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Cited by 31Neurogenesis and neuroplasticity mechanismsTraumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury Research

Traumatic brain injury stimulates neural stem cell proliferation via mammalian target of rapamycin signaling pathway activation

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Wang, Xiaoting, Seekaew, Pich, Gao, Xiang, Chen, Jinhui·2016·eneuro
DOI 10.1523/eneuro.0162-16.2016PMC PMC5089538
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Abstract

Neural stem cells in the adult brain possess the ability to remain quiescent until needed in tissue homeostasis or repair. It was previously shown that traumatic brain injury (TBI) stimulated neural stem cell (NSC) proliferation in the adult hippocampus, indicating an innate repair mechanism, but it is unknown how TBI promotes NSC proliferation. In the present study, we observed dramatic activation of mammalian target of rapamycin complex 1 (mTORC1) in the hippocampus of mice with TBI from controlled cortical impact (CCI). The peak of mTORC1 activation in the hippocampal subgranular zone, where NSCs reside, is 24–48 h after trauma, correlating with the peak of TBI-enhanced NSC proliferation. By use of a Nestin-GFP transgenic mouse, in which GFP is ectopically expressed in the NSCs, we found that TBI activated mTORC1 in NSCs. With 5-bromo-2′-deoxyuridine labeling, we observed that TBI increased mTORC1 activation in proliferating NSCs. Furthermore, administration of rapamycin abolished TBI-promoted NSC proliferation. Taken together, these data indicate that mTORC1 activation is required for NSC proliferation postinjury, and thus might serve as a therapeutic target for interventions to augment neurogenesis for brain repair after TBI.

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  • These findings suggest that mTORC1 and mTORC2 may be differentially regulated across hippocampal subregions and molecular layers.

    “These findings suggest that mTORC1 and mTORC2 may be differentially regulated across hippocampal subregions and molecular layers. 73 , 74”

    From Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations (2026) · cites this paper as [74]

    The Results (page unavailable) show mTORC1 activation in the hippocampus after traumatic brain injury and examine the dentate gyrus and subgranular zone. The Discussion (page unavailable) describes variation by cell type and time. The paper does not assess mTORC2 or compare regulation of the two complexes across hippocampal subregions and molecular layers. (LLM, conf=0.77)

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Sorted by citations

Authors
Wang, X., Seekaew, P., Gao, X., & Chen, J.
Affiliations
Indiana University Indianapolis (US)
Corresponding author
Chen, Jinhui
ORCID
Venue
eneuro
Publisher
Society for Neuroscience
Published
2016-09
Volume
3
Issue
5
Pages
ENEURO.0162-16.2016
ISSN
2373-2822 (ISSN-L)
DOI
10.1523/eneuro.0162-16.2016
PMC
PMC5089538
OpenAlex
W2537276296
Cited by
31
References
5
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 1
FWCI
2.38
Type
journal article
Language
en
Open access
Licence
Locations
  • eNeuro (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion, cc-by)
  • Purdue University Indianapolis (Indiana University) (submittedVersion, cc-by)
  • PMC
Funders
Indiana Spinal Cord and Brain Injury Trust (03)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
traumatic brain injury, neural stem cells, mTORC1 signaling, neural stem cell proliferation, hippocampus, controlled cortical impact, rapamycin, subgranular zone, neurogenesis, brain repair
MeSH terms
Brain Injuries, Traumatic, Mechanistic Target of Rapamycin Complex 1, Animals, Disease Models, Animal, Hippocampus, Male, Mice, Inbred C57BL, Mice, Transgenic, Multiprotein Complexes, Green Fluorescent Proteins, Stem Cell Niche, Neurogenesis, TOR Serine-Threonine Kinases, Neural Stem Cells, Nestin

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