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Cited by 435

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

Open access
Issa, AM, Rowe, W, Gauthier, S, Meaney, MJ·1990·The Journal of Neuroscience
DOI 10.1523/jneurosci.10-10-03247.1990
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Abstract

There is a tendency for increased hypothalamic-pituitary-adrenal (HPA) activity with age in the rat, and the resulting elevations in circulating glucocorticoid levels have been implicated in the occurrence of hippocampal pathology and memory deficits. In the experiments reported here, we examined whether HPA dysfunction is selectively associated with cognitive impairments in a population of aged rats. Fifty-eight 23-27-month-old male Long-Evans rats were screened for spatial memory impairments using the Morris swim maze, and 2 groups of aged animals were selected; aged, cognitively impaired (AI) animals whose performance was significantly different (greater than 2 SD) from that of 6-month-old controls and aged, cognitively unimpaired (AU) animals whose performance was comparable to that of the young controls (a difference of less than 0.5 SD). Twenty-eight percent of the animals tested were designated as AI and 20% as AU. Histological analysis of a subset of these animals showed that, while both AU and AI animals showed neuron loss in the pyramidal cell fields of the hippocampus, the loss was significantly greater in the AI animals. The AI animals showed clear evidence of increased HPA activity. Thus, basal ACTH and corticosterone levels were significantly higher in the AI animals compared with both AU animals and young controls, especially during the dark phase of the cycle. The AI, AU, and young animals exhibited comparable corticosterone levels during a 20-min immobilization stress; however, following the termination of the stressor, corticosterone levels in AI animals were significantly elevated compared with both AU animals and controls.(ABSTRACT TRUNCATED AT 250 WORDS)

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Metadata

Authors
Issa, A., Rowe, W., Gauthier, S., & Meaney, M.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1990-10-01
Volume
10
Issue
10
Pages
3247-3254
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.10-10-03247.1990
OpenAlex
W2134033459
Cited by
435
References
3
FWCI
5.38
Type
journal article
Language
en
Open access
hybrid

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