The DOI matches its Crossref record; 98 of the 102 references it cites were found in a registry or an index.
Oral delivery of peptides and proteins using lipid-based drug delivery systems
Abstract
INTRODUCTION: In order to successfully develop lipid-based drug delivery systems (DDS) for oral administration of peptides and proteins, it is important to gain an understanding of the colloid structures formed by these DDS, the mode of peptide and protein incorporation as well as the mechanism by which intestinal absorption of peptides and proteins is promoted. AREAS COVERED: The present paper reviews the literature on lipid-based DDS, employed for oral delivery of peptides and proteins and highlights the mechanisms by which the different lipid-based carriers are expected to overcome the two most important barriers (extensive enzymatic degradation and poor transmucosal permeability). This paper also gives a clear-cut idea about advantages and drawbacks of using different lipidic colloidal carriers ((micro)emulsions, solid lipid core particles and liposomes) for oral delivery of peptides and proteins. EXPERT OPINION: Lipid-based DDS are safe and suitable for oral delivery of peptides and proteins. Significant progress has been made in this area with several technologies on clinical trials. However, a better understanding of the mechanism of action in vivo is needed in order to improve the design and development of lipid-based DDS with the desired bioavailability and therapeutic profile.
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“Copper-peptides can be also taken orally as a dietary supplement in liposomal form [51].”
From Skin Regenerative and Anti-Cancer Actions of Copper Peptides (2018) · cites this paper as [51]
Citations
Cites
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Solid lipid nanoparticles as a drug delivery system for peptides and proteins☆
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Kumar, P., Kizhakkedathu, J. N., & Straus, S. K. (2018) · Biomolecules · doi:10.3390/biom8010004 · Cited by 1,233
Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
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Promises and Pitfalls of Intracellular Delivery of Proteins
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Peptide design for antimicrobial and immunomodulatory applications
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Micro and nanoscale technologies in oral drug delivery
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Metadata
- Authors
- Li, P., Nielsen, H. M., & Müllertz, A.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2012-08-17
- Volume
- 9
- Issue
- 10
- Pages
- 1289-1304
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2049764487
- Cited by
- 116
- References
- 102
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 14 · 2013: 9
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Mokslo, Inovaciju ir Technologiju Agentura
- Danish Agency for Science and Higher Education
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- oral drug delivery, peptides, proteins, lipid-based drug delivery, microemulsions, liposomes, enzymatic degradation, intestinal absorption, bioavailability
- MeSH terms
- Administration, Oral, Animals, Biological Availability, Drug Carriers, Emulsions, Humans, Intestinal Absorption, Lipids, Liposomes, Peptides, Permeability, Proteins, Drug Delivery Systems
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