The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Prenatal Nicotine Exposure Mouse Model Showing Hyperactivity, Reduced Cingulate Cortex Volume, Reduced Dopamine Turnover, and Responsiveness to Oral Methylphenidate Treatment
Open accessAbstract
Cigarette smoking, nicotine replacement therapy, and smokeless tobacco use during pregnancy are associated with cognitive disabilities later in life in children exposed prenatally to nicotine. The disabilities include attention deficit hyperactivity disorder (ADHD) and conduct disorder. However, the structural and neurochemical bases of these cognitive deficits remain unclear. Using a mouse model we show that prenatal nicotine exposure produces hyperactivity, selective decreases in cingulate cortical volume, and radial thickness, as well as decreased dopamine turnover in the frontal cortex. The hyperactivity occurs in both male and female offspring and peaks during the "active" or dark phase of the light/dark cycle. These features of the mouse model closely parallel the human ADHD phenotype, whether or not the ADHD is associated with prenatal nicotine exposure. A single oral, but not intraperitoneal, administration of a therapeutic equivalent dose (0.75 mg/kg) of methylphenidate decreases the hyperactivity and increases the dopamine turnover in the frontal cortex of the prenatally nicotine exposed mice, once again paralleling the therapeutic effects of this compound in ADHD subjects. Collectively, our data suggest that the prenatal nicotine exposure mouse model has striking parallels to the ADHD phenotype not only in behavioral, neuroanatomical, and neurochemical features, but also with respect to responsiveness of the behavioral phenotype to methylphenidate treatment. The behavioral, neurochemical, and anatomical biomarkers in the mouse model could be valuable for evaluating new therapies for ADHD and mechanistic investigations into its etiology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Similarly, a study using a mouse model found that PNE produced hyperactivity that was associated with selective decreases in cingulate cortical volume and radial thickness and a decrease in drug-induced dopamine release in the frontal cortex”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [36]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
The cited source says what the claim attributes to it.
In the citing paper
“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
The cited source says what the claim attributes to it.
In the citing paper
“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
International Journal of Epidemiology
Rothman, N., Garcia-closas, M., & Hein, D. W. (1973) · Journal of Medical Genetics · doi:10.1136/jmg.10.1.100-a · Cited by 2,837
Metabolism and Disposition Kinetics of Nicotine
Hukkanen, J., Jacob, P., & Benowitz, N. L. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.3 · Cited by 1,583
Bush, G., Frazier, J. A., Rauch, S. L., Seidman, L. J., Whalen, P. J., Jenike, M. A., Rosen, B. R., & Biederman, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00083-9 · Cited by 866
Self-citationBehavioral and Neural Consequences of Prenatal Exposure to Nicotine
ERNST, M., MOOLCHAN, E. T., & ROBINSON, M. L. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200106000-00007 · Cited by 590
Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
Chesselet, M.-F. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90058-7 · Cited by 577
Slotkin, T. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.06.001 · Cited by 544
Stimulants: Therapeutic Actions in ADHD
Arnsten, A. F. T. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301164 · Cited by 473
Makris, N., Biederman, J., Valera, E. M., Bush, G., Kaiser, J., Kennedy, D. N., Caviness, V. S., Faraone, S. V., & Seidman, L. J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl047 · Cited by 450
Self-citationRodent Models of Attention-Deficit/Hyperactivity Disorder
