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Prenatal Nicotine Exposure Mouse Model Showing Hyperactivity, Reduced Cingulate Cortex Volume, Reduced Dopamine Turnover, and Responsiveness to Oral Methylphenidate Treatment
Open accessAbstract
Cigarette smoking, nicotine replacement therapy, and smokeless tobacco use during pregnancy are associated with cognitive disabilities later in life in children exposed prenatally to nicotine. The disabilities include attention deficit hyperactivity disorder (ADHD) and conduct disorder. However, the structural and neurochemical bases of these cognitive deficits remain unclear. Using a mouse model we show that prenatal nicotine exposure produces hyperactivity, selective decreases in cingulate cortical volume, and radial thickness, as well as decreased dopamine turnover in the frontal cortex. The hyperactivity occurs in both male and female offspring and peaks during the "active" or dark phase of the light/dark cycle. These features of the mouse model closely parallel the human ADHD phenotype, whether or not the ADHD is associated with prenatal nicotine exposure. A single oral, but not intraperitoneal, administration of a therapeutic equivalent dose (0.75 mg/kg) of methylphenidate decreases the hyperactivity and increases the dopamine turnover in the frontal cortex of the prenatally nicotine exposed mice, once again paralleling the therapeutic effects of this compound in ADHD subjects. Collectively, our data suggest that the prenatal nicotine exposure mouse model has striking parallels to the ADHD phenotype not only in behavioral, neuroanatomical, and neurochemical features, but also with respect to responsiveness of the behavioral phenotype to methylphenidate treatment. The behavioral, neurochemical, and anatomical biomarkers in the mouse model could be valuable for evaluating new therapies for ADHD and mechanistic investigations into its etiology.
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“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
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“Similarly, a study using a mouse model found that PNE produced hyperactivity that was associated with selective decreases in cingulate cortical volume and radial thickness and a decrease in drug-induced dopamine release in the frontal cortex”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [36]
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“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
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“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
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“For example, a mouse model has demonstrated that fetal exposure to nicotine yields hyperactivity, reduces cingulate cortex volume, reduces dopamine turnover and responsiveness to methylphenidate and might thereby lead to the identification of new pharmacotherapies 58 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [58]
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Metadata
- Authors
- Zhu, J., Zhang, X., Xu, Y., Spencer, T. J., Biederman, J., & Bhide, P. G.
- Affiliations
- Florida State University (US)
- Harvard University (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-07-04
- Volume
- 32
- Issue
- 27
- Pages
- 9410-9418
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3417040
- OpenAlex
- W2027221598
- Cited by
- 125
- References
- 53
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 15 · 2021: 7 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 1
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R21DA027358, R01DA020796)
- National Institute of Neurological Disorders and Stroke (P30NS045776)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prenatal nicotine exposure, attention deficit hyperactivity disorder, methylphenidate, dopamine turnover, cingulate cortex, cortical thickness, hyperactivity, frontal cortex, mouse model, maternal smoking, sex differences
- MeSH terms
- Animals, Attention Deficit Disorder with Hyperactivity, Disease Models, Animal, Dopamine, Female, Gyrus Cinguli, Male, Methylphenidate, Mice, Inbred C57BL, Models, Neurological, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Smoking, Mice
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