Cited by 116Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsProteins in Food Systems

The DOI matches its Crossref record; 98 of the 102 references it cites were found in a registry or an index.

Oral delivery of peptides and proteins using lipid-based drug delivery systems

Li, Ping, Nielsen, Hanne Mørck, Müllertz, Anette·2012·Expert Opinion on Drug Delivery

DOI 10.1517/17425247.2012.717068

Open this paper in CoChat — free account

Abstract

INTRODUCTION: In order to successfully develop lipid-based drug delivery systems (DDS) for oral administration of peptides and proteins, it is important to gain an understanding of the colloid structures formed by these DDS, the mode of peptide and protein incorporation as well as the mechanism by which intestinal absorption of peptides and proteins is promoted. AREAS COVERED: The present paper reviews the literature on lipid-based DDS, employed for oral delivery of peptides and proteins and highlights the mechanisms by which the different lipid-based carriers are expected to overcome the two most important barriers (extensive enzymatic degradation and poor transmucosal permeability). This paper also gives a clear-cut idea about advantages and drawbacks of using different lipidic colloidal carriers ((micro)emulsions, solid lipid core particles and liposomes) for oral delivery of peptides and proteins. EXPERT OPINION: Lipid-based DDS are safe and suitable for oral delivery of peptides and proteins. Significant progress has been made in this area with several technologies on clinical trials. However, a better understanding of the mechanism of action in vivo is needed in order to improve the design and development of lipid-based DDS with the desired bioavailability and therapeutic profile.

