CSF, blood-brain barrier, and brain drug delivery

null

null (2016) · Philosophy Study · doi:10.17265/2159-5313/2016.09.003 · Cited by 28,317

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Drug-like properties and the causes of poor solubility and poor permeability

Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,776

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

Brightman, M., & Reese, T. S. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.40.3.648 · Cited by 2,457

The Permeability of Capillaries in Various Organs as Determined by Use of the ‘Indicator Diffusion’ Method

Crone, C. (1963) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1963.tb02652.x · Cited by 1,157

Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study.

Butt, A. M., Jones, H. C., & Abbott, N. J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018243 · Cited by 775

Evidence for a ‘Paravascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space

Rennels, M. L., Gregory, T. F., Blaumanis, O. R., Fujimoto, K., & Grady, P. A. (1985) · Brain Research · doi:10.1016/0006-8993(85)91383-6 · Cited by 752

Principles of neural science

de Jong, J. M. B. V. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90083-3 · Cited by 666

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

Pardridge, W. M., Boado, R. J., & Farrell, C. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38267-x · Cited by 606

Radioimmunotherapy of human tumours

Larson, S. M., Carrasquillo, J. A., Cheung, N. V., & Press, O. W. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3925 · Cited by 540

Targeting the Choroid Plexuses for Protein Drug Delivery

Bryniarski, M. A., Ren, T., Rizvi, A. R., Snyder, A. M., & Morris, M. E. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100963 · Cited by 28

Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study

Saleh, M. A. A., & de Lange, E. C. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13010095 · Cited by 26

IgNAR antibody: Structural features, diversity and applications

Khalid, Z., Chen, Y., Du, Y., Abbas, M., Ma, H., Naz, Z., Mengist, H. M., Cao, M., & Jin, T. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.01.027 · Cited by 27

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

Yang, H., George, S. J., Thompson, D., Silverman, H. A., Tsaava, T., Tynan, A., Pavlov, V. A., Chang, E. H., Andersson, U., Brines, M. L., et al. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00483-8 · Cited by 28

IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport

Boado, R. J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071476 · Cited by 27

Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis

Mwema, A., Muccioli, G. G., & Rieux, A. D. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.052 · Cited by 27

Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells

Zorniak, M., Clark, P. A., Umlauf, B. J., Cho, Y. K., Shusta, E. V., & Kuo, J. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-16066-1 · Cited by 26

Recent Update on Pharmacokinetics and Drug Metabolism in CNS-based Drug Discovery

Sanap, S. N., Bisen, A. C., Kedar, A. S., Agrawal, S., & Bhatta, R. S. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230707121415 · Cited by 26

The construction of the multifunctional targeting ursolic acids liposomes and its apoptosis effects to C6 glioma stem cells

Ying, X., Wang, Y., Xu, H., Li, X., Yan, H., Tang, H., Chen, W., & Li, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.19784 · Cited by 25

RNA therapies for CNS diseases

Francesco, V. D., Chua, A. J. K., Huang, D., D’souza, A. A., Yang, A., Bleier, B. S., & Amiji, M. M. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115283 · Cited by 27

Advancements in strategies for overcoming the blood–brain barrier to deliver brain-targeted drugs

Qu, Z., Luo, J., Li, Z., Yang, R., Zhao, J., Chen, X., Yu, S., & Shu, H. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1353003 · Cited by 28

Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice

Hawley, Z. C. E., Pardo, I. D. R., Cao, S., Zavodszky, M. I., Casey, F., Ferber, K. L., Luo, Y., Hana, S., Chen, S. K., Doherty, J., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.11.029 · Cited by 26

Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

Ríos, X., Gómez‐Vallejo, V., Martín, A., Cossío, U., Morcillo, M. Á., Alemi, M., Cardoso, I., Quintana, J. R., Jiménez‐Barbero, J., Cotrina, E. Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50071-w · Cited by 24

