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Cited by 65Cellular transport and secretionAlzheimer's disease research and treatmentsReceptor Mechanisms and Signaling

Sorting receptor SORLA: cellular mechanisms and implications for disease

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Schmidt, Vanessa, Subkhangulova, Aygul, Willnow, Thomas E.·2017·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-016-2410-zPMC PMC5357279
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Abstract

Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer's disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases.

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  • SORL1 shuttles APP from early endosomes back to the Golgi apparatus and subsequently impairs its trafficking to the cell surface.

    “Interestingly, SORL1 has also been described to shuttle APP from early endosomes back to the Golgi apparatus and to subsequently impair its trafficking to the cell surface [1, 114].”

    From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [114]

    The section “SORLA controls amyloidogenic processes in the brain” states that SORLA shuttles internalized APP from endosomes back to the trans-Golgi network. Our copy does not say that this subsequently impairs APP trafficking to the cell surface; the cell-surface trafficking described in “Cell biology of SORLA sorting” concerns SORLA itself or ligands generally, not specifically APP. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

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Authors
Schmidt, V., Subkhangulova, A., & Willnow, T. E.
Affiliations
Max Delbrück Center (DE)
Corresponding author
Schmidt, Vanessa
ORCID
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2016-11-10
Volume
74
Issue
8
Pages
1475-1483
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
DOI
10.1007/s00018-016-2410-z
PMC
PMC5357279
OpenAlex
W2549135004
Cited by
65
References
8
Citations by year
2026: 6 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 4
FWCI
0.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Cellular and Molecular Life Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
Funders
ERC (BeyOND No. 335692)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
SorLA, sorting receptor, cargo sorting, intracellular trafficking, Alzheimer's disease, atherosclerosis, obesity, receptor dysfunction, kinases, phosphatase, signaling receptors, disease genetics
MeSH terms
Alzheimer Disease, Amino Acid Sequence, Animals, Brain, Humans, Nerve Growth Factors, Obesity, Protein Conformation, Signal Transduction, Genetic Predisposition to Disease, Protein Transport, LDL-Receptor Related Proteins, Membrane Transport Proteins, Atherosclerosis

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