Integrity signals

Registry

Crossref · 10.1517/17425247.2012.717068

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art
MÃ¼ller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,836
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Lai, S. K., Wang, Y.-Y., & Hanes, J. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,863
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems
Pouton, C. W. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00167-6 · Cited by 1,232
Solid lipid nanoparticles as a drug delivery system for peptides and proteins☆
Almeida, A. J., & Souto, E. B. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.007 · Cited by 817
Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects
Constantinides, P. P. (1995) · Pharmaceutical Research · doi:10.1023/a:1016268311867 · Cited by 751
Oral drug absorption enhancement by chitosan and its derivatives
Thanou, M., Verhoef, J. C., & Junginger, H. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00231-9 · Cited by 705
Cubic phase gels as drug delivery systems
Shah, J. C. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00108-9 · Cited by 626
Nutritional and Functional Characteristics of Whey Proteins in Food Products
de Wit, J. N. (1998) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(98)75613-9 · Cited by 565
Mucoadhesive nanoparticulate systems for peptide drug delivery
洋文, 竹., Yamamoto, H., & Kawashima, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00120-4 · Cited by 500
Mucoadhesive nanoparticulate systems for peptide drug delivery.
Takéuchi, Hirofumi, Yamamoto, Y., Hiromitsu, Kawashima, & Yoshiaki (2002) · 岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy · Cited by 432
Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery
Tan, M. L., Choong, P. F. M., & Dass, C. R. (2010) · Peptides · doi:10.1016/j.peptides.2009.10.002 · Cited by 350
Transmucosal macromolecular drug delivery
Prego, C., García-Fuentes, M., Torres, D., & Alonso, M. J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.030 · Cited by 345
Microemulsions as carriers for drugs and nutraceuticals
Spernath, A., & Aserin, A. (2006) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2006.11.016 · Cited by 329
The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins
Bernkop‐Schnürch, A. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00204-6 · Cited by 310
Absorption Enhancers: Applications and Advances
Aungst, B. J. (2011) · The AAPS Journal · doi:10.1208/s12248-011-9307-4 · Cited by 309
New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs
Müllertz, A., Ogbonna, A., Ren, S., & Rades, T. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01107.x · Cited by 301
Self-citation
Oral insulin delivery by means of solid lipid nanoparticles.
Sarmento, B. F. C. C., Martins, S., Ferreira, D., & Souto, E. B. (2007) · PubMed Central · Cited by 299
In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin
Pardakhty, A., Varshosaz, J., & Rouholamini, A. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.002 · Cited by 292
Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin
Zhang, N., Ping, Q. N., Huang, G., Xu, W., Cheng, Y., & Han, X. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.07.026 · Cited by 286
Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: Preparation and characterization
LIU, J., Gong, T., Wang, C. C., Zhong, Z., & ZHANG, Z. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.03.009 · Cited by 282
Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules
García-Fuentes, M., Torres, D., & Alonso, M. J. (2002) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(02)00053-x · Cited by 272
Oral protein delivery: Current status and future prospect
Park, K., Kwon, I. C., & Park, K. (2010) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2010.10.002 · Cited by 266
A classification of biologic lipids based upon their interaction in aqueous systems
SMALL, D. M. (1968) · Journal of the American Oil Chemists Society · doi:10.1007/bf02915334 · Cited by 256
Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies
Pauletti, G. M. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00045-8 · Cited by 234
Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic
Maher, S., Leonard, T. W., Jacobsen, J. B., & Brayden, D. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.09.006 · Cited by 231
The Influence of Peptide Structure on Transport Across Caco-2 Cells
Conradi, R. A., Hilgers, A. R., Ho, N. F. H., & Burton, P. S. (1991) · Pharmaceutical Research · doi:10.1023/a:1015825912542 · Cited by 228
Permeation enhancer effect of chitosan and chitosan derivatives: Comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells
Sadeghi, A. M. M., Dorkoosh, F. A., Avadi, M. R., Weinhold, M. X., BAYAT, A., Delié, F., Gurny, R., Larijani, B. A., Rafiee‐Tehrani, M., & Junginger, H. E. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.03.004 · Cited by 223
Polymers and nanoparticles: Intelligent tools for intracellular targeting?
Breunig, M., Bauer, S., & Göpferich, A. M. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.06.010 · Cited by 216
Cell-penetrating peptides for drug delivery across membrane barriers
Foged, C., & Nielsen, H. M. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.1.105 · Cited by 212
Self-citation
Paracellular Diffusion in Caco-2 Cell Monolayers: Effect of Perturbation on the Transport of Hydrophilic Compounds That Vary in Charge and Size
Knipp, G. T., Ho, N. F. H., Barsuhn, C. L., & Borchardt, R. T. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js9700309 · Cited by 208
Structural requirements for intestinal absorption of peptide drugs
Pauletti, G. M., Gangwar, S., Knipp, G. T., Nerurkar, M. M., Okumu, F. W., Tamura, K., Siahaan, T. J., & Borchardt, R. T. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(96)01352-1 · Cited by 199
Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters
Almeida, A. J., Runge, S., & Müller, R. H. (1997) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)04885-0 · Cited by 193
Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs
Takeuchi, H., Matsui, Y., Sugihara, H., Yamamoto, H., & Kawashimà, Y. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.06.028 · Cited by 191
Oral particulate delivery: status and future trends
Chen, H. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00047-7 · Cited by 181
Devices based on intelligent biopolymers for oral protein delivery
Peppas, N. A. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.03.001 · Cited by 174
Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs
Rao, S. V. R., & Shao, J. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.05.018 · Cited by 172
The challenge of proteolytic enzymes in intestinal peptide delivery
Langguth, P., Bohner, V., Heizmann, J., Merkle, H. P., Wolffram, S., Amidon, G. L., & Yamashita, S. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(96)01586-6 · Cited by 171
A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery
García-Fuentes, M., Prego, C., Torres, D., & Alonso, M. J. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.02.008 · Cited by 170
Preparation and characterization of solid lipid nanoparticles containing peptide
Hu, F. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.12.016 · Cited by 168
Investigation of lectin-modified insulin liposomes as carriers for oral administration
Zhang, N., Ping, Q. N., Huang, G., & Xu, W. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.01.018 · Cited by 162
Novel Delivery Technologies for Protein and Peptide Therapeutics
Kumar, T. S., Soppimath, K. S., & Nachaegari, S. (2006) · Current Pharmaceutical Biotechnology · doi:10.2174/138920106777950852 · Cited by 161
Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin–liposome nanocomplexes
Thirawong, N., Thongborisute, J., Takeuchi, H., & Sriamornsak, P. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.023 · Cited by 155
(B) Mechanisms of peptide and protein absorption
Nellans, H. N. (1991) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(91)90013-3 · Cited by 153
Application of surface‐coated liposomes for oral delivery of peptide: Effects of coating the liposome's surface on the GI transit of insulin
Iwanaga, K., Ono, S., Narioka, K., Kakemi, M., Morimoto, K., Yamashita, S., Namba, Y., & Oku, N. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js980235x · Cited by 153
Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
Delié, F., & Blanco‐Prieto, M. J. (2005) · Molecules · doi:10.3390/10010065 · Cited by 150
Microemulsions for oral delivery of insulin: Design, development and evaluation in streptozotocin induced diabetic rats
Sharma, G., Wilson, K., van der Walle, C. F., Sattar, N. A., Petrie, J. R., & Kumar, M. N. V. R. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.07.002 · Cited by 140
Nanoparticle strategies for the oral delivery of insulin
Damgé, C., Reis, C. P., & Maincent, P. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.1.45 · Cited by 136
Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET™
Leonard, T. W., Lynch, J. J., McKenna, M. J., & Brayden, D. J. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.5.685 · Cited by 135
Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs
Cheng, J., Teply, B. A., Jeong, S. Y., Yim, C. H., Ho, D. C., Sherifi, I., Jon, S., Farokhzad, O. C., Khademhosseini, A., & Langer, R. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-9444-5 · Cited by 134
Structural Development of Self Nano Emulsifying Drug Delivery Systems (SNEDDS) During In Vitro Lipid Digestion Monitored by Small-angle X-ray Scattering
Fatouros, D. G., Deen, G. R., Arleth, L., Bergenståhl, B., Nielsen, F. S., Pedersen, J. S., & Müllertz, A. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9304-6 · Cited by 132
Self-citation
In Vitro and in Vivo Evaluation of Mucoadhesive Microspheres Prepared for the Gastrointestinal Tract Using Polyglycerol Esters of Fatty Acids and a Poly(acrylic acid) Derivative
Akiyama, Y., Nagahara, N., Kashihara, T., Hirai, S., & Toguchi, H. (1995) · Pharmaceutical Research · doi:10.1023/a:1016208703380 · Cited by 130
Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins
Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. M. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.515584 · Cited by 130
Thymopentin in solid lipid nanoparticles
Morel, S., Ugazio, E., Cavalli, R., & Gasco, M. R. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)04388-8 · Cited by 123
Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides
Couvreur, P., Blanco‐Prieto, M. J., Puisieux, F., Roques, B. P., & Fattal, E. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00052-5 · Cited by 119
Effect of chitosan coating in overcoming the phagocytosis of insulin loaded solid lipid nanoparticles by mononuclear phagocyte system
Sarmento, B. F. C. C., Mazzaglia, D., Bonferoni, M. C., Neto, A. P., Monteiro, M. D. C., & Seabra, V. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.12.042 · Cited by 115
Bioadhesive polymeric platforms for transmucosal drug delivery systems – a review
Roy, S., & Prabhakar, B. R. (2010) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v9i1.52043 · Cited by 110
Chemical Stability of Nucleic Acid–Derived Drugs
Pogocki, D., & Schöneich, C. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/(sici)1520-6017(200004)89:4 · Cited by 100
Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion–diffusion technique
Trotta, M., Cavalli, R., Carlotti, M. E., Battaglia, L., & Debernardi, F. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.10.014 · Cited by 99
An enteric-coated dry emulsion formulation for oral insulin delivery
Toorisaka, E., Hashida, M., Kamiya, N., Ono, H., Kokazu, Y., & Goto, M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.05.022 · Cited by 98
Microencapsulation of protein particles within lipids using a novel supercritical fluid process
Santos, I. R. D., Richard, J., Pech, B., Thies, C., & Benoît, J. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00149-7 · Cited by 96
Cubic Phases as Delivery Systems for Peptide Drugs
Ericsson, B., Eriksson, P. O., Löfroth, J., & Engström, S. (1991) · ACS symposium series · doi:10.1021/bk-1991-0469.ch022 · Cited by 93
Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion
Toorisaka, E. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00674-9 · Cited by 92
Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment
Langkjær, L., Brange, J., Grodsky, G. M., & Guy, R. H. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00155-7 · Cited by 86
Oral Protein Drug Delivery
Wang, W. (1996) · Journal of drug targeting · doi:10.3109/10611869608995624 · Cited by 85
Oral peptide and protein delivery: unfulfilled promises?
Shen, W. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02692-8 · Cited by 83
Investigation of archaeosomes as carriers for oral delivery of peptides
Li, Z., Chen, J., Sun, W., & Xu, Y. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.041 · Cited by 82
