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UNC-31 (CAPS) Is Required for Dense-Core Vesicle But Not Synaptic Vesicle Exocytosis in Caenorhabditis elegans
Open accessAbstract
Previous studies indicated that CAPS (calcium-dependent activator protein for secretion) functions as an essential component for the Ca2+-dependent exocytosis of dense-core vesicles in neuroendocrine cells. However, recent mouse knock-out studies suggested an alternative role in the vesicular uptake or storage of catecholamines. To genetically assess the functional role of CAPS, we characterized the sole Caenorhabditis elegans CAPS ortholog UNC-31 (uncoordinated family member) and determined its role in dense-core vesicle-mediated peptide secretion and in synaptic vesicle recycling. Novel assays for dense-core vesicle exocytosis were developed by expressing a prepro-atrial natriuretic factor-green fluorescent protein fusion protein in C. elegans. unc-31 mutants exhibited reduced peptide release in vivo and lacked evoked peptide release in cultured neurons. In contrast, cultured neurons from unc-31 mutants exhibited normal stimulated synaptic vesicle recycling measured by FM4-64 [N-(3-triethylammoniumpropyl)-4-(6-(4-diethylamino)phenyl)hexatrienyl)pyridinium dibromide] dye uptake. Conversely, UNC-13, which exhibits sequence homology to CAPS/UNC-31, was found to be essential for synaptic vesicle but not dense-core vesicle exocytosis. These findings indicate that CAPS/UNC-31 function is not restricted to catecholaminergic vesicles but is generally required for and specific to dense-core vesicle exocytosis. Our results suggest that CAPS/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system.
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“rund-1 and unc-31 mutants also have defects in egg-laying and defecation, and enter the dauer diapause stage at high temperature”
From Two Rab2 Interactors Regulate Dense-Core Vesicle Maturation (2014) · cites this paper as Speese et al., 2007
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“CAPS is required for DCV fusion”
From Two Rab2 Interactors Regulate Dense-Core Vesicle Maturation (2014) · cites this paper as Speese et al., 2007
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Metadata
- Authors
- Speese, S., Petrie, M., Schuske, K., Ailion, M., Ann, K., Iwasaki, K., Jorgensen, E. M., & Martin, T. F. J.
- Affiliations
- University of Utah (US)
- University of Wisconsin–Madison (US)
- Northwestern University (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-06
- Volume
- 27
- Issue
- 23
- Pages
- 6150-6162
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672138
- OpenAlex
- W2025681452
- Cited by
- 333
- References
- 74
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 35 · 2023: 19 · 2022: 22 · 2021: 24 · 2020: 15 · 2019: 10 · 2018: 17 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 18 · 2013: 14 · 2012: 11
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Department of Agriculture
- McKnight Foundation
- National Institutes of Health
- Cooperative State Research, Education, and Extension Service
- National Institute of Mental Health (MH60997, R01MH060997)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 40428, R01DK040428)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- unc-31, CAPS, synaptic vesicle recycling, UNC-13, peptide secretion, atrial natriuretic peptide, Caenorhabditis elegans neurons, calcium-dependent exocytosis, neuroendocrine cells
- MeSH terms
- Amino Acid Sequence, Animals, Calcium-Binding Proteins, Carrier Proteins, Exocytosis, Molecular Sequence Data, Synaptic Vesicles, Caenorhabditis elegans, Secretory Vesicles, Caenorhabditis elegans Proteins
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