Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis

Veldhuis, Johannes D.; Sharma, Animesh; Roelfsema, Ferdinand

doi:10.1016/j.ecl.2013.02.002

Cited by 110Stress Responses and CortisolAdrenal Hormones and DisordersEstrogen and related hormone effects

Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis

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Veldhuis, Johannes D., Sharma, Animesh, Roelfsema, Ferdinand·2013·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2013.02.002PMC PMC3675779

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Abstract

Tightly regulated output of glucocorticoids is critical to maintaining immune competence, the structure of neurons, muscle, and bone, blood pressure, glucose homeostasis, work capacity, and vitality in the human and experimental animal. Age, sex steroids, gender, stress, body composition, and disease govern glucocorticoid availability through incompletely understood mechanisms. According to an ensemble concept of neuroendocrine regulation, successful stress adaptations require repeated incremental signaling adjustments among hypothalamic corticotropin-releasing hormone and arginine vasopressin, pituitary adrenocorticotropic hormone, and adrenal corticosteroids. Signals are transduced via (positive) feedforward and (negative) feedback effects. Age and gonadal steroids strongly modulate stress-adaptive glucocorticoid secretion by such interlinked pathways.

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Older men have a phase-advanced acrophase of almost 3 h.
“Older men have a phase-advanced acrophase of almost 3 h”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [67]
The Diurnal Adrenocorticotropic Hormone and Cortisol Rhythms section reports an acrophase around 06:30 in older people versus 09:00 in young people—a phase advance of about 2.5 hours. It does not specify that this comparison applies to older men in particular. (LLM, conf=0.83)
Experimental — accuracy not yet measured
The 1500-1800 time period represents a later circadian time in older men compared to young men.
“so the 1500 to 1800 time period represents a later circadian time compared to young men [67].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [67]
Age is associated with higher late-afternoon and early-evening cortisol, and an advance in the timing of the cortisol rhythm, but not with cortisol-binding protein.
“These [65, 66] and other [67] studies are consistent in showing that age is associated with higher late-afternoon and early-evening cortisol, and an advance in the timing (i.e. phase) of the cortisol rhythm, but not with cortisol-binding protein [68].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [67]
The citation [68] is attached most directly to the claim that age is not associated with cortisol-binding protein. The paper’s ‘Delineating Relevant in Vivo Cortisol Feedback Signals’ section discusses cortisol-binding globulin but does not state whether it changes with age. I searched for age-related changes in cortisol-binding globulin; the ‘Diurnal Adrenocorticotropic Hormone and Cortisol Rhythms’ section supports the separate claim about an advanced cortisol rhythm, but does not settle the binding-protein claim. (LLM, conf=0.72)
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Measures of Social Position and Cortisol Secretion in an Aging Population: Findings From the Whitehall II Study
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Intensive venous sampling paradigms disclose high frequency adrenocorticotropin release episodes in normal men
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Reconstruction of in vivo time-evolving neuroendocrine dose–response properties unveils admixed deterministic and stochastic elements
Keenan, D. M., Alexander, S., Irvine, C. H. G., Clarke, I., Scott, C., Turner, A., Tilbrook, A. J., Canny, B. J., & Veldhuis, J. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0300619101 · Cited by 70 · see citing works
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Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects
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Age-Related Changes in Glucocorticoid Fast Feedback Inhibition of Adrenocorticotropin in Man1
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Modulation of the Cytosolic Androgen Receptor in Striated Muscle by Sex Steroids*
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The cortisol awakening response is related to executive function in older age
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Sex differences in the human metabolism of cortisol
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Subjective memory complaints in aging are associated with elevated cortisol levels
