Cited by 278Stress Responses and CortisolAdrenal Hormones and DisordersNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress

Open access

Shanks, N, Larocque, S, Meaney, MJ·1995·The Journal of Neuroscience

DOI 10.1523/jneurosci.15-01-00376.1995PMC PMC6578303

Open this paper in CoChat — free account Open PDF

Abstract

The long-term consequences of neonatal endotoxin exposure on hypothalamic-pituitary-adrenal axis (HPA) function were assessed in adult female and male Long-Evans rats. At 3 and 5 d of age, pups were administered endotoxin (Salmonella enteritidis, 0.05 mg/kg, i.p.) at a dose that provokes a rapid and sustained physiological response, but with no mortality. As adults, neonatally endotoxin-treated animals exhibited significantly greater adrenocorticotrophic hormone (ACTH) and corticosterone responses to restraint stress than controls. In addition, dexamethasone pretreatment was less effective in suppressing ACTH responses to restraint stress in endotoxin-treated animals than in controls, suggesting decreased negative-feedback sensitivity to glucocorticoids. Neonatal endotoxin treatment elevated resting-state median eminence levels of corticotropin-releasing hormone (CRH) and arginine vasopressin in adult male animals, and arginine vasopressin in both adult males and females. Neonatal exposure to endotoxin also increased CRH mRNA expression in the paraventricular nucleus of the hypothalamus of adult males, with no difference in females. Finally, glucocorticoid receptor density was reduced across a wide range of brain regions in the neonatal endotoxin-treated, adult animals. These data illustrate the interactive nature of immune and endocrine systems during development. It appears that endotoxin exposure during critical stages of development decreases glucocorticoid negative-feedback inhibition of ACTH secretagogue synthesis, thus increasing HPA responsiveness to stress. The implication of these findings is that exposure to gram-negative LPS in early life can alter the development of neural systems which govern endocrine responses to stress and may thereby predispose individuals to stress-related pathology.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.15-01-00376.1995

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Self-citation
Adrenal steroid receptors and actions in the nervous system
McEwen, B. S., de Kloet, E. R., & Rostène, W. H. (1986) · Physiological Reviews · doi:10.1152/physrev.1986.66.4.1121 · Cited by 1,238
The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress
Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151
Self-citation
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965
Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat
VIAU, V., & MEANEY, M. J. (1991) · Endocrinology · doi:10.1210/endo-129-5-2503 · Cited by 666
Self-citation
Physiological and behavioral effects of infantile stimulation
Levine, S., Haltmeyer, G. C., Karas, G. G., & Denenberg, V. H. (1967) · Physiology & Behavior · doi:10.1016/0031-9384(67)90011-x · Cited by 553

Show all 66 references

Research works printed but not linked: 5

Bhatnagar S, Shanks N, Meaney MJ (in press) Hypothalamic-pitui- tary-adrenal function in chronic, intermittently cold stressed handled and nonhandled rats. J Neuroendocrinol, in press.
O'Grady MP, Hall NRS (199 1) Long-term effects of neuroendocrine- immune interactions during early development. In: Psychoneuroim- munology, Second Edition (Ader R, Felten DL, Cohen N, eds), pp 561-572. San Diego: Academic.
Shanks N, LaRocque S, Meaney MJ (in press a) Hypothalamic-pi- tuitary-adrenal responses to endotoxin challenge in neonatal rats: me- diation via CRH. J Neuroendocrinol, in press.
Shanks N, McCormick CM, Meaney MJ (in press b) Sex differences in HPA responses to endotoxin challenge in the neonate: reversal by gonadectomy. Dev Brain Res, in press.
Viau V, Meaney MJ (in press) Androgen regulation of hypothalamic- pituitary-adrenal responses to stress in male rats: role of the medial preoptic area. J Neurosci, in press.

