Comparative study of dopamine- and noradrenaline-immunoreactive terminals in the paraventricular and supraoptic nuclei of the rat
Abstract
The distribution of dopaminergic and noradrenergic terminal fields of the paraventricular (PVN) and supraoptic (SON) nuclei of the rat was investigated at the optic and electron microscopical level using antibodies directed against dopamine (DA) and noradrenaline (NA). The DA innervation was uniform among these nuclei, although more important in the PVN than in the SON. NA fibers were preferentially distributed in the parvocellular parts of the PVN and in areas of the magnocellular nuclei where vasopressinergic neurons were mainly located. Both DA and NA terminals synaptically contacted magnocellular neurons on their cell body or dendrites. This study thus provides morphological evidence for a double and independent catecholaminergic control, by DA and NA, on neuroendocrine mechanisms at the hypothalamic level.
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The PVN and the SON express DA receptors and receive dopaminergic innervations, possibly from the VTA.
“Additionally, the PVN and the SON express DA receptors and receive dopaminergic innervations, possibly from the VTA (Buijs et al., 1984; Decavel et al., 1987; He et al., 2021; Rivkees and Lachowicz, 1997).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Decavel et al., 1987
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“Additionally, the PVN and the SON express DA receptors and receive dopaminergic innervations, possibly from the VTA (Buijs et al., 1984; Decavel et al., 1987; He et al., 2021; Rivkees and Lachowicz, 1997).”
Background
- Authors
- Decavel, C., Geffard, M., & Calas, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Decavel, C.
- ORCID
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1987-06
- Volume
- 77
- Issue
- 2
- Pages
- 149-154
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2062346821
- Cited by
- 83
- References
- 23
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 3 · 2012: 1
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- dopamine, norepinephrine, dopaminergic terminals, noradrenergic terminals, paraventricular nucleus, supraoptic nucleus, hypothalamus, magnocellular neurons, parvocellular neurons, vasopressin, catecholaminergic innervation, neuroendocrine regulation, synaptic connectivity
- MeSH terms
- Animals, Dopamine, Enzyme-Linked Immunosorbent Assay, Histocytochemistry, Microscopy, Electron, Norepinephrine, Paraventricular Hypothalamic Nucleus, Supraoptic Nucleus, Rats
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