Cited by 116Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsProteins in Food Systems

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Oral delivery of peptides and proteins using lipid-based drug delivery systems

Li, Ping, Nielsen, Hanne Mørck, Müllertz, Anette·2012·Expert Opinion on Drug Delivery

DOI 10.1517/17425247.2012.717068

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Abstract

INTRODUCTION: In order to successfully develop lipid-based drug delivery systems (DDS) for oral administration of peptides and proteins, it is important to gain an understanding of the colloid structures formed by these DDS, the mode of peptide and protein incorporation as well as the mechanism by which intestinal absorption of peptides and proteins is promoted. AREAS COVERED: The present paper reviews the literature on lipid-based DDS, employed for oral delivery of peptides and proteins and highlights the mechanisms by which the different lipid-based carriers are expected to overcome the two most important barriers (extensive enzymatic degradation and poor transmucosal permeability). This paper also gives a clear-cut idea about advantages and drawbacks of using different lipidic colloidal carriers ((micro)emulsions, solid lipid core particles and liposomes) for oral delivery of peptides and proteins. EXPERT OPINION: Lipid-based DDS are safe and suitable for oral delivery of peptides and proteins. Significant progress has been made in this area with several technologies on clinical trials. However, a better understanding of the mechanism of action in vivo is needed in order to improve the design and development of lipid-based DDS with the desired bioavailability and therapeutic profile.

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Authors: Li, P., Nielsen, H. M., & Müllertz, A.
Affiliations: University of Copenhagen (DK)
ORCID: Li, Ping
Nielsen, Hanne Mørck
Müllertz, Anette
Venue: Expert Opinion on Drug Delivery
Publisher: Informa Healthcare
Published: 2012-08-17
Volume: 9
Issue: 10
Pages: 1289-1304
ISSN: 1742-5247 (ISSN-L)
1744-7593
DOI: 10.1517/17425247.2012.717068
OpenAlex: W2049764487
Cited by: 116
References: 102
Citations by year: 2026: 4 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 14 · 2013: 9
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Drug Delivery (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Mokslo, Inovaciju ir Technologiju Agentura
Danish Agency for Science and Higher Education
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Keywords: oral drug delivery, peptides, proteins, lipid-based drug delivery, microemulsions, liposomes, enzymatic degradation, intestinal absorption, bioavailability
MeSH terms: Administration, Oral, Animals, Biological Availability, Drug Carriers, Emulsions, Humans, Intestinal Absorption, Lipids, Liposomes, Peptides, Permeability, Proteins, Drug Delivery Systems

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Oral delivery of peptides and proteins using lipid-based drug delivery systems

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