Sorted by citations

Items 101–200 of 278

Adolescent escitalopram prevents the effects of maternal separation on depression‐ and anxiety‐like behaviours and regulates the levels of inflammatory cytokines in adult male mice
Wang, Q., Dong, X., Wang, Y., Liu, M., Sun, A., Li, N., Lin, Y., Geng, Z., Jin, Y., & Li, X. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.07.007 · Cited by 47
Lifetime modulation of the pain system via neuroimmune and neuroendocrine interactions
Zouikr, I., & Karshikoff, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00276 · Cited by 45
Neonatal immune challenge does not affect body weight regulation in rats
Spencer, S. J., Mouihate, A., Galic, M. A., Ellis, S., & Pittman, Q. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2007 · Cited by 45
Postnatal programming of the innate immune response
Galic, M. A., Spencer, S. J., Mouihate, A., & Pittman, Q. J. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp025 · Cited by 45
Postnatally induced differences in adult pain sensitivity depend on genetics, gender and specific experiences: reversal of maternal deprivation effects by additional postnatal tactile stimulation or chronic imipramine treatment
Stephan, M., Helfritz, F., Pabst, R., & von Hörsten, S. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00468-5 · Cited by 44
Hormones Are Key Actors in Gene X Environment Interactions Programming the Vulnerability to Parkinson's Disease: Glia as a Common Final Pathway
Marchetti, B., Serra, P. A., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., S, C., Gennuso, F., Rocchitta, G., Desole, M. S., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1356.023 · Cited by 44
Neonatal exposure to LPS leads to heightened exploratory activity in adolescent rats
Rico, J. L., Ferraz, D. B., Ramalho-Pinto, F. J., & Morato, S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.001 · Cited by 44
Neonatal Lipopolysaccharide Exposure Exacerbates Stress-Induced Suppression of Luteinizing Hormone Pulse Frequency in Adulthood
Li, X., Kinsey‐Jones, J. S., Knox, A. M. I., Wu, X., Tahsinsoy, D., Brain, S. D., Lightman, S. L., & O’Byrne, K. T. (2007) · Endocrinology · doi:10.1210/en.2007-0710 · Cited by 43
Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.
Hennessy, M. B., Paik, K. D., Caraway, J. D., Schiml, P. A., & Terrence Deak, B. (2011) · Behavioral Neuroscience · doi:10.1037/a0023559 · Cited by 41
Tumor necrosis factor-alpha during neonatal brain development affects anxiety- and depression-related behaviors in adult male and female mice
Babri, S., Doosti, M.-H., & Salari, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.037 · Cited by 41
Neonatal lipopolysaccharide treatment alters hippocampal neuroinflammation, microglia morphology and anxiety-like behavior in rats selectively bred for an infantile trait
Claypoole, L. D., Zimmerberg, B., & Williamson, L. L. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.017 · Cited by 41
Early-life lipopolysaccharide exposure potentiates forebrain expression of NLRP3 inflammasome proteins and anxiety-like behavior in adolescent rats
Lei, Y., Chen, C., Yan, X., Li, Z., & Deng, X. (2017) · Brain Research · doi:10.1016/j.brainres.2017.06.014 · Cited by 40
Neonatal programming by immunological challenge: effects on ovarian function in the adult rat
Wu, X.-Q., Li, X.-F., Ye, B., Popat, N., Milligan, S. R., Lightman, S. L., & O'Byrne, K. T. (2010) · Reproduction · doi:10.1530/rep-10-0252 · Cited by 41
Developmental changes in the responses of preterm infants to a painful stressor
Lucas‐Thompson, R. G., Townsend, E. L., Gunnar, M. R., Georgieff, M., Guiang, S. F., Cifuentes, R. F., Lussky, R. C., & Davis, E. P. (2008) · Infant Behavior and Development · doi:10.1016/j.infbeh.2008.07.004 · Cited by 41
Development of Individual Differences in Behavioral and Endocrine Responses to Stress: Role of the Postnatal Environment
Caldji, C., Liu, D., Sharma, S., Diorio, J. C., Francis, D. D., Meaney, M. J., & Plotsky, P. M. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070413 · Cited by 41
Self-citation
Stress resilience and the risk of inflammatory bowel disease: A cohort study of men living in Sweden
