The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
β-Amyloid-Mediated Inhibition of NMDA Receptor-Dependent Long-Term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide
Open accessAbstract
The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloidβ-peptide (Aβ) were investigated in the medial perforant path of the rat and mouse dentate gyrus in vitro. Evidence is presented in this study that the Aβ-mediated inhibition of LTP induction involves activation of microglia and production of reactive oxygen and nitrogen species. In control slices, Aβ strongly inhibited induction of NMDA receptor-dependent (NMDAR-dependent) LTP, although not induction of NMDAR-independent LTP or long-term depression (LTD). The inhibition of NMDAR-dependent LTP was prevented by minocycline, an agent that prevents activation of microglia. The involvement of inducible nitric oxide synthase (iNOS) was shown by the inability of Aβ to inhibit LTP induction in iNOS knock-out mice and also by the ability of two iNOS inhibitors, aminoguanidine and 1400W, to prevent the Aβ-mediated inhibition of LTP induction. The Aβ-mediated inhibition of LTP induction also was prevented by the superoxide scavenger superoxide dismutase applied together with catalase. Evidence for involvement of superoxide in the action of Aβ on LTP induction was shown by the ability of an inhibitor of NADPH oxidase to prevent the Aβ-mediated inhibition of LTP induction. The study thus provides evidence that the Aβ-mediated inhibition of LTP induction involves an inflammatory-type reaction in which activation of microglia results in the production of nitric oxide and superoxide and thence possibly peroxynitrite, a highly reactive oxidant.
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Cited by
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Metadata
- Authors
- Wang, Q., Rowan, M. J., & Anwyl, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-07-07
- Volume
- 24
- Issue
- 27
- Pages
- 6049-6056
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2132573038
- Cited by
- 193
- References
- 15
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, Q., Rowan, M. J., & Anwyl, R. (2004). β-Amyloid-Mediated Inhibition of NMDA Receptor-Dependent Long-Term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0233-04.2004
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