Nanomedicine Against Malaria
Abstract
Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium sp. The clinical, social and economic burden of malaria has led for the last 100 years to several waves of serious efforts to reach its control and eventual eradication, without success to this day. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial drugs exclusively to Plasmodium-infected cells. Different types of encapsulating structure, targeting molecule, and antimalarial compound will be discussed for the assembly of Trojan horse nanocapsules capable of targeting with complete specificity diseased cells and of delivering inside them their antimalarial cargo with the objective of eliminating the parasite with a single dose. Nanotechnology can also be applied to the discovery of new antimalarials through single-molecule manipulation approaches for the identification of novel drugs targeting essential molecular components of the parasite. Finally, methods for the diagnosis of malaria can benefit from nanotools applied to the design of microfluidic-based devices for the accurate identification of the parasite's strain, its precise infective load, and the relative content of the different stages of its life cycle, whose knowledge is essential for the administration of adequate therapies. The benefits and drawbacks of these nanosystems will be considered in different possible scenarios, including cost-related issues that might be hampering the development of nanotechnology-based medicines against malaria with the dubious argument that they are too expensive to be used in developing areas.
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Blood stage parasites are the main therapeutic target, and researchers are developing various approaches to target antimalarials to infected RBCs.
“Given that blood stage parasites are the main therapeutic target, researchers are developing various approaches to target antimalarials to infected RBCs 105-107 , thereby maximizing their therapeutic window.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [107]
Cites
1 retracted
Vaccines for preventing malaria
Graves, P. M., & Gelband, H. (2003) · doi:10.1002/14651858.cd000129 · Cited by 63 · see citing works
RetractedBiodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549 · see citing works
Artemisinin Resistance in <i>Plasmodium falciparum</i> Malaria
Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424 · see citing works
Recent advances on chitosan-based micro- and nanoparticles in drug delivery
Agnihotri, S. A., Nadagouda, M. N., & Aminabhavi, T. M. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.010 · Cited by 2,589 · see citing works
Dynamic strength of molecular adhesion bonds
Evans, E., & Ritchie, K. P. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78802-7 · Cited by 2,556 · see citing works
The economic and social burden of malaria
Sachs, J., & Malaney, P. (2002) · Nature · doi:10.1038/415680a · Cited by 2,248 · cited 1× · see citing works
“The appearance and spread of resistance does not only lead to an increase in therapeutic failures and mortalities, but it also increases the costs associated with treatment and control of the disease [186].”
BackgroundIntegrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications.
Katz, E., & Willner, I. (2004) · Angewandte Chemie · doi:10.1002/anie.200400651 · Cited by 2,138 · see citing works
Evidence of Artemisinin-Resistant Malaria in Western Cambodia
Noedl, H., Se, Y., Schaecher, K. E., Smith, B. L., Socheat, D., & Fukuda, M. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0805011 · Cited by 1,789 · see citing works
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,754 · see citing works
Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy
Merkel, R., Nassoy, P., Leung, A., Ritchie, K. P., & Evans, E. A. (1999) · Nature · doi:10.1038/16219 · Cited by 1,724 · see citing works
Rapid Diagnostic Tests for Malaria Parasites
Moody, A. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.1.66-78.2002 · Cited by 1,418 · see citing works
Humans as the World's Greatest Evolutionary Force
Palumbi, S. R. (2001) · Science · doi:10.1126/science.293.5536.1786 · Cited by 1,290 · see citing works
White, N. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21682 · Cited by 1,254 · see citing works
Boas, U., & Heegaard, P. M. H. (2003) · Chemical Society Reviews · doi:10.1039/b309043b · Cited by 1,184 · see citing works
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.
Jomaa, H., Wiesner, J., Sanderbrand, S., Altincicek, B., Weidemeyer, C., Hintz, M., Türbachova, I., Eberl, M., Zeidler, J., Lichtenthaler, H., et al. (1999) · Science · doi:10.1126/science.285.5433.1573 · Cited by 1,177 · see citing works
Hinterdorfer, P., Baumgärtner, W., Gruber, H. J., Schilcher, K., & Schindler, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3477 · Cited by 1,170 · see citing works
Adherence of <i>Plasmodium falciparum</i> to Chondroitin Sulfate A in the Human Placenta
Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108 · see citing works
Artemisinins target the SERCA of Plasmodium falciparum
Eckstein‐Ludwig, U., Webb, R. J., van Goethem, I. D. A., East, J. M., Lee, A. G., Kimura, M., O’Neill, P. M., Bray, P. G., Ward, S. A., & Krishna, S. (2003) · Nature · doi:10.1038/nature01813 · Cited by 1,029 · see citing works
Ashley, C. E., Carnes, E. C., Phillips, G. K., Padilla, D., Durfee, P. N., Brown, P. A., Hanna, T. N., Liu, J., Phillips, B., Carter, M. B., et al. (2011) · Nature Materials · doi:10.1038/nmat2992 · Cited by 1,021 · see citing works
The global distribution and population at risk of malaria: past, present, and future
Hay, S. I., Guerra, C. A., Tatem, A. J., Noor, A. M., & Snow, R. W. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01043-6 · Cited by 1,002 · see citing works
Thousands of chemical starting points for antimalarial lead identification
Gamo, F., Sanz, L. M., Vidal, J., de Cózar, C., Álvarez, E. F., Lavandera, J.-L., Vanderwall, D. E., Green, D. V. S., Kumar, V. D., Hasan, S., et al. (2010) · Nature · doi:10.1038/nature09107 · Cited by 991 · see citing works
Hemilability of Hybrid Ligands and the Coordination Chemistry of Oxazoline-Based Systems
Braunstein, P., & Naud, F. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010216)40:4 · Cited by 951 · see citing works
Invasion of Red Blood Cells by Malaria Parasites
Cowman, A. F., & Crabb, B. S. (2006) · Cell · doi:10.1016/j.cell.2006.02.006 · Cited by 944 · see citing works
A Review of Malaria Diagnostic Tools: Microscopy and Rapid Diagnostic Test (RDT)
Wongsrichanalai, C., Barcus, M. J., Muth, S., Sutamihardja, A., & Wernsdorfer, W. H. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.119 · Cited by 940 · see citing works
Antimalarial drug discovery: efficacy models for compound screening
Fidock, D. A., Rosenthal, P. J., Croft, S. L., Brun, R., & Nwaka, S. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1416 · Cited by 863 · see citing works
Where will new antibiotics come from?
