The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate
Open accessAbstract
The developmental expression and the cellular localization of neurogranin (formerly designated p17), a brain-specific protein kinase C (PKC) substrate, were investigated. The developmental expression of neurogranin was studied by immunoblotting of rat brain and neuronal cell-culture extracts using neurogranin polyclonal antibodies. Neurogranin synthesis was found to be developmentally regulated, with no expression in the embryonic and neonatal period and an abrupt increase between 2 and 3 weeks of age. By immunohistochemistry, neurogranin was found essentially in the adult rat telencephalon, specifically located in the cell bodies and dendritic processes of neurons of the cerebral cortex, hippocampus, striatum, and a few other discreet areas. Neurogranin immunoreactivity was nearly absent in the thalamus, cerebellum, and brain stem. The late developmental expression and the dendritic localization of neurogranin in neurons are 2 features that also characterize the type I PKC isozyme. The specific localization of the protein in integrative areas of the rat brain suggests a highly specialized function of neurogranin in the CNS. A possible role for neurogranin in the transduction of the PKC activation signals at the postsynaptic level is suggested.
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Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP
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The mechanism of protein kinase C activation
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Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.
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Long-Term Potentiation in the Motor Cortex
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Rice, D., & Barone, S. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3511 · Cited by 2,944
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Blennow, K., & Zetterberg, H. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12816 · Cited by 1,000
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Diamond, J., Holmes, M., & Coughlin, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01454.1992 · Cited by 347
Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer’s disease
Portelius, E., Zetterberg, H., Skillbäck, T., Törnqvist, U., Andreasson, U., Trojanowski, J. Q., Weiner, M. W., Shaw, L. M., & Mattsson, N. (2015) · Brain · doi:10.1093/brain/awv267 · Cited by 279
Metadata
- Authors
- Represa, A., Deloulme, J., Sensenbrenner, M., Ben-Ari, Y., & Baudier, J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1990-12-01
- Volume
- 10
- Issue
- 12
- Pages
- 3782-3792
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1575693343
- Cited by
- 273
- References
- 25
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Represa, A., Deloulme, J., Sensenbrenner, M., Ben-Ari, Y., & Baudier, J. (1990). Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.10-12-03782.1990
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
