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Cited by 166

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Two-photon polymerization of microneedles for transdermal drug delivery

Open access
Gittard, Shaun D, Ovsianikov, Aleksandr, Chichkov, Boris N, Doraiswamy, Anand, Narayan, Roger J·2010·Expert Opinion on Drug Delivery

Abstract

IMPORTANCE OF THE FIELD: Microneedles are small-scale devices that are finding use for transdermal delivery of protein-based pharmacologic agents and nucleic acid-based pharmacologic agents; however, microneedles prepared using conventional microelectronics-based technologies have several shortcomings, which have limited translation of these devices into widespread clinical use. AREAS COVERED IN THIS REVIEW: Two-photon polymerization is a laser-based rapid prototyping technique that has been used recently for direct fabrication of hollow microneedles with a wide variety of geometries. In addition, an indirect rapid prototyping method that involves two-photon polymerization and polydimethyl siloxane micromolding has been used for fabrication of solid microneedles with exceptional mechanical properties. WHAT THE READER WILL GAIN: In this review, the use of two-photon polymerization for fabricating in-plane and out-of-plane hollow microneedle arrays is described. The use of two-photon polymerization-micromolding for fabrication of solid microneedles is also reviewed. In addition, fabrication of microneedles with antimicrobial properties is discussed; antimicrobial microneedles may reduce the risk of infection associated with the formation of channels through the stratum corneum. TAKE HOME MESSAGE: It is anticipated that the use of two-photon polymerization as well as two-photon polymerization-micromolding for fabrication of microneedles and other microstructured drug delivery devices will increase over the coming years.

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Metadata

Authors
Gittard, S. D., Ovsianikov, A., Chichkov, B. N., Doraiswamy, A., & Narayan, R. J.
Venue
Expert Opinion on Drug Delivery
Published
2010-03-07
Volume
7
Issue
4
Pages
513-533
ISSN
  • 1742-5247 (ISSN-L)
  • 1744-7593
OpenAlex
W2138926733
Cited by
166
References
3
FWCI
3.49
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Two-photon polymerization of microneedles for transdermal drug delivery. https://app.cochat.ai/papers/10.1517/17425241003628171
The paper
Gittard, S. D., Ovsianikov, A., Chichkov, B. N., Doraiswamy, A., & Narayan, R. J. (2010). Two-photon polymerization of microneedles for transdermal drug delivery. Expert Opinion on Drug Delivery. https://doi.org/10.1517/17425241003628171

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.