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Racial and ethnic differences in diurnal cortisol rhythms in preadolescents: The role of parental psychosocial risk and monitoring
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Is there a gender difference in the associations of birthweight and adult hypothalamic–pituitary–adrenal axis activity?
Reynolds, R. M., Walker, B. R., Syddall, H. E., Andrew, R., Wood, P. J., & Phillips, D. I. W. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01846 · Cited by 62 · see citing works
Steroid Hormones and Steroid Hormone Binding Globulins in Cerebrospinal Fluid Studied in Individuals with Intact and with Disturbed Blood-Cerebrospinal Fluid Barrier
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Relationship between cortisol and age-related memory impairments in Holocaust survivors with PTSD
Yehuda, R., Golier, J. A., Harvey, P. D., Stavitsky, K., Kaufman, S., Grossman, R. A., & Tischler, L. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.007 · Cited by 61 · see citing works
Hypothalamus-Pituitary-Adrenal Hyperactivity in Human Aging Is Partially Refractory to Stimulation by Mineralocorticoid Receptor Blockade
Giordano, R., Bo, M., Pellegrino, M., Vezzari, M., Baldi, M., Picu, A., Balbo, M. L., Bonelli, L., Migliaretti, G., Ghigo, E., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0105 · Cited by 61 · see citing works
Physiological correlates of cognitive functioning in an elderly population
Wright, C. E., Kunz-Ebrecht, S., Iliffe, S., Foese, O., & Steptoe, A. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.001 · Cited by 60 · see citing works
The cortisol awakening response and memory performance in older men and women
Almela, M., van der Meij, L., Hidalgo, V., Villada, C., & Salvador, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.009 · Cited by 60 · see citing works
A Revised Role for P-Glycoprotein in the Brain Distribution of Dexamethasone, Cortisol, and Corticosterone in Wild-Type and ABCB1A/B-Deficient Mice
Mason, B. L., Pariante, C. M., & Thomas, S. A. (2008) · Endocrinology · doi:10.1210/en.2008-0041 · Cited by 59 · see citing works
Sex Differences in the Hypothalamo-Pituitary-Adrenal Axis Response to Inflammatory and Neuroendocrine Stressors
Spinedi, E., Salas, M. A., Chisari, A. N., Perone, M. J., Carino, M. H., & Gaillard, R. C. (2008) · Neuroendocrinology · doi:10.1159/000126804 · Cited by 58 · see citing works
Ovulatory cycle influences the stimulatory effect of stress on the expression of corticotropin-releasing factor receptor messenger ribonucleic acid in the paraventricular nucleus of the female rat hypothalamus
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Cortisol response to diazepam: its relationship to age, dose, duration of treatment, and presence of generalized anxiety disorder
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Neuroendocrine features in extreme longevity
Ferrari, E., Cravello, L., Falvo, F., Barili, L., Solerte, S. B., Fioravanti, M., & Magri, F. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.010 · Cited by 56 · see citing works
Corticotropin Secretory Dynamics in Humans under Low Glucocorticoid Feedback
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Ageing, physical function, and the diurnal rhythms of cortisol and dehydroepiandrosterone
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The Modulatory Role of Estrogens on Corticotropin‐Releasing Factor Gene Expression in the Hypothalamic Paraventricular Nucleus of Ovariectomized Rats: Role of the Adrenal Gland
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Hypothalamic-Pituitary-Adrenal Axis Response and Recovery from High-Intensity Exercise in Women: Effects of Aging and Fitness
Traustadóttir, T., Bosch, P. R., Cantu, T., & Matt, K. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031713 · Cited by 54 · see citing works
Impact of Age on Cortisol Secretory Dynamics Basally and as Driven by Nutrient-Withdrawal Stress
Bergendahl, M., Iranmanesh, A., Mulligan, T., & Veldhuis, J. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6628 · Cited by 53 · see citing works
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Mineralocorticoid Receptor-Mediated Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Aged Humans
Otte, C., Yassouridis, A., Jahn, H., Maass, P., Stober, N., Wiedemann, K., & Kellner, M. B. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.10.b900 · Cited by 53 · see citing works
Intrahypothalamic estradiol modulates hypothalamus-pituitary-adrenal-axis activity in female rats.
Liu, J., Bisschop, P., Eggels, L., Foppen, E., Fliers, E., Zhou, J.-N., & Kalsbeek, A. (2012) · Endocrinology · doi:10.1210/en.2011-2176 · Cited by 53 · see citing works
