Effects of β-Hydroxy β-Methylbutyrate on Power Performance and Indices of Muscle Damage and Stress During High-Intensity Training
Abstract
Twenty-six members of a collegiate football team were randomly assigned to either a supplement (S) (3 g of beta-hydroxy beta-methylbutyrate [HMB] per day) or placebo (P) group. Testing occurred before (PRE) and at the end of 10 days of preseason football training camp (POST). During each testing session, subjects performed an anaerobic power test, and blood samples were obtained for testosterone, cortisol, creatine kinase, and myoglobin analysis. No differences in anaerobic power were seen between PRE and POST in either group. Cortisol concentrations were significantly decreased from PRE (333 +/- 81 nmol.L(-1)) to POST (246 +/- 79 nmol.L(-1)), and a sixfold increase was seen in creatine kinase concentrations at POST. However, no significant differences between the groups were seen. No significant time or group effects were observed in testosterone or myoglobin concentrations. Results suggest that short duration HMB supplementation does not provide any ergogenic benefit in collegiate football players during preseason training camp.
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HMB supplementation failed to improve anaerobic power production in collegiate football players.
“Hoffman and colleagues [573] reported that HMB supplementation failed to improve anaerobic power production in collegiate football players”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [573]
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Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945 · see citing works
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Kreider, R. B., Wilborn, C. D., Taylor, L., Campbell, B., Almada, A. L., Collins, R., Cooke, M., Earnest, C. P., Greenwood, M., Kalman, D. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-7 · Cited by 428 · see citing works
Wilson, G. J., Wilson, J. M., & Manninen, A. H. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-1 · Cited by 306 · see citing works
Holeček, M. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12208 · Cited by 287 · see citing works
The creatine kinase response to resistance exercise.
Koch, A. J., Pereira, R., & Machado, M. (2014) · PubMed · Cited by 227 · see citing works
International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)
Wilson, J. M., Fitschen, P. J., Campbell, B., Wilson, G. J., Zanchi, N., Taylor, L., Wilborn, C., Kalman, D. S., Stout, J. R., Hoffman, J. R., et al. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-6 · Cited by 196 · see citing works
Self-citationKornasio, R., Riederer, I., Butler-Browne, G. S., Mouly, V., Uni, Z., & Halevy, O. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.017 · Cited by 182 · see citing works
Dietary Supplements and Team-Sport Performance
Bishop, D. J. (2010) · Sports Medicine · doi:10.2165/11536870-000000000-00000 · Cited by 175 · see citing works
HMB supplementation: clinical and athletic performance-related effects and mechanisms of action
Zanchi, N. E., Gerlinger‐Romero, F., Guimarães‐Ferreira, L., Filho, M. A. D. S., Felitti, V., Lira, F. S., Seelaender, M. C. L., & Lancha, A. H. (2010) · Amino Acids · doi:10.1007/s00726-010-0678-0 · Cited by 151 · see citing works
Performance-Enhancing Substances in Sports: A Review of the Literature
Momaya, A. M., Fawal, M., & Estes, R. (2015) · Sports Medicine · doi:10.1007/s40279-015-0308-9 · Cited by 142 · see citing works
Wilson, J. M., Lowery, R. P., Joy, J. M., Andersen, J. C., Wilson, S. M. C., Stout, J. R., Duncan, N., Fuller, J. C., Baier, S. M., Naimo, M. A., et al. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2854-5 · Cited by 123 · see citing works
Molfino, A., Gioia, G., Fanelli, F. R., & Muscaritoli, M. (2013) · Amino Acids · doi:10.1007/s00726-013-1592-z · Cited by 99 · see citing works
Bongiovanni, T., Genovesi, F., Nemmer, M., Carling, C., Alberti, G., & Howatson, G. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04432-3 · Cited by 96 · see citing works
