The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Chronic Pain: Lost Inhibition?
Open accessAbstract
Human brain imaging has revealed that acute pain results from activation of a network of brain regions, including the somatosensory, insular, prefrontal, and cingulate cortices. In contrast, many investigations report little or no alteration in brain activity associated with chronic pain, particularly neuropathic pain. It has been hypothesized that neuropathic pain results from misinterpretation of thalamocortical activity, and recent evidence has revealed altered thalamocortical rhythm in individuals with neuropathic pain. Indeed, it was suggested nearly four decades ago that neuropathic pain may be maintained by a discrete central generator, possibly within the thalamus. In this investigation, we used multiple brain imaging techniques to explore central changes in subjects with neuropathic pain of the trigeminal nerve resulting in most cases (20 of 23) from a surgical event. Individuals with chronic neuropathic pain displayed significant somatosensory thalamus volume loss (voxel-based morphometry) which was associated with decreased thalamic reticular nucleus and primary somatosensory cortex activity (quantitative arterial spin labeling). Furthermore, thalamic inhibitory neurotransmitter content was significantly reduced (magnetic resonance spectroscopy), which was significantly correlated to the degree of functional connectivity between the somatosensory thalamus and cortical regions including the primary and secondary somatosensory cortices, anterior insula, and cerebellar cortex. These data suggest that chronic neuropathic pain is associated with altered thalamic anatomy and activity, which may result in disturbed thalamocortical circuits. This disturbed thalamocortical activity may result in the constant perception of pain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Second, it fits data about the presence of GABA-glutamate unbalance [136–138], and the finding of glutamic acid decarboxylase decrease in FM patients [139].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [138]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Ashburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Sensory disturbances from cerebral lesions
HEAD, H., & HOLMES, G. (1911) · Brain · doi:10.1093/brain/34.2-3.102 · Cited by 1,852
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434
Llinás, R. R., Ribary, U., Jeanmonod, D., Kronberg, E., & Mitra, P. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15222 · Cited by 1,395
Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms
von Hehn, C. A., Baron, R., & Woolf, C. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.008 · Cited by 824
The thalamic reticular nucleus: structure, function and concept
Pinault, D. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.008 · Cited by 715
Central post-stroke pain: clinical characteristics, pathophysiology, and management
Klit, H., Finnerup, N. B., & Jensen, T. S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70176-0 · Cited by 693
Central representation of chronic ongoing neuropathic pain studied by positron emission tomography
Hsieh, J., Belfrage, M., Stone‐Elander, S., Hansson, P. T., & Ingvar, M. (1995) · Pain · doi:10.1016/0304-3959(95)00048-w · Cited by 644
Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami
Steriade, M., Deschenes, M., Domich, L., & Mulle, C. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.6.1473 · Cited by 624
Increased EEG power and slowed dominant frequency in patients with neurogenic pain
Sarnthein, J., Stern, J., Aufenberg, C., Rousson, V., & Jeanmonod, D. (2005) · Brain · doi:10.1093/brain/awh631 · Cited by 485
Scholz, J., Broom, D. C., Youn, D. H., Mills, C. D., Kohno, T., Suter, M. R., Moore, K. A., Décosterd, I., Coggeshall, R. E., & Woolf, C. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-05.2005 · Cited by 437
Trigeminal neuralgia—pathophysiology, diagnosis and current treatment
Nurmikko, T. J., & Eldridge, P. R. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.117 · Cited by 421
A method for removal of global effects from fMRI time series
Macey, P. M., Macey, K. E., Kumar, R., & Harper, R. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.042 · Cited by 407
Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients
Stern, J., Jeanmonod, D., & Sarnthein, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.042 · Cited by 367
Brain imaging of neuropathic pain
