Cited by 761Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsMemory Processes and Influences

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

Akers, Katherine G., Martinez-Canabal, Alonso, Restivo, Leonardo, Yiu, Adelaide P., De Cristofaro, Antonietta, Hsiang, Hwa-Lin (Liz), Wheeler, Anne L., Guskjolen, Axel +7 more·2014·Science

Abstract

Forget It!: When examining the relationship between the production of new neurons in the hippocampus and memory, studies have generally first manipulated hippocampal neurogenesis and afterward investigated memory formation and found that new neurons help to encode new memories. However, when investigating how similar manipulations of neurogenesis impact established hippocampus-dependent memories, Akers et al. (p. 598 ; see the Perspective by Mongiat and Schinder ) uncovered a role for neurogenesis in memory clearance. Thus, the continuous addition of new neurons both degrades existing information stored in hippocampal circuits and simultaneously provides substrates for new learning.

Integrity signals

Registry

Crossref · 10.1126/science.1248903

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Such alterations promote an increased participation of these cells during learning and memory tasks and a reconfiguration of DG-CA3 circuits that degrade stored memories.

    “Consequently, such alterations promote an increased participation of these cells during learning and memory tasks35 and a reconfiguration of DG-CA3 circuits that degrade stored memories.36”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H.-L. (., Wheeler, A. L., Guskjolen, A., Niibori, Y., Shoji, H., Ohira, K., Richards, B. A., Miyakawa, T., Josselyn, S. A., & Frankland, P. W.
Affiliations
  • Hospital for Sick Children (CA)
  • Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.
  • University of Toronto (CA)
  • Fujita Health University (JP)
Corresponding author
  • Akers, Katherine G.
  • Restivo, Leonardo
  • Josselyn, Sheena A.
  • Frankland, Paul W.
Venue
Science
Published
2014-05-09
Volume
344
Issue
6184
Pages
598-602
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2130169724
Cited by
761
References
57
Citations by year
2026: 34 · 2025: 71 · 2024: 47 · 2023: 50 · 2022: 49 · 2021: 68 · 2020: 72 · 2019: 81 · 2018: 66 · 2017: 56 · 2016: 75 · 2015: 57 · 2014: 33 · 2013: 1
FWCI
25.59
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research (MOP74650, MOP- 86762)
  • Japan Society for the Promotion of Science (25116526, 25242078)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampal neurogenesis, forgetting, infantile amnesia, dentate gyrus, memory consolidation, adult neurogenesis, guinea pig, degu, computational model of memory
MeSH terms
Amnesia, Animals, Female, Guinea Pigs, Hippocampus, Male, Memory, Mice, Inbred C57BL, Neurons, Dentate Gyrus, Mice, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review