Walsh, C. T. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro727 · Cited by 758 · see citing works
Alonso, P. L., Sacarlal, J., Aponte, J. J., Leach, A. J., Macete, E., Milman, J. B., Mandomando, I., Spiessens, B., Guinovart, C., Espasa, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17223-1 · Cited by 749 · see citing works
Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations
Sidhu, A. B. S., Verdier-Pinard, D., & Fidock, D. A. (2002) · Science · doi:10.1126/science.1074045 · Cited by 723 · see citing works
Biomedical applications of dendrimers: a tutorial
Mintzer, M. A., & Grinstaff, M. W. (2010) · Chemical Society Reviews · doi:10.1039/b901839p · Cited by 674 · see citing works
Artemisinin-Based Combination Treatment of Falciparum Malaria
Nosten, F. H., & White, N. J. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.181 · Cited by 663 · see citing works
A Research Agenda to Underpin Malaria Eradication
Alonso, P. L., Brown, G., Arévalo‐Herrera, M., Binka, F. N., Chitnis, C. E., Collins, F., Doumbo, O. K., Greenwood, B. M., Hall, B., Levine, M. M., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1000406 · Cited by 661 · see citing works
Pathogenesis, clinical features, and neurological outcome of cerebral malaria
Idro, R., Jenkins, N. E., & Newton, C. R. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70247-7 · Cited by 576 · see citing works
Assessment of the pharmacodynamic properties of antimalarial drugs in vivo
White, N. J. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.7.1413 · Cited by 574 · see citing works
The silent path to thousands of merozoites: the Plasmodium liver stage
Prudêncio, M., Rodrı́guez, A., & Mota, M. M. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1529 · Cited by 507 · see citing works
Polyester Dendritic Systems for Drug Delivery Applications: In Vitro and In Vivo Evaluation
Padilla De Jesús, O. L., Ihre, H. R., Gagne, L., Fréchet, J. M. J., & Szoka, F. C. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010103m · Cited by 507 · see citing works
Update on Rapid Diagnostic Testing for Malaria
Murray, C. K., Gasser, R. A., Magill, A. J., & Miller, R. S. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00035-07 · Cited by 507 · see citing works
Deoxyxylulose phosphate pathway to terpenoids
Eisenreich, W., Rohdich, F., & Bacher, A. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01812-4 · Cited by 503 · see citing works
Takahashi, S., Kuzuyama, T., Watanabe, H., & Seto, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9879 · Cited by 470 · see citing works
Plasmodium knowlesi: The Fifth Human Malaria Parasite
White, N. J. (2007) · Clinical Infectious Diseases · doi:10.1086/524889 · Cited by 447 · see citing works
Tension-induced fusion of bilayer membranes and vesicles
Shillcock, J., & Lipowsky, R. (2005) · Nature Materials · doi:10.1038/nmat1333 · Cited by 411 · see citing works
Some Lessons for the Future from the Global Malaria Eradication Programme (1955–1969)
Nájera, J. A., González-Silva, M., & Alonso, P. L. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1000412 · Cited by 406 · see citing works
Baruch, D. I., Gormely, J. A., Ma, C., Howard, R. J., & Pasloske, B. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3497 · Cited by 399 · see citing works
Grabbing the cat by the tail: manipulating molecules one by one
Bustamante, C., Macosko, J. C., & Wuite, G. J. L. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040072 · Cited by 398 · see citing works
Antigenic Variation at the Infected Red Cell Surface in Malaria
Kyes, S., Horrocks, P., & Newbold, C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.673 · Cited by 393 · see citing works
Delves, M. J., Plouffe, D., Scheurer, C., Meister, S., Wittlin, S., Winzeler, E. A., Sinden, R. E., & Leroy, D. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001169 · Cited by 378 · see citing works
Effectiveness of Antimalarial Drugs
Baird, J. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043207 · Cited by 375 · see citing works
Plasmodium falciparum rosetting is associated with malaria severity in Kenya
Rowe, J. A., Obeiro, J., Newbold, C., & Marsh, K. (1995) · Infection and Immunity · doi:10.1128/iai.63.6.2323-2326.1995 · Cited by 357 · see citing works
Ensuring quality and access for malaria diagnosis: how can it be achieved?