Sagvolden, T., Russell, V. A., Aase, H., Johansen, E. B., & Farshbaf, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.002 · Cited by 448
Cited by
Sorted by citations
Attention-deficit/hyperactivity disorder
Faraone, S. V., Asherson, P., Banaschewski, T., Biederman, J., Buitelaar, J. K., Ramos-Quiroga, J. A., Rohde, L. A., Sonuga-Barke, E. J. S., Tannock, R., & Franke, B. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.20 · Cited by 1,479
Self-citationDevelopmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn
Ross, E. J., Graham, D. L., Money, K. M., & Stanwood, G. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.147 · Cited by 515
Human brain organoid-on-a-chip to model prenatal nicotine exposure
Wang, Y., Wang, L., Zhu, Y., & Qin, J. (2018) · Lab on a Chip · doi:10.1039/c7lc01084b · Cited by 330
Cigarette smoking and thinning of the brain’s cortex
Karama, S., Ducharme, S., Corley, J., Chouinard-Decorte, F., Starr, J. M., Wardlaw, J. M., Bastin, M. E., & Deary, I. J. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.187 · Cited by 185
Maternal Smoking and Attention-Deficit/Hyperactivity Disorder in Offspring: A Meta-analysis
Huang, L., Wang, Y., Zhang, L., Zheng, Z., Zhu, T., Qu, Y., & Mu, D. (2018) · Pediatrics · doi:10.1542/peds.2017-2465 · Cited by 179
Yohn, N. L., Bartolomei, M. S., & Blendy, J. A. (2015) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2015.03.002 · Cited by 143
Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants
McCarthy, D. M., Morgan, T. J., Lowe, S. E., Williamson, M. J., Spencer, T. J., Biederman, J., & Bhide, P. G. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006497 · Cited by 140
Self-citationDong, T., Hu, W., Zhou, X., Lin, H., Lan, L., Hang, B., Lv, W., Geng, Q., & Xia, Y. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.12.010 · Cited by 108
Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD
Zhu, J., Lee, K. P., Spencer, T. J., Biederman, J., & Bhide, P. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4402-13.2014 · Cited by 92
Self-citationYochum, C. L., Doherty-Lyons, S., Hoffman, C. A., Hossain, M. M., Zelikoff, J. T., & Richardson, J. R. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.016 · Cited by 90
Is There Evidence for Potential Harm of Electronic Cigarette Use in Pregnancy?
Suter, M., Mastrobattista, J. M., Kahr, M. K., & Aagaard, K. M. (2014) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.23333 · Cited by 78
Attention and working memory deficits in a perinatal nicotine exposure mouse model
Zhang, L., Spencer, T. J., Biederman, J., & Bhide, P. G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198064 · Cited by 75
Self-citationNicotine addiction and psychiatric disorders
Kutlu, M. G., Parikh, V., & Gould, T. J. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.08.004 · Cited by 65
Molecular mechanisms for nicotine intoxication
Alkam, T., & Nabeshima, T. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.02.006 · Cited by 67
A Potential Role for Neuroinflammation in ADHD
Vázquez-González, D., Carreón-Trujillo, S., Álvarez‐Arellano, L., Abarca-Merlin, D. M., Domínguez-López, P., Salazar–García, M., & Corona, J. C. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_15 · Cited by 65
Buck, J. M., Sanders, K. N., Wageman, C. R., Knopik, V. S., Stitzel, J. A., & O’Neill, H. C. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.006 · Cited by 60
Shen, E., Jiang, Y., Javidfar, B., Kassim, B. S., Loh, Y. E., Ma, Q., Mitchell, A., Pothula, V., Stewart, A. F., Ernst, P., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.144 · Cited by 53
Zhu, J., Fan, F., McCarthy, D. M., Zhang, L., Cannon, E. N., Spencer, T. J., Biederman, J., & Bhide, P. G. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.01.014 · Cited by 54
Self-citationAoyama, Y., Toriumi, K., Mouri, A., Hattori, T., Ueda, E., Shimato, A., Sakakibara, N., Soh, Y., Mamiya, T., Nagai, T., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.186 · Cited by 52
