The role of aldehyde oxidase in drug metabolism

Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

Enroth, C., Eger, B. T., Okamoto, K., Nishino, T., Nishino, T., & Pai, E. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.10723 · Cited by 733 · see citing works

Molybdenum and tungsten in biology

Hille, R. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02107-2 · Cited by 430 · see citing works

Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase

Nishino, T., Okamoto, K., Eger, B. T., PAI, E. F., & Nishino, T. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06489.x · Cited by 387 · see citing works

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

Pryde, D. C., Dalvie, D., Hu, Q., Jones, P., Obach, R. S., & Tran, T.-D. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100888d · Cited by 346 · see citing works

Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2* activities

Relling, M. V., Lin, J., Ayers, G. D., & Evans, W. E. (1992) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1992.203 · Cited by 314 · see citing works

Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology

Garattini, E., Mendel, R. R., Romão, M. J., Wright, R. M., & Terao, M. (2003) · Biochemical Journal · doi:10.1042/bj20030121 · Cited by 240 · see citing works

Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs

Obach, R. S., Huynh, P. T., Allen, M. C., & Beedham, C. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003260336 · Cited by 224 · see citing works

Drug-Metabolizing Ability of Molybdenum Hydroxylases

Kitamura, S., Sugihara, K., & Ohta, S. (2006) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.21.83 · Cited by 216 · see citing works

Mammalian aldehyde oxidases: genetics, evolution and biochemistry

Garattini, E., Fratelli, M., & Terao, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7398-y · Cited by 188 · see citing works

POTENT INHIBITION OF HUMAN LIVER ALDEHYDE OXIDASE BY RALOXIFENE

Obach, R. S. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.1.89 · Cited by 168 · see citing works

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.

Rashidi, M., Smith, J. A., Clarke, S. E., & Beedham, C. (1997) · PubMed · Cited by 157 · see citing works

Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene

Rodrı́guez-Trelles, F., Tarrı́o, R., & Ayala, F. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1835646100 · Cited by 146 · see citing works

Ziprasidone Metabolism, Aldehyde Oxidase, and Clinical Implications

Beedham, C., Miceli, J. J., & Obach, R. S. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000084028.22282.f2 · Cited by 141 · see citing works

3 Molybdenum Hydroxylases: Biological Distribution and Substrate-Inhibitor Specificity

Beedham, C. (1987) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(08)70420-x · Cited by 129 · see citing works

In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase

Zientek, M. A., Jiang, Y., Youdim, K. A., & Obach, R. S. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033555 · Cited by 127 · see citing works

Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo

Terao, M., Cazzaniga, G., Ghezzi, P., Bianchi, M., Francesco Falciani, B., Perani, P., & Garattini, E. (1992) · Biochemical Journal · doi:10.1042/bj2830863 · Cited by 117 · see citing works

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

Garattini, E., & Terao, M. (2011) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.560606 · Cited by 111 · see citing works

The mammalian aldehyde oxidase gene family

Garattini, E., Fratelli, M., & Terao, M. (2009) · Human Genomics · doi:10.1186/1479-7364-4-2-119 · Cited by 111 · see citing works

Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase

Kuwabara, Y., Nishino, T., Okamoto, K., Matsumura, T., Eger, B. T., PAI, E. F., & Nishino, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431485100 · Cited by 107 · see citing works

The enzyme “aldehyde oxidase” is an iminium oxidase. Reaction with nicotine Δ1′(5′) iminium ion

Brandänge, S., & Lindblom, L. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)91977-6 · Cited by 107 · see citing works

Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase

Li-Calzi, M., Raviolo, C., Ghibaudi, E., De Gioia, L., Salmona, M., Cazzaniga, G., Kurosaki, M., Terao, M., & Garattini, E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31037 · Cited by 107 · see citing works

Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice

Yoo, C. B., Chuang, J. C., Byun, H., Egger, G., Yang, A. S., Dubeau, L., Long, T. I., Laird, P. W., Márquez, V. E., & Jones, P. A. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-07-0008 · Cited by 102 · see citing works

Species variation in hepatic aldehyde oxidase activity

Beedham, C., Bruce, S. E., Critchley, D. J. P., Al-Tayib, Y., & Rance, D. J. (1987) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03189919 · Cited by 96 · see citing works

Substrate Specificity of Human Liver Aldehyde Oxidase toward Substituted Quinazolines and Phthalazines: A Comparison with Hepatic Enzyme from Guinea Pig, Rabbit, and Baboon

Beedham, C., Critchley, D. J. P., & Rance, D. J. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1320 · Cited by 95 · see citing works

Stereoselective Biotransformation of the Selective Serotonin Reuptake Inhibitor Citalopram and Its Demethylated Metabolites by Monoamine Oxidases in Human Liver

Rochat, B., Kosel, M., Boss, G., Testa, B., Gillet, M., & Baumann, P. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00008-2 · Cited by 93 · see citing works

Variation of Hepatic Methotrexate 7-Hydroxylase Activity in Animals and Humans

Kitamura, S., Sugihara, K., Nakatani, K., Ohta, S., Oh-hara, T., Ninomiya, S.-I., Green, C. E., & Tyson, C. A. (1999) · IUBMB Life · doi:10.1080/713803569 · Cited by 93 · see citing works

Aldehyde Oxidase-catalysed Oxidation of Methotrexate in the Liver of Guinea-pig, Rabbit and Man

Jordan, C. G. M., Rashidi, M. R., Laljee, H., Clarke, S. E., Brown, J. E., & Beedham, C. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991772619 · Cited by 90 · see citing works

Systematic Structure Modifications of Imidazo[1,2-a]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)

Linton, A., Kang, P., Ornelas, M. A., Kephart, S. E., Hu, Q., Pairish, M., Jiang, Y., & Guo, C. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2010942 · Cited by 83 · see citing works

The role of non-P450 enzymes in drug oxidation.