Portal, S., Zadik, Z., Rabinowitz, J., Pilz-Burstein, R., Adler-Portal, D., Meckel, Y., Cooper, D. M., Eliakim, A., & Nemet, D. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1855-x · Cited by 90 · see citing works
Bloomer, R. J. (2007) · Sports Medicine · doi:10.2165/00007256-200737060-00005 · Cited by 86 · see citing works
Durkalec-Michalski, K., Jeszka, J., & Podgórski, T. (2017) · Nutrients · doi:10.3390/nu9070753 · Cited by 78 · see citing works
Pinheiro, C. H. D. J., Gerlinger-Romero, F., Guimarães-Ferreira, L., de Souza-Jr, A. L., Vitzel, K. F., Nachbar, R. T., Nunes, M. T., & Curi, R. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2224-5 · Cited by 77 · see citing works
The Applied Physiology of American Football
Hoffman, J. R. (2008) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.3.3.387 · Cited by 77 · see citing works
Self-citationMedication and supplement use by athletes
Ciocca, M. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2005.03.005 · Cited by 72 · see citing works
Greenham, G., Buckley, J. D., Garrett, J. M., Eston, R. G., & Norton, K. I. (2018) · Sports Medicine · doi:10.1007/s40279-018-0969-2 · Cited by 69 · see citing works
Townsend, J. R., Fragala, M. S., Jajtner, A. R., Gonzalez, A. M., Wells, A. J., Mangine, G. T., Robinson, E. H., McCormack, W. P., Beyer, K. S., Pruna, G. J., et al. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00738.2013 · Cited by 63 · see citing works
Self-citationMcLellan, T. M., Pasiakos, S. M., & Lieberman, H. R. (2014) · Sports Medicine · doi:10.1007/s40279-013-0133-y · Cited by 62 · see citing works
Nutritional Compounds to Improve Post-Exercise Recovery
O’Connor, E. B., Mündel, T., & Barnes, M. J. (2022) · Nutrients · doi:10.3390/nu14235069 · Cited by 67 · see citing works
Silva, V. R., Belozo, F. L., Micheletti, T. O., Conrado, M., Stout, J. R., Pimentel, G. D., & Gonzalez, A. M. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.07.008 · Cited by 56 · see citing works
Durkalec-Michalski, K., & Jeszka, J. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0092-9 · Cited by 48 · see citing works
Nutritional Supplementation, Performance, and Oxidative Stress in College Soccer Players
Arent, S. M., Pellegrino, J. K., Williams, C. A., DiFabio, D., & Greenwood, J. C. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181cb70b8 · Cited by 48 · see citing works
Bloomer, R. J., Fry, A. C., Schilling, B. K., Chiu, L. Z. F., Hori, N., & Weiss, L. W. (2005) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.15.4.401 · Cited by 47 · see citing works
Portal, S., Eliakim, A. R., Nemet, D., Halevy, O., & Zadik, Z. (2010) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2010.23.7.641 · Cited by 45 · see citing works
Supplements and the Endocrine System in Athletes
Di Luigi, L. (2008) · Clinics in Sports Medicine · doi:10.1016/j.csm.2007.09.003 · Cited by 43 · see citing works
Asadi, A., Arazi, H., & Suzuki, K. (2017) · Nutrients · doi:10.3390/nu9121316 · Cited by 42 · see citing works
Rahimi, M. H., Mohammadi, H., Eshaghi, H., Askari, G., & Miraghajani, M. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1451789 · Cited by 40 · see citing works
Gonzalez, A. M., Stout, J. R., Jajtner, A. R., Townsend, J. R., Wells, A. J., Beyer, K. S., Boone, C. H., Pruna, G. J., Mangine, G. T., Scanlon, T. C., et al. (2014) · Amino Acids · doi:10.1007/s00726-014-1722-2 · Cited by 38 · see citing works
Self-citationEffects of Amino Acid Derivativeson Physical, Mental, and Physiological Activities
Luckose, F., Pandey, M. C., & Radhakrishna, K. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.708368 · Cited by 38 · see citing works
International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB)
Rathmacher, J. A., Pitchford, L. M., Stout, J. R., Townsend, J. R., Jäger, R., Kreider, R. B., Campbell, B. I., Kerksick, C. M., Harty, P. S., Candow, D. G., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2434734 · Cited by 37 · see citing works
