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Evidence for Reduced Experience-Dependent Dendritic Spine Plasticity in the Aging Prefrontal Cortex

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Bloss, Erik B., Janssen, William G., Ohm, Daniel T., Yuk, Frank J., Wadsworth, Shannon, Saardi, Karl M., McEwen, Bruce S., Morrison, John H.·2011·The Journal of Neuroscience

DOI 10.1523/jneurosci.0839-11.2011PMC PMC3398699

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Abstract

Cognitive functions that require the prefrontal cortex are highly sensitive to aging in humans, nonhuman primates, and rodents, although the neurobiological correlates of this vulnerability remain largely unknown. It has been proposed that dendritic spines represent the primary site of structural plasticity in the adult brain, and recent data have supported the hypothesis that aging is associated with alterations of dendritic spine morphology and plasticity in prefrontal cortex. However, no study to date has directly examined whether aging alters the capacity for experience-dependent spine plasticity in aging prefrontal neurons. To address this possibility, we used young, middle-aged, and aged rats in a behavioral stress paradigm known to produce spine remodeling in prefrontal cortical neurons. In young rats, stress resulted in dendritic spine loss and altered patterns of spine morphology; in contrast, spines from middle-aged and aged animals were remarkably stable and did not show evidence of remodeling. The loss of stress-induced spine plasticity observed in aging rats occurred alongside robust age-related reductions in spine density and shifts in remaining spine morphology. Together, the data presented here provide the first evidence that experience-dependent spine plasticity is altered by aging in prefrontal cortex, and support a model in which dendritic spines become progressively less plastic in the aging brain.

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Authors: Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Rockefeller University (US)
ORCID: Bloss, Erik B.
Janssen, William G.
Ohm, Daniel T.
Saardi, Karl M.
McEwen, Bruce S.
Morrison, John H.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-05-25
Volume: 31
Issue: 21
Pages: 7831-7839
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0839-11.2011
PMC: PMC3398699
OpenAlex: W2065400194
Cited by: 219
References: 56
Citations by year: 2026: 16 · 2025: 8 · 2024: 8 · 2023: 19 · 2022: 13 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 18 · 2017: 10 · 2016: 18 · 2015: 17 · 2014: 14 · 2013: 18 · 2012: 21
FWCI: 7.55
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R37AG006647, F31AG034794)
National Institute of Mental Health (MH-58911, P50MH058911)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: dendritic spine plasticity, aging, prefrontal cortex, experience-dependent plasticity, dendritic spine density, dendritic spine morphology, cognitive aging
MeSH terms: Aging, Animals, Cognition, Learning, Male, Neuronal Plasticity, Rats, Sprague-Dawley, Prefrontal Cortex, Dendritic Spines, Rats

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Evidence for Reduced Experience-Dependent Dendritic Spine Plasticity in the Aging Prefrontal Cortex

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