The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Evidence for Reduced Experience-Dependent Dendritic Spine Plasticity in the Aging Prefrontal Cortex
Open accessAbstract
Cognitive functions that require the prefrontal cortex are highly sensitive to aging in humans, nonhuman primates, and rodents, although the neurobiological correlates of this vulnerability remain largely unknown. It has been proposed that dendritic spines represent the primary site of structural plasticity in the adult brain, and recent data have supported the hypothesis that aging is associated with alterations of dendritic spine morphology and plasticity in prefrontal cortex. However, no study to date has directly examined whether aging alters the capacity for experience-dependent spine plasticity in aging prefrontal neurons. To address this possibility, we used young, middle-aged, and aged rats in a behavioral stress paradigm known to produce spine remodeling in prefrontal cortical neurons. In young rats, stress resulted in dendritic spine loss and altered patterns of spine morphology; in contrast, spines from middle-aged and aged animals were remarkably stable and did not show evidence of remodeling. The loss of stress-induced spine plasticity observed in aging rats occurred alongside robust age-related reductions in spine density and shifts in remaining spine morphology. Together, the data presented here provide the first evidence that experience-dependent spine plasticity is altered by aging in prefrontal cortex, and support a model in which dendritic spines become progressively less plastic in the aging brain.
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“As dendritic spines appear to lose their resilience in very old brains (Bloss et al., 2011)”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Bloss et al., 2011
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“In young adult rodents, layer II/III PFC pyramidal cell dendrites can regrow with sufficient time spent under safe conditions, but this plasticity is lost with advanced age76.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [76]
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- 10.1210/edrv-7-3-284 · DOI · Paper page
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Extraordinary neoteny of synaptic spines in the human prefrontal cortex
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The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079
Self-citationThe ageing cortical synapse: hallmarks and implications for cognitive decline
Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965
Self-citationEfficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve
Barulli, D., & Stern, Y. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.012 · Cited by 1,006
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Metadata
- Authors
- Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Rockefeller University (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-05-25
- Volume
- 31
- Issue
- 21
- Pages
- 7831-7839
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3398699
- OpenAlex
- W2065400194
- Cited by
- 219
- References
- 56
- Citations by year
- 2026: 16 · 2025: 8 · 2024: 8 · 2023: 19 · 2022: 13 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 18 · 2017: 10 · 2016: 18 · 2015: 17 · 2014: 14 · 2013: 18 · 2012: 21
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R37AG006647, F31AG034794)
- National Institute of Mental Health (MH-58911, P50MH058911)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dendritic spine plasticity, aging, prefrontal cortex, experience-dependent plasticity, dendritic spine density, dendritic spine morphology, cognitive aging
- MeSH terms
- Aging, Animals, Cognition, Learning, Male, Neuronal Plasticity, Rats, Sprague-Dawley, Prefrontal Cortex, Dendritic Spines, Rats
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