Novel genetic loci associated with hippocampal volume
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Abstract The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes ( ASTN2 , DPP4 and MAST4 ) and one is found 200 kb upstream of SHH . A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease ( r g =−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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Sample and SNP-level quality control was performed in PLINK in accordance with the ENIGMA consortium protocol.
“Sample and SNP-level quality control was performed in PLINK in accordance with the ENIGMA consortium protocol, described previously [43].”
From Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity (2019) · cites this paper as [43]
The Methods section, “Genetic imputation and quality control” (page unavailable), describes excluding ancestry outliers and filtering SNPs by allele frequency, Hardy–Weinberg equilibrium, and call rate. The copy does not say that this quality control was performed in PLINK or explicitly identify those steps as the ENIGMA consortium protocol; it refers readers to supplementary details. (LLM, conf=0.84)
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Self-citationThe Rotterdam Study: 2018 update on objectives, design and main results
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Genetic architecture of subcortical brain structures in 38,851 individuals
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Self-citationShared mechanisms across the major psychiatric and neurodegenerative diseases
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ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
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Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain
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Self-citationCausal associations between modifiable risk factors and the Alzheimer's phenome
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m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases
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Self-citationDiscovery of 42 genome-wide significant loci associated with dyslexia
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Self-citationBrain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
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Self-citationNeandertal Introgression Sheds Light on Modern Human Endocranial Globularity
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“The BIG dataset has been described in several previous studies [42, 43].”
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Self-citationShared heritability of human face and brain shape
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Self-citationThe reliability and heritability of cortical folds and their genetic correlations across hemispheres
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Genetic architecture of the structural connectome
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Self-citation1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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Self-citationEvaluating brain structure traits as endophenotypes using polygenicity and discoverability
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Motor hyperactivation during cognitive tasks: An endophenotype of juvenile myoclonic epilepsy
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Genetics of Alzheimer’s Disease in the African American Population
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Self-citation
- Authors
- Hibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., Renteria, M. E., Bis, J. C., Arias-Vasquez, A., Ikram, M. K., Desrivières, S., Vernooij, M. W., Abramovic, L., Alhusaini, S., Amin, N., Andersson, M., Arfanakis, K., Aribisala, B. S., Armstrong, N. J., Athanasiu, L., Axelsson, T., Beecham, A. H., Beiser, A., Bernard, M., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chen, Q., Ching, C. R. K., Chouraki, V., Cuellar-Partida, G., Crivello, F., Den Braber, A., Doan, N. T., Ehrlich, S., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Grimm, O., Griswold, M. E., Guadalupe, T., Gutman, B. A., Hass, J., Haukvik, U. K., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Jørgensen, K. N., Karbalai, N., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A. F., Matarin, M., Mather, K. A., Mattheisen, M., McKay, D. R., Milaneschi, Y., Muñoz Maniega, S., Nho, K., Nugent, A. C., Nyquist, P., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pirpamer, L., Pütz, B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Ropele, S., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Saremi, A., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Trompet, S., Vaidya, D., Van der Grond, J., Van der Lee, S. J., Van der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Wolfers, T., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Cheng, C.-Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Craen, A. J. M., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Deary, I. J., Debette, S., DeCarli, C., Delanty, N., Depondt, C., DeStefano, A., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Enzinger, C., Erk, S., Espeseth, T., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Fornage, M., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Håberg, A. K., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B.-C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J.-J., Huentelman, M., Hulshoff Pol, H. E., Ikeda, M., Jack Jr, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J.-L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schmidt, H., Schofield, P. R., Sigursson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Tsolaki, M., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van der Brug, M., van der Lugt, A., van der Wee, N. J. A., Van Haren, N. E. M., van ’t Ent, D., Van Tol, M.-J., Vardarajan, B. N., Vellas, B., Veltman, D. J., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, R. H., Zonderman, A. B., Martin, N. G., Van Duijn, C. M., Wright, M. J., Longstreth, W. T., Schumann, G., Grabe, H. J., Franke, B., Launer, L. J., Medland, S. E., Seshadri, S., Thompson, P. M., & Ikram, M. A.