Alkam, T., Mamiya, T., Kimura, N., Yoshida, A., Kihara, D., Tsunoda, Y., Aoyama, Y., Hiramatsu, M., Kim, H.-C., & Nabeshima, T. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4591-z · Cited by 50
Church, J. S., Chace-Donahue, F., Blum, J. L., Ratner, J. R., Zelikoff, J. T., & Schwartzer, J. J. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6067 · Cited by 55
Biederman, J., Petty, C. R., Spencer, T. J., Woodworth, K. Y., Bhide, P. G., Zhu, J., & Faraone, S. V. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.756585 · Cited by 49
Self-citationWells, A. C., & Lotfipour, S. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11628 · Cited by 50
mGluR5 Ablation in Cortical Glutamatergic Neurons Increases Novelty-Induced Locomotion
Jew, C. P., Wu, C., Sun, H., Zhu, J., Huang, J.-Y., Yu, D., Justice, N. J., & Lu, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070415 · Cited by 42
Self-citationYONEDA, N., TAKADA, T., Hirano, T., Yanai, S., YAMAMOTO, A., MANTANI, Y., YOKOYAMA, T., KITAGAWA, H., Tabuchi, Y., & Hoshi, N. (2018) · Journal of Veterinary Medical Science · doi:10.1292/jvms.18-0014 · Cited by 39
Polli, F. S., Scharff, M. B., Ipsen, T. H., Aznar, S., Kohlmeier, K. A., & Andreasen, J. T. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172951 · Cited by 38
Prenatal Nicotine Exposure Impairs Executive Control Signals in Medial Prefrontal Cortex
Bryden, D. W., Burton, A. C., Barnett, B. R., Cohen, V. J., Hearn, T., Jones, E. A. A., Kariyil, R., Kunin, A., Kwak, S. I., Lee, J., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.197 · Cited by 38
Contreras, D., Piña, R., Carvallo, C., Godoy, F., Ugarte, G., Zeise, M., Rozas, C., & Morales, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137099 · Cited by 35
Ugarte, G., Piña, R., Contreras, D., Godoy, F., Rubio, D., Rozas, C., Zeise, M. L., Vidal, R., Escobar, J., & Morales, B. (2023) · Biology · doi:10.3390/biology12091241 · Cited by 35
Kantak, K. M. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173378 · Cited by 36
Zhang, M., Zhang, D., Dai, J., Cao, Y., Xu, W., He, G., Wang, Z., Wang, L., Li, R., & Qiao, Z. (2020) · Toxicology · doi:10.1016/j.tox.2020.152367 · Cited by 33
Wendt, F. R., Garcia‐Argibay, M., Cabrera‐Mendoza, B., Valdimarsdóttir, U. A., Gelernter, J. E., Stein, M. B., Nivard, M. G., Maihofer, A. X., Maihofer, A. X., Choi, K. W., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.08.012 · Cited by 33
Buck, J. M., O’Neill, H. C., & Stitzel, J. A. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.08.003 · Cited by 29
Toxic effects of smokeless tobacco on female reproductive health: A review
Laldinsangi, C. (2022) · Current Research in Toxicology · doi:10.1016/j.crtox.2022.100066 · Cited by 27
Jamshed, L., Perono, G. A., Jamshed, S., & Holloway, A. C. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa127 · Cited by 29
Ireland, D., Zhang, S., Bochenek, V., Hsieh, J., Rabeler, C., Meyer, Z., & Collins, E. S. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.948455 · Cited by 28
Muñoz‐Villegas, P., Rodríguez, V. M., Giòrdano, M., & Juárez, J. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.12.011 · Cited by 27
Piña, R., Rozas, C., Contreras, D., Hardy, P., Ugarte, G., Zeise, M. L., Rojas, P., & Morales, B. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.040 · Cited by 30
Brockett, A. T., Pribut, H. J., Vázquez, D., & Roesch, M. R. (2018) · Learning & Memory · doi:10.1101/lm.047001.117 · Cited by 28
Eicher, J. D., Powers, N. R., Cho, K., Miller, L. L., Mueller, K. L., Ring, S. M., Tomblin, J. B., & Gruen, J. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063762 · Cited by 26
Martin, M. M., McCarthy, D. M., Schatschneider, C. W., Trupiano, M. X., Jones, S. K., Kalluri, A., & Bhide, P. G. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz207 · Cited by 26
Self-citationPolli, F. S., Ipsen, T. H., Caballero-Puntiverio, M., Østerbøg, T. B., Aznar, S., Andreasen, J. T., & Kohlmeier, K. A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01854-9 · Cited by 25
