Biotechnol., 2011, 6, 815.
  12. Y. Miura, T. Takenaka, K. Toh, S. Wu, H. Nishihara, M. R. Kano, Y. Ino, T. Nomoto, Y. Matsumoto, H. Koyama, H. Cabral, N. Nishiyama and O. , K. Kataoka, ACS Nano, 2013, 7, 8583.
  13. K. Sano, T. Nakajima, P. L. Choyke and H. Kobayashi, ACS Nano, 2013, 7, 717.
  14. M. Kozlov, N. Melik-Nubarov, E. Batrakova and A. Kabanov, Macromolecules, 2000, 33, 3305.
  15. K. Nakamura, E. Ryuichi and M. Takeda, J. Polym. Sci., 1976, 14, 1287.
  16. I. Astaeva, X. Zhong and F. A. Eisenberg, Macromolecules, 1993, 26, 7339.
  17. M. Yokoyama, T. Sugiyama, T. Okano, Y. Sakurai, M. Naito and K. Kataoka, Pharm. Res., 1993, 10, 895.
  18. G. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai and K. Kataoka, Langmuir, 1993, 9, 945.
  19. A. V. Kabanov and V. Y. Alakov, Crit. Rev. Ther. Drug Carrier Syst., 2002, 19, 1.
  20. I. Kabanov, I. Nazarova, E. Astaeva, V. Batrakova, A. Alakhov, V. Yaroslavov and V. Kabanov, Macromolecules, 1995, 28, 2303.
  21. Z. Sezgin, N. Yuksel and T. Baykara, Eur. J. Pharm. Biopharm., 2006, 64, 261.
  22. G. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai and K. Kataoka, J. Controlled Release, 1997, 48, 195.
  23. J. Xia, H. Zhang, D. R. Rigsbee, P. L. Dubin and T. Shaikh, Macromolecules, 1993, 26, 2759.
  24. Y. Q. Yang, L. S. Zheng, X. D. Guo, Y. Qian and L. J. Zhang, Biomacromolecules, 2011, 12, 116.
  25. F. Kohori, M. Yokoyama, K. Sakai and T. Okano, J. Controlled Release, 2002, 78, 155.
  26. P. K. Sharma and S. R. Bhatia, Int. J. Pharm., 2004, 278, 361.
  27. R. Jalil and J. R. Nixon, J. Microencapsulation, 1990, 7, 297.
  28. R. Basak and R. Bandyopadhyay, Langmuir, 2013, 29, 4350.
  29. S. S. Desale, S. M. Cohen, Y. Zhao, A. V. Kabanov and T. K. Bronich, J. Controlled Release, 2013, 171, 339.
  30. C. S. Fang, L. W. Fen, W. Z. Yong, L. Qiang and C. J. Hai, Pharmazie, 2012, 67, 781.
  31. P. T. Vladimir, J. Controlled Release, 2001, 73, 137.
  32. D. A. Chiappetta and A. Sosnik, Eur. J. Pharm. Biopharm., 2007, 66, 303.
  33. J. D. Jonkman-de Vries, K. P. Flora, A. Bult and J. H. Beijnen, Drug Dev. Ind. Pharm., 1996, 22, 475.
  34. A. J. Tim, J. Verweij, W. J. Loos and A. Sparreboom, Clin. Pharmacokinet., 2003, 42, 665.
  35. M. C. Jones and J. C. Leroux, Eur. J. Pharm. Biopharm., 1999, 48, 101.
  36. K. Kataoka, G. S. Kwon, M. Yokoyama, T. Okano and Y. Sakurai, J. Controlled Release, 1993, 24, 119.
  37. A. Yokoyama, Y. Satoh, T. Sakurai, Y. Okano, T. Matsumura and K. K. Kataoka, J. Controlled Release, 1998, 55, 219.
  38. V. P. Torchilin, J. Controlled Release, 2001, 73, 137.
  39. B. G. Yu, T. Okano, K. Kataoka and G. Kwon, J. Controlled Release, 1998, 53, 131.
  40. Y. Kadam, U. Yerramilli and A. Bahadur, Colloids Surf., B, 2009, 72, 141.
  41. Z. Attia, J. Ong, P. Hedrick, P. Lee, P. Rachel, P. Hammond and Y. Yang, Curr. Opin. Colloid Interface Sci., 2011, 16, 182.
