Cited by 26Neurotransmitter Receptor Influence on BehaviorMemory Processes and InfluencesMemory and Neural Mechanisms

Emotion-Induced Retrograde Amnesia Is Determined by a 5-HTT Genetic Polymorphism

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Strange, Bryan A., Kroes, Marijn C. W., Roiser, Jonathan P., Tan, Geoffrey C. Y., Dolan, Raymond J.·2008·The Journal of Neuroscience

Abstract

A polymorphism in the human serotonin transporter (5-HTT) gene is implicated in susceptibility to anxiety and depression and in enhanced emotion-induced activation in the amygdala. A role for 5-HTT polymorphism in the emotional modulation of human episodic memory has yet to be demonstrated. Here, we demonstrate that whereas emotional memory for aversive events per se is not influenced by 5-HTT polymorphism, an emotion-induced retrograde amnesia is expressed solely in the presence of the short allele. The findings indicate a critical role for the serotonin system in emotion-mediated memory disruption.

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Crossref · 10.1523/jneurosci.0834-08.2008

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  • 5-HTTLPR status had no effect on verbal emotional memory.

    “Not all studies of affective bias have reported effects; 5-HTTLPR status had no effect on an affective Go/No-Go task (Roiser et al., 2007) or verbal emotional memory (Roiser et al., 2007;Strange et al., 2008).”

    From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Strange et al., 2008

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Authors
Strange, B. A., Kroes, M. C. W., Roiser, J. P., Tan, G. C. Y., & Dolan, R. J.
Affiliations
Wellcome Centre for Human Neuroimaging (GB)
Venue
The Journal of Neuroscience
Published
2008-07-09
Volume
28
Issue
28
Pages
7036-7039
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2018381565
Cited by
26
References
37
Citations by year
2025: 1 · 2024: 2 · 2020: 2 · 2019: 2 · 2016: 2 · 2015: 1 · 2012: 2
FWCI
2.02
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders
Wellcome Trust (078865)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
serotonin transporter gene, 5-HTT polymorphism, short allele, emotional memory, episodic memory, serotonergic system, aversive events, memory disruption
MeSH terms
Adult, Amnesia, Retrograde, Analysis of Variance, Emotions, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Genetic, Case-Control Studies, Genetic Predisposition to Disease, Serotonin Plasma Membrane Transport Proteins

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