Traumatic brain injury: A risk factor for Alzheimer's disease
Abstract
Traumatic brain injury (TBI) constitutes a major global health and socio-economic problem with neurobehavioral sequelae contributing to long-term disability. It causes brain swelling, axonal injury and hypoxia, disrupts blood brain barrier function and increases inflammatory responses, oxidative stress, neurodegeneration and leads to cognitive impairment. Epidemiological studies show that 30% of patients, who die of TBI, have Aβ plaques which are pathological features of Alzheimer's disease (AD). Thus TBI acts as an important epigenetic risk factor for AD. This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease. Such understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TBI increases the risk of Alzheimer's disease.
“As TBI increases the risk of PTSD109 and Alzheimer’s disease110, these data may help us understand the factors that make higher brain circuits so vulnerable to insult.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [110]
Cites
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression
Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605 · see citing works
Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587 · see citing works
Pathophysiology of traumatic brain injury
Greve, M. W., & Zink, B. J. (2009) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20104 · Cited by 477 · cited 1× · see citing works
“This holds some promise in the development of biomarkers to assess the severity of TBI and also to understand some of the cellular processes that may occur in the injury and post injury period (Greve and Zink, 2009).”
BackgroundZhang, X., Zhou, K., Wang, R., Cui, J., Lipton, S. A., Liao, F.-F., Xu, H., & Zhang, Y.-W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608856200 · Cited by 436 · see citing works
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
Ikonomovic, M. D., Uryu, K., Abrahamson, E. E., Ciallella, J. R., Trojanowski, J. Q., Lee, V. M.-Y., Clark, R. S., Marion, D. W., Wisniewski, S. R., & DeKosky, S. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.011 · Cited by 399 · see citing works
Young-Pearse, T. L., Bai, J., Chang, R., Zheng, J. B., LoTurco, J. J., & Selkoe, D. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4701-07.2007 · Cited by 369 · see citing works
Frugier, T., Morganti-Kossmann, M. C., O'Reilly, D., & McLean, C. A. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1120 · Cited by 278 · see citing works
Pathobiology of traumatically induced axonal injury in animals and man
Povlishock, J. T. (1993) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(05)82738-6 · Cited by 236 · cited 1× · see citing works
“Patients with DAI are more likely to develop persistent oma and are less likely to return to previous level of functionng (Maxwell et al., 1997; Povlishock, 1993).”
BackgroundMild traumatic brain injury: a risk factor for neurodegeneration
Gavett, B. E., Stern, R. A., Cantu, R. C., Nowinski, C. J., & McKee, A. C. (2010) · Alzheimer's Research & Therapy · doi:10.1186/alzrt42 · Cited by 216 · see citing works
Abrahamson, E. E., Ikonomovic, M. D., Ciallella, J. R., Hope, C. E., Paljug, W. R., Isanski, B. A., Flood, D. G., Clark, R. S. B., & DeKosky, S. T. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.10.011 · Cited by 90 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Inflammation as a central mechanism in Alzheimer's disease
Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752 · see citing works
Prakash, R., & Carmichael, S. T. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000248 · Cited by 296 · see citing works
Molecular mechanisms of cognitive dysfunction following traumatic brain injury
Walker, K. R., & Tesco, G. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00029 · Cited by 265 · see citing works
Optimally controlling the human connectome: the role of network topology
Betzel, R. F., Gu, S., Medaglia, J. D., Pasqualetti, F., & Bassett, D. S. (2016) · Scientific Reports · doi:10.1038/srep30770 · Cited by 247 · see citing works
Traumatic Brain Injury Induces Tau Aggregation and Spreading
Edwards, G., Zhao, J., Dash, P. K., Soto, C., & Moreno-Gonzalez, I. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2018.6348 · Cited by 195 · see citing works
Chronic traumatic encephalopathy: Where are we and where are we going?
Mez, J., Stern, R. A., & McKee, A. C. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0407-7 · Cited by 120 · see citing works
Rubenstein, R., Chang, B., Davies, P., Wagner, A. K., Robertson, C. S., & Wang, K. K. W. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3548 · Cited by 116 · see citing works
A critical review of chronic traumatic encephalopathy
Iverson, G. L., Gardner, A. J., McCrory, P., Zafonte, R., & Castellani, R. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.008 · Cited by 103 · see citing works
Banik, A., Brown, R. E., Bamburg, J., Lahiri, D. K., Khurana, D., Friedland, R. P., Chen, W., Ding, Y., Mudher, A., Padjen, A. L., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150136 · Cited by 102 · see citing works
The impact of alcohol on Alzheimer's disease: A systematic review
Piazza-Gardner, A. K., Gaffud, T. J. B., & Barry, A. E. (2013) · Aging & Mental Health · doi:10.1080/13607863.2012.742488 · Cited by 94 · see citing works
Arnsten, A. F. T., Datta, D., Leslie, S., Yang, S.-T., Wang, M., & Nairn, A. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903671116 · Cited by 74 · see citing works
Functional Neuroimaging in Traumatic Brain Injury: From Nodes to Networks
Medaglia, J. D. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00407 · Cited by 63 · see citing works
Spilman, P. R., Corset, V., Gorostiza, O., Poksay, K. S., Galvan, V., Zhang, J., Rao, R., Peters-Libeu, C., Vincelette, J., McGeehan, A., et al. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-151046 · Cited by 39 · see citing works
- Authors
- Sivanandam, T. M., & Thakur, M. K.
- Affiliations
- Central University of Kerala (IN)
- Banaras Hindu University (IN)
- Corresponding author
- Thakur, Mahendra Kumar
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 36
- Issue
- 5
- Pages
- 1376-1381
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2028265367
- Cited by
- 326
- References
- 10
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 17 · 2023: 16 · 2022: 31 · 2021: 21 · 2020: 19 · 2019: 23 · 2018: 25 · 2017: 24 · 2016: 30 · 2015: 39 · 2014: 22 · 2013: 26 · 2012: 8
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Council of Scientific and Industrial Research, India
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- traumatic brain injury, Alzheimer's disease, risk factors, amyloid plaques, neuroinflammation, oxidative stress, neurodegeneration, blood-brain barrier, axonal injury, cognitive impairment, disease progression
- MeSH terms
- Alzheimer Disease, Animals, Apolipoproteins E, Axons, Brain Injuries, Disease Models, Animal, Humans, Models, Neurological, Risk Factors, Gene Expression, Amyloid beta-Protein Precursor, tau Proteins, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
