The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The role of microneedles for drug and vaccine delivery
Abstract
INTRODUCTION: Transdermal drug delivery offers a number of advantages for the patient, not only due to its non-invasive and convenient nature, but also due to factors such as avoidance of first-pass metabolism and prevention of gastrointestinal degradation. It has been demonstrated that microneedles (MNs) can increase the number of compounds amenable to transdermal delivery by penetrating the skin's protective barrier, the stratum corneum, and creating a pathway for drug permeation to the dermal tissue below. AREAS COVERED: MNs have been extensively investigated for drug and vaccine delivery. The different types of MN arrays and their delivery capabilities are discussed in terms of drugs, including biopharmaceutics and vaccines. Patient usage and effects on the skin are also considered. EXPERT OPINION: MN research and development is now at the stage where commercialisation is a viable possibility. There are a number of long-term safety questions relating to patient usage which will need to be addressed moving forward. Regulatory guidance is awaited to direct the scale-up of the manufacturing process alongside provision of clearer patient instruction for safe and effective use of MN devices.
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Cites
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974
McAllister, D. V., Wang, P. M., Davis, S. P., Park, J.-H., Canatella, P. J., Allen, M. G., & Prausnitz, M. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2331316100 · Cited by 859
Silicon micromachined hollow microneedles for transdermal liquid transport
Gardeniers, H. J. G. E., Luttge, R., Berenschot, E. J. W., de Boer, M. J., Yeshurun, S. Y., Hefetz, M., van-t Oever, R., & van den Berg, A. (2003) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2003.820293 · Cited by 413
Cited by
Larrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2016.03.001 · Cited by 964
Self-citationTransdermal patches: history, development and pharmacology
Pastore, M. N., Kalia, Y. N., Horstmann, M., & Roberts, M. S. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13059 · Cited by 586
Current trends in polymer microneedle for transdermal drug delivery
Ahmed Saeed AL-Japairai, K., Mahmood, S., Hamed Almurisi, S., Reddy Venugopal, J., Rebhi Hilles, A., Azmana, M., & Raman, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119673 · Cited by 448
Microneedles: A New Frontier in Nanomedicine Delivery
Larrañeta, E., McCrudden, M. T. C., Courtenay, A. J., & Donnelly, R. F. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1885-5 · Cited by 339
Self-citationRecent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing
Wang, M., Hu, L., & Xu, C. (2017) · Lab on a Chip · doi:10.1039/c7lc00016b · Cited by 285
Metadata
- Authors
- Quinn, H. L., Kearney, M.-C., Courtenay, A. J., McCrudden, M. T., & Donnelly, R. F.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2014-07-14
- Volume
- 11
- Issue
- 11
- Pages
- 1769-1780
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2108686532
- Cited by
- 174
- References
- 4
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Quinn, H. L., Kearney, M.-C., Courtenay, A. J., McCrudden, M. T., & Donnelly, R. F. (2014). The role of microneedles for drug and vaccine delivery. Expert Opinion on Drug Delivery. https://doi.org/10.1517/17425247.2014.938635
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