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Bakker, C., van der Aart, J., Hart, E. P., Klaassen, E. S., Bergmann, K. R., van Esdonk, M. J., Kay, D. G., & Groeneveld, G. J. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12093 · Cited by 24

Carbon Nanotube Exposure Triggers a Cerebral Peptidomic Response: Barrier Compromise, Neuroinflammation, and a Hyperexcited State

Mostovenko, E., Saunders, S., Muldoon, P. P., Bishop, L. M., Campen, M. J., Erdely, A., & Ottens, A. K. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab042 · Cited by 24

Regulation of the Fructose Transporter Gene Slc2a5 Expression by Glucose in Cultured Microglial Cells

Mizuno, T. M., Lew, P. S., & Jhanji, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312668 · Cited by 27

Therapeutic nanotechnologies for Alzheimer’s disease: A critical analysis of recent trends and findings

Delbreil, P., Rabanel, J., Banquy, X., & Brambilla, D. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114397 · Cited by 25

Modelling the Human Blood–Brain Barrier in Huntington Disease

Vignone, D., Paz, O. G., Fini, I., Cellucci, A., Auciello, G., Battista, M. R., Gloaguen, I., Fortuni, S., Cariulo, C., Khetarpal, V. K., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147813 · Cited by 25

Distribution Assessments of Coumarins from Angelicae Pubescentis Radix in Rat Cerebrospinal Fluid and Brain by Liquid Chromatography Tandem Mass Spectrometry Analysis

Yang, Y., Zhang, L., & Yang, X. (2018) · Molecules · doi:10.3390/molecules23010225 · Cited by 24

Emergence of the brain-border immune niches and their contribution to the development of neurodegenerative diseases

Tan, L. Y., Cunliffe, G., Hogan, M. P., Yeo, X. Y., Oh, C., Jin, B., Kang, J., Park, J., Kwon, M., Kim, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1380063 · Cited by 23

Deep Tissue Penetration of Bottle-Brush Polymers via Cell Capture Evasion and Fast Diffusion

Rabanel, J., Mirbagheri, M., Olszewski, M., Xie, G., Goas, M. L., Latreille, P., Counil, H., Hervé, V., Silva, R. O., Zaouter, C., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c10554 · Cited by 23

Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein

Baringer, S. L., Neely, E. B., Palsa, K., Simpson, I. A., & Connor, J. R. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00345-9 · Cited by 21

Simultaneous Intranasal Codelivery of Donepezil and Memantine in a Nanocolloidal Carrier: Optimization, Pharmacokinetics, and Pharmacodynamics Studies

Handa, M., Sanap, S. N., Bhatta, R. S., Patil, G. P., Palkhade, R., Singh, D. P., & Shukla, R. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00454 · Cited by 23

Distribution of Monocarboxylate Transporters in Brain and Choroid Plexus Epithelium

Ueno, M., Chiba, Y., Murakami, R., Miyai, Y., Matsumoto, K., Wakamatsu, K., Takebayashi, G., Uemura, N., & Yanase, K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082062 · Cited by 25

Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery

Schwinghamer, K., & Siahaan, T. J. (2023) · Journal of Nanotheranostics · doi:10.3390/jnt4040020 · Cited by 21

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain BarrierPreprint

Barker, S. J., Thayer, M. B., Kim, C., Tatarakis, D., Simon, M. J., Dial, R. L., Nilewski, L., Wells, R. C., Zhou, Y., Afetian, M. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.25.538145 · Cited by 21

Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier

Lafrance‐Vanasse, J., Sadekar, S., Yang, Y., Yadav, D. B., Meilandt, W. J., Wetzel-Smith, M. K., Cai, H., Crowell, S. R., Nguyen, V., Lee, V., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59447-1 · Cited by 20

Targeting Human Endothelial Cells with Glutathione and Alanine Increases the Crossing of a Polypeptide Nanocarrier through a Blood–Brain Barrier Model and Entry to Human Brain Organoids

