Neurexin‐β mediates the synaptogenic activity of amyloid precursor protein
Open accessAbstract
In addition to its role in Alzheimer's disease, amyloid precursor protein (APP) has physiological roles in synapse development and function. APP induces presynaptic differentiation when presented to axons, but the mechanism is unknown. Here we show that APP binds neurexin to mediate this synaptogenic activity. APP specifically binds β not α neurexins modulated by splice site 4. Binding to neurexin heparan sulfate glycan and LNS protein domains is required for high-affinity interaction and for full-length APP to recruit axonal neurexin. The synaptogenic activity of APP is abolished by triple knockdown of neurexins in hippocampal neurons pooled from male and female rats. Based on these and previous results, our model is that a dendritic-axonal trans dimer of full-length APP binds to axonal neurexin-β to promote synaptic differentiation and function. Furthermore, soluble sAPPs also bind neurexin-β and inhibit its interaction with neuroligin-1, raising the possibility that disruption of neurexin function by altered levels of full-length APP and its cleavage products may contribute to early synaptic deficits in Alzheimer's disease. SIGNIFICANCE STATEMENT The prevailing model for the basis of Alzheimer's disease is the amyloid cascade triggered by altered cleavage of amyloid precursor protein (APP). APP also has physiological roles at the synapse, but the molecular basis for its synaptic functions is not well understood. Here, we show that APP binds the presynaptic organizing prote…
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Neurexins can bind to Aβ and APP, thereby preventing Aβ-induced synaptic pathology and mediating the synaptogenic activity of APP.
“In addition, neurexins can bind to Aβ and amyloid precursor protein (APP), thereby preventing Aβ‐induced synaptic pathology and mediating the synaptogenic activity of APP. 56 , 57 , 58”
From Deletion of neuronal <i>Idol</i> ameliorates Alzheimer's disease–related pathologies via APOE receptors (2025) · cites this paper as [56]
Neurexins have been shown to regulate APP synaptic functions and/or modulate Aβ-induced synaptotoxicity.
“neurexins have been shown to regulate APP synaptic functions and/or modulate Aβ-induced synaptotoxicity36,37,48.”
From PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures (2026) · cites this paper as [48]
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САБУРОВА, Е. А., Sarantseva, S. V., & Krivoi, I. I. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026040174
- Authors
- Cvetkovska, V., Ge, Y., Xu, Q., Li, S., Zhang, P., & Craig, A. M.
- Affiliations
- University of British Columbia (CA)
- Case Western Reserve University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2022-10-19
- Volume
- 42
- Issue
- 48
- Pages
- 8936-8947
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC9732828
- OpenAlex
- W4306842413
- Cited by
- 17
- References
- 53
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 4
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gouvernement du Canada | Canadian Institutes of Health Research (FDN-143206)
- Michael Smith Foundation for Health Research (Fellowship)
- Pacific Alzheimer Research Foundation (Fellowship)
- SFARI (Bridge to Independence)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid precursor protein, synaptogenesis, presynaptic differentiation, neuroligin-1, Alzheimer's disease, hippocampal neurons, synaptic dysfunction
- MeSH terms
- Alzheimer Disease, Animals, Female, Male, Nerve Tissue Proteins, Neurons, Synapses, Amyloid beta-Protein Precursor, Rats
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