  42. V. G. Kwon, Langmuir, 2006, 23, 9723.
  43. V. Alakhov, E. Klinski, S. Li, G. Pietrzynski, A. Venne, E. Batrakova, T. Bronitch and A. Kabanov, Colloids Surf., B, 1999, 16, 113.
  44. Y. Gao, L. Li and G. Zhai, Colloids Surf., B, 2008, 64, 194.
  45. Y. Wang, L. Yu, L. Han, X. Sha and X. Fang, Int. J. Pharm., 2007, 337, 63.
  46. Z. Wei, J. Hao, S. Yuan, Y. Li, W. Juan, X. Sha and X. Fang, Int. J. Pharm., 2009, 376, 176.
  47. Z. Wei, S. Yuan, Y. Chen, S. Yu, J. Hao, J. Luo, X. Sha and X. Fang, Eur. J. Pharm. Biopharm., 2010, 75, 341.
  48. W. Zhang, Y. Shi, Y. Chen, J. Ye, X. Sha and X. Fang, Biomaterials, 2011, 32, 2894.
  49. K. Oh, T. Bronich and A. Kabanov, J. Controlled Release, 2004, 94, 411.
  50. E. Lee, Y. Oh, Y. Youn, M. Nam, B. Park, J. Yun, J. Kim, H. Song and K. Oh, Colloids Surf., B, 2011, 82, 190.
  51. V. Alakhov and A. Kabanov, Expert Opin. Invest. Drugs, 1998, 7, 1453.
  52. R. Nagarajan, M. Barry and E. Ruckenstein, Langmuir, 1986, 2, 210.
  53. S. K. Patel, A. Lavasanifar and P. Choi, Biomacromolecules, 2009, 10, 2584.
  54. K. K. Jette, D. Law, E. A. Schmitt and G. S. Kwon, Pharm. Res., 2004, 21, 1184.
  55. X. T. Shuai, H. Ai, N. Nasongkla, S. Kim and J. M. Gao, J. Controlled Release, 2004, 98, 415.
  56. J. E. Chung, M. Yokoyama, K. Suzuki, T. Aoyagi, Y. Sakurai and T. Okano, Colloids Surf., B, 1997, 9, 37.
  57. J. Lavasanifar, S. Samuel, G. S. Sattari and B. Kwon, Pharm. Res., 2002, 19, 418.
  58. F. A. Lavasanifar, Macromol. Biosci., 2010, 10, 648.
  59. F. A. Lavasanifar, Colloids Surf., B, 2010, 8, 313.
  60. O. Molavi, Z. Ma, A. Mahmud, A. Alshamsan, J. Samuel, R. Lai, G. S. Kwon and A. Lavasanifar, Int. J. Pharm., 2008, 347, 118.
  61. T. Rupei, J. Weihang and W. Chun, Macromol. Chem. Phys., 2011, 212, 1185.
  62. Y. Chuan, B. Amalina, A. Ebrahim, P. K. T. Jeremy, K. Xiyu and G. Shujun, Biomaterials, 2012, 33, 2971.
  63. L. J. Samuel and G. S. Kwon, Colloids Surf., B, 2001, 22, 115.
  64. H. K. Kataoka, Macromolecules, 1995, 28, 5294.
  65. A. V. Kabanov, T. K. Bronich, V. A. Kabanov, K. Yu and A. Eisenberg, Macromolecules, 1996, 29, 6797.
  66. J. F. Gohy, S. K. Varshney, S. Antoun and R. Jerome, Macromolecules, 2000, 33, 9298.
  67. M. Iijima, Y. Nagasaki, T. Okada, M. Kato and K. Kataoka, Macromolecules, 1999, 32, 1140.
  68. J. Q. Jiang, B. Qi, M. Lepage and Y. Zhao, Macromolecules, 2007, 40, 790.
  69. J. H. Kim, K. Emoto, M. Iijima, Y. Nagasaki, T. Aoyagi, T. Okano, Y. Sakurai and K. Kataoka, Polym. Adv. Technol., 1999, 10, 647.