Mészáros, M., Phan, T. H. M., Vigh, J. P., Porkoláb, G., Kocsis, A. E., Páli, E. K., Polgár, T. F., Walter, F. R., Bolognin, S., Schwamborn, J. C., et al. (2023) · Cells · doi:10.3390/cells12030503 · Cited by 21

Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia

Shiwaku, H., Katayama, S., Gao, M., Kondo, K., Nakano, Y., Motokawa, Y., Toyoda, S., Yoshida, F., Hori, H., Kubota, T., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.03.028 · Cited by 20

Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling

Ni, J., Chen, C., Wang, S., Liu, X., Tan, L., Li, L., Fan, Y., Hou, Y., Dou, H., & Liang, J. F. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03146-z · Cited by 20

Single domain antibody-based vectors in the delivery of biologics across the blood–brain barrier: a review

Gao, Y., Zhu, J., & Lu, H. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00873-7 · Cited by 19

MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder

Yao, T.-T., Chen, L., Du, Y., Jiang, Z., & Cheng, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04582-x · Cited by 22

Trojan Horse Delivery Strategies of Natural Medicine Monomers: Challenges and Limitations in Improving Brain Targeting

Lei, K., Zhou, L., Dan, M., Yang, F., Jian, T., Xin, J., Yu, Z., & Wang, Y. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030280 · Cited by 20

A novel strategy for delivering N iemann‐ P ick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus

Rasmussen, C. L. M., Hede, E., Routhe, L. G., Körbelin, J., Helgudóttir, S. S., Thomsen, L. B., Schwaninger, M., Burkhart, A., & Moos, T. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15621 · Cited by 20

Neuroprotection by resveratrol: A review on brain delivery strategies for Alzheimer's and Parkinson's disease

Chinraj, V., & Sureshkumar, R. (2022) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2022.120701 · Cited by 24

Update on Therapeutic potential of emerging nanoformulations of phytocompounds in Alzheimer's and Parkinson's disease

Kanojia, N., Thapa, K., Kaur, G., Sharma, A., Puri, V., & Verma, N. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.104074 · Cited by 19

Application of Nanomaterials in Neurodegenerative Diseases

Cui, W., Fu, W., Lin, Y., & Zhang, T. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200326093410 · Cited by 20

Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

Vyver, A. J. V. D., Walz, A., Heins, M., Abdolzade‐Bavil, A., Kraft, T. E., Waldhauer, I., & Otteneder, M. B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.958543 · Cited by 20

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Pauwels, M. J., Xie, J., Ceroi, A., Balusu, S., Castelein, J., Wonterghem, E. V., Imschoot, G. V., Ward, A., Menheniott, T. R., Gustafsson, O., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121830 · Cited by 19

Microbial metabolites regulate social novelty via CaMKII neurons in the BNST

Liou, C.-W., Cheng, S., Yao, T.-H., Lai, T.-T., Tsai, Y.-H., Chien, C.-W., Kuo, Y., Chou, S.-H., Hsu, C., & Wu, W. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.06.029 · Cited by 20

Transport pathways and kinetics of cerebrospinal fluid tracers in mouse brain observed by dynamic contrast-enhanced MRI

Zhu, Y., Wang, G., Kolluru, C., Gu, Y., Gao, H., Zhang, J., Wang, Y., Wilson, D. L., Zhu, X., Flask, C. A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-40896-x · Cited by 21

A tailored phytosomes based nose-to-brain drug delivery strategy: Silver bullet for Alzheimer's disease

Xiao, Y., Guo, H., Wang, G., Li, J., Zhai, Z., Wang, Z., Wang, W., Zhao, Z., Xia, X., Chen, C., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.039 · Cited by 20

Location matters: highly divergent protein levels in samples from different CNS compartments in a clinical trial of rituximab for progressive MS