Melinder, C., Hiyoshi, A., Fall, K., Halfvarson, J., & Montgomery, S. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014315 · Cited by 40
Long-term dysregulation of brain corticotrophin and glucocorticoid receptors and stress reactivity by single early-life pain experience in male and female rats
Victoria, N. C., Inoue, K., Young, L. J., & Murphy, A. Z. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.013 · Cited by 40
Neuroendocrine–immune (NEI) circuitry from neuron–glial interactions to function: Focus on gender and HPA–HPG interactions on early programming of the NEI system
Morale, M. C., Gallo, F., Tirolo, C., Testa, N., Caniglia, S., Marletta, N., Spina‐Purrello, V., Avola, R., Caucci, F., Tomasi, P. A., et al. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.01030.x · Cited by 41
Neonatal LPS injection alters the body weight regulation systems of rats under non‐stress and immune stress conditions
Iwasa, T., Matsuzaki, T., Kinouchi, R., Fujisawa, S., Murakami, M., Kiyokawa, M., Kuwahara, A., Yasui, T., & Irahara, M. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.08.015 · Cited by 38
Different effects of acute neonatal stressors and long-term postnatal handling on stress-induced changes in behavior and in ornithine decarboxylase activity of adult rats
Gilad, V. H., Rabey, J. M., Eliyayev, Y., & Gilad, G. M. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00012-2 · Cited by 39
Temperament in young adulthood and later mortality: prospective observational study
McCarron, P., Gunnell, D., Harrison, G. L., Okasha, M., & Smith, G. D. (2003) · Journal of Epidemiology & Community Health · doi:10.1136/jech.57.11.888 · Cited by 38
Sexually dimorphic effects of neonatal immune system activation with lipopolysaccharide on the behavioural response to a homotypic adult immune challenge
Tenk, C. M., Kavaliers, M., & Ossenkopp, K. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.01.001 · Cited by 38
Neonatal dexamethasone and chronic tianeptine treatment inhibit ligature‐induced periodontitis in adult rats
Breivik, T. J., Gundersen, Y., Osmundsen, H., Fonnum, F., & Opstad, P. K. (2005) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2005.00833.x · Cited by 39
Perinatal nutrition programs neuroimmune function long-term: mechanisms and implications
Spencer, S. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00144 · Cited by 37
Minireview: Early-Life Programming by Inflammation of the Neuroendocrine System
Kentner, A. C., & Pittman, Q. J. (2010) · Endocrinology · doi:10.1210/en.2010-0583 · Cited by 37
How gut microbiota may impact ocular surface homeostasis and related disorders
Labétoulle, M., Baudouin, C., del Castillo, J. M. B., Rolando, M., Rescigno, M., Messmer, E. S. B. M., & Aragona, P. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101250 · Cited by 38
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors
Lucchina, L., Carola, V., Pitossi, F. J., & Depino, A. M. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.032 · Cited by 36
Early life programming of pain: focus on neuroimmune to endocrine communication
Zouikr, I., Bartholomeusz, M. D., & Hodgson, D. M. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0879-8 · Cited by 37
Exposure to a Dysfunctional Glucocorticoid Receptor from Early Embryonic Life Programs the Resistance to Experimental Autoimmune Encephalomyelitis Via Nitric Oxide-Induced Immunosuppression
Marchetti, B., Morale, M. C., Brouwer, J. P., Tirolo, C., Testa, N., Caniglia, S., Barden, N., Amor, S., Smith, P. A., & Dijkstra, C. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5848 · Cited by 36
Maternal behavior changes after immune challenge of neonates with developmental effects on adult social behavior
Hood, K. E., Dreschel, N. A., & Granger, D. A. (2002) · Developmental Psychobiology · doi:10.1002/dev.10076 · Cited by 35
Atopic dermatitis, educational attainment and psychological functioning: a national cohort study
Smirnova, J., Kobyletzki, L. B., Lindberg, M., Svensson, Å., Langan, S., & Montgomery, S. (2018) · British Journal of Dermatology · doi:10.1111/bjd.17330 · Cited by 34
Challenges in researching the immune pathways between early life adversity and psychopathology
Reid, B. M., & Danese, A. (2020) · Development and Psychopathology · doi:10.1017/s0954579420001157 · Cited by 37
