The hypothalamic-neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: an old concept revisited
Abstract
Mammals respond to challenging situations with characteristic changes in their behaviour as well as in autonomic and neuroendocrine parameters aimed at reinstating their disturbed homeostasis. Among such so-called coping strategies, alterations of the hypothalamic-pituitary-adrenal (HPA) axis play a crucial role. Today it is generally accepted that parvocellular neurones of the hypothalamic paraventricular nucleus control the secretion of corticotropin and corticosterone by synthesising and releasing both the corticotropin-releasing hormone and vasopressin (AVP). Recent evidence supports and embellishes the old hypothesis that AVP and the structurally related neuropeptide, oxytocin, originating from the hypothalamic-neurohypophysial system (HNS) might directly affect HPA axis activity. This review presents data supporting the concept of HNS effects on HPA axis activity and outlines their possible impact on some aspects of behavioural regulation and psychopathology.
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As female prairie voles reach puberty, only about 50% will spontaneously retrieve, lick/groom, and hover over pups presented to them, with the remainder either ignoring or attacking pups.
“However, as females reach puberty, only about 50% of the females will spontaneously retrieve, lick/groom, and hover over pups presented to them, with the remainder of the females either ignoring or attacking pups [38-40].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [39]
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“This separation of projection targets is supported by microdialysis studies showing that peripheral and central release are dissociated under certain circumstances [128-130].”
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- Authors
- Engelmann, M., Landgraf, R., & Wotjak, C. T.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- Max Planck Society (DE)
- Corresponding author
- Engelmann, Mario
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 25
- Issue
- 3-4
- Pages
- 132-149
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2081567401
- Cited by
- 450
- References
- 158
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 13 · 2023: 17 · 2022: 14 · 2021: 27 · 2020: 17 · 2019: 19 · 2018: 23 · 2017: 12 · 2016: 22 · 2015: 19 · 2014: 24 · 2013: 26 · 2012: 29
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- hypothalamic-pituitary-adrenal axis, stress, vasopressin, oxytocin, paraventricular nucleus, corticotropin-releasing factor, corticosterone, coping strategies, behavioral regulation, psychopathology
- MeSH terms
- Adaptation, Physiological, Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Corticotropin-Releasing Hormone, Cortisone, Dominance-Subordination, Humans, Hypothalamo-Hypophyseal System, Mammals, Oxytocin, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Stress, Physiological
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