Molecular Mechanisms Underlying NMDARs Dysfunction and Their Role in ADHD Pathogenesis
Kuś, J., Saramowicz, K., Czerniawska, M., Wiese, W., Siwecka, N., Rozpędek‐Kamińska, W., Kucharska-Lusina, A., Strzelecki, D., & Majsterek, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612983 · Cited by 28
Micalizzi, L., & Knopik, V. S. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001687 · Cited by 28
Buck, J. M., O’Neill, H. C., & Stitzel, J. A. (2020) · Epigenetics & Chromatin · doi:10.1186/s13072-020-00332-0 · Cited by 26
Lacy, R. T., Brown, R. W., Morgan, A. J., Mactutus, C. F., & Harrod, S. B. (2016) · Developmental Neuroscience · doi:10.1159/000446563 · Cited by 24
Morgan, A., Harrod, S. B., Lacy, R. T., Stanley, E. M., & Fadel, J. R. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.04.003 · Cited by 23
Is it safe to use smoking cessation therapeutics during pregnancy?
Long, N. E. D., Barra, N. G., Hardy, D. B., & Holloway, A. C. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.973846 · Cited by 23
Zugno, A. I., Fraga, D. B., De Luca, R. D., Ghedim, F. V., Deroza, P. F., Cipriano, A. L., Oliveira, M. B., Heylmann, A. S. A., Budni, J., Souza, R. P., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.001 · Cited by 23
Abreu‐Villaça, Y., Carvalho-Graça, A. C., Skinner, G. O., Denucci, B. L., Pinheiro, V. H. S. D., Ribeiro‐Carvalho, A., Manhães, A. C., & Filgueiras, C. C. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.04.003 · Cited by 24
Prenatal Nicotine Exposure in Rodents: Why Are There So Many Variations in Behavioral Outcomes?
Polli, F. S., & Kohlmeier, K. A. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz196 · Cited by 24
Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice
Huang, Z., Hoffman, C. A., Chelette, B. M., Thiebaud, N., & Fadool, D. A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00049 · Cited by 20
Perinatal nicotine exposure impairs the maturation of glutamatergic inputs in the auditory brainstem
Baumann, V. J., & Koch, U. (2017) · The Journal of Physiology · doi:10.1113/jp274059 · Cited by 21
McCarthy, D. M., Lowe, S. E., Morgan, T. J., Cannon, E. N., Biederman, J., Spencer, T. J., & Bhide, P. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-68883-6 · Cited by 22
Self-citationMorris, M., Shaw, A., Lambert, M., Perry, H. H., Lowenstein, E. G., Valenzuela, D., & Velazquez-Ulloa, N. A. (2018) · BMC Developmental Biology · doi:10.1186/s12861-018-0172-6 · Cited by 20
Heritable consequences of paternal nicotine exposure: from phenomena to mechanisms†
McCarthy, D. M., & Bhide, P. G. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab116 · Cited by 17
Self-citationDopamine Receptor and Gα(olf) Expression in DYT1 Dystonia Mouse Models during Postnatal Development
Zhang, L., McCarthy, D. M., Sharma, N., & Bhide, P. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123104 · Cited by 18
Self-citationNeurobiology of Attention Deficit Hyperactivity Disorder
Faraone, S. V., Bhide, P. G., & Biederman, J. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0064 · Cited by 18
Self-citationChristensen, M. H., Nielsen, M. L., & Kohlmeier, K. A. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s204017441400049x · Cited by 17
Nicotine and the developing brain: Insights from preclinical models
McCarthy, D. M., Zhang, L., Wilkes, B. J., Vaillancourt, D. E., Biederman, J., & Bhide, P. G. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173355 · Cited by 22
Self-citationNucleosome Repositioning: A Novel Mechanism for Nicotine- and Cocaine-Induced Epigenetic Changes
Brown, A. N., Vied, C., Dennis, J. H., & Bhide, P. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139103 · Cited by 16
Self-citationZhang, L., McCarthy, D. M., Jaunarajs, K. L. E., Biederman, J., Spencer, T. J., & Bhide, P. G. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa238 · Cited by 16
Self-citationIs There a Causal Relation between Maternal Acetaminophen Administration and ADHD?