- Affiliations
- University of Southern California (US)
- Erasmus MC (NL)
- Université de Bordeaux (FR)
- University of North Carolina at Chapel Hill (US)
- Medical University of Graz (AT)
- University of Washington (US)
- National Institutes of Health (US)
- King's College London (GB)
- University Medical Center Utrecht (NL)
- Montreal Neurological Institute and Hospital (CA)
- Sahlgrenska University Hospital (SE)
- Rush University Medical Center (US)
- Lagos State University (NG)
- Murdoch University (AU)
- Oslo University Hospital (NO)
- Uppsala University (SE)
- University of Miami (US)
- Boston University (US)
- University of Toronto (CA)
- Radboud University Nijmegen (NL)
- Columbia University Irving Medical Center (US)
- Pennington Biomedical Research Center (US)
- Douglas Mental Health University Institute (CA)
- Lieber Institute for Brain Development (US)
- Centre National de la Recherche Scientifique (FR)
- University of Oslo (NO)
- Massachusetts General Hospital (US)
- Iowa State University (US)
- Johns Hopkins University (US)
- Heidelberg University (DE)
- University of Mississippi Medical Center (US)
- Max Planck Institute for Psycholinguistics (NL)
- Georgia Institute of Technology (US)
- Max Planck Institute of Psychiatry (DE)
- University Hospital Heidelberg (DE)
- Universitätsmedizin Greifswald (DE)
- Indiana University Indianapolis (US)
- Broad Institute (US)
- University of Edinburgh (GB)
- UNSW Sydney (AU)
- University of Bonn (DE)
- Yale University (US)
- Amsterdam Neuroscience (NL)
- University College Dublin (IE)
- University of California, Los Angeles (US)
- Vrije Universiteit Amsterdam (NL)
- University of Bern (CH)
- Trinity College Dublin (IE)
- The University of Melbourne (AU)
- University of California San Diego (US)
- Wuhan University (CN)
- University of Iceland (IS)
- The University of Queensland (AU)
- King Faisal Specialist Hospital & Research Centre (SA)
- Leiden University Medical Center (NL)
- Georgia State University (US)
- The University of Texas Rio Grande Valley (US)
- The Royal Melbourne Hospital (AU)
- Inserm (FR)
- Texas Biomedical Research Institute (US)
- University of Pittsburgh (US)
- Maastricht University Medical Centre (NL)
- Russian Academy of Sciences (RU)
- Mind Research Network (US)
- Royal College of Surgeons in Ireland (IE)
- National University of Singapore (SG)
- Karolinska Institutet (SE)
- Utrecht University (NL)
- Forschungszentrum Jülich (DE)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Université Libre de Bruxelles (BE)
- Janssen Research & Development (United States) (US)
- Stiftung Charité (DE)
- University of Glasgow (GB)
- Indiana University School of Medicine (US)
- Rensselaer Polytechnic Institute (US)
- Okayama University (JP)
- Harvard University (US)
- UCL Queen Square Institute of Neurology (GB)
- University Medical Center Groningen (NL)
- St Olav's University Hospital (NO)
- University of Iowa (US)
- HolsboerMaschmeyer NeuroChemie (Germany) (DE)
- Fujita Health University (JP)
- Araya Inc. (Japan) (JP)
- University of Maryland, Baltimore (US)
- Royal Edinburgh Hospital (GB)
- Université de Cergy-Pontoise (FR)
- Université Paris-Sud (FR)
- Unité de Nutrition Humaine (FR)
- United States Department of Health and Human Services (US)
- University of New Mexico (US)
- Australian National University (AU)
- QIMR Berghofer Medical Research Institute (AU)
- University of Liverpool (GB)
- Umeå University (SE)
- University of Calgary (CA)
- University of California, Irvine (US)
- Kaiser Permanente Washington Health Research Institute (US)
- Cedars-Sinai Medical Center (US)
- Munich University of Applied Sciences (DE)
- Maastricht University (NL)
- Icelandic Heart Association (IS)
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
- San Francisco VA Medical Center (US)
- Corresponding author
- Thompson, Paul M.
- Ikram, M. Arfan
- ORCID
- Adams, Hieab H. H.
- Jahanshad, Neda
- Chauhan, Ganesh
- Stein, Jason L.
- Hofer, Edith
- Bis, Joshua C.