Bergman, J., Svenningsson, A., Liv, P., Bergenheim, T. A., & Burman, J. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00205-4 · Cited by 17

Gene Therapy for Rare Neurological Disorders

Flotte, T. R., & Gessler, D. J. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2543 · Cited by 20

Apolipoprotein B-100-mediated motor neuron degeneration in sporadic amyotrophic lateral sclerosis

Wong, J. K., Roselle, A. K., Shue, T. M., Shimshak, S. J. E., Beaty, J. M., Celestin, N., Gao, I., Griffin, R., Cudkowicz, M., & Sadiq, S. A. (2022) · Brain Communications · doi:10.1093/braincomms/fcac207 · Cited by 17

The development and function of the brain barriers – an overlooked consideration for chemical toxicity

Bell, K. S., & O’Shaughnessy, K. L. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.1000212 · Cited by 18

Mechanisms of the Ping-wei-san plus herbal decoction against Parkinson’s disease: Multiomics analyses

Ding, L., You, H.-J., Hu, G.-J., Yao, R., Xie, A., & Li, X.-Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.945356 · Cited by 18

A Rapid and Sensitive UHPLC–MS/MS Method for Determination of Chlorogenic Acid and Its Application to Distribution and Neuroprotection in Rat Brain

Bai, C., Zhou, X., Yu, L., Wu, A., Yang, L., Chen, J., Tang, X., Zou, W., Wu, J., & Zhu, L. (2023) · Pharmaceuticals · doi:10.3390/ph16020178 · Cited by 17

Precision Medicine in Lymphoma by Innovative Instrumental Platforms

Paolo, A. D., Arrigoni, E., Luci, G., Cucchiara, F., Danesi, R., & Galimberti, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01417 · Cited by 18

VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring after Maternal Immune Activation

Sideromenos, S., Lindtner, C., Zambon, A., Horváth, O., Berger, A., & Pollak, D. D. (2020) · Cells · doi:10.3390/cells9041048 · Cited by 17

Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice

Roda, A. R., Montoliu‐Gaya, L., Serra-Mir, G., & Villegas, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186630 · Cited by 17

Evaluation of capacitive micromachined ultrasonic transducers for passive monitoring of microbubble-assisted ultrasound therapies

Dauba, A., Goulas, J., Colin, L., Jourdain, L., Larrat, B., Gennisson, J., Certon, D., & Novell, A. (2020) · The Journal of the Acoustical Society of America · doi:10.1121/10.0002096 · Cited by 16

Transporters, Ion Channels, and Junctional Proteins in Choroid Plexus Epithelial Cells

Ueno, M., Chiba, Y., Murakami, R., Miyai, Y., Matsumoto, K., Wakamatsu, K., Nakagawa, T., Takebayashi, G., Uemura, N., Yanase, K., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12040708 · Cited by 16

H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions

Nonnenbroich, L. F., Bouchal, S. M., Millesi, E., Rechberger, J. S., Khatua, S., & Daniels, D. J. (2024) · Cells · doi:10.3390/cells13131122 · Cited by 18

Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine

Blomqvist, K. J., Skogster, M. O. B., Kurkela, M. J., Rosenholm, M., Ahlström, F. H. G., Airavaara, M., Backman, J. T., Rauhala, P. V., Kalso, E. A., & Lilius, T. O. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.022 · Cited by 17

Brain delivery of biotherapeutics via receptor-mediated transcytosis across the blood–brain barrier

Boado, R. J. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00204d · Cited by 19

Molecular fMRI of neurochemical signaling

Wei, H., Frey, A. M., & Jasanoff, A. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109372 · Cited by 15

Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid

Custers, M., Nestor, L., Bundel, D. D., Eeckhaut, A. V., & Smolders, I. J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051051 · Cited by 15

Characteristics of Focused Ultrasound Mediated Blood-Brain Barrier Opening in Magnetic Resonance Images