Saad, A. F., Hegde, S., Kechichian, T. B., Gamble, P., Rahman, M., Stutz, S. J., Anastasio, N. C., Alshehri, W., Lei, J., Mori, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157380 · Cited by 16
The prevalence, mechanism of action, and toxicity of Nigerian psychoactive plants
Fasakin, O. W., Oboh, G., & Ademosun, A. O. (2022) · Comparative Clinical Pathology · doi:10.1007/s00580-022-03374-w · Cited by 15
Saito, H., Furukawa, Y., Sasaki, T., Kitajima, S., Kanno, J., & Tanemura, K. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1239808 · Cited by 16
Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the Embryonic and Adult Brain
McCarthy, D. M., Mueller, K. A., Cannon, E. N., Huizenga, M. N., Darnell, S. B., Bhide, P. G., & Sadri‐Vakili, G. (2016) · Developmental Neuroscience · doi:10.1159/000453609 · Cited by 14
Self-citationGavini, K., Yang, E., & Parameshwaran, K. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.07.030 · Cited by 15
Addressing the Complexity of Tourette's Syndrome through the Use of Animal Models
Nespoli, E., Rizzo, F. R., Boeckers, T. M., Hengerer, B., & Ludolph, A. G. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00133 · Cited by 16
Karatayev, O., Collier, A. D., Targoff, S. R., & LEIBOWITZ, S. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158341 · Cited by 18
Kohlmeier, K. A. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000531 · Cited by 13
Ipsen, T. H., Polli, F. S., & Kohlmeier, K. A. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22607 · Cited by 11
Opiate Antagonists Do Not Interfere With the Clinical Benefits of Stimulants in ADHD
Spencer, T. J., Bhide, P. G., Zhu, J., Faraone, S. V., Fitzgerald, M., Yule, A. M., Uchida, M., Spencer, A. E., Hall, A. M., Koster, A. J., et al. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m11012 · Cited by 12
Self-citationPavlock, S., McCarthy, D. M., Kesarwani, A., Jean‐Pierre, P., & Bhide, P. G. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1896508 · Cited by 12
Self-citationNicotine as a female reproductive toxicant—A review
Bhardwaj, J. K., Siwach, A., & Sachdeva, S. N. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4702 · Cited by 14
Buck, J. M., Yu, L., Knopik, V. S., & Stitzel, J. A. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab138 · Cited by 11
mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity
Wu, C., Jew, C. P., Sun, H., Ballester‐Rosado, C. J., & Lu, H. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05367-0 · Cited by 11
Reversal of neurobehavioral teratogenicity in animal models and human: Three decades of progress
Yanai, J., Vigoda, M. J., & Ornoy, A. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.06.009 · Cited by 11
Stankovic, I. N., & Colak, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.848648 · Cited by 10
Lee, W.-S., & Yoon, B. (2023) · Biomedicines · doi:10.3390/biomedicines11051260 · Cited by 10
Yim, G., Roberts, A., Ascherio, A., Wypij, D., Kioumourtzoglou, M.-A., & Weisskopf, A. M. G. (2022) · Epidemiology · doi:10.1097/ede.0000000000001467 · Cited by 9
Current Perspectives on Attention-deficit Hyperactivity Disorder
Shafiullah, S., & Dhaneshwar, S. S. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230522145950 · Cited by 9
Xie, T., & Mao, Y. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.196 · Cited by 6
Buck, J. M., O’Neill, H. C., & Stitzel, J. A. (2021) · Behavior Genetics · doi:10.1007/s10519-021-10071-x · Cited by 6
Nicotine-induced dopamine plasticity: a gateway to neurotransmitter replacement?