Age-Related Changes in Glucocorticoid Fast Feedback Inhibition of Adrenocorticotropin in Man
Boscaro, M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.4.1380 · Cited by 52 · see citing works
Interference with Feedback Inhibition of Adrenocorticotropin Release by Protein Binding of Corticosterone
Kawai, A., & Yates, F. E. (1966) · Endocrinology · doi:10.1210/endo-79-6-1040 · Cited by 50 · see citing works
High Intensity Exercise Promotes Escape of Adrenocorticotropin and Cortisol from Suppression by Dexamethasone: Sexually Dimorphic Responses1
Deuster, P. A., Petrides, J. S., Singh, A. P., Lucci, E. B., Chrousos, G. P., & Gold, P. W. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5110 · Cited by 50 · see citing works
Aging, health behaviors, and the diurnal rhythm and awakening response of salivary cortisol
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SLEEP IMPAIRMENTS IN HEALTHY SENIORS: ROLES OF STRESS, CORTISOL, AND INTERLEUKIN-1 BETA
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The role of mineralocorticoid receptors in the circadian activity of the human hypothalamus–pituitary–adrenal system:
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Sex-specific differences in cortisol production rates in humans
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The hypothalamic-pituitary-adrenal axis in rat pregnancy and lactation: circadian variation and interrelationship of plasma adrenocorticotropin and corticosterone
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Understanding the relationships between physiological and psychosocial stress, cortisol and cognition
James, K. A., Stromin, J., Steenkamp, N., & Combrinck, M. I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1085950 · Cited by 461 · see citing works
The physiology of endocrine systems with ageing
van den Beld, A. W., Kaufman, J.-M., Zillikens, M. C., Lamberts, S. W. J., Egan, J. M., & van der Lely, A. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30026-3 · Cited by 349 · see citing works
The use of hair cortisol for the assessment of stress in animals
Heimbürge, S., Kanitz, E., & Otten, W. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.09.016 · Cited by 329 · see citing works
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging
Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 196 · see citing works
Emergence of sex differences in the development of substance use and abuse during adolescence
Kuhn, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.003 · Cited by 182 · see citing works
Sleep and circadian regulation of cortisol: A short review
O'Byrne, N. A., Yuen, F., Butt, W. Z., & Liu, P. Y. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.011 · Cited by 145 · see citing works
The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions
Hantsoo, L., Jagodnik, K., Novick, A. M., Baweja, R., di Scalea, T. L., Özerdem, A., McGlade, E. C., Simeonova, D. I., Dekel, S., Kornfield, S. L., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1295261 · Cited by 139 · see citing works
Sexual dimorphism in COVID-19: potential clinical and public health implications
Bechmann, N., Barthel, A., Schedl, A., Herzig, S., Varga, Z., Gebhard, C., Mayr, M., Hantel, C., Beuschlein, F., Wolfrum, C., et al. (2022) · Publikationen an der Universität Bielefeld (Universität Bielefeld) · Cited by 110 · see citing works
Sexual dimorphism in COVID-19: potential clinical and public health implications
Bechmann, N., Barthel, A., Schedl, A., Herzig, S., Varga, Z., Gebhard, C., Mayr, M., Hantel, C., Beuschlein, F., Wolfrum, C., et al. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00346-6 · Cited by 116 · see citing works
Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults
Roelfsema, F., van Heemst, D., Iranmanesh, A., Takahashi, P., Yang, R., & Veldhuis, J. D. (2017) · Endocrine Connections · doi:10.1530/ec-17-0160 · Cited by 100 · see citing works
“Although the HPA axis has been studied for several decades, published reports on the influence of age, sex and body mass on HPA dynamics are conflicting (3, 4, 5, 6, 10, 11, 12, 13, 14, 15, 16, 17, 18).”
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Hormones and Aging: An Endocrine Society Scientific Statement
Cappola, A. R., Auchus, R. J., Fuleihan, G. E., Handelsman, D. J., Kalyani, R. R., McClung, M. R., Stuenkel, C. A., Thorner, M. O., & Verbalis, J. G. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad225 · Cited by 102 · see citing works
Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men
Wannamethee, S. G., Welsh, P. I., Papacosta, O., LENNON, L. T., Whincup, P. H., & Sattar, N. A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2362 · Cited by 89 · see citing works