Bell, D., Wongsrichanalai, C., & Barnwell, J. W. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1474 · Cited by 354 · see citing works
Frevert, U., Sinnis, P., Cerami, C., Shreffler, W. G., Takács, B., & Nussenzweig, V. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.5.1287 · Cited by 351 · see citing works
The New Toxicology of Sophisticated Materials: Nanotoxicology and Beyond
Maynard, A., Warheit, D. B., & Philbert, M. A. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq372 · Cited by 351 · see citing works
Cardiotoxicity of antimalarial drugs
White, N. J. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70187-1 · Cited by 349 · see citing works
New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance
Price, R. N., Douglas, N. M., & Anstey, N. M. (2009) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32832f14c1 · Cited by 342 · see citing works
Chloroquine Resistance inPlasmodium vivax
Baird, J. K. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.11.4075-4083.2004 · Cited by 336 · see citing works
ACP Broadsheet no 148. July 1996. Laboratory diagnosis of malaria.
Warhurst, D. C., & Williams, J. E. O. (1996) · Journal of Clinical Pathology · doi:10.1136/jcp.49.7.533 · Cited by 331 · see citing works
Polyester Dendritic Systems for Drug Delivery Applications: Design, Synthesis, and Characterization
Ihre, H. R., Jesús, O. L. P. D., Szoka, F. C., & Fréchet, J. M. J. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010102u · Cited by 329 · see citing works
Curcumin and its analogues: Potential anticancer agents
Agrawal, D. K., & Mishra, P. K. (2009) · Medicinal Research Reviews · doi:10.1002/med.20188 · Cited by 311 · see citing works
Adjalley, S. H., Johnston, G. L., Li, T., Eastman, R. T., Ekland, E. H., Eappen, A. G., Richman, A. M., Sim, B. K. L., Lee, M., Hoffman, S. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112037108 · Cited by 311 · see citing works
Identification of a Platelet Membrane Glycoprotein as a Falciparum Malaria Sequestration Receptor
Ockenhouse, C. F., Tandon, N. N., Magowan, C., Jamieson, G. A., & Chulay, J. D. (1989) · Science · doi:10.1126/science.2467377 · Cited by 310 · see citing works
Drug‐resistant malaria: Molecular mechanisms and implications for public health
Petersen, I., Eastman, R., & Lanzer, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.042 · Cited by 304 · see citing works
O’Driscoll, C. M., & Griffin, B. T. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.012 · Cited by 301 · see citing works
Stabilized plasmid-lipid particles: construction and characterization
Wheeler, J. J., Palmer, L., Ossanlou, M., MacLachlan, I., Graham, R. W., Zhang, Y. P., Hope, M. J., Scherrer, P., & Cullis, P. R. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300821 · Cited by 300 · see citing works
Chen, Q., Barragán, A., Fernandez, V., Sundström, A., Schlichtherle, M., Sahlén, A., Carlson, J., Datta, S., & Wahlgren, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.1.15 · Cited by 294 · see citing works
Nanotechnology applied to the treatment of malaria
Santos-Magalhães, N. S., & Mosqueira, V. C. F. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.024 · Cited by 286 · see citing works
Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting
Bhadra, D., Yadav, A. K., Bhadra, S., & Jain, N. K. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.01.026 · Cited by 280 · see citing works
Microsample preparation by dielectrophoresis: isolation of malaria
Gascoyne, P. R. C., Mahidol, C., Ruchirawat, M., et al. (2002) · Lab on a Chip · doi:10.1039/b110990c · Cited by 278 · see citing works
UK malaria treatment guidelines
Lalloo, D. G., Shingadia, D. V., Pasvol, G., et al. (2007) · Journal of Infection · doi:10.1016/j.jinf.2006.12.003 · Cited by 272 · see citing works
Probing the chemistry of thioredoxin catalysis with force
Wiita, A. P., Pérez‐Jiménez, R., Walther, K. A., Gräter, F., Berne, B. J., Holmgren, A., Sánchez‐Ruiz, J. M., & Fernández, J. M. (2007) · Nature · doi:10.1038/nature06231 · Cited by 270 · see citing works
Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination
Wells, T. N. C., Burrows, J. N., & Baird, J. K. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2009.12.005 · Cited by 262 · see citing works
Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives.
