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Cited by 408

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura

Open access
Zhang, X., Levy, D., Noseda, R., Kainz, V., Jakubowski, M., Burstein, R.·2010·Journal of Neuroscience
DOI 10.1523/jneurosci.0511-10.2010
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Abstract

Attacks of migraine with aura represent a phenomenon in which abnormal neuronal activity in the cortex produces sensory disturbances (aura) some 20-40 min before the onset of headache. The purpose of this study was to determine whether cortical spreading depression (CSD)--an event believed to underlie visual aura--can give rise to activation of nociceptors that innervate the meninges--an event believed to set off migraine headache. CSD was induced in anesthetized male rats by stimulation of the visual cortex with electrical pulses, pin prick, or KCl; single-unit activity of meningeal nociceptors was monitored in vivo in the rat before and after CSD. Regardless of the method of cortical stimulation, induction of CSD was recorded in 64 trials. In 31 of those trials, CSD induced a twofold increase in meningeal nociceptor firing rate that persisted for 37.0 +/- 4.6 min in trials in which activity returned to baseline, or >68 min in trials in which activity remained heightened at the time recording was interrupted. In two-thirds of the trials, onset of long-lasting neuronal activation began approximately 14 min after the wave of CSD. The findings demonstrates for the first time that induction of CSD by focal stimulation of the rat visual cortex can lead to long-lasting activation of nociceptors that innervate the meninges. We suggest that migraine with aura is initiated by waves of CSD that lead up to delayed activation of the trigeminovascular pathway.

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Metadata

Authors
Zhang, X., Levy, D., Noseda, R., Kainz, V., Jakubowski, M., & Burstein, R.
Venue
Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2010-06-30
Volume
30
Issue
26
Pages
8807-8814
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.0511-10.2010
OpenAlex
W2152830480
Cited by
408
References
42
FWCI
15.35
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura. https://app.cochat.ai/papers/10.1523/jneurosci.0511-10.2010
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Zhang, X., Levy, D., Noseda, R., Kainz, V., Jakubowski, M., & Burstein, R. (2010). Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0511-10.2010

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.