Pardridge, William M.

The blood-brain barrier: Bottleneck in brain drug development

Pardridge, W. M. (2005) · NeuroRX

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 2,798

Drug Transport across the Blood–Brain Barrier

Pardridge, W. M. (2012) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 1,994

Blood–brain barrier delivery

Pardridge, W. M. (2007) · Drug Discovery Today

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 1,191

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

Pardridge, W. M., Boado, R. J., & Farrell, C. R. (1990) · Journal of Biological Chemistry

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 606

CSF, blood-brain barrier, and brain drug delivery

Pardridge, W. M. (2016) · Expert Opinion on Drug Delivery

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 508

Strategies to advance translational research into brain barriers

Neuwelt, E., Abbott, N. J., Abrey, L., Banks, W. A., Blakley, B., Davis, T., Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., et al. (2008) · The Lancet Neurology

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 474

CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport

Pardridge, W. M. (1998) · Journal of Neurochemistry

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 460

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain

Pardridge, W. M. (2020) · Frontiers in Aging Neuroscience

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 405

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo.

Pardridge, W. M., Buciak, J. L., & Friden, P. M. (1991) · The Journal of Pharmacology and Experimental Therapeutics

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 358

Drug transport in brain via the cerebrospinal fluid.

Pardridge, W. M. (2011) · Fluids and Barriers of the CNS

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 316

Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study.

Farrell, C. L., & Pardridge, W. M. (1991) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 314

A Historical Review of Brain Drug Delivery

Pardridge, W. M. (2022) · Pharmaceutics

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 219

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

Zhang, Y., Calon, F., Zhu, C., Boado, R. J., & Pardridge, W. M. (2003) · Human Gene Therapy

RNA Interference and Gene DeliveryParkinson's Disease Mechanisms and Treatments

Cited by 194

Downregulation of Blood-Brain Barrier Glucose Transporter in Experimental Diabetes

Pardridge, W. M., Triguero, D., & Farrell, C. R. (1990) · Diabetes

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 184

shRNA and siRNA delivery to the brain

Pardridge, W. M. (2007) · Advanced Drug Delivery Reviews

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 176

Neuroprotection in Transient Focal Brain Ischemia After Delayed Intravenous Administration of Brain-Derived Neurotrophic Factor Conjugated to a Blood-Brain Barrier Drug Targeting System

Zhang, Y., & Pardridge, W. M. (2001) · Stroke

Barrier Structure and Function StudiesNeuroprotection in Cerebral Ischemia

Cited by 175

Blood—Brain Barrier Genomics

Li, J. Y., Boado, R. J., & Pardridge, W. M. (2001) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 164

Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

Pardridge, W. M. (2015) · Expert Opinion on Therapeutic Targets

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

Cited by 159

Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

Pardridge, W. M. (2015) · Expert Opinion on Drug Delivery

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 152

Delivery of Biologics Across the Blood–Brain Barrier with Molecular Trojan Horse Technology

Pardridge, W. M. (2017) · BioDrugs

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 152

Rat Blood–Brain Barrier Genomics. II

Li, J. Y., Boado, R. J., & Pardridge, W. M. (2002) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 46

Re-engineering iduronate 2-sulfatase for penetration of the blood-brain barrier via transport on the insulin receptor

Boado, R. J., Hui, E. K.-W., Lu, J. Z., & Pardridge, W. M. (2014) · Molecular Genetics and Metabolism

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 3