Oral Colon-Specific Drug Delivery of Protein and Peptide Drugs
Sinha, V. R., Singh, A., Kumar, R. V., Singh, S. K., Kumria, R., & Bhinge, J. R. (2007) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v24.i1.30 · Cited by 79
Prodrugs of Peptides and Proteins for Improved Formulation and Delivery
Oliyai, R., & Stella, V. J. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.002513 · Cited by 79
Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
Cheng, M.-B., Wang, J., Li, Y., Liu, X.-Y., Zhang, X., Chen, D., Zhou, S., & Zhang, Q. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.03.018 · Cited by 76
Cubic liquid crystalline glyceryl monooleate matrices for oral delivery of enzyme
Shah, M. H., & Paradkar, A. R. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.01.019 · Cited by 72
Enhanced oral absorption of insulin from desolvated fatty acid-sodium glycocholate emulsions
Mesiha, M. S., Plakogiannis, F. M., & Vejosoth, S. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90343-3 · Cited by 67
The effect of particle structure of chitosan-coated liposomes and type of chitosan on oral delivery of calcitonin
Thongborisute, J., Tsuruta, A., Kawabata, Y., & Takeuchi, H. (2006) · Journal of drug targeting · doi:10.1080/10611860600648346 · Cited by 67
Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats
Liu, H., Tang, R., Pan, W., Zhang, Y., & Liu, H. (2003) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022052 · Cited by 65
In-vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion
Watnasirichaikul, S., Rades, T., Tucker, I. G., & Davies, N. M. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021778736 · Cited by 64
Reversible Increase in Tight Junction Permeability to Macromolecules in Rat Ileal Mucosa In Vitro by Sodium Caprate, a Constituent of Milk Fat
Söderholm, J. D., Öman, H., Blomquist, L., Veen, J., Lindmark, T., & Olaison, G. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018823100761 · Cited by 60
Pathway of Oral Absorption of Heparin with Sodium N-[8-(2-Hydroxybenzoyl)Amino]Caprylate
Malkov, D., Wang, H., Dinh, S. M., & Gómez-Orellana, I. (2002) · Pharmaceutical Research · doi:10.1023/a:1019802310702 · Cited by 48
Biopharmaceutical characterisation of insulin and recombinant human growth hormone loaded lipid submicron particles produced by supercritical gas micro-atomisation
Salmaso, S., Bersani, S., Elvassore, N., Bertucco, A., & Caliceti, P. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.014 · Cited by 45
In vitro and in vivo evaluation of a novel oral insulin formulation
Erli, M., Ma, H., Zheng, L. I. U., Zheng, C., & Duan, M. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00424.x · Cited by 45
Oral multiple w/o/w emulsion formulation of a peptide salmon calcitonin: in vitro-in vivo evaluation
Dogru, S. T., Çalış, S., & Öner, F. (2000) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2000.00306.x · Cited by 41
BILE SALTS—THEIR PHYSIOLOGICAL FUNCTIONS IN THE GASTROINTESTINAL TRACT
Borgström, B. (1974) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1974.tb00958.x · Cited by 40
Lyophilization of water-in-oil emulsions to prepare phospholipid-based anhydrous reverse micelles for oral peptide delivery
Wang, T., Wang, N., Hao, A., He, X., Li, T., & Deng, Y. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.01.006 · Cited by 40
Double Liposomes: Hypoglycemic Effects of Liposomal Insulin on Normal Rats
Katayama, K., Katō, Y., Onishi, H., Nagai, T., & Machida, Y. (2003) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120021771 · Cited by 40
Enhancement of nasal and intestinal calcitonin delivery by the novel Pheroid™ fatty acid based delivery system, and by N-trimethyl chitosan chloride
Plessis, D., Lubbe, J. J. P., Strauss, T., & Kotzé, A. F. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.10.031 · Cited by 39
N-Trimethyl chitosan-coated multivesicular liposomes for oxymatrine oral delivery
Cao, J., Sun, J., Wang, X., Li, X., & Deng, Y. (2009) · Drug Development and Industrial Pharmacy · doi:10.3109/03639040902902427 · Cited by 37
Solubilisation of hydrophilic drugs in oily formulations
New, R. R. C., & Kirby, C. J. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00491-7 · Cited by 36
Freeze- or spray-dried gluten hydrolysates. 1. Biochemical and emulsifying properties as a function of drying process
Linarès, E., Larré, C., & Popineau, Y. (2001) · Journal of Food Engineering · doi:10.1016/s0260-8774(00)00148-5 · Cited by 35
Absorption enhancement of calcitonin in the rat intestine by carbopol-containing submicron emulsions
Baluom, M. (1997) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)00140-3 · Cited by 34
Oil-based formulations for oral delivery of insulin
Li, C., & Deng, Y. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357044175 · Cited by 34
A spin labelling study of immunomodulating peptidoglycan monomer and adamantyltripeptides entrapped into liposomes
Frkanec, R., Noethig‐Laslo, V., Vranešić, B., Mirosavljević, K., & Tomašić, J. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00054-3 · Cited by 32
Design of Redispersible Dry Emulsion as an Advanced Dosage Form of Oily Drug (Vitamin E Nicotinate) by Spray-Drying Technique
Takeuchi, H., SASAKI, H., Niwa, T., Hino, T., Kawashimà, Y., Uesugi, K., & Ozawa, H. (1992) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049209069307 · Cited by 31
Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: Development, characterization and interaction with leuprolide
Carafa, M., Marianecci, C., Annibaldi, V., Stefano, A. D., Sozio, P., & Santucci, E. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.06.040 · Cited by 27
Preparation and characterization of a peptide containing w/o emulsion
Trenktrog, T. (1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)00057-p · Cited by 20
Multivesicular liposomes for oral delivery of recombinant human epidermal growth factor
Li, H., An, J. H., Park, J., & Han, K. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02973888 · Cited by 20
Absorption of Calcitonin in Oral and Pulmonary Administration with Polymer-coated Liposomes
Takeuchi, H., & Sugihara, H. (2010) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.130.1135 · Cited by 17
Freeze- or spray-dried gluten hydrolysates. 2.
Linarès, E., Larré, C., & Popineau, Y. (2001) · Journal of Food Engineering · doi:10.1016/s0260-8774(00)00149-7 · Cited by 14
Incorporation in lipospheres of [D-Trp-6]LHRH
(1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(95)90676-x · Cited by 7