Beedham, C. (1997) · Pharmacy World & Science · doi:10.1023/a:1008668913093 · Cited by 81 · see citing works

Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro

Neumeier, M., Weigert, J., Schäffler, A., Weiß, T. S., Schmidl, C., Büttner, R., Bollheimer, C., Aslanidis, C., Schölmerich, J., & Buechler, C. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.101 · Cited by 78 · see citing works

Aldehyde Oxidase Activity and Inhibition in Hepatocytes and Cytosolic Fraction from Mouse, Rat,Monkey and Human

Sahi, J., Khan, K. K., & Black, C. (2008) · Drug Metabolism Letters · doi:10.2174/187231208785425818 · Cited by 72 · see citing works

Cross-Species Comparison of the Metabolism and Excretion of Zoniporide: Contribution of Aldehyde Oxidase to Interspecies Differences

Dalvie, D., Zhang, C., Chen, W., Smolarek, T. A., Obach, R. S., & Loi, C. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.030783 · Cited by 72 · see citing works

Comparative histochemical and immunohistochemical study on xanthine oxidoreductase/xanthine oxidase in mammalian corneal epithelium

Ardan, T., Kovačeva, J., & Cejkova, J. (2004) · Acta Histochemica · doi:10.1016/j.acthis.2003.08.001 · Cited by 71 · see citing works

Cloning of the cDNAs Coding for Two Novel Molybdo-flavoproteins Showing High Similarity with Aldehyde Oxidase and Xanthine Oxidoreductase

Terao, M., Kurosaki, M., Saltini, G., Demontis, S., Marini, M., Salmona, M., & Garattini, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005355200 · Cited by 70 · see citing works

Contribution of Aldehyde Oxidase, Xanthine Oxidase, and Aldehyde Dehydrogenase on the Oxidation of Aromatic Aldehydes

Panoutsopoulos, G. I., Kouretas, D., & Beedham, C. (2004) · Chemical Research in Toxicology · doi:10.1021/tx030059u · Cited by 68 · see citing works

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: Influence of sex and inhibitors

Klecker, R. W., Cysyk, R. L., & Collins, J. M. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.07.053 · Cited by 67 · see citing works

Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone

Kurosaki, M., Demontis, S., Barzago, M. M., Garattini, E., & Terao, M. (1999) · Biochemical Journal · doi:10.1042/bj3410071 · Cited by 66 · see citing works

Small‐interference RNA‐mediated knock‐down of aldehyde oxidase 1 in 3T3‐L1 cells impairs adipogenesis and adiponectin release

Weigert, J., Neumeier, M., Bauer, S., Mages, W., Schnitzbauer, A. A., Obed, A., Gröschl, B., Hartmann, A., Schäffler, A., Aslanidis, C., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.07.034 · Cited by 65 · see citing works

Reduction of tertiary amine N-oxides by liver preparations: Function of aldehyde oxidase as a major N-oxide reductase

Kitamura, S., & Tatsumi, K. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90742-3 · Cited by 64 · see citing works

Inhibition of zaleplon metabolism by cimetidine in the human liver:in vitrostudies with subcellular fractions and precision-cut liver slices

Renwick, A. B., Ball, S. E., Tredger, J. M., Price, R. J., Walters, D. G., Kao, J., Scatina, J., & Lake, B. G. (2002) · Xenobiotica · doi:10.1080/00498250210158221 · Cited by 63 · see citing works

The Aldehyde Oxidase Gene Cluster in Mice and Rats

Kurosaki, M., Terao, M., Barzago, M. M., Bastone, A., Bernardinello, D., Salmona, M., & Garattini, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408734200 · Cited by 62 · see citing works

Involvement of liver aldehyde oxidase in the reduction of nicotinamide N-oxide

Kitamura, S., & Tatsumi, K. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91297-x · Cited by 61 · see citing works

Avian and Canine Aldehyde Oxidases

Terao, M., Kurosaki, M., Barzago, M. M., Varasano, E., Boldetti, A., Bastone, A., Fratelli, M., & Garattini, E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600850200 · Cited by 61 · see citing works

Inhibitory Effects of Ruta graveolens L. Extract on Guinea Pig Liver Aldehyde Oxidase

Pirouzpanah, S., Reza, R. M., Delazar, A., Razavieh, S. V., & Hamidi, A. (2006) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.54.9 · Cited by 60 · see citing works

Role of the Molybdoflavoenzyme Aldehyde Oxidase Homolog 2 in the Biosynthesis of Retinoic Acid: Generation and Characterization of a Knockout Mouse

Terao, M., Kurosaki, M., Barzago, M. M., Fratelli, M., Bagnati, R., Bastone, A., Giudice, C., Scanziani, E., Mancuso, A., Tiveron, C., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01385-08 · Cited by 60 · see citing works

Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin

Terao, M., Kurosaki, M., Demontis, S., Zanotta, S., & Garattini, E. (1998) · Biochemical Journal · doi:10.1042/bj3320383 · Cited by 59 · see citing works

Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada

STEINBERG, K. K., Relling, M. V., Gallagher, M. L., Greene, C. N., Rubin, C. S., French, D., Holmes, A. K., Carroll, W. L., Koontz, D. A., Sampson, E. J., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9025 · Cited by 56 · see citing works

In Vitro Study of 6-mercaptopurine Oxidation Catalysed by Aldehyde Oxidase and Xanthine Oxidase

Rashidi, M., Beedham, C., Smith, J. S., & Davaran, S. (2007) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.22.299 · Cited by 52 · see citing works

Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver

Sugihara, K., Kitamura, S., Tatsumi, K., Asahara, T., & Dohi, K. (1997) · IUBMB Life · doi:10.1080/15216549700202241 · Cited by 51 · see citing works

Purification and Mechanism of Human Aldehyde Oxidase Expressed in Escherichia coli

Alfaro, J. F., Joswig-Jones, C. A., Ouyang, W., Nichols, J., Crouch, G. J., & Jones, J. P. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.029520 · Cited by 50 · see citing works

Chromosomal Mapping, Isolation, and Characterization of the Mouse Xanthine Dehydrogenase Gene

Cazzaniga, G., Terao, M., Schiavo, P. L., Galbiati, F., Segalla, F., Seldin, M. F., & Garattini, E. (1994) · Genomics · doi:10.1006/geno.1994.1515 · Cited by 49 · see citing works

Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials.