Chang, K. W., Hong, S. W., Chang, W. S., Jung, H. H., & Chang, J. W. (2023) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2022.0236 · Cited by 15

Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategies

Zaghmi, A., Drouin‐Ouellet, J., Brambilla, D., & Gauthier, M. A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120461 · Cited by 17

Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central nervous system

Chang, H.-Y., Wu, S., Chowdhury, E. A., & Shah, D. K. (2022) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-021-09800-w · Cited by 16

Effect of the Size of Protein Therapeutics on Brain Pharmacokinetics Following Systematic Administration

Chang, H.-Y., Wu, S., Li, Y., Guo, L., Li, Y., & Shah, D. K. (2022) · The AAPS Journal · doi:10.1208/s12248-022-00701-5 · Cited by 16

A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology

Vogelbaum, M. A., Li, G., Heimberger, A. B., Lang, F. F., Fueyo-Margareto, J., Gomez‐Manzano, C., & Sanai, N. (2022) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_349175 · Cited by 15

The Blood brain-barrier and its role in Alzheimer’s disease

Storck, S. E., & Pietrzik, C. U. (2018) · e-Neuroforum · doi:10.1515/nf-2018-a014 · Cited by 16

Leptomeningeal metastases from non-small cell lung cancer: state of the art and recent advances

Pellerino, A., Internò, V., Muscolino, E., Mo, F., Bruno, F., Pronello, E., Franchino, F., Soffietti, R., & Rudà, R. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.80 · Cited by 15

Strategies for Drug Delivery into the Brain: A Review on Adenosine Receptors Modulation for Central Nervous System Diseases Therapy

Fernández, M., Nigro, M., Travagli, A., Pasquini, S., Vincenzi, F., Varani, K., Borea, P. A., Merighi, S., & Gessi, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102441 · Cited by 16

Nose to Brain Drug Delivery: A Recent Update

Chatterjee, B. (2018) · Journal of Formulation Science & Bioavailability · doi:10.4172/2577-0543.1000105 · Cited by 14

Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads

Aguiar, S. I., Dias, J., Manuel, A. M., Russo, R. L., Góis, P. M. P., Aires‐da‐Silva, F., & Gonçalves, J. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.03.002 · Cited by 14

Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease micePreprint

Chou, S.-W., Mortberg, M. A., Marlen, K., Ojala, D. S., Parman, T., Howard, M., DeSouza-Lenz, K., Lian, Y., Mehrabian, M., Tiffany, M. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.05.636713 · Cited by 14

Mechanistic Modeling of Spatial Heterogeneity of Drug Penetration and Exposure in the Human Central Nervous System and Brain Tumors

Li, J., Wickramasinghe, C. D., Jiang, J., Wu, A., Jiang, Y., Tovmasyan, A. G., Kim, S., & Sanai, N. (2024) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3505 · Cited by 16

Nasal nanotherapeutics for central nervous system disorders: Bridging the translational gap in central nervous system drug delivery

Zhang, Y.-B., Liu, M., Wang, Y., Hu, D., Wu, S., Zhao, B., Zhou, B., & Yang, L. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177958 · Cited by 14

Miniaturized neural implants for localized and controllable drug delivery in the brain

Zhao, X., Deng, M., Wang, J., Liu, B., Dong, Y., & Li, Z. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00728f · Cited by 14

Cell-Penetrating Peptides-Mediated Therapeutic Agents Delivery into the Central Nervous System

Wei, Y., Bao, H., Wang, L., Cao, Y., Liu, Z., Zhu, X., Chen, T., Wu, A., & Li, J. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.4c00397 · Cited by 13

Advances in nanotherapeutic strategies for Huntington's disease: Design, delivery, and neuroprotective mechanisms

Khan, S., Bano, N., Ahamad, S., Dar, N. J., Nazir, A., & Bhat, S. A. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216206 · Cited by 14