Price, R. N., van Vugt, M., Phaipun, L., Luxemburger, C., Simpson, J. A., McGready, R. M., ter Kuile, F. O., Kham, A., Chongsuphajaisiddhi, T., White, N. J., et al. (1999) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1999.60.547 · Cited by 261 · see citing works
Bzik, D. J., Li, W. B., Horii, T., et al. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8360 · Cited by 259 · see citing works
Craig, A. G. (2001) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(01)00275-4 · Cited by 254 · see citing works
Reeder, J. C., Cowman, A. F., Davern, K. M., Beeson, J. G., Thompson, J. K., Rogerson, S. J., & Brown, G. V. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5198 · Cited by 252 · see citing works
Cui, L., Miao, J., & Cui, L. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01238-06 · Cited by 248 · see citing works
Antiparasitic Agent Atovaquone
Baggish, A. L., & Hill, D. R. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.5.1163-1173.2002 · Cited by 245 · see citing works
Agrawal, P., Gupta, U. D., & Jain, N. K. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.04.004 · Cited by 242 · see citing works
Molecular Aspects of Severe Malaria
Chen, Q., Schlichtherle, M., & Wahlgren, M. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.3.439 · Cited by 242 · see citing works
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs
Fitch, C. D. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.003 · Cited by 241 · see citing works
That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda
Kappe, S. H. I., Vaughan, A. M., Boddey, J. A., & Cowman, A. F. (2010) · Science · doi:10.1126/science.1184785 · Cited by 238 · see citing works
Treatment of Malaria in the United States
Griffith, K., Lewis, L. S., Mali, S., & Parise, M. E. (2007) · JAMA · doi:10.1001/jama.297.20.2264 · Cited by 235 · see citing works
Possible modes of action of the artemisinin-type compounds
Olliaro, P., Haynes, R. K., Meunier, B., & Yuthavong, Y. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(00)01838-9 · Cited by 230 · see citing works
Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes
Udomsangpetch, R., Wåhlin, B., Carlson, J., Berzins, K., Torii, M., Aikawa, M., Perlmann, P., & Wahlgren, M. (1989) · Journal of Experimental Medicine · doi:10.1084/jem.169.5.1835 · Cited by 229 · see citing works
Tan, K. R., Magill, A. J., Parise, M. E., & Arguin, P. M. (2011) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2011.10-0285 · Cited by 229 · see citing works
Sukhorukov, G. B., Rogach, A. L., Garstka, M. A., Springer, S., Parak, W. J., Muñoz‐Javier, A., Kreft, O., Skirtach, A. G., Susha, A. S., Ramaye, Y., et al. (2007) · Small · doi:10.1002/smll.200600622 · Cited by 227 · see citing works
Drug delivery in biotechnology: present and future
Orive, G., Hernández, R. M., Rodríguez‐Gascón, A., et al. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.10.007 · Cited by 223 · see citing works
Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine
Singh, K. K., & Vingkar, S. K. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.035 · Cited by 215 · see citing works
Glucose-6-Phosphate Dehydrogenase Deficiency and Antimalarial Drug Development
Beutler, E., Duparc, S., & _, _. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.779 · Cited by 215 · see citing works
The Significance of Glycosylated Proteins
WINTERBURN, P. J., & PHELPS, C. F. (1972) · Nature · doi:10.1038/236147a0 · Cited by 213 · see citing works
Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice
Akhtar, F., Rizvi, M. M. A., & Kar, S. K. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.05.009 · Cited by 212 · see citing works
Access to Hematin: The Basis of Chloroquine Resistance
Bray, P. G., Mungthin, M., Ridley, R. G., et al. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.170 · Cited by 209 · see citing works
Nanotechnology: basic science and emerging technologies
(2003) · Choice Reviews Online · doi:10.5860/choice.40-3423 · Cited by 208 · see citing works
Microfluidic approaches to malaria detection
Gascoyne, P. R. C., Satayavivad, J., & Ruchirawat, M. (2003) · Acta Tropica · doi:10.1016/j.actatropica.2003.11.009 · Cited by 203 · see citing works
The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates
Rohdich, F., Kis, K., Bacher, A., et al. (2001) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00240-4 · Cited by 201 · see citing works
In vitro activities of and mechanisms of resistance to antifol antimalarial drugs
Milhous, W. K., Weatherly, N. F., Bowdre, J. H., & Desjardins, R. E. (1985) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.27.4.525 · Cited by 197 · see citing works
The apicoplast as an antimalarial drug target
Ralph, S. A., D’Ombrain, M. C., & McFadden, G. I. (2001) · Drug Resistance Updates · doi:10.1054/drup.2001.0205 · Cited by 196 · see citing works
Boyle, M. J., Richards, J. S., Gilson, P. R., et al. (2010) · Blood · doi:10.1182/blood-2009-09-243725 · Cited by 194 · see citing works
