The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET
Open accessAbstract
The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant right hand during serial positron emission tomography (PET) imaging of relative cerebral blood flow (relCBF). The effect of motor execution, rather than learning, was identified by a comparison of four motor performance scans with two control scans (eye movements only). Motor execution was associated with activation of a distributed network involving cortical, striatonigral, and cerebellar sites. Second, the effect of early motor learning was examined. Performance improved from 17% to 66% mean time on target across the four PET scans obtained during pursuit rotor performance. Across the same scans, significant longitudinal increases of relCBF were located in the left primary motor cortex, the left supplementary motor area, and the left pulvinar thalamus. The results demonstrate that changes of regional cerebral activity associated with early learning of skilled movements occur in sites that are a subset of a more widely distributed network that is active during motor execution.
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“The putamen is often implicated in procedural learning (Grafton et al., 1992; Miyachi et al., 1997, 2002; Jueptner and Weiller, 1998; Turner et al., 2003).”
From Neural Correlates of Long-Term Memory Enhancement Following Retrieval Practice (2021) · cites this paper as Grafton et al., 1992
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Cites
Comparing Functional (PET) Images: The Assessment of Significant Change
Friston, K. J., Frith, C., Liddle, P. F., & Frackowiak, R. S. J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.122 · Cited by 1,626
Supplementary motor area and other cortical areas in organization of voluntary movements in man
Roland, P. E., Larsen, B., Lassen, N. A., & Skinhöj, E. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.1.118 · Cited by 1,517 · cited 1×
“Neuronal discharges of the SMA typically precede motor cortex activity and also are active during motor ideation, independent of performance (Orgogozo and Larsen, 1979; Roland et al., 1980; Deecke et al., 1985).”
BackgroundIto, M. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000505 · Cited by 1,167
Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
Raichle, M. E., Martin, W. R. W., Herscovitch, P., Mintun, M. A., & Markham, J. (1983) · PubMed · Cited by 1,015
The Relationship between Global and Local Changes in PET Scans
Friston, K. J., Frith, C., Liddle, P. F., Dolan, R. J., Lammertsma, A. A., & Frackowiak, R. S. J. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.88 · Cited by 858
Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis.
Herscovitch, P., Markham, J., & Raichle, M. E. (1983) · PubMed · Cited by 835
Reliability and validity of some handedness questionnaire items
Raczkowski, D., Kalat, J. W., & Nebes, R. D. (1974) · Neuropsychologia · doi:10.1016/0028-3932(74)90025-6 · Cited by 611
Regional cerebral blood flow during voluntary arm and hand movements in human subjects
Colebatch, J. G., Deiber, M., Passingham, R. E., Friston, K. J., & Frackowiak, R. S. J. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.65.6.1392 · Cited by 603
Neural design of the cerebellar motor control system
Ito, M. (1972) · Brain Research · doi:10.1016/0006-8993(72)90110-2 · Cited by 591 · cited 1×
“The cerebellum has long been described as a “teaching machine” ofthe motor cortex (Marr, 1969; Ito, 1972; Thach, 1978).”
BackgroundThe Neural Basis of Motor Control
Brooks, V. B. (1986) · Medical Entomology and Zoology · Cited by 517
Thach, W. T. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.3.654 · Cited by 475 · cited 1×
“The cerebellum has long been described as a “teaching machine” ofthe motor cortex (Marr, 1969; Ito, 1972; Thach, 1978).”
BackgroundThe colour centre in the cerebral cortex of man
Lueck, C. J., Zeki, S., Friston, K. J., Deiber, M., Cope, P., Cunningham, V. J., Lammertsma, A. A., Christopher Kennard, C., & Frackowiak, R. S. J. (1989) · Nature · doi:10.1038/340386a0 · Cited by 458
The Neural Basis of Motor Control.
Kehne, J. H. (1987) · The Yale Journal of Biology and Medicine · Cited by 455
Positron emission tomographic measurements of pulvinar activity during an attention task
LaBerge, D., & Buchsbaum, M. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00613.1990 · Cited by 353
Orgogozo, J. M., & Larsen, B. (1979) · Science · doi:10.1126/science.493986 · Cited by 346 · cited 1×
“Neuronal discharges of the SMA typically precede motor cortex activity and also are active during motor ideation, independent of performance (Orgogozo and Larsen, 1979; Roland et al., 1980; Deecke et al., 1985).”
BackgroundMOTOR LEARNING IN PATIENTS WITH CEREBELLAR DYSFUNCTION
Sanes, J. N., Dimitrov, B., & Hallett, M. (1990) · Brain · doi:10.1093/brain/113.1.103 · Cited by 274 · cited 1×
“Clinical observations from patients and nonhuman primates with injury to the striatum or cerebellum confirm that the entire loop must be intact for the motor skill to be assimilated (Mishkin et al., 1984; Inhoff et al., 1989; Halsband and Freund, 1990; Sanes et al., 1990).”
BackgroundPlastic Transformation of PET Images
Friston, K. J., Frith, C., Liddle, P. F., & Frackowiak, R. S. J. (1991) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199107000-00020 · Cited by 268
Fox, P. T., Mintun, M. A., Raichle, M. E., & Herscovitch, P. (1984) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1984.49 · Cited by 242
Grafton, S. T., Woods, R. P., Mazziotta, J. C., & Phelps, M. E. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.3.735 · Cited by 240
Procedural memory in Parkinson's disease: Impaired motor but not visuoperceptual learning
Harrington, D. L., Haaland, K. Y., Yeo, R. A., & Marder, E. (1990) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639008400978 · Cited by 221
Bergström, M., Litton, J.-E., Eriksson, L., Böhm, C., & Blomqvist, G. (1982) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198204000-00022 · Cited by 214 · cited 1×
“Each sinogram of projection data was analyzed using a boundary detection algorithm, and emission scans were reconstructed using a calculated attenuation correction method (Bergstrom et al., 1982).”