  70. X. T. Shuai, T. Merdan, A. K. Schaper, F. Xi and T. Kissel, Bioconjugate Chem., 2004, 15, 441.
  71. J. Tao and G. J. Liu, Macromolecules, 1997, 30, 2408.
  72. T. G. J. Liu, J. F. Ding and M. L. Yang, Macromolecules, 1997, 30, 4084.
  73. K. Procházka, M. K. Baloch and Z. Tuzar, Makromol. Chem., 1979, 180, 2521.
  74. R. K. O'Reilly, M. J. Joralemon, C. J. Hawker and K. L. Wooley, New J. Chem., 2007, 31, 718.
  75. Q. Jin, X. Liu, G. Liu and J. Ji, Polymer, 2010, 51, 1311.
  76. L. J. Samuel and G. S. Kwon, J. Controlled Release, 2002, 79, 165.
  77. R. S. Stock and W. H. Fay, J. Polym. Sci., Polym. Phys. Ed., 1985, 23, 1393.
  78. G. S. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai and K. Kataoka, Pharm. Res., 1995, 12, 192.
  79. K. Ulbrich, C. Konak, Z. Tuzar and J. Kopecek, Makromol. Chem., 1987, 188, 1261.
  80. V. S. Trubetskoy and V. P. Torchilin, STP Pharma Sci., 1996, 6, 79.
  81. V. Weissig, K. R. Whiteman and V. P. Torchilin, Pharm. Res., 1998, 15, 1552.
  82. K. Kataoka, H. Togawa, A. Harada, K. Yasugi, T. Matsumoto and S. Katayose, Macromolecules, 1996, 29, 8556.
  83. S. Katayose and K. Kataoka, J. Pharm. Sci., 1998, 87, 160.
  84. M. Yokoyama, A. Satoh, Y. Sakurai, T. Okano, Y. Matsumara, T. Kakizoe and K. Kataoka, J. Controlled Release, 1998, 55, 219.
  85. S. A. Hagan, G. A. Coombes, M. C. Garnett, S. E. Dunn, M. C. Davies, L. Illum, S. S. Davis, S. E. Harding, S. Purkiss and P. R. Gellert, Langmuir, 1996, 12, 2153.
  86. A. Lavasanifar, J. Samuel and G. S. Kwon, Adv. Drug Delivery Rev., 2002, 54, 169.
  87. Z. M. Miao, S. X. Zhang and R. X. Zhuo, Biomacromolecules, 2006, 7, 2020.
  88. M. Shahin and L. Afsaneh, Int. J. Pharm., 2010, 389, 213.
  89. L. Bromberg, Macromolecules, 1998, 31, 6148.
  90. A. W. Alani, Y. Bae, D. A. Rao and G. S. Kwon, Biomaterials, 2010, 31, 1765.
  91. G. Kwon, S. Suwa, M. Yokoyama, T. Okano, Y. Sakurai and K. Kataoka, J. Controlled Release, 1994, 29, 17.
  92. A. Rolland, J. E. O'Mullane, P. Goddard, L. Brookman and K. Petrak, J. Appl. Polym. Sci., 1992, 44, 1195.
  93. H. Maeda, L. W. Seymour and Y. Miyamoto, Bioconjugate Chem., 1992, 3, 351.
  94. R. K. Jain, Adv. Drug Delivery Rev., 1997, 26, 71.
  95. F. Yuan, M. Leunig, S. K. Huang, D. A. Berk, D. Papahadjopoulos and R. K. Jain, Cancer Res., 1994, 54, 3352.
  96. F. Yuan, M. Dellian, D. Fukumura, M. Leunig, D. A. Berk, V. P. Torchilin and R. K. Jain, Cancer Res., 1995, 55, 3752.
  97. X. Zhang, H. M. Burt, G. Mangold, D. Dexter, D. Von Hoff, L. Mayer and W. L. Hunter, Anti-Cancer Drugs, 1997, 8, 686. 101