Beedham, C., Al-Tayib, Y., & Smith, J. A. (1992) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08810-5 · Cited by 49 · see citing works

Purification of the Aldehyde Oxidase Homolog 1 (AOH1) Protein and Cloning of the AOH1 and Aldehyde Oxidase Homolog 2 (AOH2) Genes

Terao, M., Kurosaki, M., Marini, M., Vanoni, M. A., Saltini, G., Bonetto, V., Bastone, A., Federico, C., Saccone, S., Fanelli, R., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105744200 · Cited by 47 · see citing works

Regulation and Biochemistry of Mouse Molybdo-flavoenzymes

Vilà, R., Kurosaki, M., Barzago, M. M., Kolek, M., Bastone, A., Colombo, L., Salmona, M., Terao, M., & Garattini, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308137200 · Cited by 46 · see citing works

Elevation of molybdenum hydroxylase levels in rabbit liver after ingestion of phthalazine or its hydroxylated metabolite

Johnson, C., Stubley-Beedham, C., & Stell, J. G. P. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90159-x · Cited by 46 · see citing works

Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro

Rodrigues, A. D. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90240-2 · Cited by 46 · see citing works

Substrate Specificity of Rabbit Aldehyde Oxidase for Nitroguanidine and Nitromethylene Neonicotinoid Insecticides

Dick, R. A., Kanne, D. B., & Casida, J. E. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050230x · Cited by 45 · see citing works

Metabolism of Retinaldehyde and Other Aldehydes in Soluble Extracts of Human Liver and Kidney

Ambroziak, W., Izaguirre, G., & Pietruszko, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33366 · Cited by 45 · see citing works

Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase

Acheampong, A., Chien, D. S., Lam, S., Vekich, S., Breau, A., Usansky, J., Harcourt, D. M., MUNK, S. A., Nguyen, H. Q., Garst, M., et al. (1996) · Xenobiotica · doi:10.3109/00498259609167421 · Cited by 45 · see citing works

Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes.

Panoutsopoulos, G. I., & Beedham, C. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3550 · Cited by 44 · see citing works

Expression of xanthine oxidoreductase in mouse mammary epithelium during pregnancy and lactation: regulation of gene expression by glucocorticoids and prolactin

Kurosaki, M., Zanotta, S., Calzi, M. L., Garattini, E., & Terao, M. (1996) · Biochemical Journal · doi:10.1042/bj3190801 · Cited by 43 · see citing works

The Biotransformation of Nitrogen Containing Xenobiotics to Lactams

Vickers, S., & Polsky, S. B. (2000) · Current Drug Metabolism · doi:10.2174/1389200003338929 · Cited by 43 · see citing works

Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes

Sanoh, S., Nozaki, K., Murai, H., Terashita, S., Teramura, T., & Ohta, S. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.041954 · Cited by 43 · see citing works

Inhibitory effects of flavonoids on aldehyde oxidase activity

Pirouzpanah, S., Hanaee, J., Razavieh, S. V., & Rashidi, M. (2008) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360701841301 · Cited by 43 · see citing works

Developmental Changes of Aldehyde Oxidase Activity in Young Japanese Children

Tayama, Y., Miyake, K., Sugihara, K., Kitamura, S., Kobayashi, M., Morita, S., Ohta, S., & Kihira, K. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100078 · Cited by 42 · see citing works

Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes

Rivera, S. P., Choi, H. H., Chapman, B., Whitekus, M. J., Terao, M., Garattini, E., & Hankinson, O. (2004) · Toxicology · doi:10.1016/j.tox.2004.10.009 · Cited by 41 · see citing works

Site Directed Mutagenesis of Amino Acid Residues at the Active Site of Mouse Aldehyde Oxidase AOX1

Schumann, S., Terao, M., Garattini, E., Saggu, M., Lendzian, F., Hildebrandt, P., & Leimkühler, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005348 · Cited by 40 · see citing works

The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans.

Rodrigues, A. D., Ferrero, J. L., Amann, M. T., Rotert, G. A., Cepa, S. P., Surber, B. W., Machinist, J. M., Tich, N., Sullivan, J. P., & Garvey, D. S. (1994) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07569-5 · Cited by 37 · see citing works

In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase

Moriwaki, Y., Yamamoto, T., Nasako, Y., Takahashi, S., Suda, M., Hiroishi, K., Hada, T., & Higashino, K. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90661-f · Cited by 36 · see citing works

Role of Aldehyde Oxidase in the Hepatic in Vitro Metabolism of 3-Methylindole in Pigs

Díaz, G. J., & Squires, E. J. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990805u · Cited by 35 · see citing works

5-fluoro-2-pyrimidinone, a liver aldehyde oxidase-activated prodrug of 5-fluorouracil

Guo, X., Lerner-Tung, M. B., Hong-xing, C., Chang, C.-N., Zhu, J., Chang, C.-P., Pizzorno, G., Lin, T., & Cheng, Y. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)98508-7 · Cited by 35 · see citing works

Disposition of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘- (methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by Novel Metabolic Pathways. Characterization of Unusual Metabolites by Liquid Chromatography/Mass Spectrometry and NMR

Mutlib, A. E., Shockcor, J. P., Chen, S.-Y., Espina, R. J., Pinto, D. J. P., Orwat, M. J., Prakash, S. R., & Gan, L.-S. L. (2001) · Chemical Research in Toxicology · doi:10.1021/tx0101191 · Cited by 32 · see citing works

Quantitative Study of the Structural Requirements of Phthalazine/Quinazoline Derivatives for Interaction with Human Liver Aldehyde Oxidase.

Ghafourian, T., & Rashidi, M. (2001) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.49.1066 · Cited by 30 · see citing works

Species Differences in Oral Bioavailability of Methotrexate between Rats and Monkeys.

Kuroda, T., NAMBA, K., TORIMARU, T., Kawashima, K., & Hayashi, M. (2000) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.23.334 · Cited by 28 · see citing works

The xanthine oxidoreductase gene: structure and regulation

Terao, M., Kurosaki, M., Zanotta, S., & Garattini, E. (1997) · Biochemical Society Transactions · doi:10.1042/bst0250791 · Cited by 28 · see citing works

Lack of dimer formation ability in rat strains with low aldehyde oxidase activity

Itoh, K., Maruyama, H., Adachi, M., Hoshino, K., Watanabe, N., & Tanaka, Y. (2007) · Xenobiotica · doi:10.1080/00498250701397713 · Cited by 27 · see citing works

Biotransformation of carbazeran in guinea pig: Effect of hydralazine pretreatment

Critchley, D. J. P., Rance, D. J., & Beedham, C. (1994) · Xenobiotica · doi:10.3109/00498259409043219 · Cited by 26 · see citing works

Cytosol mediated metabolism of the experimental antitumour agent acridine carboxamide to the 9-acridone derivative

Robertson, I. G. C., Palmer, B. D., Officer, M., Siegers, D. J., Paxton, J. W., & Shaw, G. J. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90585-s · Cited by 26 · see citing works

Acidic metabolites of tamoxifen. Aspects of formation and fate in the female rat.