Gupta, Y., Jain, A., & Jain, S. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.7.0004 · Cited by 193 · see citing works
Curcumin-Artemisinin Combination Therapy for Malaria
Nandakumar, D. N., Nagaraj, V. A., Vathsala, P. G., et al. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.5.1859-1860.2006 · Cited by 183 · see citing works
Biochemistry of Polyisoprenoid Biosynthesis
Beytía, E., & Porter, J. W. (1976) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.45.070176.000553 · Cited by 183 · see citing works
Liposome–Nanoparticle Hybrids for Multimodal Diagnostic and Therapeutic Applications
Al-Jamal, W. T., & Kostarelos, K. (2007) · Nanomedicine · doi:10.2217/17435889.2.1.85 · Cited by 178 · see citing works
Marcos, M., Martín‐Rapún, R., Omenat, A., et al. (2007) · Chemical Society Reviews · doi:10.1039/b611123h · Cited by 172 · see citing works
Nosten, F. H., Luxemburger, C., Kyle, D. E., Ballou, W. R., Wittes, J., Wah, E., Chongsuphajaisiddhi, T., Gordon, D. M., White, N. J., SADOFF, J. C., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04465-0 · Cited by 169 · see citing works
Clindamycin as an Antimalarial Drug: Review of Clinical Trials
Lell, B., & Kremsner, P. G. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.8.2315-2320.2002 · Cited by 167 · see citing works
Kolhe, P., Khandare, J. J., Pillai, O., Kannan, S., Lieh-Lai, M. W., & Kannan, R. M. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.06.007 · Cited by 166 · see citing works
Nanotechnology diagnostics for infectious diseases prevalent in developing countries
Hauck, T. S., Giri, S., Gao, Y., & Chan, W. C. W. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.015 · Cited by 165 · see citing works
Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria
ter Kuile, F. O., Nosten, F. H., Chongsuphajaisiddhi, T., White, N. J., Dolan, G., Luxemburger, C., Phaipun, L., Edstein, M. D., & Webster, H. K. (1993) · The Lancet · doi:10.1016/0140-6736(93)92409-m · Cited by 160 · see citing works
Rapid diagnostic testing for malaria
Murray, C. K., Bell, D., Gasser, R. A., & Wongsrichanalai, C. (2003) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.2003.01115.x · Cited by 157 · see citing works
Drug delivery using multifunctional dendrimers and hyperbranched polymers
Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.534981 · Cited by 156 · see citing works
Silvestrini, F., Bozdech, Z., Lanfrancotti, A., et al. (2005) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2005.04.015 · Cited by 156 · see citing works
Malaria sporozoites and circumsporozoite proteins bind specifically to sulfated glycoconjugates
Pancake, S. J., Holt, G. D., Mellouk, S., & Hoffman, S. L. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.6.1351 · Cited by 155 · see citing works
The MEP Pathway: A New Target for the Development of Herbicides, Antibiotics and Antimalarial Drugs
Rodrı́guez-Concepción, M. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384006 · Cited by 154 · see citing works
Fosmidomycin for the treatment of malaria
Wiesner, J., Borrmann, S., & Jomaa, H. (2003) · Parasitology Research · doi:10.1007/s00436-002-0770-9 · Cited by 152 · see citing works
Nanoparticles-mediated drug delivery approaches for cancer targeting: a review
Sultana, S., Khan, M. R., Kumar, M., Kumar, S., & Ali, M. (2012) · Journal of drug targeting · doi:10.3109/1061186x.2012.712130 · Cited by 152 · see citing works
Introduction to micro-analytical systems: bioanalytical and pharmaceutical applications
Huikko, K., Kostiainen, R. K., & Kotiaho, T. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(03)00147-7 · Cited by 152 · see citing works
Bray, P. G., Janneh, O., Raynes, K. J., Mungthin, M., Ginsburg, H., & Ward, S. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.2.363 · Cited by 150 · see citing works
Vogt, A. M., Barragán, A., Chen, Q., Kironde, F., Spillmann, D., & Wahlgren, M. (2003) · Blood · doi:10.1182/blood-2002-07-2016 · Cited by 150 · see citing works
Reliability of malaria microscopy in epidemiological studies: results of quality control
Kilian, A. H. D., Metzger, W. G., Mutschelknauss, E. J., Kabagambe, G., Langi, P., Korte, R., & von Sonnenburg, F. (2000) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.2000.00509.x · Cited by 145 · see citing works
Liang, C. O., & Fréchet, J. M. J. (2005) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2005.01.004 · Cited by 144 · see citing works
Shanmugam, S., Baskaran, R., Balakrishnan, P., et al. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.04.012 · Cited by 143 · see citing works
Bizzarri, A. R., & Cannistraro, S. (2009) · Chemical Society Reviews · doi:10.1039/b811426a · Cited by 142 · see citing works
The Selection Landscape of Malaria Parasites
Mackinnon, M. J., & Marsh, K. (2010) · Science · doi:10.1126/science.1185410 · Cited by 137 · see citing works
Leishmanicidal Effect of Curcumin in Vitro.