Moisset, X., & Bouhassira, D. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.054 · Cited by 338
Iadarola, M. J., Max, M. B., Berman, K. F., Byas‐Smith, M. G., Coghill, R. C., Gracely, R. H., & Bennett, G. J. (1995) · Pain · doi:10.1016/0304-3959(95)00015-k · Cited by 337
Phantom body pain in paraplegics: Evidence for a central “pattern generating mechanism” for pain
Melzack, R., & Loeser, J. D. (1977) · Pain · doi:10.1016/0304-3959(77)90133-6 · Cited by 317
Model‐free arterial spin labeling quantification approach for perfusion MRI
Petersen, E. T., Lim, C. C. T., & Golay, X. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20784 · Cited by 306
Lenz, F. A., Kwan, H. C., Dostrovsky, J. O., & Tasker, R. R. (1989) · Brain Research · doi:10.1016/0006-8993(89)91088-3 · Cited by 303
Schmidt‐Wilcke, T., Luerding, R., Weigand, T., Jürgens, T. P., Schuierer, G. R., Leinisch, E., & Bogdahn, U. (2007) · Pain · doi:10.1016/j.pain.2007.05.010 · Cited by 301
Gustin, S. M., Peck, C. C., Wilcox, S. L., Nash, P. G., Murray, G. M., & Henderson, L. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5980-10.2011 · Cited by 245
Self-citationThermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus
Lenz, F. A., Seike, M., Richardson, R. T., Lin, Y., Baker, F., Khoja, I., Jaeger, C. J., & Gracely, R. H. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.200 · Cited by 237
Increased gray matter density in young women with chronic vulvar pain
Schweinhardt, P., Kuchinad, A., Pukall, C. F., & Bushnell, M. C. (2008) · Pain · doi:10.1016/j.pain.2008.09.014 · Cited by 194
Younger, J., Shen, Y. F., Goddard, G., & Mackey, S. (2010) · Pain · doi:10.1016/j.pain.2010.01.006 · Cited by 193
Chronic pain: a PET study of the central effects of percutaneous high cervical cordotomy
Piero, V. D., Jones, A. K. P., Iannotti, F., Powell, M. P., Perani, D., Lenzi, G. L., & Frackowiak, R. S. J. (1991) · Pain · doi:10.1016/0304-3959(91)90026-t · Cited by 192
Pattany, P. M., Yezierski, R. P., Widerström-Noga, E. G., Bowen, B. C., Martinez‐Arizala, A., Garcia, B. R., & Quencer, R. M. (2002) · PubMed Central · Cited by 181
Edden, R. A. E., & Barker, P. B. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21383 · Cited by 167
Pain following spinal cord injury: the clinical problem and experimental studies
Yezierski, R. P. (1996) · Pain · doi:10.1016/s0304-3959(96)03178-8 · Cited by 165
Gustin, S. M., Peck, C. C., Cheney, L. B., Macey, P. M., Murray, G. M., & Henderson, L. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1733-12.2012 · Cited by 161
Self-citationThalamic neuronal activity in rats with mechanical allodynia following contusive spinal cord injury
Gerke, M. B., Duggan, A. W., Xu, L., & Siddall, P. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00961-2 · Cited by 151
Melzack, R. (1999) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.1999.430903.x · Cited by 142
Lenz, F. A., Garonzik, I. M., Zirh, A. T., & Dougherty, P. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00099-2 · Cited by 130
Rausell, E., Cusick, C. G., Taub, E., & Jones, E. G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2571 · Cited by 129
A critical review of the role of the proposed VMpo nucleus in pain
Willis, W. D., Zhang, X., Honda, C. N., & Giesler, G. J. (2002) · Journal of Pain · doi:10.1054/jpai.2002.122949 · Cited by 126
Davis, K. D., Kiss, Z. H. T., Tasker, R. R., & Dostrovsky, J. O. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.3.1026 · Cited by 125
Cardoso-Cruz, H., Lima, D., & Galhardo, V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5197-12.2013 · Cited by 124
Kim, J. H., Greenspan, J. D., Coghill, R. C., Ohara, S., & Lenz, F. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0716-07.2007 · Cited by 119
Functional organization of the thalamic input to the thalamic reticular nucleus
Lam, Y.-W., & Sherman, S. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3073-10.2011 · Cited by 114
Injury of the Spino-Thalamo-Cortical Pathway Is Necessary for Central Post-Stroke Pain
Hong, J. H., Bai, D.-S., Jeong, J. Y., Choi, B. Y., Chang, C. H., Kim, S. H., Ahn, S. H., & Jang, S. H. (2010) · European Neurology · doi:10.1159/000319040 · Cited by 77
Punwani, S., Ordidge, R. J., Cooper, C. E., Amess, P., & Clemence, M. (1998) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199810)11:6 · Cited by 74
Recordings of Abnormal Activity in Patients with Deafferentation and Central Pain