Ruenitz, P. C., & Bai, X. (1995) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06739-x · Cited by 26 · see citing works

Oxidation of Selected Pteridine Derivatives by Mammalian Liver Xanthine Oxidase and Aldehyde Oxidase

Hodnett, C. N., McCormack, J. J., & Sabean, J. A. (1976) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600650806 · Cited by 25 · see citing works

Studies on the mode of oxidation of pyrazolo(3,4-d)pyrimidine by aldehyde oxidase and xanthine oxidase

Johns, D. G., Spector, T., & ROBINS, R. K. (1969) · Biochemical Pharmacology · doi:10.1016/0006-2952(69)90352-9 · Cited by 25 · see citing works

Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2'-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design.

Kinsella, T. J., Schupp, J. E., Davis, T. W., Berry, S. E., Hwang, H. S., Warren, K. E., Balis, F. M., Barnett, J., & Sands, H. (2000) · PubMed · Cited by 25 · see citing works

An extremely potent anilinoacridine inhibitor of aldehyde oxidase

Gormley, P. E., Rossitch, E., D'Anna, M. E., & Cysyk, R. L. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)90589-2 · Cited by 24 · see citing works

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABAA α5 inverse agonist for cognitive dysfunction

JONES, P. G., Atack, J. R., Braun, M. P., Cato, B. P., Chambers, M. S., O'Connor, D. V., Cook, S. M., Hobbs, S. C., Maxey, R., Szekeres, H. J., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.11.012 · Cited by 23 · see citing works

5-Ethynyl-2(1H)-pyrimidinone: Aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase

Porter, D. J. T., Harrington, J. A., Almond, M. R., Lowen, G. T., Zimmerman, T. P., & Spector, T. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90388-3 · Cited by 21 · see citing works

Genetic Polymorphism of Aldehyde Oxidase in Donryu Rats

Itoh, K., Masubuchi, A., Sasaki, T., Adachi, M., Watanabe, N., Nagata, K., Yamazoe, Y., Hiratsuka, M., Mizugaki, M., & Tanaka, Y. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.011502 · Cited by 21 · see citing works

Methadone: a potent inhibitor of rat liver aldehyde oxidase

Robertson, I. G. C., & Gamage, R. S. K. A. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90192-9 · Cited by 20 · see citing works

Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution

Itoh, K., Maruyama, H., Adachi, M., Hoshino, K., Watanabe, N., & Tanaka, Y. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.015503 · Cited by 18 · see citing works

Construction and Expression of Mutant cDNAs Responsible for Genetic Polymorphism in Aldehyde Oxidase in Donryu Strain Rats

Adachi, M., Itoh, K., Masubuchi, A., Watanabe, N., & Tanaka, Y. (2007) · BMB Reports · doi:10.5483/bmbrep.2007.40.6.1021 · Cited by 17 · see citing works

Metabolism of Isovanillin by Aldehyde Oxidase, Xanthine Oxidase, Aldehyde Dehydrogenase and Liver Slices

Panoutsopoulos, G. I., & Beedham, C. (2004) · Pharmacology · doi:10.1159/000082860 · Cited by 16 · see citing works

Drugs That Inhibit Oxidation Reactions Catalyzed by Aldehyde Oxidase Do Not Inhibit the Reductive Metabolism of Ziprasidone to its Major Metabolite, S-Methyldihydroziprasidone

Obach, R. S., & Walsky, R. L. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000186740.22395.50 · Cited by 15 · see citing works

Developmental Changes of Aldehyde Oxidase in Postnatal Rat Liver

Tayama, Y., Moriyasu, A., Sugihara, K., Ohta, S., & Kitamura, S. (2007) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.22.119 · Cited by 15 · see citing works

Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents

Ohkubo, M., Sakiyama, S., & Fujimura, S. (1983) · Cancer Letters · doi:10.1016/0304-3835(83)90205-7 · Cited by 15 · see citing works

Development and evaluation of oral controlled release chlorpheniramine-ion exchange resinate suspension

Kadam, A., Sakarkar, D., & Kawtikwar, P. S. (2008) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.44613 · Cited by 14 · see citing works

Aldehyde oxidase and its contribution to the metabolism of a structurally novel, functionally selective GABAAα5-subtype inverse agonist

O'Connor, D. V., JONES, P. G., Chambers, M. S., Maxey, R., Szekeres, H. J., Szeto, N., Scott‐Stevens, P., MacLeod, A. M., Braun, M. P., & Cato, B. P. (2006) · Xenobiotica · doi:10.1080/00498250600567903 · Cited by 14 · see citing works

Phenylacetaldehyde Oxidation by Freshly Prepared and Cryopreserved Guinea Pig Liver Slices: The Role of Aldehyde Oxidase

Panoutsopoulos, G. I. (2005) · International Journal of Toxicology · doi:10.1080/10915810590936373 · Cited by 14 · see citing works

Isolation of liver aldehyde oxidase containing fractions from different animals and determination of kinetic parameters for benzaldehyde

Iyer, K., & Kadam, R. (2008) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.40337 · Cited by 10 · see citing works

Substrate specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase for methyl- and nitrobenzaldehydes

Veskoukis, A. S., Kouretas, D., & Panoutsopoulos, G. I. (2006) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190636 · Cited by 9 · see citing works

Metabolism of Homovanillamine to Homovanillic Acid in Guinea Pig Liver Slices

Panoutsopoulos, G. I. (2005) · Cellular Physiology and Biochemistry · doi:10.1159/000086409 · Cited by 9 · see citing works

Bioavailability and pharmacokinetics of the investigational anticancer agent XK469 (NSC 698215) in rats following oral and intravenous administration

Boinpally, R., Zhou, S.-L., LoRusso, P. M., & Parchment, R. E. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-004-0862-6 · Cited by 7 · see citing works

Contribution of Aldehyde Oxidizing Enzymes on the Metabolism of 3,4-Dimethoxy-2-phenylethylamine to 3,4-Dimethoxyphenylacetic Acid by Guinea Pig Liver Slices

Panoutsopoulos, G. I. (2006) · Cellular Physiology and Biochemistry · doi:10.1159/000091463 · Cited by 7 · see citing works

Metabolism of 2-phenylethylamine to phenylacetic acid, via the intermediate phenylacetaldehyde, by freshly prepared and cryopreserved guinea pig liver slices.