Neonatal immune system activation with lipopolysaccharide enhances behavioural sensitization to the dopamine agonist, quinpirole, in adult female but not male rats
Tenk, C. M., Foley, K. A., Kavaliers, M., & Ossenkopp, K. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.03.001 · Cited by 31
Neonatal immune activation depletes the ovarian follicle reserve and alters ovarian acute inflammatory mediators in neonatal rats†
Fuller, E. A., Sominsky, L., Sutherland, J. M., Redgrove, K. A., Harms, L. R., McLaughlin, E. A., & Hodgson, D. M. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox123 · Cited by 33
A profile of the immediate endocrine, metabolic and behavioural responses following a dual exposure to endotoxin in early life
WALKER, F., Brogan, A. J., Smith, R., & Hodgson, D. M. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.030 · Cited by 32
Adolescent fluoxetine treatment decreases the effects of neonatal immune activation on anxiety-like behavior in mice
Zolbanin, J. M., Azarfarin, M., Samadi, H., Enayati, M., & Salari, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.003 · Cited by 34
Neonatal immune challenge affects the regulation of estrus cyclicity and feeding behavior in female rats
Iwasa, T., Matsuzaki, T., Murakami, M., Kinouchi, R., Shimizu, F., Kuwahara, A., Yasui, T., & Irahara, M. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.10.003 · Cited by 32
Stress Hormones, Genotype, and Brain Organization Implications for Aggressiona
de Kloet, E. R., Korte, S. M., Rots, N. Y., & Kruk, M. R. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32520.x · Cited by 32
Biochemical, Histopathological and Morphological Profiling of a Rat Model of Early Immune Stimulation: Relation to Psychopathology
Kubesova, A., Tejkalová, H., Syslová, K., Kačer, P., Vondroušová, J., Tylš, F., Fujáková, M., Páleníček, T., & Horáček, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115439 · Cited by 31
Targeted sensory enrichment interventions protect against behavioral and neuroendocrine consequences of early life stress
Kentner, A. C., Scalia, S., Shin, J., Migliore, M. M., & Rondón-Ortiz, A. N. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.029 · Cited by 31
Neuroendocrine-immune interactions in the neonate
Matteri, R. L., Klir, J. J., Fink, B. N., & Johnson, R. W. (1998) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(98)00024-1 · Cited by 31
The neuroendocrinology of depression
Checkley, S. A. (1996) · International Review of Psychiatry · doi:10.3109/09540269609051552 · Cited by 36
The molecular neurobiology of stress – evidence from genetic and epigenetic models
Steckler, T. (2001) · Behavioural Pharmacology · doi:10.1097/00008877-200111000-00002 · Cited by 30
Neonatal treatment with lipopolysaccharide differentially affects adult anxiety responses in the light–dark test and taste neophobia test in male and female rats
Tenk, C. M., Kavaliers, M., & Ossenkopp, K. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.12.004 · Cited by 28
Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring
Niu, X., Wu, X., Ying, A., Shao, B., Li, X., Zhang, W., Lin, C., & Lin, Y. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.003 · Cited by 29
Prenatal Dexamethasone Treatment Does Not Prevent Alterations of the Hypothalamic Pituitary Adrenal Axis in Steroid 21-Hydroxylase Deficient Mice
Tajima, T., Ma, X., Bornstein, S. R., & Aguilera, G. (1999) · Endocrinology · doi:10.1210/endo.140.7.6755 · Cited by 29
Neuropsychiatric Systemic Lupus Erythematosus
Moore, P. M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48376.x · Cited by 29
Maternal Depression and Risk for Postpartum Complications: Role of Prenatal Corticotropin-releasing Hormone and Interleukin-1 Receptor Antagonist
Schmeelk‐Cone, K., Granger, D. A., Susman, E. J., & Chrousos, G. P. (1999) · Behavioral Medicine · doi:10.1080/08964289909595741 · Cited by 28
A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge
Sidor, M. M., Amath, A., MacQUEEN, G. M., & Foster, J. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.060 · Cited by 27
Endotoxin exposure during late pregnancy alters ovine offspring febrile and hypothalamic–pituitary–adrenal axis responsiveness later in life
