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Cited by 133Stress Responses and CortisolBirth, Development, and HealthNeuroendocrine regulation and behavior

Progeny of mothers drinking corticosterone during lactation has lower stress-induced corticosterone secretion and better cognitive performance

Catalani, Assia, Marinelli, Michela, Scaccianoce, Sergio, Nicolai, Raffaella, Muscolo, Luisa A.A., Porcu, Alessandra, Kora´nyi, Lajos, Piazza, Pier Vincenzo +1 more·1993·Brain Research
DOI 10.1016/0006-8993(93)90079-3
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Abstract

In order to test the hypothesis that maternal corticosterone influences hypothalamus-pituitary-adrenal (HPA) system activity in the adult rat and behaviors related to it, we induced a moderate increase in maternal plasma level of corticosterone by adding the hormone to the drinking water of the dams (200 micrograms/ml) from the day after delivery to weaning. Our previous experiments have shown that this procedure produces plasma levels of the hormone in the range of those following a mild psychic stress (from 4.3 +/- 0.5 to 9.5 +/- 1.8 micrograms/100 ml in the dams, and from 0.7 +/- 0.1 to 1.2 +/- 0.2 micrograms/100 ml in the pups at 10 days of lactation). Adrenal weights were slightly and temporarily decreased by treatment in both mothers and offspring. Only the male progeny was investigated in this study. Corticosterone-nursed rats had significantly less corticosterone and ACTH in basal conditions and after a 2 min restraint stress at 3 months of age, and showed better performances at weaning and at 1, 2 and 3 months of life in the Morris water maze. Our results demonstrate that a moderate increase in maternal corticosterone during lactation influences the activity of HPA axis and improves spatial learning ability of the adult offspring.

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  • Early care and controlled experience with stress help produce an overall lower level of physiological reactivity to stress.

    “The idea here, which finds support in the animal literature (Catalani et al., 1993; Parker, Buckmaster, Justus, Schatzberg, & Lyons, 2005), is that early care and controlled experience with stress help to produce an overall lower level of physiological reactivity to stress.”

    From Stress and the development of self-regulation in context (2010) · cites this paper as Catalani et al., 1993

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Authors
Catalani, A., Marinelli, M., Scaccianoce, S., Nicolai, R., Muscolo, L. A. A., Porcu, A., Kora´nyi, L., Piazza, P. V., & Angelucci, L.
Affiliations
  • Sapienza University of Rome (IT)
  • Université de Bordeaux (FR)
Corresponding author
Catalani, Assia
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
1993-10
Volume
624
Issue
1-2
Pages
209-215
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(93)90079-3
OpenAlex
W2057837936
Cited by
133
References
43
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 9
FWCI
0.60
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
maternal corticosterone, lactation, hypothalamic-pituitary-adrenal axis, ACTH, spatial learning, cognitive performance, offspring, restraint stress, adrenal weight, maternal stress exposure
MeSH terms
Adrenal Glands, Adrenocorticotropic Hormone, Analysis of Variance, Animals, Cognition, Corticosterone, Drinking, Female, Lactation, Male, Memory, Organ Size, Osmolar Concentration, Reaction Time, Solutions, Space Perception, Stress, Psychological, Rats, Wistar, Rats

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