The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET
Open accessAbstract
The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant right hand during serial positron emission tomography (PET) imaging of relative cerebral blood flow (relCBF). The effect of motor execution, rather than learning, was identified by a comparison of four motor performance scans with two control scans (eye movements only). Motor execution was associated with activation of a distributed network involving cortical, striatonigral, and cerebellar sites. Second, the effect of early motor learning was examined. Performance improved from 17% to 66% mean time on target across the four PET scans obtained during pursuit rotor performance. Across the same scans, significant longitudinal increases of relCBF were located in the left primary motor cortex, the left supplementary motor area, and the left pulvinar thalamus. The results demonstrate that changes of regional cerebral activity associated with early learning of skilled movements occur in sites that are a subset of a more widely distributed network that is active during motor execution.
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“The putamen is often implicated in procedural learning (Grafton et al., 1992; Miyachi et al., 1997, 2002; Jueptner and Weiller, 1998; Turner et al., 2003).”
From Neural Correlates of Long-Term Memory Enhancement Following Retrieval Practice (2021) · cites this paper as Grafton et al., 1992
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Cites
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“Neuronal discharges of the SMA typically precede motor cortex activity and also are active during motor ideation, independent of performance (Orgogozo and Larsen, 1979; Roland et al., 1980; Deecke et al., 1985).”
BackgroundIto, M. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000505 · Cited by 1,167
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BackgroundThe Neural Basis of Motor Control
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Statistical parametric maps in functional imaging: A general linear approach
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“In activation studies this may be the time on target during a visuomotor tracking paradigm [Grafton et al., 19921, performance on free recall [Grasby et al., 19921 or frequency of stimulus presentation [Price et al., 19921.”
BackgroundImaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
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The plastic human brain cortex
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BackgroundFunctional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
Metadata
- Authors
- Grafton, S., Mazziotta, J., Presty, S., Friston, K., Frackowiak, R., & Phelps, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1992-07-01
- Volume
- 12
- Issue
- 7
- Pages
- 2542-2548
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6575851
- OpenAlex
- W2124365503
- Cited by
- 607
- References
- 34
- Citations by year
- 2025: 3 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 16 · 2014: 16 · 2013: 10 · 2012: 12
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- U.S. Department of Energy (FC03-87ER60615)
- National Institutes of Health (5r01mh037916-10)
- National Institute of Mental Health (R01 MH 37916)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- procedural learning, motor skill learning, pursuit rotor task, relative cerebral blood flow, primary motor cortex, supplementary motor area, cerebellum, motor execution
- MeSH terms
- Adult, Brain, Brain Mapping, Cerebrovascular Circulation, Eye Movements, Female, Humans, Functional Laterality, Learning, Male, Motor Activity, Movement, Organ Specificity, Regional Blood Flow, Tomography, Emission-Computed
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