  98. M. Ramaswamy, X. Zhang, H. M. Burt and K. M. Wasan, J. Pharm. Sci., 1997, 86, 460. 102
  99. M. Yokoyama, M. Miyauchi, N. Yamada, T. Okano, Y. Sakurai, K. Kataoka and S. Inoue, Cancer Res., 1990, 50, 1700.
  100. X. Zhang, H. M. Burt, D. Von Hoff, D. Dexter, G. Mangold, D. Degen, A. M. Oktaba and W. L. Hunter, Cancer Chemother. Pharmacol., 1997, 40, 81. 104
  101. M. Yokoyama, T. Okano, Y. Sakurai, H. Ekimoto, C. Shibazaki and K. Kataoka, Cancer Res., 1991, 51, 3229. 105
  102. M. Yokoyama, S. Fukushima, R. Uehara, K. Okamoto, K. Kataoka, Y. Sakurai and T. Okano, J. Controlled Release, 1998, 50, 79. 106
  103. A. V. Kabanov, V. P. Chekhonin, V. Y. Alakhov, E. V. Batrakova, A. S. Lebedev, N. S. Melik-Nubarov, S. A. Arzhakov, A. V. Levashov, G. V. Morozov, E. S. Severin and V. A. Kabanov, FEBS Lett., 1989, 258, 343.
  104. A. V. Kabanov, E. V. Batrakova, N. S. Melik-Nubarov, N. A. Fedoseev, T. Y. Dorodnich, V. Y. Alakhov, V. P. Chekhonin, I. R. Nazarova and V. A. Kabanov, J. Controlled Release, 1992, 22, 141. 108
  105. S. Schreier, S. V. P. Malheiros and E. Paula, Biochim. Biophys. Acta, Biomembr., 2000, 1508, 210. 109
  106. B. G. Yu, T. Okano, K. Kataoka, S. Sardari and G. S. Kwon, J. Controlled Release, 1998, 56, 285. 110
  107. K. Kataoka, G. S. Kwon, M. Yokoyama, T. Okano and Y. Sakurai, J. Controlled Release, 1993, 24, 119. 111
  108. C. S. Cho, M. Y. Chang, H. C. Lee, S. C. Song, M. Goto and T. Akaike, Proc. Int. Symp. Controlled Release Bioact. Mater., 1998, 25, 721. 112
  109. S. Cammas, K. Suzuki, C. Sone, Y. Sakurai, K. Kataoka and T. Okano, J. Controlled Release, 1997, 48, 157. 113
  110. J. E. Chung, M. Yokoyama, T. Aoyagi, Y. Sakurai and T. Okano, J. Controlled Release, 1998, 53, 119. 114
  111. O. Meyer, D. Papahadjopoulos and J. C. Leroux, FEBS Lett., 1998, 42, 61. 115
  112. J. E. Chung, M. Yamato, M. Yokoyama, T. Aoyagi, Y. Sakurai and T. Okano, Proc. Int. Symp. Controlled Release Bioact. Mater., 1998, 25, 380. 116
  113. G. Helmlinger, F. Yuan, M. Dellian and R. K. Jain, Nat. Med., 1997, 3, 77. 117
  114. I. F. Tannock and D. Rotin, Cancer Res., 1989, 49, 4373. 118
  115. D. C. Litzinger and L. Huang, Biochim. Biophys. Acta, 1992, 1113, 201. 119
  116. M. K. Pratten and J. B. Lloyd, Makromol. Chem., 1985, 186, 725. 17038 | RSC Adv., 2014, 4, 17028-17038 This journal is © The Royal Society of Chemistry 2014

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Authors
Ahmad, Z., Shah, A., Siddiq, M., & Kraatz, H.-B.
Affiliations
  • Quaid-i-Azam University (PK)
  • University of Toronto (CA)
Corresponding author
  • Shah, Afzal
  • Kraatz, Heinz-Bernhard
ORCID
Venue
RSC Adv.
Publisher
Royal Society of Chemistry (RSC)
Published
2014
Volume
4
Issue
33
Pages
17028-17038
ISSN
2046-2069 (ISSN-L)
DOI
10.1039/c3ra47370h
OpenAlex
W2005419668
Cited by
610
References
111
Citations by year
2026: 29 · 2025: 53 · 2024: 62 · 2023: 67 · 2022: 72 · 2021: 67 · 2020: 61 · 2019: 45 · 2018: 48 · 2017: 29 · 2016: 41 · 2015: 34 · 2014: 2
FWCI
13.31
Type
journal article
Language
en
Open access
Locations
RSC Advances (publishedVersion)
Funders
  • University of Toronto
  • Quaid-i-Azam University
  • University of Toronto Scarborough
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
polymeric micelles, drug carriers, hydrophobic drug delivery, nanocarriers

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