Expert consensus on the use of third-generation EGFR-TKIs in EGFR-mutated advanced non-small cell lung cancer with various T790M mutations post-resistance to first-/second-generation EGFR-TKIs

Ma, J., Huang, L., & Han, C. (2024) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359241289648 · Cited by 13

A narrative review on potential applications of spanlastics for nose-to-brain delivery of therapeutically active agents

Nadim, N., Khan, A. A., Khan, S. M., Parveen, R., & Ali, J. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103341 · Cited by 13

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease

Schartmann, E., Schemmert, S., Ziehm, T., Leithold, L. H. E., Jiang, N., Tusche, M., Shah, N. J., Langen, K., Kutzsche, J., Willbold, D., et al. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.12.005 · Cited by 13

Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic

Ljubimov, V. A., Ramesh, A., Davani, S., Danielpour, M., Breunig, J. J., & Black, K. L. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114033 · Cited by 13

Accumulation of extracellular elastin‐derived peptides disturbed neuronal morphology and neuron–microglia crosstalk in aged brain

Ma, J., Wang, B., Wei, X., Tian, M., Bao, X., Zhang, Y., Qi, H., Zhang, Y., & Hu, M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16039 · Cited by 12

Delayed Gadolinium Leakage in Ocular Structures

Galmiche, C., Moal, B., Marnat, G., Sagnier, S., Schweitzer, C., Dousset, V., Sibon, I., & Tourdias, T. (2021) · Investigative Radiology · doi:10.1097/rli.0000000000000757 · Cited by 12

Nose-to-brain drug delivery for the treatment of glioblastoma multiforme: nanotechnological interventions

Kumar, N., Khurana, B., & Arora, D. (2023) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2023.2285506 · Cited by 12

Legumain-induced intracerebrally crosslinked vesicles for suppressing efflux transport of Alzheimer's disease multi-drug nanosystem

Jiang, F., Ren, J., Gao, Y., Wang, J., Zhao, Y., & Dai, F. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.11.024 · Cited by 11

Twofold Saddle-Point Formulation of Biot Poroelasticity with Stress-Dependent Diffusion

Gómez-Vargas, B., Mardal, K., Ruíz-Baier, R., & Vinje, V. (2023) · SIAM Journal on Numerical Analysis · doi:10.1137/21m1449695 · Cited by 14

Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation for BNCT in a Rat Melanoma Model

Kusaka, S., Morizane, Y., Tokumaru, Y., Tamaki, S., Maemunah, I. R., Akiyama, Y., Sato, F., & Murata, I. (2022) · Biology · doi:10.3390/biology11030397 · Cited by 11

Cerebrospinal fluid-based boron delivery system may help increase the uptake boron for boron neutron capture therapy in veterinary medicine: A preliminary study with normal rat brain cells

Kusaka, S., Morizane, Y., Tokumaru, Y., Tamaki, S., Maemunah, I. R., Akiyama, Y., Sato, F., & Murata, I. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.04.008 · Cited by 11

Glymphatic System in Ocular Diseases: Evaluation of MRI Findings

Manava, P., Eckrich, C., Luciani, F., Schmidbauer, J. M., Lell, M., & Detmar, K. (2022) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7552 · Cited by 12

Long non-coding RNAs as biomarkers and therapeutic targets for ischemic stroke

Суфианова, Г. З., Shumadalova, A. V., Wenhao, Y., & Фанилевич, Г. И. (2022) · Non-coding RNA Research · doi:10.1016/j.ncrna.2022.09.004 · Cited by 11

Polymer nanocarriers for targeted local delivery of agents in treating brain tumors

Josowitz, A. D., Bindra, R. S., & Saltzman, W. M. (2022) · Nanotechnology · doi:10.1088/1361-6528/ac9683 · Cited by 12

Application of Nanotechnology-Based Products in Stroke

Wang, C., Sun, J., Chen, Q., Chen, J., Wan, H., Ni, Q., Yuan, H., Wu, J., Wang, Y., & Sun, B. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00804 · Cited by 11