- Ikram, M. Kamran
- Desrivières, Sylvane
- Vernooij, Meike W.
- Abramovic, Lucija
- Alhusaini, Saud
- Amin, Najaf
- Andersson, Micael
- Arfanakis, Konstantinos
- Aribisala, Benjamin S.
- Armstrong, Nicola J.
- Athanasiu, Lavinia
- Beecham, Ashley H.
- Beiser, Alexa
- Bernard, Manon
- Blanton, Susan H.
- Boks, Marco P.
- Bralten, Janita
- Brickman, Adam M.
- Carmichael, Owen
- Chakravarty, M. Mallar
- Ching, Christopher R. K.
- Chouraki, Vincent
- Crivello, Fabrice
- Doan, Nhat Trung
- Ehrlich, Stefan
- Goldman, Aaron L.
- Gottesman, Rebecca F.
- Gutman, Boris A.
- Haukvik, Unn K.
- Hoehn, David
- Holmes, Avram J.
- Hoogman, Martine
- Janowitz, Deborah
- Jia, Tianye
- Jørgensen, Kjetil N.
- Kim, Sungeun
- Klein, Marieke
- Lee, Phil H.
- Liewald, David C. M.
- Lopez, Lorna M.
- Mather, Karen A.
- Mattheisen, Manuel
- Milaneschi, Yuri
- Nho, Kwangsik
- Nugent, Allison C.
- Loohuis, Loes M. Olde
- Oosterlaan, Jaap
- Pirpamer, Lukas
- Pütz, Benno
- Ramasamy, Adaikalavan
- Richards, Jennifer S.
- Risacher, Shannon L.
- Rommelse, Nanda
- Ropele, Stefan
- Rose, Emma J.
- Rundek, Tatjana
- Saremi, Arvin
- Satizabal, Claudia L.
- Schmaal, Lianne
- Schork, Andrew J.
- Shen, Li
- Shin, Jean
- Shumskaya, Elena
- Smith, Albert V.
- Sprooten, Emma
- Strike, Lachlan T.
- Teumer, Alexander
- Toro, Roberto
- Trabzuni, Daniah
- Trompet, Stella
- Vaidya, Dhananjay
- Van der Lee, Sven J.
- Walton, Esther
- Westlye, Lars T.
- Whelan, Christopher D.
- Winkler, Anderson M.
- Wittfeld, Katharina
- Yanek, Lisa R.
- Zwiers, Marcel P.
- Agartz, Ingrid
- Almasy, Laura
- Amouyel, Philippe
- Andreassen, Ole A.
- Barral, Sandra
- Bastin, Mark E.
- Bennett, David A.
- Blangero, John
- Boomsma, Dorret I.
- Brodaty, Henry
- Brouwer, Rachel M.
- Brunner, Han G.
- Buckner, Randy L.
- Buitelaar, Jan K.
- Bulayeva, Kazima B.
- Cahn, Wiepke
- Calhoun, Vince D.
- Cannon, Dara M.
- Cavalleri, Gianpiero L.
- Cichon, Sven
- Cookson, Mark R.
- Corvin, Aiden
- Curran, Joanne E.
- Czisch, Michael
- Dale, Anders M.
- Deary, Ian J.
- Debette, Stéphanie
- DeCarli, Charles
- Delanty, Norman
- Depondt, Chantal
- DeStefano, Anita
- Dillman, Allissa
- Djurovic, Srdjan
- Donohoe, Gary
- Dyer, Thomas D.
- Enzinger, Christian
- Erk, Susanne
- Espeseth, Thomas
- Fedko, Iryna O.
- Fernández, Guillén
- Ferrucci, Luigi
- Fisher, Simon E.
- Fleischman, Debra A.
- Ford, Ian
- Fornage, Myriam
- Foroud, Tatiana M.
- Fox, Peter T.
- Francks, Clyde
- Fukunaga, Masaki
- Gibbs, J. Raphael
- Gollub, Randy L.
- Göring, Harald H. H.
- Green, Robert C.
- Gruber, Oliver
- Gudnason, Vilmundur
- Guelfi, Sebastian
- Hansell, Narelle K.
- Hardy, John
- Hartman, Catharina A.