MethodRetinotopic organization of macaque pulvinar.
Bender, D. B. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.46.3.672 · Cited by 202
PREMOTOR CORTEX AND CONDITIONAL MOTOR LEARNING IN MAN
Halsband, U., & Freund, H. (1990) · Brain · doi:10.1093/brain/113.1.207 · Cited by 184
(1985) · PubMed · Cited by 181
Mazziotta, J. C., Huang, S., Phelps, M. E., Carson, R. E., MacDonald, N. S., & Mahoney, K. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.10 · Cited by 166
Sakamoto, T., Porter, L. L., & Asanuma, H. (1987) · Brain Research · doi:10.1016/0006-8993(87)91029-8 · Cited by 147 · cited 1×
“Electrophysiological studies of motor learning in animals have implicated both long-term potentiation and long-term depression (in the cerebellum) as modulators of synaptic activity (Sakamoto et al., 1987; Asanuma, 1989; Ito, 1989).”
BackgroundTHE ROLE OF CEREBELLAR STRUCTURES IN THE EXECUTION OF SERIAL MOVEMENTS
Inhoff, A. W., Diener, H. C., Rafal, R. D., & Ivry, R. B. (1989) · Brain · doi:10.1093/brain/112.3.565 · Cited by 145 · cited 1×
“Clinical observations from patients and nonhuman primates with injury to the striatum or cerebellum confirm that the entire loop must be intact for the motor skill to be assimilated (Mishkin et al., 1984; Inhoff et al., 1989; Halsband and Freund, 1990; Sanes et al., 1990).”
BackgroundReminiscence, Motivation, and Personality
Eysenck, H. J., & Frith, C. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2244-3 · Cited by 132 · cited 1×
“It has been proposed that, at the beginning of practice for a new motor skill, the performer adopts a strategy of constructing and facilitating subskills previously retained from other well-learned tasks (Eysenck and Frith, 1977).”
BackgroundAmmons, R. B. (1947) · Journal of Experimental Psychology · doi:10.1037/h0054334 · Cited by 125 · cited 1×
“Validation of this instrument for measuring visuomotor skill learning has been reported in detail over the past 40 years (Ammons, 1947; Ammons et al., 1958; Wisner et al., 1988).”
MethodSwash, M. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.7.627-a · Cited by 98
Strick, P. L. (1988) · PubMed · Cited by 59
Visual responses of pulvinar and collicular neurons during eye movements of awake, trained macaques
Robinson, D. L., McClurkin, J. W., Kertzman, C., & Petersen, S. E. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.2.485 · Cited by 50
Anatomical and physiological organization of the non-primary motor cortex
Wise, S. P., & Strick, P. L. (1984) · Trends in Neurosciences · doi:10.1016/s0166-2236(84)80150-2 · Cited by 47 · cited 1×
“The somatotopic organization of the frontal lobe is exceptionally complex, with multiple maps and overlapping cortical fields (Wise and Strick, 1984; Strick, 1988).”
BackgroundRotary Pursuit Performance as a Function of Sex, Sex-Role, and Intertrial Interval
Wisner, B. L., Lombardo, J. P., & Catalano, J. F. (1988) · Perceptual and Motor Skills · doi:10.2466/pms.1988.66.2.443 · Cited by 4
Research works printed but not linked: 1
- Talairach J, -Toumoux P (1988) -Co-planar stereotaxic atlas of the brain. New York: Thieme.
Cited by
Sorted by citations
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
“In activation studies this may be the time on target during a visuomotor tracking paradigm [Grafton et al., 19921, performance on free recall [Grasby et al., 19921 or frequency of stimulus presentation [Price et al., 19921.”
BackgroundImaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
The plastic human brain cortex
Pascual-Leone, A., Amedi, A., Fregni, F., & Merabet, L. B. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144216 · Cited by 1,929
“A growing number of neuroimaging studies have suggested a similar two-step process (Seitz et al. 1990; Grafton et al. 1992; Jenkins et al. 1994; Karni et al. 1995, 1998).”
BackgroundFunctional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
Metadata
- Authors
- Grafton, S., Mazziotta, J., Presty, S., Friston, K., Frackowiak, R., & Phelps, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1992-07-01
- Volume
- 12
- Issue
- 7
- Pages
- 2542-2548
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6575851
- OpenAlex
- W2124365503
- Cited by
- 607
- References
- 34
- Citations by year
- 2025: 3 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 16 · 2014: 16 · 2013: 10 · 2012: 12
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- U.S. Department of Energy (FC03-87ER60615)
- National Institutes of Health (5r01mh037916-10)
- National Institute of Mental Health (R01 MH 37916)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- procedural learning, motor skill learning, pursuit rotor task, relative cerebral blood flow, primary motor cortex, supplementary motor area, cerebellum, motor execution
- MeSH terms
- Adult, Brain, Brain Mapping, Cerebrovascular Circulation, Eye Movements, Female, Humans, Functional Laterality, Learning, Male, Motor Activity, Movement, Organ Specificity, Regional Blood Flow, Tomography, Emission-Computed
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