A 3D brain unit model to further improve prediction of local drug distribution within the brain

Vendel, E., Rottschäfer, V., & de Lange, E. C. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238397 · Cited by 11

Quantitative and qualitative analysis of direct nose-to-brain drug delivery

Belgamwar, V. S., Bhoyar, V. T., Trivedi, S., & Pardeshi, C. V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822522-6.00027-8 · Cited by 11

Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics

Chan, M., Huang, W., Satpathy, A., Su, T., Hsiao, M., & Liu, R. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020456 · Cited by 11

Signaling pathways driving multiple sclerosis: From mechanisms to natural‑product interventions

El‐Dessouki, A. M., Shalaby, H. N., Khalaf, S. S., Abd‐Elmawla, M. A., Ghaiad, H. R., Mageed, S. S. A., El‐Shiekh, R. A., Ahmed, S., & Khalifa, H. O. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119543 · Cited by 10

Multidisciplinary management of HER2-positive breast cancer with brain metastases: An evidence-based pragmatic approach moving from pathophysiology to clinical data

Giordano, G., Griguolo, G., Landriscina, M., Meattini, I., Carbone, F., Leone, A., Re, M. D., Fogli, S., Danesi, R., Colamaria, A., et al. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104185 · Cited by 12

Mechanistic Modeling of Intrathecal Chemotherapy Pharmacokinetics in the Human Central Nervous System

Li, J., Wu, A., & Kim, S. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3062 · Cited by 10

Focused ultrasound therapy as a strategy for improving glioma treatment

Young, J. S., Semonche, A. M., Morshed, R. A., Al-Adli, N. N., Haddad, A. F., Gerritsen, J. K. W., Saggi, S. S., Narsinh, K. H., de Groot, J., & Aghi, M. K. (2025) · Journal of neurosurgery · doi:10.3171/2024.9.jns24721 · Cited by 11

Nano-biohybrids with cell-penetrating peptides: A molecular trojans for glioblastoma precision medicine

Phatale, V., Khairnar, P., Shukla, S., Puri, N., Sahane, P., & Srivastava, S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126077 · Cited by 11

Hampering Brain Tumor Proliferation and Migration Using Peptide Nanofiber:si PLK1 / MMP2 Complexes

Mazza, M., Ahmad, H., Hadjidemetriou, M., Agliardi, G., Pathmanaban, O. N., King, A. T., Bigger, B., Vranic, S., & Kostarelos, K. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0298 · Cited by 10

Exploring the Potential of Mesenchymal Stem Cell-Based Therapy in Mouse Models of Vascular Cognitive Impairment

Lee, N. K., Kim, H., Chang, J. W., Jang, H., Kim, H., Yang, J., Kim, J., Son, J. P., & Na, D. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155524 · Cited by 10

Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting

Wang, R., & Sha, X. (2021) · Current Drug Targets · doi:10.2174/1389450122666210114095859 · Cited by 10

Blood-Brain Barrier Transport and Drug Targeting to the Brain

Hosoya, K., Ohtsuki, S., & Terasaki, T. (2002) · Springer eBooks · doi:10.1007/978-1-4757-4627-3_16

Drug transport in brain via the cerebrospinal fluid.

Pardridge, W. M. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-7 · Cited by 316

- Transport and Drug Delivery through the Blood–Brain Barrier and Cerebrospinal Fluid

Peattie, R. A., Fisher, R. J., Bronzino, J. D., & Peterson, D. R. (2012) · CRC Press eBooks · doi:10.1201/b12937-12

Delivery Considerations for Targeting the Choroid Plexus–Cerebrospinal Fluid Route

Chen, T. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801740-1.00009-3

Distributed model for drug delivery to CSF and brain tissue

Collins, J. M., & Dedrick, R. L. (1983) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1983.245.3.r303 · Cited by 108