Fisher, R. E., Karrow, N. A., Quinton, M., Finegan, E. J., Miller, S. P., Atkinson, J. L., & Boermans, H. J. (2010) · Stress · doi:10.3109/10253891003663762 · Cited by 28
Neonatal immune challenge exacerbates experimental colitis in adult rats: potential role for TNF-α
Spencer, S. J., Hyland, N. P., Sharkey, K. A., & Pittman, Q. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00398.2006 · Cited by 28
Potentiation of tumor metastasis in adulthood by neonatal endotoxin exposure: sex differences
Hodgson, D. M., & Knott, B. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00080-4 · Cited by 28
Hormonal Interactions in the Effects of Halogenated Aromatic Hydrocarbons On the Developing Brain
MacLusky, N. J., Brown, T. J., Schantz, S. L., Seo, B. W., & Peterson, R. E. (1998) · Toxicology and Industrial Health · doi:10.1177/074823379801400112 · Cited by 28
Neonatal Programming by Neuroimmune Challenge: Effects on Responses and Tolerance to Septic Doses of Lipopolysaccharide in Adult Male and Female Rats
Spencer, S. J., Field, E., & Pittman, Q. J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01967.x · Cited by 27
The impact of early repeated pain experiences on stress responsiveness and emotionality at maturity in rats
Page, G. G., Blakely, W. P., & Kim, M. T. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.05.002 · Cited by 27
Neonatal lipopolysaccharide exposure attenuates the homotypic stress‐induced suppression of LH secretion in adulthood in male rat
Iwasa, T., Matsuzaki, T., Murakami, M., Kinouchi, R., Ogata, R., Kuwahara, A., Yasui, T., & Irahara, M. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.03.004 · Cited by 27
Neonatal lipopolysaccharide treatment has long‐term effects on monoaminergic and cannabinoid receptors in the rat
Zavitsanou, K., Dalton, V. S., Walker, A. K., Weickert, C. S., Sominsky, L., & Hodgson, D. M. (2013) · Synapse · doi:10.1002/syn.21640 · Cited by 26
Brief ReviewEffects of Stress on Inflammatory Autoimmune Disease: Destructive or Protective?
Jessop, D. S., Richards, L. J., & Harbuz, M. S. (2004) · Stress · doi:10.1080/10253890400025497 · Cited by 26
Immediate and longterm effects of immune stimulation: hypothesis linking the immune response to subsequent physical and psychological wellbeing
Hurwitz, E. L., & Morgenstern, H. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1217 · Cited by 25
The Fetal Brain in Bovine Viral Diarrhea Virus-infected Calves: Lesions, Distribution, and Cellular Heterogeneity of Viral Antigen at 190 Days Gestation
Montgomery, D. L., van Olphen, A. L., Campen, H. V., & Hansen, T. R. (2008) · Veterinary Pathology · doi:10.1354/vp.45-3-288 · Cited by 24
Abnormal immune system development and function in schizophrenia helps reconcile diverse findings and suggests new treatment and prevention strategies
Anders, S. L., & Kinney, D. K. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.043 · Cited by 26
Individual differences in glucose homeostasis: Do our early life interactions with bacteria matter?
Walker, F. R., Owens, J. A., Ali, S. O., & Hodgson, D. M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.11.004 · Cited by 24
Altered Formalin-Induced Pain and Fos Induction in the Periaqueductal Grey of Preadolescent Rats following Neonatal LPS Exposure
Zouikr, I., James, M. H., Campbell, E. J., Clifton, V. L., Beagley, K. W., Dayas, C. V., & Hodgson, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098382 · Cited by 23
Neonatal proinflammatory stress induces accumulation of corticosterone and interleukin-6 in the hippocampus of juvenile rats: Potential mechanism of synaptic plasticity impairments
Onufriev, M. V., Freiman, S. V., Peregud, D., Kudryashova, I. V., Тишкина, А. О., Stepanichev, M. Y., & Gulyaeva, N. V. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917030051 · Cited by 24
Individual differences in the recovery of the hypothalamic–pituitary–adrenal axis after termination of exposure to a severe stressor in outbred male Sprague–Dawley rats
García, A. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00060-3 · Cited by 23
Developmental alterations in CNS stress-related gene expression following postnatal immune activation