Koide, T., Nose, M., Ogihara, Y., et al. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.131 · Cited by 134 · see citing works
Pinzon-Ortiz, C., Friedman, J. F., Esko, J. D., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104038200 · Cited by 132 · see citing works
Cytotoxic effect of curcumin on Giardia lamblia trophozoites
Pérez-Arriaga, L., Mendoza-Magaña, M. L., Cortés-Zárate, R., et al. (2006) · Acta Tropica · doi:10.1016/j.actatropica.2006.03.005 · Cited by 131 · see citing works
Molecular Engineering of Dendritic Polymers and Their Application as Drug and Gene Delivery Systems
Paleos, C. M., Tsiourvas, D., & Sideratou, Z. (2007) · Molecular Pharmaceutics · doi:10.1021/mp060076n · Cited by 129 · see citing works
Robert, C., Pouvelle, B., Meyer, P., Muanza, K., Fujioka, H., Aikawa, M., Scherf, A., & Gysin, J. (1995) · Research in Immunology · doi:10.1016/0923-2494(96)81042-x · Cited by 128 · see citing works
Meissner, P. E., Mandi, G., Coulibaly, B., et al. (2006) · Malaria Journal · doi:10.1186/1475-2875-5-84 · Cited by 127 · see citing works
Supramolecular structures from dendrons and dendrimers
Al‐Jamal, K. T., Ramaswamy, C., & Florence, A. J. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.015 · Cited by 126 · see citing works
Hempelmann, E. (2006) · Parasitology Research · doi:10.1007/s00436-006-0313-x · Cited by 124 · see citing works
Peptide Dendrimers Based on Polyproline Helices
Crespo, L., Sanclimens, G., Montaner, B., et al. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020364m · Cited by 121 · see citing works
Surface modification of PAMAM dendrimer improves its biocompatibility
Ciołkowski, M., Petersen, J. F., Ficker, M., et al. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.03.009 · Cited by 120 · see citing works
The role of nanobiotechnology in drug discovery.
Jain, K. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03573-7 · Cited by 116 · see citing works
Cell-Penetrating cis-γ-Amino- l -Proline-Derived Peptides
Farrera‐Sinfreu, J., Giralt, E., Castel, S., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051648k · Cited by 114 · see citing works
Malaria's Drug Miracle in Danger
Enserink, M. (2010) · Science · doi:10.1126/science.328.5980.844 · Cited by 114 · see citing works
Call to action: priorities for malaria elimination
Feachem, R. G., Phillips, A. A., Targett, G. A. T., & Snow, R. W. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61500-0 · Cited by 114 · see citing works
Kienberger, F., Kada, G., Mueller, H., et al. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.01.042 · Cited by 112 · see citing works
Release of Sequestered Malaria Parasites upon Injection of a Glycosaminoglycan
Vogt, A. M., Pettersson, F., Moll, K., Jonsson, C., Normark, J., Ribacke, U., Egwang, T. G., Ekre, H.-P. T., Spillmann, D., Chen, Q., et al. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020100 · Cited by 111 · see citing works
Borrmann, S., Lundgren, I., Oyakhirome, S., et al. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00392-06 · Cited by 111 · see citing works
Protein trafficking in Plasmodium falciparum-infected red blood cells
Cooke, B. M., Lingelbach, K. R., Bannister, L. H., & Tilley, L. M. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.09.008 · Cited by 110 · see citing works
Nanomaterials: An Introduction to Synthesis, Properties and Applications
Vollath, D. (2008) · Cited by 108 · see citing works
Recent advances in antimalarial drug development
Vangapandu, S., Jain, M., Kaur, K., Patil, P., Patel, S. R., & Jain, R. (2007) · Medicinal Research Reviews · doi:10.1002/med.20062 · Cited by 108 · see citing works
Akoachere, M., Buchholz, K., Fischer, E., Burhenne, J., Haefeli, W. E., Schirmer, R. H., & Becker, K. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.11.4592-4597.2005 · Cited by 108 · see citing works
Mosqueira, V. C. F., Loiseau, P. M., Bories, C., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1222-1228.2004 · Cited by 108 · see citing works
Membrane structure and function of malaria parasites and the infected erythrocyte
Sherman, I. W. (1985) · Parasitology · doi:10.1017/s0031182000062843 · Cited by 107 · see citing works
Owais, M., Varshney, G. C., Choudhury, A., Chandra, S., & Gupta, C. M. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.1.180 · Cited by 104 · see citing works
Putaporntip, C., Buppan, P., & Jongwutiwes, S. (2011) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03507.x · Cited by 103 · see citing works
Nanoparticles for Targeted and Temporally Controlled Drug Delivery
Swami, A., Shi, J., Gadde, S., Votruba, A. R., Kolishetti, N., & Farokhzad, O. C. (2012) · Nanostructure science and technology · doi:10.1007/978-1-4614-2305-8_2 · Cited by 102 · see citing works
Zoungrana, A., Coulibaly, B., Sié, A., Walter‐Sack, I., Mockenhaupt, F. P., Kouyaté, B. A., Schirmer, R. H., Klose, C., Mansmann, U., Meissner, P. E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001630 · Cited by 102 · see citing works
Zwang, J., Ashley, E. A., Karema, C., D’Alessandro, U., Smithuis, F. M., Dorsey, G., Janssens, B., Mayxay, M., Newton, P. N., Singhasivanon, P., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006358 · Cited by 102 · see citing works
PEGylated Peptide Dendrimeric Carriers for the Delivery of Antimalarial Drug Chloroquine Phosphate
Bhadra, D., Bhadra, S., & Jain, N. K. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-9396-9 · Cited by 102 · see citing works
Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes
Goldberg, D. E., & Cowman, A. F. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2420 · Cited by 99 · see citing works
Singh, K., Gittis, A. G., Nguyen, P., Gowda, D. C., Miller, L. H., & Garboczi, D. N. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1479 · Cited by 99 · see citing works
Adhesion of malaria-infected red blood cells to chondroitin sulfate A under flow conditions
Cooke, B., Rogerson, S. J., Brown, G. V., et al. (1996) · Blood · doi:10.1182/blood.v88.10.4040.bloodjournal88104040 · Cited by 96 · see citing works
Antimalarial chemotherapy: young guns or back to the future?