Panoutsopoulos, G. I. (2004) · PubMed · Cited by 5 · see citing works

Modern advances in heterocyclic chemistry in drug discovery

Taylor, A. P., Robinson, R. P., Fobian, Y. M., Blakemore, D. C., Jones, L. H., & Fadeyi, O. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob00936k · Cited by 895 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Pharmacokinetics

Fan, J., & de Lannoy, I. A. M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.09.007 · Cited by 309 · see citing works

The role of drug metabolizing enzymes in clearance

Di, L. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.876006 · Cited by 208 · see citing works

Aldehyde toxicity and metabolism: the role of aldehyde dehydrogenases in detoxification, drug resistance and carcinogenesis

Laskar, A. A., & Younus, H. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1555587 · Cited by 202 · see citing works

Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development

Lai, Y., Chu, X., Di, L., Gao, W., Guo, Y., Liu, X., Lu, C., Mao, J., Shen, H., Tang, H., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.03.009 · Cited by 169 · see citing works

Prevalence and Clinical Implications of Epstein-Barr Virus Infection in de novo Diffuse Large B-Cell Lymphoma in Western Countries

Chi, Y.-O., Li, L., Xu-Monette, Z. Y., Visco, C., Tzankov, A., Manyam, G., Montes-Moreno, S., Dybkær, K., Chiu, A., Orazi, A., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3157 · Cited by 134 · see citing works

Comparison of minipig, dog, monkey and human drug metabolism and disposition

Dalgaard, L. (2015) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2014.12.005 · Cited by 132 · see citing works

Mutations Associated with Functional Disorder of Xanthine Oxidoreductase and Hereditary Xanthinuria in Humans

Ichida, K., Amaya, Y., Okamoto, K., & Nishino, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131115475 · Cited by 119 · see citing works

Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics

Foti, R., & Dalvie, D. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.071753 · Cited by 117 · see citing works

Structure and function of mammalian aldehyde oxidases

Terao, M., Romão, M. J., Leimkühler, S., Bolis, M., Fratelli, M., Coelho, C., Santos-Silva, T., & Garattini, E. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1683-1 · Cited by 112 · see citing works

Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases

Kumar, R., Joshi, G., Kler, H., Kalra, S., Kaur, M., & Arya, R. (2017) · Medicinal Research Reviews · doi:10.1002/med.21457 · Cited by 106 · see citing works

Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites

Diao, X., & HUESTIS, M. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.534 · Cited by 104 · see citing works

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

Hutzler, J. M., Obach, R. S., Dalvie, D., & Zientek, M. A. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.738668 · Cited by 96 · see citing works

Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review

Kazem, S., Linssen, E. C., & Gibbs, S. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.06.002 · Cited by 95 · see citing works

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase

Coelho, C., Foti, A., Hartmann, T., Santos‐Silva, T., Leimkühler, S., & Romão, M. J. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1895 · Cited by 92 · see citing works

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance

Argikar, U. A., Potter, P. M., Hutzler, J. M., & Marathe, P. H. (2016) · The AAPS Journal · doi:10.1208/s12248-016-9962-6 · Cited by 89 · see citing works

Aldehyde oxidase and its role as a drug metabolizing enzyme

Dalvie, D., & Di, L. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.011 · Cited by 90 · see citing works

Clinical Pharmacokinetic and Pharmacodynamic Profile of Idelalisib

Ramanathan, S., Jin, F., Sharma, S., & Kearney, B. P. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0304-0 · Cited by 84 · see citing works

Potential Implication of The Chemical Properties and Bioactivity of Nitrone Spin Traps for Therapeutics

Villamena, F. A., Das, A. K., & Nash, K. M. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.74 · Cited by 79 · see citing works

Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

Sanoh, S., Tayama, Y., Sugihara, K., Kitamura, S., & Ohta, S. (2014) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2014.10.009 · Cited by 77 · see citing works

Hydralazine As a Selective Probe Inactivator of Aldehyde Oxidase in Human Hepatocytes: Estimation of the Contribution of Aldehyde Oxidase to Metabolic Clearance

Strelevitz, T. J., Orozco, C. C., & Obach, R. S. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.045195 · Cited by 77 · see citing works

Nitrite‐dependent nitric oxide synthesis by molybdenum enzymes

Bender, D. A., & Schwarz, G. (2018) · FEBS Letters · doi:10.1002/1873-3468.13089 · Cited by 73 · see citing works

Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes

Terao, M., Garattini, E., Romão, M. J., & Leimkühler, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007741 · Cited by 73 · see citing works

Molybdenum’s Role as an Essential Element in Enzymes Catabolizing Redox Reactions: A Review

Adamus, J. P., Ruszczyńska, A., & Wyczałkowska-Tomasik, A. (2024) · Biomolecules · doi:10.3390/biom14070869 · Cited by 68 · see citing works

Aldehyde oxidase and its importance in novel drug discovery: present and future challenges

Garattini, E., & Terao, M. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.788497 · Cited by 68 · see citing works

Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite

Glaenzel, U., Jin, Y., Hansen, R., Schroer, K., Rahmanzadeh, G., Pfaar, U., van Lier, J. J., Borell, H., Meissner, A., Camenisch, G., et al. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.119.090324 · Cited by 63 · see citing works

Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression

Kurosaki, M., Bolis, M., Fratelli, M., Barzago, M. M., Pattini, L., Perretta, G., Terao, M., & Garattini, E. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1229-5 · Cited by 61 · see citing works

Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis

Herter, S., McKenna, S. M., Frazer, A. R., Leimkühler, S., Carnell, A. J., & Turner, N. J. (2015) · ChemCatChem · doi:10.1002/cctc.201500218 · Cited by 62 · see citing works

Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite—Resolution for Clinical Development