- Hashimoto, Ryota
- Hegenscheid, Katrin
- Heinz, Andreas
- Hernandez, Dena G.
- Ho, Beng-Choon
- Hosten, Norbert
- Hottenga, Jouke-Jan
- Huentelman, Matthew
- Ikeda, Masashi
- Jenkinson, Mark
- Jönsson, Erik G.
- Jukema, J. Wouter
- Kahn, René S.
- Knopman, David S.
- Kwok, John B.
- Lawrie, Stephen M.
- Lemaître, Hervé
- Longo, Dan L.
- Lovestone, Simon
- Martinot, Jean-Luc
- Mattay, Venkata S.
- McDonald, Colm
- McIntosh, Andrew M.
- McMahon, Francis J.
- McMahon, Katie L.
- Mecocci, Patrizia
- Melle, Ingrid
- Mohnke, Sebastian
- Montgomery, Grant W.
- Morris, Derek W.
- Mosley, Thomas H.
- Nichols, Thomas E.
- Niessen, Wiro J.
- Nöthen, Markus M.
- Nyberg, Lars
- Ohi, Kazutaka
- Olvera, Rene L.
- Ophoff, Roel A.
- Pandolfo, Massimo
- Penninx, Brenda W. J. H.
- Pike, G. Bruce
- Potkin, Steven G.
- Psaty, Bruce M.
- Reppermund, Simone
- Roffman, Joshua L.
- Rotter, Jerome I.
- Ryten, Mina
- Sachdev, Perminder S.
- Saykin, Andrew J.
- Schmidt, Reinhold
- Schofield, Peter R.
- Simmons, Andrew
- Singleton, Andrew
- Sisodiya, Sanjay M.
- Smoller, Jordan W.
- Soininen, Hilkka
- Stott, David J.
- Thalamuthu, Anbupalam
- Toga, Arthur W.
- Traynor, Bryan J.
- Tsolaki, Magda
- Tzourio, Christophe
- Vardarajan, Badri N.
- Vellas, Bruno
- Veltman, Dick J.
- Völzke, Henry
- Walter, Henrik
- Wardlaw, Joanna M.
- Wassink, Thomas H.
- Weale, Michael E.
- Weinberger, Daniel R.
- Weiner, Michael W.
- Westman, Eric
- Zonderman, Alan B.
- Martin, Nicholas G.
- Wright, Margaret J.
- Franke, Barbara
- Launer, Lenore J.
- Medland, Sarah E.
- Seshadri, Sudha
- Thompson, Paul M.
- Ikram, M. Arfan
- Venue
- Nature Communications
- Published
- 2017-01-18
- Volume
- 8
- Issue
- 1
- Pages
- 13624-13624
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5253632
- OpenAlex
- W2574432813
- Cited by
- 299
- References
- 73
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 31 · 2023: 29 · 2022: 34 · 2021: 36 · 2020: 47 · 2019: 38 · 2018: 32 · 2017: 22 · 2015: 1
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
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- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
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- Funders
- McKnight Foundation
- Brigham and Women's Hospital
- Massachusetts General Hospital
- Yale University
- University of Southern California
- University of Miami
- University of Pennsylvania
- Harvard University
- School of Medicine, Boston University
- Alzheimer's Disease Neuroimaging Initiative
- Aarhus Universitet
- University of Washington
- Johns Hopkins University
- University of Pittsburgh
- Universität Basel
- Georgia State University
- Harvard T.H. Chan School of Public Health
- McGill University
- Rush University
- University of Bern
- Norges Teknisk-Naturvitenskapelige Universitet
- National University of Ireland
- Wellcome Trust (104036, 100309/A/12/Z)
- Deutsches Zentrum für Herz-Kreislaufforschung
- University of Texas Health Science Center at Houston
- Neuroscience Research Australia
- Royal College of Surgeons in Ireland
- QIMR Berghofer Medical Research Institute
- Broad Institute
- University of Texas Rio Grande Valley
- Duke-NUS Medical School
- Child Mind Institute
- International Max Planck Research School for Environmental, Cellular and Molecular Microbiology
- National Institute for Health and Care Research (ACF-2012-17-017)
- Parkinson's UK (J-1403)
- University of Warwick
- Imperial College London
- King's College London
- University College London
- University of Oxford
- University of Sussex
- University of Glasgow
- National University of Singapore
- Singapore Eye Research Institute
- University of Galway
- Trinity College Dublin
- Institut National de la Santé et de la Recherche Médicale (U1167, U1219)
