The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Differential properties of tetrodotoxin-sensitive and tetrodotoxin- resistant sodium channels in rat dorsal root ganglion neurons
Open accessAbstract
TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) sodium channel currents were analyzed in acutely dissociated dorsal root ganglion (DRG) neurons isolated from 3–12-d-old and adult rats. Currents were recorded using the whole-cell patch-clamp technique. TTX-R current was more likely to be present in younger animals (3–7 d), whereas TTX-S current was more common in older animals (7–10 d), although TTX-R current was recorded from adult rat DRG neurons. The TTX-R and TTX-S currents differed in their steady-state inactivation, with 50% inactivation voltage at -40 +/- 5 mV (n = 10) for TTX-R currents and -70 +/- 4 mV (n = 10) for TTX- S currents. These current types also differed in their activation kinetics, with 50% activation values of -15 +/- 5 mV (n = 5) for TTX-R currents and -26 +/- 6 mV (n = 5) for TTX-S currents. The interactions of TTX-R and TTX-S channels with various pharmacological agents and divalent cations were studied. The Kd values for TTX-S and TTX-R currents were estimated to be 0.3 nM and 100 microM for TTX, 0.5 nM and 10 microM for saxitoxin, and 50 microM and 200 microM for lidocaine, respectively. TTX-S channels did not exhibit a marked use-dependent block by lidocaine, whereas lidocaine significantly decreased TTX-R current in a use-dependent manner at frequencies ranging from 1 to 33.3 Hz. Several external divalent cations exerted different effects on these current types.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cites
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Stys, P., Waxman, S., & Ransom, B. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00430.1992 · Cited by 662
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Woolf, C. J., & Costigan, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7723 · Cited by 555
Dib-Hajj, S. D., Tyrrell, L., Black, J. A., & Waxman, S. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8963 · Cited by 503
Chronic pain, chronic stress and depression: Coincidence or consequence?
Blackburn‐Munro, G., & Blackburn‐Munro, R. E. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2001.00727.x · Cited by 493
Metadata
- Authors
- Roy, M., & Narahashi, T.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1992-06-01
- Volume
- 12
- Issue
- 6
- Pages
- 2104-2111
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2134321467
- Cited by
- 533
- References
- 18
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Roy, M., & Narahashi, T. (1992). Differential properties of tetrodotoxin-sensitive and tetrodotoxin- resistant sodium channels in rat dorsal root ganglion neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.12-06-02104.1992
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