Zheng, J., Xin, Y., Zhang, J., Subramanian, R., Murray, B. P., Whitney, J. A., Warr, M. R., Ling, J. R., Moorehead, L., Kwan, E., et al. (2018) · Drug Metabolism and Disposition · doi:10.1124/dmd.117.078899 · Cited by 60 · see citing works

Characterization of 6-mercaptopurine binding to bovine serum albumin and its displacement from the binding sites by quercetin and rutin

Ehteshami, M., Rasoulzadeh, F., Mahboob, S., & Rashidi, M. (2012) · Journal of Luminescence · doi:10.1016/j.jlumin.2012.10.044 · Cited by 59 · see citing works

Epigenomic profiling of DNA methylation in paired prostate cancer versus adjacent benign tissue

Geybels, M. S., Zhao, S., Wong, C.-J., Bibikova, M. V., Klotzle, B., Wu, M. C., Ostrander, E. A., Fan, J., Feng, Z., & Stanford, J. L. (2015) · The Prostate · doi:10.1002/pros.23093 · Cited by 58 · see citing works

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

O’Hara, F., Burns, A. C., Collins, M. R., Dalvie, D., Ornelas, M. A., Vaz, A. D. N., Fujiwara, Y., & Baran, P. S. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm4017976 · Cited by 53 · see citing works

Aldehyde Oxidase: Reaction Mechanism and Prediction of Site of Metabolism

Montefiori, M., Jørgensen, F. S., & Olsen, L. (2017) · ACS Omega · doi:10.1021/acsomega.7b00658 · Cited by 51 · see citing works

Interspecies variation in the metabolism of zoniporide by aldehyde oxidase

Dalvie, D., Xiang, C. D., Kang, P., & Zhou, S. (2012) · Xenobiotica · doi:10.3109/00498254.2012.727499 · Cited by 47 · see citing works

From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions

Cruciani, G., Milani, N., Benedetti, P., Lepri, S., Cesarini, L., Baroni, M., Spyrakis, F., Tortorella, S., Mosconi, E., & Goracci, L. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01552 · Cited by 46 · see citing works

Aldehyde Oxidase Activity in Donor-Matched Fresh and Cryopreserved Human Hepatocytes and Assessment of Variability in 75 Donors

Hutzler, J. M., Yang, Y.-S., Brown, C., Heyward, S. A., & Moeller, T. A. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.057984 · Cited by 46 · see citing works

Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics

Martinez, M. N., Mochel, J. P., Neuhoff, S., & Pade, D. (2021) · The AAPS Journal · doi:10.1208/s12248-021-00590-0 · Cited by 47 · see citing works

Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways

Toselli, F., Fredenwall, M., Svensson, P., Li, X., Johansson, A., Weidolf, L. O. G., & Hayes, M. A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00030 · Cited by 43 · see citing works

The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5

Morrison, R. D., Blobaum, A. L., Byers, F. W., Santomango, T. S., Bridges, T. M., Stec, D. F., Brewer, K. A., Sánchez-Ponce, R., Corlew, M. M., Rush, R., et al. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.046136 · Cited by 42 · see citing works

Evidence for Substrate-Dependent Inhibition Profiles for Human Liver Aldehyde Oxidase

Barr, J., & Jones, J. P. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.048546 · Cited by 42 · see citing works

In Vitro Oxidative Metabolism of 6-Mercaptopurine in Human Liver: Insights into the Role of the Molybdoflavoenzymes Aldehyde Oxidase, Xanthine Oxidase, and Xanthine Dehydrogenase

Choughule, K. V., Barnaba, C., Joswig-Jones, C. A., & Jones, J. P. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.058107 · Cited by 40 · see citing works

Effect of Structural Variation on Aldehyde Oxidase-Catalyzed Oxidation of Zoniporide

Dalvie, D., Sun, H., Xiang, C. D., Hu, Q., Jiang, Y., & Kang, P. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.045823 · Cited by 39 · see citing works

Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms

Foti, A., Hartmann, T., Coelho, C., Santos‐Silva, T., Romão, M. J., & Leimkühler, S. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.068395 · Cited by 39 · see citing works

Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study

Siah, M., Farzaei, M. H., Ashrafi-Kooshk, M. R., Adibi, H., Arab, S. S., Rashidi, M., & Khodarahmi‬, R. (2015) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2015.12.004 · Cited by 38 · see citing works

A Critical Review of Bioaccumulation and Biotransformation of Organic Chemicals in Birds

Kuo, D. T. F., Rattner, B. A., Marteinson, S. C., Letcher, R. J., Fernie, K. J., Treu, G., Deutsch, M., Johnson, M. S., Déglin, S. E., & Embry, M. R. (2022) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/s44169-021-00007-1 · Cited by 37 · see citing works

Time Course of Aldehyde Oxidase and Why It Is Nonlinear

Abbasi, A., Paragas, E. M., Joswig-Jones, C. A., Rodgers, J. T., & Jones, J. P. (2019) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.085787 · Cited by 37 · see citing works

Evaluation of Rhesus Monkey and Guinea Pig Hepatic Cytosol Fractions as Models for Human Aldehyde Oxidase

Choughule, K. V., Barr, J., & Jones, J. P. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.052985 · Cited by 35 · see citing works

Evaluation of Cytochrome P450 Selectivity for Hydralazine as an Aldehyde Oxidase Inhibitor for Reaction Phenotyping

Yang, X., Johnson, N., & Di, L. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2018.11.007 · Cited by 34 · see citing works

Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions

Rendić, S., Crouch, R. D., & Guengerich, F. P. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03304-3 · Cited by 34 · see citing works

Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase

Choughule, K. V., Joswig-Jones, C. A., & Jones, J. P. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.05.010 · Cited by 34 · see citing works

Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant)

Crouch, R. D., Blobaum, A. L., Felts, A. S., Conn, P. J., & Lindsley, C. W. (2017) · Drug Metabolism and Disposition · doi:10.1124/dmd.117.077552 · Cited by 33 · see citing works

Why Do Most Human Liver Cytosol Preparations Lack Xanthine Oxidase Activity?