Biagini, G. A., O’Neill, P. M., Nzila, A. M., et al. (2003) · Trends in Parasitology · doi:10.1016/j.pt.2003.09.011 · Cited by 96 · see citing works
Barragán, A., Fernandez, V., Chen, Q., von Euler, A., Wahlgren, M., & Spillmann, D. (2000) · Blood · doi:10.1182/blood.v95.11.3594.011k21_3594_3599 · Cited by 95 · see citing works
Uninfected Erythrocytes form “Rosettes” Around Plasmodium Falciparum Infected Erythrocytes
Handunnetti, S. M., David, P. H., Perera, K. L., et al. (1989) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1989.40.115 · Cited by 95 · see citing works
Complications of Falciparum Malaria and Their Treatment
Sheehy, T. W., & Reba, R. C. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-66-4-807 · Cited by 94 · see citing works
Ancsin, J. B., & Kisilevsky, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401979200 · Cited by 92 · see citing works
A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue
Tanaka, T. Q., & Williamson, K. C. (2011) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2011.02.005 · Cited by 92 · see citing works
Newman, D. M., Heptinstall, J., Matelon, R. J., Savage, L., Wears, M. L., Beddow, J., Cox, M. J., Schallig, H. D. F. H., & Mens, P. F. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.128140 · Cited by 90 · see citing works
Urbán, P., Estelrich, J., Cortés, A., & Fernàndez-Busquets, X. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.001 · Cited by 90 · see citing works
Carlson, J., Ekre, H. P., Helmby, H., et al. (1992) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1992.46.595 · Cited by 89 · see citing works
Bronzan, R. N., McMorrow, M., & Kachur, S. P. (2008) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256295 · Cited by 86 · see citing works
Looareesuwan, S., Wilairatana, P., Chalermarut, K., et al. (1999) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1999.60.526 · Cited by 85 · see citing works
Juul, S., Nielsen, C. J. F., Labouriau, R., Roy, A., Tesauro, C., Jensen, P. W., Harmsen, C., Kristoffersen, E. L., Chiu, Y., Frøhlich, R. F., et al. (2012) · ACS Nano · doi:10.1021/nn3038594 · Cited by 85 · see citing works
Affinity-Matured Recombinant Antibody Fragments Analyzed by Single-Molecule Force Spectroscopy
Morfill, J., Blank, K. G., Zahnd, C., et al. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.112532 · Cited by 85 · see citing works
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria
Amukoye, E., Winstanley, P., Watkins, W. M., et al. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.10.2261 · Cited by 85 · see citing works
Pérez‐Jiménez, R., Li, J., Kosuri, P., Sánchez-Romero, I., Wiita, A. P., Rodríguez‐Larrea, D., Chueca, A., Holmgren, A., Miranda‐Vizuete, A., Becker, K., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1627 · Cited by 84 · see citing works
Characterization of macromolecular transport pathways in malaria-infected erythrocytes
Goodyer, I. D., Pouvelle, B., Schneider, T. G., et al. (1997) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(97)00039-x · Cited by 83 · see citing works
Curcumin treatment provides protection against Trypanosoma cruzi infection
Nagajyothi, F., Zhao, D., Weiss, L. M., & Tanowitz, H. B. (2012) · Parasitology Research · doi:10.1007/s00436-011-2790-9 · Cited by 83 · see citing works
Malaria eradication: the economic, financial and institutional challenge
Mills, A., Lubell, Y., & Hanson, K. (2008) · Malaria Journal · doi:10.1186/1475-2875-7-s1-s11 · Cited by 83 · see citing works
The contributions of Paul Ehrlich to infectious disease
Gensini, G. F., Conti, A. A., & Lippi, D. (2006) · Journal of Infection · doi:10.1016/j.jinf.2004.05.022 · Cited by 82 · see citing works
Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome
Lal, K., Prieto, J. H., Bromley, E., et al. (2009) · PROTEOMICS · doi:10.1002/pmic.200800404 · Cited by 80 · see citing works
INTRAVASCULAR COAGULATION IN FALCIPARUM MALARIA
Jaroonvesama, N. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90621-6 · Cited by 80 · see citing works
Eubanks, L. M., & Poulter, C. D. (2003) · Biochemistry · doi:10.1021/bi0205303 · Cited by 80 · see citing works
Longmuir, K. J., Robertson, R. T., Haynes, S. M., Baratta, J. L., & Waring, A. J. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9609-x · Cited by 79 · see citing works
Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal
Rodrigues, T., Prudêncio, M., Moreira, R., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm201095h · Cited by 78 · see citing works
Chimanuka, B., Gabriëls, M., Detaevernier, M. R., & Plaizier-vercammen, J. A. (2002) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(01)00611-2 · Cited by 77 · see citing works
Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base
Bouchaud, O., Imbert, P., Touze, J. E., et al. (2009) · Malaria Journal · doi:10.1186/1475-2875-8-289 · Cited by 76 · see citing works
Roos, J. M., Aubry, M.-C., & Edwards, W. D. (2002) · Cardiovascular Pathology · doi:10.1016/s1054-8807(02)00118-7 · Cited by 76 · see citing works
Pegylated lysine based copolymeric dendritic micelles for solubilization and delivery of artemether.
