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Synaptic plasticity in the rat supraoptic nucleus during lactation involves GABA innervation and oxytocin neurons: a quantitative immunocytochemical analysis
Open accessAbstract
The hypothalamic supraoptic nucleus (SON) is known to undergo synaptic remodeling in response to physiological stimuli, such as lactation. We here investigated the involvement of the GABAergic innervation in such plasticity by carrying out comparative ultrastructural analyses after postembedding immunogold labeling for GABA on sections of the SON from virgin and lactating rats. Using random single-section analysis to estimate the numerical density of synapses (from areal measurements of the anterior, mid, and posterior portions of the nucleus), we found that the overall density in either group was about 35 x 10(6) synapses/mm3, of which over one-third were GABA immunoreactive. The GABAergic terminals formed mainly symmetrical synaptic contact on neurosecretory somata and dendrites; the density of axodendritic contacts was twice that of axosomatic contacts. Despite hypertrophy of the neurosecretory neurons in lactating rats, the overall synaptic density did not diminish and was similar to that evaluated in virgin rats. When we estimated synaptic densities in the neuropil (by subtracting the proportion of sampled areas occupied by soma profiles), we found a statistically significant increase in the density of GABAergic synapses, in particular in the mid and posterior portions of the SON in lactating animals. On the other hand, the density of GABA- immunonegative synapses did not differ in the two groups. Terminals contacting more than one postsynaptic element in the same plane of section (“shared” synapses) were visible in the nuclei of virgin and lactating rats and about half in each group were GABAergic. They were comparatively rare but their incidence doubled in lactating animals.(ABSTRACT TRUNCATED AT 250 WORDS)
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“Hypothalamic inhibition increases during lactation46 and might prevent the activation of oxytocin neurons by sparse synaptic inputs”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [46]
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Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,141
Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
Poulain, D. A., & Wakerley, J. B. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90044-6 · Cited by 816
GABA: A dominant neurotransmitter in the hypothalamus
Decavel, C., & van den Pol, A. N. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020423 · Cited by 575
Glutamate, the Dominant Excitatory Transmitter in Neuroendocrine Regulation
van den Pol, A. N., Wuarin, J., & Dudek, F. E. (1990) · Science · doi:10.1126/science.1978759 · Cited by 544
Rhodes, C. H., Morriell, J. I., & Pfaff, D. W. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980106 · Cited by 536
Hatton, G. I. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90017-b · Cited by 439
Sawchenko, P. E., Swanson, L. W., Steinbusch, H. W. M., & Verhofstad, A. A. J. (1983) · Brain Research · doi:10.1016/0006-8993(83)90945-9 · Cited by 380
Roland, B. L., & Sawchenko, P. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903320109 · Cited by 334
Antibodies against gamma-aminobutyric acid: specificity studies and immunocytochemical results.
Séguéla, P., Geffard, M., Buijs, R. M., & Moal, M. L. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3888 · Cited by 331
Ben-Barak, Y., Russell, J., Whitnall, M., Ozato, K., & Gainer, H. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-01-00081.1985 · Cited by 313
Activity-dependent neuronal-glial and synaptic plasticity in the adult mammalian hypothalamus
Theodosis, D. T., & Poulain, D. A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90002-w · Cited by 273
Self-citationOxytocin induces morphological plasticity in the adult hypothalamo-neurohypophysial system
Theodosis, D. T., Montagnese, C. M., Rodriguez, F., Vincent, J., & Poulain, D. A. (1986) · Nature · doi:10.1038/322738a0 · Cited by 211
Self-citationWitkin, J. W., Ferin, M., Popilskis, S. J., & Silverman, A. (1991) · Endocrinology · doi:10.1210/endo-129-2-1083 · Cited by 207
Synaptic remodeling in the rat arcuate nucleus during the estrous cycle
Olmos, G., Naftolin, F. N., Perez, J., Tranque, P., & García‐Segura, L. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90288-1 · Cited by 205
Theodosis, D. T., & Poulain, D. A. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90222-7 · Cited by 191
Self-citationTheodosis, D. T., Paut-Pagano, L., & Tappaz, M. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90016-3 · Cited by 179
Self-citationTheodosis, D. T., Chapman, D. B., Montagnese, C. M., Poulain, D. A., & Morris, J. F. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90038-2 · Cited by 177
Self-citationTheodosis, D. T., Poulain, D. A., & Vincent, J. D. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90173-1 · Cited by 176
Self-citationTribollet, E., Armstrong, W. E., Dubois‐Dauphin, M., & Dreifuss, J. J. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90128-9 · Cited by 158