- Rijksuniversiteit Groningen
- University of New South Wales
- University of Melbourne
- Queensland University of Technology
- Murdoch University
- Technische Universiteit Delft
- Radboud Universiteit
- Vrije Universiteit Amsterdam
- King Faisal Specialist Hospital and Research Centre
- Technische Universität Dresden
- GGZ inGeest
- Lundbeckfonden (R155-2014-1724)
- University of Toronto
- Universitair Medisch Centrum Utrecht
- Karolinska Institutet
- Maastricht Universitair Medisch Centrum
- Centre National de la Recherche Scientifique (UMR5293)
- Umeå Universitet (901 87)
- Universitetet i Bergen
- Leids Universitair Medisch Centrum
- Universitair Medisch Centrum Groningen
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Universitetet i Oslo
- Háskóli Íslands
- Uniwersytet Łódzki
- Hospital for Sick Children
- Radboud Universitair Medisch Centrum
- Université de Bordeaux
- Universidad de Cantabria
- Centre d'Imagerie BioMédicale
- Vifor Pharma
- Centro de Investigación Biomédica en Red de Salud Mental
- Uppsala Universitet
- Diakonhjemmet
- Fujita Health University
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Science for Life Laboratory
- Haukeland Universitetssjukehus
- Università degli Studi di Perugia
- National University Health System
- Hjartavernd
- Centre for Cognitive Ageing and Cognitive Epidemiology
- Epilepsy Society
- Instituto de Investigación Marqués de Valdecilla
- Amsterdam Neuroscience
- Avera Institute for Human Genetics
- Max Planck Instituut voor Psycholinguïstiek
- National Institutes of Health (1r01hl120393-01a1, 5u01hl096899-08, 5u01hl096902-08, UL1TR001863)
- University of California, Los Angeles
- University of California, San Diego
- Perelman School of Medicine, University of Pennsylvania
- Leonard M. Miller School of Medicine
- School of Medicine, Indiana University
- Stanley Center for Psychiatric Research, Broad Institute
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
- Medical Research Council (MR/K01417X/1, MR/N008324/1, 98101, MR/K026992/1, MR/M013111/1, MR/L016400/1)
- Brain Research Imaging Centre, University of Edinburgh
- Queensland Brain Institute
- Erasmus Universitair Medisch Centrum Rotterdam
- National Institute on Aging (R01AG017917, P30AG010129, U01AG049505, R01AG040060, R01AG015819, P30AG010161, R01AG040039, P50AG005142, P50AG005146, RF1AG041915, RF1AG015819, R01AG008122)
- National Heart, Lung, and Blood Institute (R01-HL120393, U01HL130114, U01HL096814, U01-HL-096899, U01-HL-096902, R01HL105756, U01HL096917, U01HL096812)
- National Institute of Mental Health (R01MH042191, R01MH078111, R00MH101367, R01MH083824, R00MH102357, T32MH073526, K01MH099232, R01MH090553)
- National Institute of Neurological Disorders and Stroke (T32NS048004, R01NS017950)
- National Institute of Biomedical Imaging and Bioengineering (U54EB020403)
- U.S. National Library of Medicine (R00LM011384, R01LM012535)
- National Center for Advancing Translational Sciences
- National Institute for Physiological Sciences (444-8585)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- hippocampal volume, hippocampal subfields, genetic loci, ASTN2, dipeptidyl peptidase IV, Sonic hedgehog, MSRB3, dentate gyrus, subiculum, CA1, Alzheimer's disease risk, neuropsychiatric disorders, brain structure genetics
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Child, Female, Glycoproteins, Hippocampus, Humans, Male, Microtubule-Associated Proteins, Middle Aged, Nerve Tissue Proteins, Organ Size, Cohort Studies, Protein Serine-Threonine Kinases, Dipeptidyl Peptidase 4, Genetic Predisposition to Disease, Methionine Sulfoxide Reductases, Genome-Wide Association Study, Young Adult, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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