Dulcis, D., & Lai, I. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.264451 · Cited by 6
Zhang, L., Levenson, C. W., Salazar, V. C., McCarthy, D. M., Biederman, J., ZAFONTE, R. D., & Bhide, P. G. (2021) · Developmental Neuroscience · doi:10.1159/000515198 · Cited by 5
Self-citationMamiya, T., Tanase, S., Takeuchi, S., Kato, S., Ito, A., Hiramatsu, M., & Nabeshima, T. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114139 · Cited by 6
Rose, J. K., Miller, M. K., Crane, S. A., Hope, K. A., & Pittman, P. G. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.07.007 · Cited by 6
Treatment of Comorbid Substance Use Disorders and ADHD in Youth
Carrellas, N. W., Wilens, T. E., & Anselmo, R. (2016) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-016-0072-y · Cited by 6
Polli, F. S., & Kohlmeier, K. A. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i2.212 · Cited by 6
Developmental Neurotoxicity of Nicotine and Tobacco
Levin, E. D., & Abreu‐Villaça, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00039-0 · Cited by 5
Schmidt, S. (2020) · Environmental Health Perspectives · doi:10.1289/ehp7315 · Cited by 6
Karatayev, O., & LEIBOWITZ, S. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157143 · Cited by 4
Vidal, R., Lopez, I., Ugarte, G., Contreras, D., Piña, R., Godoy, F., Rozas, C., Rubio, D., Mantellero, C. A., Constandil, L., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323756 · Cited by 4
Trans-generational effects of parental exposure to drugs of abuse on offspring memory functions
Riyahi, J., Taslimi, Z., Gelfo, F., Petrosini, L., & Haghparast, A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105644 · Cited by 4
Zhang, L., Levenson, C. W., Salazar, V. C., Biederman, J., ZAFONTE, R. D., & Bhide, P. G. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2021.0268 · Cited by 4
Self-citationGelner, H., Karska, J., Gawęda, Ł., Samochowiec, J., & Misiak, B. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1232606 · Cited by 8
Collier, A. D., Abdulai, A. R., & LEIBOWITZ, S. F. (2023) · Cells · doi:10.3390/cells12202505 · Cited by 4
Ireland, D., Zhang, S., Bochenek, V., Hsieh, J., Rabeler, C., Meyer, Z., & Collins, E. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.20.496617 · Cited by 4
Uygun, S. D., Kose, T. B., Bahadır‐Varol, A., Uzay, B., & Eren‐Koçak, E. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2025.2 · Cited by 3
Rodent research of attention-deficit/hyperactivity disorder: insights into widely used animal models
Corona, J. C. (2025) · Laboratory Animal Research · doi:10.1186/s42826-025-00255-5 · Cited by 3
Metadata
- Authors
- Zhu, J., Zhang, X., Xu, Y., Spencer, T. J., Biederman, J., & Bhide, P. G.
- Affiliations
- Florida State University (US)
- Harvard University (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-07-04
- Volume
- 32
- Issue
- 27
- Pages
- 9410-9418
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3417040
- OpenAlex
- W2027221598
- Cited by
- 125
- References
- 53
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 15 · 2021: 7 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 1
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R21DA027358, R01DA020796)
- National Institute of Neurological Disorders and Stroke (P30NS045776)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prenatal nicotine exposure, attention deficit hyperactivity disorder, methylphenidate, dopamine turnover, cingulate cortex, cortical thickness, hyperactivity, frontal cortex, mouse model, maternal smoking, sex differences
- MeSH terms
- Animals, Attention Deficit Disorder with Hyperactivity, Disease Models, Animal, Dopamine, Female, Gyrus Cinguli, Male, Methylphenidate, Mice, Inbred C57BL, Models, Neurological, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Smoking, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