Hatton, G. I., & Tweedle, C. D. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90046-6 · Cited by 157
Tweedle, C. D., & Hatton, G. I. (1984) · Brain Research · doi:10.1016/0006-8993(84)90607-3 · Cited by 148
Decavel, C., & van den Pol, A. N. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160109 · Cited by 145
Nerve Terminal Remodeling Visualized in Living Mice by Repeated Examination of the Same Neuron
Purves, D., Voyvodic, J. T., Magrassi, L., & Yawo, H. (1987) · Science · doi:10.1126/science.3685967 · Cited by 129
Ultrastructural localization of GABA in the supraoptic nucleus and neural lobe
Buijs, R. M., Vulpen, E. H. S. V., & Geffard, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90025-x · Cited by 128
Chapman, D. B., Theodosis, D. T., Montagnese, C. M., Poulain, D. A., & Morris, J. F. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90039-4 · Cited by 127
Self-citationQuantitative studies on the supraoptic nucleus in the rat. I. Synaptic organization
L�r�nth, C., Z�borszky, L., Márton, J., & Palkovits, M. (1975) · Experimental Brain Research · doi:10.1007/bf00237351 · Cited by 126
Fénelon, V. S., Poulain, D. A., & Theodosis, D. T. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90286-o · Cited by 125
Self-citationEstradiol induces plasticity of gabaergic synapses in the hypothalamus
Párducz, Á., Perez, J., & García‐Segura, L. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90203-r · Cited by 117
Colonnier, M., & Beaulieu, C. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902310205 · Cited by 114
Merighi, A., Polak, J. M., Fumagalli, G. F., & Theodosis, D. T. (1989) · Journal of Histochemistry & Cytochemistry · doi:10.1177/37.4.2564404 · Cited by 102
Self-citationvan den Pol, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-11-02940.1985 · Cited by 100
Effect of the richness of the environment on the cat visual cortex
Beaulieu, C., & Colonnier, M. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902660404 · Cited by 100
Actions of gamma‐aminobutyric acid on rat supraoptic nucleus neurosecretory neurones in vitro.
Randle, J. C. R., & Renaud, L. P. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016592 · Cited by 98
Quantitative studies on the supraoptic nucleus in the rat. II. Afferent fiber connections
Z�borszky, L., L�r�nth, C., Makara, G. B., & Palkovits, M. (1975) · Experimental Brain Research · doi:10.1007/bf00237352 · Cited by 94
Ultrastructural studies on the hypothalamic neurosecretory neurons of the rat
Kalimo, H., & Rinne, U. K. (1972) · Cell and Tissue Research · doi:10.1007/bf00307154 · Cited by 90
Jhamandas, J. H., Raby, W. N., Rogers, J., Buijs, R. M., & Renaud, L. P. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902820103 · Cited by 89
Montagnese, C. M., Poulain, D. A., Vincent, J. D., & Theodosis, D. T. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1150097 · Cited by 86
Self-citationDecavel, C., Geffard, M., & Calas, A. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90577-5 · Cited by 83
Theodosis, D. T., & Poulain, D. A. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90014-2 · Cited by 79
Self-citationRandle, J. C. R., Bourque, C. W., & Renaud, L. P. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.6.1703 · Cited by 76
Radial Glia‐Like Cells in the Supraoptic Nucleus of the Adult Rat
Bonfanti, L., Poulain, D. A., & Theodosis, D. T. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00357.x · Cited by 74
Self-citationMeeker, R. B., Swanson, D. J., & Hayward, J. N. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90318-7 · Cited by 72
Ultrastructural studies on the hypothalamic neurosecretory neurons of the rat
Kalimo, H. (1975) · Cell and Tissue Research · doi:10.1007/bf00221723 · Cited by 67
Modney, B. K., & Hatton, G. I. (1989) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1989.tb00072.x · Cited by 64
Hartman, R. D., Rosella-Dampman, L. M., & Summy‐Long, J. Y. (1987) · Endocrinology · doi:10.1210/endo-121-2-536 · Cited by 44
Katsumaru, H., Murakami, F., Wu, J., & Tsukahara, N. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02864.1986 · Cited by 37
Alterations in supraoptic nucleus ultrastructure of maternally behaving virgin rats
Salm, A. K., Modney, B. K., & Hatton, G. I. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90209-2 · Cited by 34
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Metadata
- Authors
- Gies, U., & Theodosis, D.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-05-01
- Volume
- 14
- Issue
- 5
- Pages
- 2861-2869
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577499
- OpenAlex
- W2119677102
- Cited by
- 125
- References
- 49
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Science Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- synaptic plasticity, supraoptic nucleus, lactation, GABAergic innervation, oxytocin neurons, synaptic density, neurosecretory cells, axodendritic synapses, hypothalamus, ultrastructure
- MeSH terms
- Animals, Antibodies, Monoclonal, Axons, Dendrites, Female, gamma-Aminobutyric Acid, Lactation, Nerve Endings, Neuronal Plasticity, Neurons, Oxytocin, Pregnancy, Supraoptic Nucleus, Synapses, Microscopy, Immunoelectron, Rats, Wistar, Rats
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