Durkalec-Michalski, K., & Jeszka, J. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001361 · Cited by 31 · see citing works
Townsend, J. R., Hoffman, J. R., Gonzalez, A. M., Jajtner, A. R., Boone, C. H., Robinson, E. H., Mangine, G. T., Wells, A. J., Fragala, M. S., Fukuda, D. H., et al. (2015) · International Journal of Endocrinology · doi:10.1155/2015/856708 · Cited by 28 · see citing works
Self-citationDoes HMB Enhance Body Composition in Athletes? A Systematic Review and Meta-analysis
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Albert, F. J., Morente-Sánchez, J., Ortega, F. B., Castillo, M. J., & Gutiérrez, Á. (2015) · PubMed · doi:10.3305/nh.2015.32.1.9101 · Cited by 23 · see citing works
β-Hydroxy-β-Methylbutyrate and Its Use in Athletics
Palisin, T. E., & Stacy, J. J. (2005) · Current Sports Medicine Reports · doi:10.1097/01.csmr.0000306211.02681.d3 · Cited by 21 · see citing works
Benefits of β-hydroxy-β-methylbutyrate supplementation in trained and untrained individuals
Gepner, Y., Varanoske, A. N., Boffey, D., & Hoffman, J. R. (2018) · Research in Sports Medicine · doi:10.1080/15438627.2018.1533470 · Cited by 20 · see citing works
Self-citationBuilding muscle: nutrition to maximize bulk and strength adaptations to resistance exercise training
Tarnopolsky, M. A. (2008) · European Journal of Sport Science · doi:10.1080/17461390801919128 · Cited by 18 · see citing works
Tinsley, G. M., Givan, A. H., Graybeal, A. J., Villarreal, M. I., & Cross, A. G. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114517003907 · Cited by 17 · see citing works
Arazi, H., Hosseini, Z., Asadi, A., Ramírez‐Campillo, R., & Suzuki, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00776 · Cited by 16 · see citing works
Stahn, A. C., Maggioni, M. A., Gunga, H., & Terblanche, E. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-0336-1 · Cited by 15 · see citing works
Correia, A. L. M., de Lima, F. D., Bottaro, M., Vieira, A., da Fonseca, A. C., & Lima, R. M. (2018) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2017-0867 · Cited by 11 · see citing works
Dietary Supplements Used in Combat Sports
Campbell, B. I., Bounty, P. M. L., & Wilborn, C. (2011) · Strength and conditioning journal · doi:10.1519/ssc.0b013e31823a4e90 · Cited by 11 · see citing works
Mangine, G. T., VanDusseldorp, T. A., Hester, G. M., Julian, J. M., & Feito, Y. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00359-4 · Cited by 10 · see citing works
Faramarzi, M., Nuri, R., & Banitalebi, E. (2009) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 9 · see citing works
Dietary Supplements and Sports Performance: Metabolites, Constituents, and Extracts
Williams, M. H. (2006) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-3-2-1 · Cited by 9 · see citing works
Li, N., Chen, S., He, Y., Chen, Y., Duan, X., He, W., Wang, Q., Liu, S., Liu, T., & Fang, H. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1522287 · Cited by 8 · see citing works
Kim, D., & Kim, J. (2022) · Physical Activity and Nutrition · doi:10.20463/pan.2022.0023 · Cited by 8 · see citing works
Pinheiro, C. H. J., Guimarães-Ferreira, L., Gerlinger-Romero, F., & Curi, R. (2013) · Nutrition and Enhanced Sports Performance · doi:10.1016/b978-0-12-396454-0.00047-3 · Cited by 7 · see citing works
McIntosh, N. D., Love, T. D., Haszard, J. J., Osborne, H., & Black, K. E. (2016) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001695 · Cited by 7 · see citing works
Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia
Álvares, T. S., & Meirelles, C. M. (2008) · Revista de Nutrição · doi:10.1590/s1415-52732008000100006 · Cited by 7 · see citing works
Zhao, L., & Mohammad, M. (2022) · Food Science & Nutrition · doi:10.1002/fsn3.2887 · Cited by 5 · see citing works
Nunes, E. A., & Fernandes, L. C. (2008) · Revista de Nutrição · doi:10.1590/s1415-52732008000200011 · Cited by 4 · see citing works
Effective Nutritional Supplement Combinations
Cooke, M. B., & Cribb, P. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-231-1_9 · Cited by 3 · see citing works