Hirayama, T., Dostrovsky, J. O., Gorecki, J. P., Tasker, R. R., & Lenz, F. A. (2007) · Stereotactic and Functional Neurosurgery · doi:10.1159/000099492 · Cited by 70
Thalamocortical dysrhythmia II. Clinical and surgical aspects
Jeanmonod, D., Magnin, M., Morel, A., Siegemund, M., Cancro, A., Lanz, M., Llinás, R., Ribary, U., Kronberg, E., Schulman, J., et al. (2001) · Thalamus & Related Systems · doi:10.1016/s1472-9288(01)00026-7 · Cited by 59
Retrosplenial cortical activation in the fibromyalgia syndrome
Wik, G., Fischer, H., Bragée, B., Kristianson, M., & Fredrikson, M. G. (2003) · Neuroreport · doi:10.1097/00001756-200303240-00019 · Cited by 57
Ralston, H. J. (2005) · Progress in brain research · doi:10.1016/s0079-6123(05)49001-9 · Cited by 47
Somatotopic organization of nucleus reticularis thalami in chronic awake cats and monkeys
Pollin, B., & Rokyta, R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90415-2 · Cited by 46
Positron emission tomography in patients with fibromyalgia syndrome and healthy controls
Yunus, M. B., Young, C. S., Saeed, S. A., Mountz, J. M., & Aldag, J. C. (2004) · Arthritis Care & Research · doi:10.1002/art.20544 · Cited by 44
Thalamic EEG recordings in patients with chronic pain
G�cer, G., Niedermeyer, E., & Long, D. M. (1978) · Journal of Neurology · doi:10.1007/bf00313368 · Cited by 43
A preoperative screening test for chronic back pain patients
Hendler, N. H., Viernstein, M. C., Gucer, P. W., & Long, D. M. (1979) · Psychosomatics · doi:10.1016/s0033-3182(79)73719-4 · Cited by 43
Mor, D., Bembrick, A. L., Austin, P. J., & Keay, K. A. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.01.004 · Cited by 40
The Relation between Perception and Brain Activity in Gaze-Evoked Tinnitus
van Gendt, M. J., Boyen, K., de Kleine, E., Langers, D. R. M., & van Dijk, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2791-12.2012 · Cited by 33
Central Pain as a Thalamocortical Dysrhythmia
Walton, K. D., & Llin√°s, R. (2009) · Frontiers in neuroscience · doi:10.1201/9781439812105-c13 · Cited by 21
Kruger, L., & Ar, L. (2010) · Cited by 17
Making Sense of Gray Matter Abnormalities in Chronic Orofacial Pain—Synthesizing Divergent Findings
Moayedi, M., DeSouza, D. D., & Erpelding, N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3103-11.2011 · Cited by 8
Research works printed but not linked: 1
- 10.1176/appi.psy.20.12.801 · DOI
Cited by
Sorted by citations
Role of the Prefrontal Cortex in Pain Processing
Ong, W., Stohler, C. S., & Herr, D. R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1130-9 · Cited by 824
Rae, C. D. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1199-5 · Cited by 524
Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain
Kuner, R., & Kuner, T. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2019 · Cited by 371
The anatomy of pain and suffering in the brain and its clinical implications
Ridder, D. D., Adhia, D. B., & Vanneste, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.013 · Cited by 298
Frontostriatal Gating of Tinnitus and Chronic Pain
Rauschecker, J. P., May, E. S., Maudoux, A., & Ploner, M. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.08.002 · Cited by 261
Metadata
- Authors
- Henderson, L. A., Peck, C. C., Petersen, E. T., Rae, C. D., Youssef, A. M., Reeves, J. M., Wilcox, S. L., Akhter, R., Murray, G. M., & Gustin, S. M.
- Affiliations
- The University of Sydney (AU)
- University Medical Center Utrecht (NL)
- Neuroscience Research Australia (AU)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-04-24
- Volume
- 33
- Issue
- 17
- Pages
- 7574-7582
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6619566
- OpenAlex
- W2112900258
- Cited by
- 180
- References
- 56
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 14 · 2022: 16 · 2021: 29 · 2020: 15 · 2019: 12 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 9 · 2014: 13 · 2013: 6
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Charles Sturt University Research Output (CRO) (submittedVersion, other-oa)
- ORBi (University of Liège) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- chronic neuropathic pain, trigeminal neuralgia, somatosensory thalamus, thalamic reticular nucleus, thalamocortical circuits, thalamic inhibition, somatosensory cortex, anterior insula, cerebellum, functional connectivity, pain perception
- MeSH terms
- Adult, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Inhibition, Pain Measurement, Trigeminal Nerve Diseases, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
