Emotion-Induced Retrograde Amnesia Is Determined by a 5-HTT Genetic Polymorphism
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A polymorphism in the human serotonin transporter (5-HTT) gene is implicated in susceptibility to anxiety and depression and in enhanced emotion-induced activation in the amygdala. A role for 5-HTT polymorphism in the emotional modulation of human episodic memory has yet to be demonstrated. Here, we demonstrate that whereas emotional memory for aversive events per se is not influenced by 5-HTT polymorphism, an emotion-induced retrograde amnesia is expressed solely in the presence of the short allele. The findings indicate a critical role for the serotonin system in emotion-mediated memory disruption.
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5-HTTLPR status had no effect on verbal emotional memory.
“Not all studies of affective bias have reported effects; 5-HTTLPR status had no effect on an affective Go/No-Go task (Roiser et al., 2007) or verbal emotional memory (Roiser et al., 2007;Strange et al., 2008).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Strange et al., 2008
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Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346 · see citing works
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- Authors
- Strange, B. A., Kroes, M. C. W., Roiser, J. P., Tan, G. C. Y., & Dolan, R. J.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-07-09
- Volume
- 28
- Issue
- 28
- Pages
- 7036-7039
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2630025
- OpenAlex
- W2018381565
- Cited by
- 26
- References
- 37
- Citations by year
- 2025: 1 · 2024: 2 · 2020: 2 · 2019: 2 · 2016: 2 · 2015: 1 · 2012: 2
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (078865)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- serotonin transporter gene, 5-HTT polymorphism, short allele, emotional memory, episodic memory, serotonergic system, aversive events, memory disruption
- MeSH terms
- Adult, Amnesia, Retrograde, Analysis of Variance, Emotions, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Genetic, Case-Control Studies, Genetic Predisposition to Disease, Serotonin Plasma Membrane Transport Proteins
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