Bhadra, D., Bhadra, S., & Jain, N. K. (2005) · PubMed · Cited by 72 · see citing works
Low Anticoagulant Heparin Disrupts Plasmodium falciparum Rosettes in Fresh Clinical Isolates
Leitgeb, A. M., Blomqvist, K., Cho‐Ngwa, F., Samje, M., Nde, P. F., Titanji, V., & Wahlgren, M. (2011) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2011.10-0256 · Cited by 72 · see citing works
Physical and chemical evaluation of liposomes, containing artesunate
Gabriëls, M. (2003) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(02)00678-7 · Cited by 71 · see citing works
Sinden, R. E., Carter, R., DRAKELEY, C. J., et al. (2012) · Malaria Journal · doi:10.1186/1475-2875-11-70 · Cited by 71 · see citing works
Solid microemulsion preconcentrate (NanOsorb) of artemether for effective treatment of malaria
Joshi, M., Pathak, S., Sharma, S., & Patravale, V. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.06.012 · Cited by 71 · see citing works
A direct method for the formation of peptide and carbohydrate dendrimers
Mitchell, J. P., Roberts, K. D., Langley, J., et al. (1999) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(99)00480-1 · Cited by 69 · see citing works
Antimalarial Drug Therapy: The Role of Parasite Biology and Drug Resistance
Daily, J. P. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006294276 · Cited by 69 · see citing works
Nash, G. B., Cooke, B., Marsh, K., et al. (1992) · Blood · doi:10.1182/blood.v79.3.798.798 · Cited by 69 · see citing works
Rathore, D., McCutchan, T. F., Garboczi, D. N., et al. (2001) · Biochemistry · doi:10.1021/bi0105476 · Cited by 68 · see citing works
Acosta, C. J., Galindo, C. M., Schellenberg, D. M., et al. (1999) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1999.00406.x · Cited by 67 · see citing works
Cellular architecture of Plasmodium falciparum-infected erythrocytes
Hanssen, E. G., McMillan, P. J., & Tilley, L. M. (2010) · International Journal for Parasitology · doi:10.1016/j.ijpara.2010.04.012 · Cited by 66 · see citing works
Quinine with Tetracycline for the Treatment of Drug-Resistant Falciparum Malaria in Thailand
Watt, G., Loesuttivibool, L., Shanks, G. D., et al. (1992) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1992.47.108 · Cited by 66 · see citing works
Andriantsoanirina, V., Ratsimbasoa, A. C., Bouchier, C., et al. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00610-09 · Cited by 66 · see citing works
Drug-resistant malaria—Occurrence, control and surveillance
Wernsdorfer, W. H., & Kouznetsov, R. L. (1982) · Journal of Infection · doi:10.1016/s0163-4453(82)92626-3 · Cited by 65 · see citing works
Alin, M. H., Ashton, M., Kihamia, C. M., et al. (1996) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1996.35116.x · Cited by 65 · see citing works
Strategies to reverse drug resistance in malaria
Egan, T. J., & Kaschula, C. H. (2007) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3282f1673a · Cited by 65 · see citing works
Channels and transporters as drug targets in the Plasmodium-infected erythrocyte
Kirk, K. (2003) · Acta Tropica · doi:10.1016/j.actatropica.2003.10.002 · Cited by 65 · see citing works
Peatey, C. L., Spicer, T., Hodder, P., et al. (2011) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2011.09.002 · Cited by 64 · see citing works
A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines
Delves, M. J., Ramakrishnan, C., Blagborough, A. M., et al. (2012) · International Journal for Parasitology · doi:10.1016/j.ijpara.2012.08.009 · Cited by 64 · see citing works
Drug resistant falciparum malaria: clinical consequences and strategies for prevention
Price, R. N., & Nosten, F. H. (2001) · Drug Resistance Updates · doi:10.1054/drup.2001.0195 · Cited by 64 · see citing works
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Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
Marques, J., Valle-Delgado, J. J., Urbán, P., Baró, E., Prohens, R., Mayor, A., Cisteró, P., Delves, M., Sinden, R. E., Grandfils, C., et al. (2017) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2016.09.010 · Cited by 64 · see citing works
- Authors
- Urban, P., & Fernandez-Busquets, X.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2014-01-31
- Volume
- 21
- Issue
- 5
- Pages
- 605-629
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2325546659
- Cited by
- 39
- References
- 313
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 3
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- malaria, Plasmodium, nanomedicine, targeted drug delivery, nanocapsules, antimalarial drugs, single-molecule manipulation, drug discovery, malaria diagnosis, microfluidics, parasite developmental stages, developing countries
- MeSH terms
- Amino Alcohols, Antimalarials, Drug Carriers, Humans, Malaria, Plasmodium, Quinolines, Drug Design, Dendrimers, Nanomedicine
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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