Sleep, testosterone and cortisol balance, and ageing men
Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80 · see citing works
Examination of peripheral basal and reactive cortisol levels in major depressive disorder and the burnout syndrome: A systematic review
Rothe, N., Steffen, J., Penz, M. S., Kirschbaum, C., & Walther, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.024 · Cited by 83 · see citing works
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction
Suda, M., Paul, K. H., Tripathi, U., Minamino, T., Tchkonia, T., & Kirkland, J. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae010 · Cited by 81 · see citing works
The Endocrinology of Ageing: A Mini-Review
Jones, C. M., & Boelaert, K. (2014) · Gerontology · doi:10.1159/000367692 · Cited by 79 · see citing works
The Impact of Traumatic Brain Injury on Later Life: Effects on Normal Aging and Neurodegenerative Diseases
Griesbach, G. S., Masel, B. E., Helvie, R. E., & Ashley, M. J. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5103 · Cited by 77 · see citing works
Sex, the brain and hypertension: brain oestrogen receptors and high blood pressure risk factors
Hay, M. (2015) · Clinical Science · doi:10.1042/cs20150654 · Cited by 73 · see citing works
Steroid secretion in healthy aging
Fiacco, S., Walther, A., & Ehlert, U. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.035 · Cited by 71 · see citing works
Hormones as “difference makers” in cognitive and socioemotional aging processes
Ebner, N. C., Kamin, H. S., Diaz, V. G., Cohen, R. A., & MacDonald, K. S. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01595 · Cited by 56 · see citing works
Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study
Katsuhara, S., Yokomoto-Umakoshi, M., Umakoshi, H., Matsuda, Y., Iwahashi, N., Kaneko, H., Ogata, M., Fukumoto, T., Terada, E., Sakamoto, R., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab862 · Cited by 55 · see citing works
A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research
Liu, P. Y. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00683 · Cited by 55 · see citing works
Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities
Singh, L., Kaur, A., Bhatti, M. S., & Bhatti, R. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02805-5 · Cited by 55 · see citing works
Sex differences in chronic stress responses and Alzheimer's disease
Yan, Y., Dominguez, S., Fisher, D. W., & Dong, H. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.03.002 · Cited by 54 · see citing works
Impact of shift work on the diurnal cortisol rhythm: a one-year longitudinal study in junior physicians
Li, J., Bidlingmaier, M., Petru, R., Gil, F. P., Loerbroks, A., & Angerer, P. (2018) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-018-0204-y · Cited by 50 · see citing works
The stress of growing old: sex- and season-specific effects of age on allostatic load in wild grey mouse lemurs
Hämäläinen, A., Heistermann, M., & Kraus, C. (2015) · Oecologia · doi:10.1007/s00442-015-3297-3 · Cited by 49 · see citing works
PTSD and obesity in younger and older veterans: Results from the mind your heart study
Smith, B. N., Tyzik, A. L., Neylan, T. C., & Cohen, B. E. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.044 · Cited by 45 · see citing works
The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature
Bird, I. M., & Abbott, D. H. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.021 · Cited by 43 · see citing works
Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsatile ACTH secretion and ACTH approximate entropy in unstressed older men and women
Sharma, A. N., Aoun, P., Wigham, J. R., Weist, S. M., & Veldhuis, J. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00551.2013 · Cited by 39 · see citing works
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Associations between the FKBP5 haplotype, exposure to violence and anxiety in females
Isaksson, J., Comasco, E., Åslund, C., Rehn, M., Tuvblad, C., Andershed, H., & Nilsson, K. W. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.07.206 · Cited by 30 · see citing works
Factors impacting on the action of glucocorticoids in patients receiving glucocorticoid therapy
Dineen, R., Stewart, P. M., & Sherlock, M. (2019) · Clinical Endocrinology · doi:10.1111/cen.13837 · Cited by 30 · see citing works
The Age-Dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent
Tezuka, Y., Atsumi, N., Blinder, A., Rege, J., Giordano, T. J., Rainey, W. E., & Turcu, A. F. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab007 · Cited by 27 · see citing works
Potential Factors That Contribute to Post-COVID-19 Fatigue in Women
Rudroff, T., Workman, C. D., & Bryant, A. (2022) · Brain Sciences · doi:10.3390/brainsci12050556 · Cited by 25 · see citing works
Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [ 11 C]NOP-1A
Narendran, R., Tollefson, S., Himes, M. L., Paris, J., Lopresti, B. J., Ciccocioppo, R., & Mason, N. S. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18081007 · Cited by 23 · see citing works
Diurnal Salivary Cortisol in Sarcopenic Postmenopausal Women: The OsteoLaus Cohort
Rodríguez, E. G., Marques-Vidal, P. M., Aubry‐Rozier, B., Papadakis, G. E., Preisig, M., Kuehner, C., Vollenweider, P., Waeber, G., Hans, D. B., & Lamy, O. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00863-y · Cited by 22 · see citing works
Prevalence of subclinical hypercortisolism in type 2 diabetic patients from the Rio de Janeiro Type 2 Diabetes Cohort Study
Costa, D., Conceição, F. L., Leite, N. C., Ferreira, M. T., Salles, G. F., & Cardoso, C. R. L. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.05.006 · Cited by 22 · see citing works
High Evening Cortisol Level Is Associated With Low TBS and Increased Prevalent Vertebral Fractures: OsteoLaus Study
Rodríguez, E. G., Lamy, O., Stoll, D., Metzger, M., Preisig, M., Kuehner, C., Vollenweider, P., Marques-Vidal, P. M., Waeber, G., Aubry‐Rozier, B., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3804 · Cited by 21 · see citing works
Can a single session of noninvasive brain stimulation applied over the prefrontal cortex prevent stress-induced cortisol release?
Vignaud, P., Adam, O., Palm, U., Baeken, C., Prieto, N., Poulet, E., & Brunelin, J. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110667 · Cited by 21 · see citing works
Lithium therapy subdues neuroinflammation to maintain pyramidal cells arborization and rescues neurobehavioural impairments in ovariectomized rats
Rana, A. K., Sharma, S., Patial, V., & Singh, D. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02719-w · Cited by 21 · see citing works
Water intake keeps type 2 diabetes away? Focus on copeptin
Muscogiuri, G., Barrea, L., Annunziata, G., Vecchiarini, M., Orio, F., Somma, C. D., Colao, A., & Savastano, S. (2018) · Endocrine · doi:10.1007/s12020-018-1680-7 · Cited by 19 · see citing works
A Gut Feeling: The Importance of the Intestinal Microbiota in Psychiatric Disorders
Ochoa‐Repáraz, J., Ramelow, C. C., & Kasper, L. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.510113 · Cited by 22 · see citing works
Stress-induced changes in the aged-rat adrenal cortex. Histological and histomorphometric study
Zaki, S. M., Gawad, F. A.-R. A., El-Shaarawy, E. A. A., Radwan, R. A. K., & Aboulhoda, B. E. (2015) · Folia Morphologica · doi:10.5603/fm.a2018.0035 · Cited by 19 · see citing works
Relationship between handgrip strength and endogenous hormones in postmenopausal women
García-Alfaro, P., García, S., Rodríguez, I., Bergamaschi, L., & Pérez-López, F. R. (2022) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002093 · Cited by 18 · see citing works
Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia
Arinami, H., Watanabe, Y., Suzuki, Y., Tajiri, M., Tsuneyama, N., & Someya, T. (2023) · Scientific Reports · doi:10.1038/s41598-023-28449-8 · Cited by 19 · see citing works
Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma
Ford, M. L., Ruwanpathirana, A., Lewis, B. W., & Britt, R. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076347 · Cited by 17 · see citing works
Changes in cortisol and cortisone in hair of pigs reared under heat stress conditions
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Authors: Veldhuis, J. D., Sharma, A., & Roelfsema, F.
Affiliations: Mayo Clinic (US)
Leiden University Medical Center (NL)
Corresponding author: Veldhuis, Johannes D.
ORCID: Veldhuis, Johannes D.
Roelfsema, Ferdinand
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2013-06
Volume: 42
Issue: 2
Pages: 201-225
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2013.02.002
PMC: PMC3675779
OpenAlex: W2070843702
Cited by: 110
References: 261
Citations by year: 2026: 8 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 12 · 2014: 8
FWCI: 0.76
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, R01DK073148, DK050456)
National Center for Research Resources (UL1RR024150)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: hypothalamic-pituitary-adrenal axis, glucocorticoid regulation, aging, sex differences, sex steroids, corticotropin-releasing factor, vasopressin, ACTH, stress adaptation, neuroendocrine regulation, glucocorticoid negative feedback, positive feedback
MeSH terms: Adrenocorticotropic Hormone, Aging, Animals, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Sex Characteristics, Feedback, Physiological

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Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis

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