Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice

Alkam, Tursun; Mamiya, Takayoshi; Kimura, Nami; Yoshida, Aya; Kihara, Daisuke; Tsunoda, Yuki; Aoyama, Yuki; Hiramatsu, Masayuki; Kim, Hyoung-Chun; Nabeshima, Toshitaka

doi:10.1007/s00213-017-4591-z

Cited by 50Prenatal Substance Exposure EffectsAttention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice

Alkam, Tursun, Mamiya, Takayoshi, Kimura, Nami, Yoshida, Aya, Kihara, Daisuke, Tsunoda, Yuki, Aoyama, Yuki, Hiramatsu, Masayuki +2 more·2017·Psychopharmacology

DOI 10.1007/s00213-017-4591-z

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Abstract

Increased risk of attention-deficit/hyperactivity disorder (AD/HD) is partly associated with the early developmental exposure to nicotine in tobacco smoke. Emerging reports link tobacco smoke exposure or prenatal nicotine exposure (PNE) with AD/HD-like behaviors in rodent models. We have previously reported that PNE induces cognitive behavioral deficits in offspring and decreases the contents of dopamine (DA) and its turnover in the prefrontal cortex (PFC) of offspring It is well known that the dysfunction of DAergic system in the brain is one of the core factors in the pathophysiology of AD/HD. Therefore, we examined whether the effects of PNE on the DAergic system underlie the AD/HD-related behavioral changes in mouse offspring. PNE reduced the release of DA in the medial PFC (mPFC) in mouse offspring. PNE reduced the number of tyrosine hydroxylase (TH)-positive varicosities in the mPFC and in the core as well as the shell of nucleus accumbens, but not in the striatum. PNE also induced behavioral deficits in cliff avoidance, object-based attention, and sensorimotor gating in offspring. These behavioral deficits were attenuated by acute treatment with atomoxetine (3 mg/kg, s.c.) or partially attenuated by acute treatment with MPH (1 mg/kg, s.c.). Taken together, our findings support the notion that PNE induces neurobehavioral abnormalities in mouse offspring by disrupting the DAergic system and improve our understanding about the incidence of AD/HD in children whose mothers were exposed to nicotine during their pregnancy.

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PNE produces disruptions to the DAergic system that induce neurobehavioral abnormalities in mouse offspring and lead to ADHD-like behaviors.
“These results indicate that PNE produces disruptions to the DAergic system that induce neurobehavioral abnormalities in mouse offspring and lead to ADHD-like behaviors”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [81]
In a mouse model, PNE reduced the number of tyrosine hydroxylase-positive varicosities in the shell of the NA and in the mPFC.
“Another study in a mouse animal model found that PNE reduced the number of tyrosine hydroxylase (TH)-positive varicosities in the shell of the NA and in the mPFC”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [81]
Acute treatment with atomoxetine (3 mg/kg) or methylphenidate (1 mg/kg) attenuated or partially attenuated behavioral deficits, respectively.
“Moreover, they found that acute treatment with atomoxetine (3 mg/kg) or with methylphenidate (MPH) (1 mg/kg) where able to attenuate or partially attenuate the behavioral deficits respectively.”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [81]
PNE induced behavioral deficits in object-based attention, sensorimotor gating, and cliff avoidance in offspring.
“They also found that PNE induced behavioral deficits in object-based attention, sensorimotor gating, and cliff avoidance in offspring.”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [81]

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Authors: Alkam, T., Mamiya, T., Kimura, N., Yoshida, A., Kihara, D., Tsunoda, Y., Aoyama, Y., Hiramatsu, M., Kim, H.-C., & Nabeshima, T.
Affiliations: Western University of Health Sciences (US)
Japanese Drug Organization of Appropriate Use and Research (JP)
Meijo University (JP)
Kangwon National University (KR)
Fujita Health University (JP)
Corresponding author: Nabeshima, Toshitaka
ORCID: Alkam, Tursun
Mamiya, Takayoshi
Yoshida, Aya
Hiramatsu, Masayuki
Kim, Hyoung-Chun
Nabeshima, Toshitaka
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2017-03-23
Volume: 234
Issue: 12
Pages: 1853-1869
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-017-4591-z
OpenAlex: W2597499553
Cited by: 50
References: 130
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 11 · 2019: 9 · 2018: 4 · 2017: 1
FWCI: 7.49
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Takeda Science Foundation
Japan Society for the Promotion of Science (17K08321)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: prenatal nicotine exposure, attention deficit hyperactivity disorder, dopamine release, medial prefrontal cortex, atomoxetine, methylphenidate, tyrosine hydroxylase, nucleus accumbens, cliff avoidance, object-based attention, sensorimotor gating, neurobehavioral deficits
MeSH terms: Atomoxetine Hydrochloride, Animals, Attention Deficit Disorder with Hyperactivity, Cognition Disorders, Dopamine, Female, Male, Mice, Inbred C57BL, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Prefrontal Cortex, Adrenergic Uptake Inhibitors, Mice

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Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice

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