Performance Enhancement Drugs and Sports Supplements for Resistance Training
Guimarães-Ferreira, L., Dantas, W., Murai, I., Duncan, M., & Zanchi, N. E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396454-0.00003-5 · Cited by 3 · see citing works
Schadock, I., Freitas, B. G., Moreira, I. D. L., Rincón, J. A. A., Corrêa, M. N., Zanella, R., da Silva, E. S., Araújo, R. C., Buchweitz, M. R. D., Helbig, E., et al. (2018) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000445 · Cited by 3 · see citing works
Relationship between Squat Mobility with Snatch and Clean & Jerk Technique
Mohamad, N. I., Alali, A. A., Malek, N. F. A., & Nadzalan, A. M. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1874/1/012017 · Cited by 3 · see citing works
Anaerobic Work Capacity Derived from Isokinetic and Isoinertial Cycling
Wiedemann, M. S. F., & Bosquet, L. (2009) · International Journal of Sports Medicine · doi:10.1055/s-0029-1233466 · Cited by 3 · see citing works
Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones
Arazi, H., Rohani, H., Ghiasi, A., & Keikanloo, N. A. (2015) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-869220152105113281 · Cited by 3 · see citing works
Shakibaee, A., Gholizadeh, M., Shirvani, H., & Samadi, M. (2023) · Sport Sciences for Health · doi:10.1007/s11332-023-01081-9 · Cited by 2 · see citing works
Saller, R., Suter, P. M., Römer-Lüthi, C., Mannhart, C., Brignoli, R., & Meier, R. F. (2008) · Schweizerische Zeitschrift für Ganzheitsmedizin / Swiss Journal of Integrative Medicine · doi:10.1159/000286170 · Cited by 2 · see citing works
Bideshki, M. V., Sadeghi, B., Behzadi, M., Jozi, H., Damaneh, H. E., & Rashidinejad, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1582135 · Cited by 1 · see citing works
Funk, P. (2015) · Journal of Nutritional Health & Food Engineering · doi:10.15406/jnhfe.2015.02.00046 · Cited by 1 · see citing works
Aerobic training effects on rate of force production
Carroll, C. K. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
Papadopoulos, N. G., Bavbek, S., Čustović, A., Eigenmann, P., Hellings, P. W., Muraro, A. M., Poulsen, L. K., Roberts, G. C., Schmid‐Grendelmeier, P., Werfel, T., et al. (2014)
β-hydroxy-β-methylbutyrate: role and prospects applications in gerontology
Nikitina, E., Orlova, S., Pigareva, Y., & Магомедова, Х. А. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-21-94-100
Pasquale, M. D. D. (2007) · Nutrition in exercise and sport · doi:10.1201/9781420043815.ch7
Beta-hydroxy-beta-methylbutyrate - from a nutritional supplement to the therapy of cachexia?
Kovarik, M. F., Muthný, T., & Holeček, M. (2007) · Klinická biochemie a metabolismus · doi:10.61568/kbm.2007.046
Beattie, A. E. (2014) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Tayebi, S. M., Mirzaei, M., & Stout, J. R. (2026) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2026.2665962
Mollahosseini, M., Rahimi, M. H., Hosseini‐Marnani, E., Yazdanpanah, Z., Mozaffari–Khosravi, H., & Hosseinzadeh, M. (2026) · فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران · doi:10.66224/iau.36.2.129
- Authors
- Hoffman, J. R., Cooper, J., Wendell, M., Im, J., & Kang, J.
- Affiliations
- The College of New Jersey (US)
- Venue
- The Journal of Strength and Conditioning Research
- Published
- 2004
- Volume
- 18
- Issue
- 4
- Pages
- 747
- ISSN
- 1064-8011 (ISSN-L)
- 1533-4287
- OpenAlex
- W2050042939
- Cited by
- 77
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 8
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Strength and Conditioning Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- beta-hydroxy-beta-methylbutyrate, HMB supplementation, ergogenic aids, anaerobic power, muscle damage, creatine kinase, cortisol, testosterone, myoglobin, high-intensity training, football players
- MeSH terms
- Administration, Oral, Adult, Analysis of Variance, Creatine Kinase, Football, Humans, Hydrocortisone, Male, Myoglobin, Surveys and Questionnaires, Testosterone, Valerates, Muscle, Skeletal, Dietary Supplements
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