The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision
Open accessAbstract
Dopamine is a key neuromodulator in the retina and brain that supports motor, cognitive, and visual function. Here, we developed a mouse model on a C57 background in which expression of the rate-limiting enzyme for dopamine synthesis, tyrosine hydroxylase, is specifically disrupted in the retina. This model enabled assessment of the overall role of retinal dopamine in vision using electrophysiological (electroretinogram), psychophysical (optokinetic tracking), and pharmacological techniques. Significant disruptions were observed in high-resolution, light-adapted vision caused by specific deficits in light responses, contrast sensitivity, acuity, and circadian rhythms in this retinal dopamine-depleted mouse model. These global effects of retinal dopamine on vision are driven by the differential actions of dopamine D1 and D4 receptors on specific retinal functions and appear to be due to the ongoing bioavailability of dopamine rather than developmental effects. Together, our data indicate that dopamine is necessary for the circadian nature of light-adapted vision as well as optimal contrast detection and acuity.
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Storch, K.-F., Paz, C., Signorovitch, J., Raviola, E., Pawlyk, B., Li, T., & Weitz, C. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.045 · Cited by 460
Bodis-Wollner, I. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90113-o · Cited by 296
Cited by
Dopamine receptors –IUPHAR R eview 13
Beaulieu, J., Espinoza, S., & Gainetdinov, R. R. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12906 · Cited by 521
Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome
Staedtke, V., Bai, R.-Y., Kim, K., Darvas, M., Davila, M. L., Riggins, G. J., Rothman, P. B., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., et al. (2018) · Nature · doi:10.1038/s41586-018-0774-y · Cited by 277
Circadian rhythms, refractive development, and myopia
Chakraborty, R., Ostrin, L. A., Nickla, D. L., Iuvone, P. M., Pardue, M. T., & Stone, R. A. (2018) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12453 · Cited by 235
Self-citationDopamine: A Modulator of Circadian Rhythms in the Central Nervous System
Korshunov, K. S., Blakemore, L. J., & Trombley, P. Q. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00091 · Cited by 173
Direct Midbrain Dopamine Input to the Suprachiasmatic Nucleus Accelerates Circadian Entrainment
Grippo, R. M., Purohit, A. M., Zhang, Q., Zweifel, L. S., & Güler, A. D. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.084 · Cited by 140
Metadata
- Authors
- Jackson, C. R., Ruan, G.-X., Aseem, F., Abey, J., Gamble, K., Stanwood, G., Palmiter, R. D., Iuvone, P. M., & McMahon, D. G.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-07-04
- Volume
- 32
- Issue
- 27
- Pages
- 9359-9368
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2057663200
- Cited by
- 277
- References
- 2
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jackson, C. R., Ruan, G.-X., Aseem, F., Abey, J., Gamble, K., Stanwood, G., Palmiter, R. D., Iuvone, P. M., & McMahon, D. G. (2012). Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0711-12.2012
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