Cited by 39Malaria Research and ControlNanoparticle-Based Drug DeliveryPharmacology and Nanomedicine Research

Nanomedicine Against Malaria

Urban, Patricia, Fernandez-Busquets, Xavier·2014·Current Medicinal Chemistry

Abstract

Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium sp. The clinical, social and economic burden of malaria has led for the last 100 years to several waves of serious efforts to reach its control and eventual eradication, without success to this day. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial drugs exclusively to Plasmodium-infected cells. Different types of encapsulating structure, targeting molecule, and antimalarial compound will be discussed for the assembly of Trojan horse nanocapsules capable of targeting with complete specificity diseased cells and of delivering inside them their antimalarial cargo with the objective of eliminating the parasite with a single dose. Nanotechnology can also be applied to the discovery of new antimalarials through single-molecule manipulation approaches for the identification of novel drugs targeting essential molecular components of the parasite. Finally, methods for the diagnosis of malaria can benefit from nanotools applied to the design of microfluidic-based devices for the accurate identification of the parasite's strain, its precise infective load, and the relative content of the different stages of its life cycle, whose knowledge is essential for the administration of adequate therapies. The benefits and drawbacks of these nanosystems will be considered in different possible scenarios, including cost-related issues that might be hampering the development of nanotechnology-based medicines against malaria with the dubious argument that they are too expensive to be used in developing areas.

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Crossref · 10.2174/09298673113206660292

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313 of 313 references verified0 citation errors · 0 not checkable

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  • Blood stage parasites are the main therapeutic target, and researchers are developing various approaches to target antimalarials to infected RBCs.

    “Given that blood stage parasites are the main therapeutic target, researchers are developing various approaches to target antimalarials to infected RBCs 105-107 , thereby maximizing their therapeutic window.”

    From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [107]

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Authors
Urban, P., & Fernandez-Busquets, X.
Venue
Current Medicinal Chemistry
Published
2014-01-31
Volume
21
Issue
5
Pages
605-629
ISSN
0929-8673 (ISSN-L)
OpenAlex
W2325546659
Cited by
39
References
313
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 3
FWCI
4.29
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
Keywords
malaria, Plasmodium, nanomedicine, targeted drug delivery, nanocapsules, antimalarial drugs, single-molecule manipulation, drug discovery, malaria diagnosis, microfluidics, parasite developmental stages, developing countries
MeSH terms
Amino Alcohols, Antimalarials, Drug Carriers, Humans, Malaria, Plasmodium, Quinolines, Drug Design, Dendrimers, Nanomedicine

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