Flagged first, then by citations

4 of the 102 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

Legrand P, 1999, Stp Pharma Sci, 9, 411
Sarmento B, 2007, Int J Nanomed, 2, 743
Lee JH, 2008, J Tisuue Eng Regen Med, 5, 215
10.1046/j.1365-2710.2000.00306.x · DOI
Cavalli R, 1999, Stp Pharma Sci, 9, 183
10.1016/j.ijpharm.2005.06.028 · DOI
10.1080/10611860600648346 · DOI

Sorted by citations

Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo
Kumar, P., Kizhakkedathu, J. N., & Straus, S. K. (2018) · Biomolecules · doi:10.3390/biom8010004 · Cited by 1,233
Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
Zhu, Q., Chen, Z., Paul, P. K., Lü, Y., Wu, W., & Qi, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.04.001 · Cited by 366
Promises and Pitfalls of Intracellular Delivery of Proteins
Fu, A., Tang, R., Hardie, J. M., Farkas, M. E., & Rotello, V. M. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500320j · Cited by 309
Peptide design for antimicrobial and immunomodulatory applications
Haney, E. F., & Hancock, R. E. W. (2013) · Biopolymers · doi:10.1002/bip.22250 · Cited by 297
Micro and nanoscale technologies in oral drug delivery
Ahadian, S., Finbloom, J. A., Mofidfar, M., Diltemiz, S. E., Nasrollahi, F., Davoodi, E., Hosseini, V., Mylonaki, I., Sangabathuni, S., Montazerian, H., et al. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.012 · Cited by 280

See all 116

Authors: Li, P., Nielsen, H. M., & Müllertz, A.
Affiliations: University of Copenhagen (DK)
ORCID: Li, Ping
Nielsen, Hanne Mørck
Müllertz, Anette
Venue: Expert Opinion on Drug Delivery
Publisher: Informa Healthcare
Published: 2012-08-17
Volume: 9
Issue: 10
Pages: 1289-1304
ISSN: 1742-5247 (ISSN-L)
1744-7593
DOI: 10.1517/17425247.2012.717068
OpenAlex: W2049764487
Cited by: 116
References: 102
Citations by year: 2026: 4 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 14 · 2013: 9
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Drug Delivery (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Mokslo, Inovaciju ir Technologiju Agentura
Danish Agency for Science and Higher Education
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Keywords: oral drug delivery, peptides, proteins, lipid-based drug delivery, microemulsions, liposomes, enzymatic degradation, intestinal absorption, bioavailability
MeSH terms: Administration, Oral, Animals, Biological Availability, Drug Carriers, Emulsions, Humans, Intestinal Absorption, Lipids, Liposomes, Peptides, Permeability, Proteins, Drug Delivery Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oral delivery of peptides and proteins using lipid-based drug delivery systems

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks