Cited by 171Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal SignalingDevelopmental Biology and Gene Regulation

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Astn2, A Novel Member of the Astrotactin Gene Family, Regulates the Trafficking of ASTN1 during Glial-Guided Neuronal Migration

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Wilson, P. M., Fryer, R. H., Fang, Y., Hatten, M. E.·2010·Journal of Neuroscience

DOI 10.1523/jneurosci.0032-10.2010PMC PMC2905051

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Abstract

Glial-guided neuronal migration is a key step in the development of laminar architecture of cortical regions of the mammalian brain. We previously reported that neuronal protein astrotactin (ASTN1) functions as a neuron-glial ligand during CNS glial-guided migration. Here, we identify a new Astn family member, Astn2, that is expressed at high levels in migrating, cerebellar granule neurons, along with Astn1, at developmental stages when glial-guided migration is ongoing. Biochemical and flow cytometry experiments show that ASTN2 forms a complex with ASTN1 and regulates surface expression of ASTN1. Live imaging of Venus-tagged ASTN1 in migrating cerebellar granule cells reveals the intracellular trafficking of ASTN1-Venus, with ASTN1-Venus accumulating in the forward aspect of the leading process where new sites of adhesion will form. Treatment of migrating neurons with Dynasore, a soluble noncompetitive inhibitor of Dynamin, rapidly arrests the migration of immature granule cells in a reversible manner, suggesting the critical importance of receptor trafficking to neuronal locomotion along Bergmann glial fibers in the developing cerebellum. Together, these findings suggest that ASTN2 regulates the levels of ASTN1 in the plasma membrane and that the release of neuronal adhesions to the glial fiber during neuronal locomotion involves the intracellular trafficking of ASTN1.

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Authors: Wilson, P. M., Fryer, R. H., Fang, Y., & Hatten, M. E.
Affiliations: Rockefeller University (US)
Corresponding author: Hatten, M. E.
ORCID: Fang, Y.
Hatten, M. E.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-06-23
Volume: 30
Issue: 25
Pages: 8529-8540
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0032-10.2010
PMC: PMC2905051
OpenAlex: W1996840895
Cited by: 169
References: 49
Citations by year: 2026: 6 · 2025: 7 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 13 · 2012: 11
FWCI: 3.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (T32GM007524, GM07524)
National Institute of Neurological Disorders and Stroke (R01NS015429, R01NS051778)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: ASTN2, cerebellar granule cells, receptor trafficking, dynamin, dynasore, leading process, cortical lamination, protein complex formation
MeSH terms: Animals, Cell Line, Cell Movement, Cells, Cultured, Cerebellum, Flow Cytometry, Glycoproteins, Hydrazones, Immunohistochemistry, Nerve Tissue Proteins, Neuroglia, Neurons, Transfection, Blotting, Northern, In Situ Hybridization, Microscopy, Confocal, Dynamins, Mice

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Astn2, A Novel Member of the Astrotactin Gene Family, Regulates the Trafficking of ASTN1 during Glial-Guided Neuronal Migration

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