Barr, J., Choughule, K. V., Nepal, S., Wong, T., Chaudhry, A. S., Joswig-Jones, C. A., Zientek, M. A., Strom, S. C., Schuetz, E. G., Thummel, K. E., et al. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.056374 · Cited by 30 · see citing works

Cytochrome P450 and Other Drug-Metabolizing Enzymes As Therapeutic Targets

Foti, R. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.001011 · Cited by 30 · see citing works

Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions

Nirogi, R. V. S., Kandikere, V. N., Palacharla, V. R. C., Bhyrapuneni, G., Kanamarlapudi, V. B., Ponnamaneni, R. K., & Manoharan, A. K. (2013) · Xenobiotica · doi:10.3109/00498254.2013.819594 · Cited by 30 · see citing works

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics

Romão, M. J., Coelho, C., Santos‐Silva, T., Foti, A., Terao, M., Garattini, E., & Leimkühler, S. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.01.005 · Cited by 29 · see citing works

Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors

Barsanti, P. A., Pan, Y., Lu, Y., Jain, R., Cox, M. O., Aversa, R. J., Dillon, M. P., Elling, R. A., Hu, C., Jin, X., et al. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml500352s · Cited by 29 · see citing works

The pharmacokinetics and safety of idelalisib in subjects with moderate or severe hepatic impairment

Jin, F., Robeson, M., Zhou, H., Hisoire, G., & Ramanathan, S. (2015) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.504 · Cited by 29 · see citing works

The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities

Marelja, Z., Dambowsky, M., Bolis, M., Georgiou, M. L., Garattini, E., Missirlis, F., & Leimkühler, S. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.102129 · Cited by 29 · see citing works

Use of Gold Nanoparticles as Additives in Protein Crystallization

Ribeiro, D. O., Kulakova, A., Quaresma, P., Pereira, E., Bonifácio, C., Romão, M. J., Franco, R., & Carvalho, A. L. (2013) · Crystal Growth & Design · doi:10.1021/cg4014398 · Cited by 29 · see citing works

An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery

Rashidi, M., & Soltani, S. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1284198 · Cited by 29 · see citing works

Not only tumor but also therapy heterogeneity

Garattini, S. K., Nerini, I. F., & D’Incalci, M. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx646 · Cited by 29 · see citing works

Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase

Isobe, T., Ohta, M., Kaneko, Y., & Kawai, H. (2015) · Xenobiotica · doi:10.3109/00498254.2015.1096981 · Cited by 27 · see citing works

A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase

Foti, A., Dorendorf, F., & Leimkühler, S. (2017) · PLOS ONE · doi:10.1371/journal.pone.0182061 · Cited by 26 · see citing works

Inhibition of Human Aldehyde Oxidase Activity by Diet-Derived Constituents: Structural Influence, Enzyme-Ligand Interactions, and Clinical Relevance

Barr, J., Jones, J. P., Oberlies, N. H., & Paine, M. F. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.061192 · Cited by 26 · see citing works

Cynomolgus Monkey as a Surrogate for Human Aldehyde Oxidase Metabolism of the EGFR Inhibitor BIBX1382

Hutzler, J. M., Cerny, M. A., Yang, Y.-S., Asher, C. O., Wong, D. F., Frederick, K. S., & Gilpin, K. E. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.059030 · Cited by 26 · see citing works

Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics

Mota, C., Coelho, C., Leimkühler, S., Garattini, E., Terao, M., Santos‐Silva, T., & Romão, M. J. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.04.006 · Cited by 26 · see citing works

Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids

Hamzeh‐Mivehroud, M., Rahmani, S., Rashidi, M., Feizi, M. A. H., & Dastmalchi, S. (2013) · Xenobiotica · doi:10.3109/00498254.2012.755228 · Cited by 25 · see citing works

Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis

Singh, K. A., Soukar, J., Zulkifli, M., Kersey, A. L., Lokhande, G. K., Ghosh, S., Murali, A., Garza, N. M., Kaur, H. P., Keeney, J. N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52276-8 · Cited by 24 · see citing works

Predicting Regioselectivity of AO, CYP, FMO, and UGT Metabolism Using Quantum Mechanical Simulations and Machine Learning

Öeren, M., Walton, P., Suri, J., Ponting, D. J., Hunt, P. A., & Segall, M. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01303 · Cited by 24 · see citing works

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase

Fan, P. W., Zhang, D., Halladay, J. S., Driscoll, J. P., & Khojasteh, S. C. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.070169 · Cited by 24 · see citing works

Molybdenum-containing nitrite reductases: Spectroscopic characterization and redox mechanism

Wang, J., Keceli, G., Cao, R., Su, J., & Mi, Z. (2016) · Redox Report · doi:10.1080/13510002.2016.1206175 · Cited by 24 · see citing works

Reduction and methylation of ziprasidone by glutathione, aldehyde oxidase, and thiol s-methyltransferase in humans: anin vitrostudy

Obach, R. S., Prakash, C., & Kamel, A. M. (2012) · Xenobiotica · doi:10.3109/00498254.2012.683203 · Cited by 24 · see citing works

Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development

Gajula, S. N. R., Nathani, T. N., Patil, R. M., Talari, S., & Sonti, R. (2022) · Drug Metabolism Reviews · doi:10.1080/03602532.2022.2144879 · Cited by 23 · see citing works

Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug–drug interactions

Takaoka, N., Sanoh, S., Okuda, K., Kotake, Y., Sugahara, G., Yanagi, A., Ishida, Y., Tateno, C., Tayama, Y., Sugihara, K., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.04.017 · Cited by 23 · see citing works

Expression of Pisum sativum PsAO3 gene, which encodes an aldehyde oxidase utilizing abscisic aldehyde, is induced under progressively but not rapidly imposed drought stress

Zdunek-Zastocka, E., & Sobczak, M. (2013) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2013.06.027 · Cited by 23 · see citing works

Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity

Terao, M., Barzago, M. M., Kurosaki, M., Fratelli, M., Bolis, M., Borsotti, A., Bigini, P., Micotti, E., Carli, M., Invernizzi, R. W., et al. (2016) · Scientific Reports · doi:10.1038/srep30343 · Cited by 22 · see citing works

In vitrometabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes

Nakagawa, T., Fowler, S. M., Takanashi, K., Youdim, K. A., Yamauchi, T., Kawashima, K., Sato-Nakai, M., Yu, L. J., & Ishigai, M. (2017) · Xenobiotica · doi:10.1080/00498254.2017.1344910 · Cited by 22 · see citing works

Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis

Janetka, J. W., Hopper, A. T., Yang, Z., Barks, J., Dhason, M. S., Wang, Q., & Sibley, L. D. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00419 · Cited by 22 · see citing works

Selective Heteroaryl N-Oxidation of Amine-Containing Molecules

Dyer, R. M. B., Hahn, P. L., & Hilinski, M. K. (2018) · Organic Letters · doi:10.1021/acs.orglett.8b00558 · Cited by 22 · see citing works

Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases

Cerqueira, N. M. F. S. A., Coelho, C., Brás, N. F., Fernandes, P. A., Garattini, E., Terao, M., Romão, M. J., & Ramos, M. J. (2014) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-014-1198-2 · Cited by 21 · see citing works

Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

Crouch, R. D., Morrison, R. D., Byers, F. W., Lindsley, C. W., Emmitte, K. A., & Daniels, J. S. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.068338 · Cited by 21 · see citing works

Aldehyde oxidase-dependent species difference in hepatic metabolism of fasudil to hydroxyfasudil

Mao, Z., Wu, Y., Li, Q., Wang, X., Liu, Y., & Di, X. (2017) · Xenobiotica · doi:10.1080/00498254.2017.1292016 · Cited by 21 · see citing works

A novelin vitroallometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry

Crouch, R. D., Hutzler, J. M., & Daniels, J. S. (2017) · Xenobiotica · doi:10.1080/00498254.2017.1296208 · Cited by 21 · see citing works

Transcriptome differences in frontal cortex between wild boar and domesticated pig

Long, K., Mao, K., Che, T., Zhang, J., Qiu, W., Wang, Y., Tang, Q., Ma, J., Li, M., & Li, X. (2018) · Animal Science Journal · doi:10.1111/asj.12999 · Cited by 21 · see citing works

Tertiary Alcohol: Reaping the Benefits but Minimizing the Drawbacks of Hydroxy Groups in Drug Discovery

Chiodi, D., & Ishihara, Y. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c03078 · Cited by 19 · see citing works

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

Kamimura, H., & Ito, S. (2015) · Xenobiotica · doi:10.3109/00498254.2015.1091113 · Cited by 19 · see citing works

N-Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by Porcine Aldehyde Oxidase SsAOX1

Mu, P., Zheng, M., Ming, X., Zheng, Y., Tang, X., Wang, Y., Wu, K., Chen, Q., Wang, L., & Deng, Y. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.055418 · Cited by 19 · see citing works

The Drug-Drug Interaction between Erlotinib and OSI-930 Is Mediated through Aldehyde Oxidase Inhibition

Tang, L. W. T., Shi, Y., Sharma, R., & Obach, R. S. (2024) · Drug Metabolism and Disposition · doi:10.1124/dmd.124.001802 · Cited by 18 · see citing works

Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells

Kamli, M. R., Kim, J., Pokharel, S., Jan, A. T., Lee, E. J., & Choi, I. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.126 · Cited by 18 · see citing works

Human Aldehyde Oxidase 1–Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes

Uehara, S., Yoneda, N., Higuchi, Y., Yamazaki, H., & Suemizu, H. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.091090 · Cited by 18 · see citing works

Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans

Uno, Y., Uehara, S., & Yamazaki, H. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114887 · Cited by 18 · see citing works

Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro–In Vivo Comparisons

Wilkinson, D., Southall, R., Li, M., Wright, L. M., Corfield, L. J., Heeley, T. A., Bratby, B., Mannu, R., Johnson, S., Shaw, V. E., et al. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0087-3 · Cited by 17 · see citing works

A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production

Muta, K., Fukami, T., & Nakajima, M. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.09.016 · Cited by 17 · see citing works

Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes

Tang, L. W. T., DaSilva, E., Lapham, K., & Obach, R. S. (2024) · Drug Metabolism and Disposition · doi:10.1124/dmd.124.001693 · Cited by 16 · see citing works

Neurotoxic and cardiotoxic effects of pyrogallol on catfish (Clarias gariepinus)

Hamed, M., Martyniuk, C. J., Soliman, H. A. M., Osman, A. G. M., & Said, R. E. M. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104481 · Cited by 16 · see citing works

Direct Comparison of the Enzymatic Characteristics and Superoxide Production of the Four Aldehyde Oxidase Enzymes Present in Mouse

Kücükgöze, G., Terao, M., Garattini, E., & Leimkühler, S. (2017) · Drug Metabolism and Disposition · doi:10.1124/dmd.117.075937 · Cited by 16 · see citing works

Human xanthine oxidase recombinant in E. coli: A whole cell catalyst for preparative drug metabolite synthesis

Antunes, M., Eggimann, F. K., Kittelmann, M., Lütz, S., Hanlon, S. P., Wirz, B., Bachler, T., & Winkler, M. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.03.045 · Cited by 15 · see citing works

Enzyme Kinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

Barr, J., Choughule, K. V., & Jones, J. P. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-758-7_9 · Cited by 15 · see citing works

Urinary Excretion of N1-methyl-2-pyridone-5-carboxamide and N1-methylnicotinamide in Renal Transplant Recipients and Donors

Deen, C. P. J., van der Veen, A., Neto, A. W. G., Geleijnse, J. M., den Berg, K. J. B., Heiner-Fokkema, M. R., Kema, I. P., & Bakker, S. J. L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020437 · Cited by 14 · see citing works

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics

Romão, M. J., Coelho, C., Santos‐Silva, T., Foti, A., Terao, M., Garattini, E., & Leimkühler, S. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.01.005 · Cited by 29 · see citing works

Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics

Mota, C., Coelho, C., Leimkühler, S., Garattini, E., Terao, M., Santos‐Silva, T., & Romão, M. J. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.04.006 · Cited by 26 · see citing works

Aldehyde oxidase and its importance in novel drug discovery: present and future challenges

Garattini, E., & Terao, M. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.788497 · Cited by 68 · see citing works

Aldehyde oxidase and its role as a drug metabolizing enzyme

Dalvie, D., & Di, L. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.011 · Cited by 90 · see citing works

Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism

Mota, C., Santos‐Silva, T., Terao, M., Garattini, E., Romão, M. J., & Leimkühler, S. (2019) · doi:10.1201/9780429295034-13 · Cited by 1 · see citing works