Amath, A., Foster, J. A., & Sidor, M. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.037 · Cited by 22
Host–microbiome intestinal interactions during early life: considerations for atopy and asthma development
Pettersen, V. K., & Arrieta, M. (2020) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000629 · Cited by 22
Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity
Zouikr, I., Ahmed, A. F., Horvat, J. C., Beagley, K. W., Clifton, V. L., Ray, A., Thorne, R. F., Jarnicki, A., Hansbro, P. M., & Hodgson, D. M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.10.014 · Cited by 22
Postnatal LPS Challenge Impacts Escape Learning and Expression of Plasticity Factors Mmp9 and Timp1 in Rats: Effects of Repeated Training
Трофимов, А. Н., Strekalova, T. V., Mortimer, N., Zubareva, O. E., Schwarz, A. P., Svirin, E. P., Umriukhin, A., Svistunov, A. A., Lesch, K., & Клименко, В. М. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9720-2 · Cited by 21
Long-term Effects of Early Postnatally Administered Interleukin-1-beta on the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Rats.
Plagemann, A., Staudt, Götz, F., Malz, U., Rohde, W., Rake, A., & Dörner, G. (1998) · PubMed · Cited by 21
The Hypothalamic-Pituitary-Adrenal Stress Axis in the Fibromyalgia Syndrome
Crofford, L. J. (1996) · Journal of Musculoskeletal Pain · doi:10.1300/j094v04n01_11 · Cited by 21
Manipulation of the Rumen Ecosystem to Support High-Performance Beef Cattle - Review -
Jouany, J. P., Michalet-Doreau, B., & Doreau, M. (2000) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2000.96 · Cited by 21
Maternal separation in early life impairs tumor immunity in adulthood in the F344 rat
Nakamura, T., Walker, A. K., Sominsky, L., Allen, T., Rosengren, S. M., & Hodgson, D. M. (2011) · Stress · doi:10.3109/10253890.2010.548014 · Cited by 19
Prenatal Exposure to Stress and Stress Hormones Influences Child Development
Davis, E. P., & Sandman, C. A. (2006) · Infants & Young Children · doi:10.1097/00001163-200607000-00008 · Cited by 20
Neonatal bacterial endotoxin challenge interacts with stress in the adult male rat to modify KLH specific antibody production but not KLH stimulated ex vivo cytokine release
Walker, F. R., Hodyl, N. A., & Hodgson, D. M. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.11.012 · Cited by 20
The Sustained Phase of Tyrosine Hydroxylase Activation In vivo
Ong, L. K., Sominsky, L., Dickson, P. W., Hodgson, D. M., & Dunkley, P. R. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0812-3 · Cited by 19
Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner
Wynne, O., Horvat, J. C., Osei-Kumah, A., Smith, R., Hansbro, P. M., Clifton, V. L., & Hodgson, D. M. (2011) · Stress · doi:10.3109/10253890.2010.532576 · Cited by 19
Distribution and Cellular Heterogeneity of Bovine Viral Diarrhea Viral Antigen Expression in the Brain of Persistently Infected Calves: A New Perspective
Montgomery, D. L. (2007) · Veterinary Pathology · doi:10.1354/vp.44-5-643 · Cited by 19
Body surface temperature of rats reveals both magnitude and sex differences in the acute stress response
Wongsaengchan, C., McCafferty, D. J., Evans, N. P., McKeegan, D. E. F., & Nager, R. G. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114138 · Cited by 18
Developmental immune activation programs adult behavior: insight from research on birds
Grindstaff, J. L. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.10.006 · Cited by 18
Early-life exposure to lipopolysaccharide reduces the severity of experimental autoimmune encephalomyelitis in adulthood and correlated with increased urine corticosterone and apoptotic CD4+ T cells
Wang, Z.-W., Wang, P., Lin, F., Li, X.-F., Li, X.-F., O'Byrne, K. T., Hou, S., & Zheng, R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.047 · Cited by 18
Use of osmotic minipumps for sustained drug delivery in rat pups: effects on physical and neurobehavioural development
Doucette, T. A., Ryan, C. L., & Tasker, R. A. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00315-2 · Cited by 18
Reduced stress fever is accompanied by increased glucocorticoids and reduced PGE2 in adult rats exposed to endotoxin as neonates
Soriano, R. N., & Branco, L. G. S. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.018 · Cited by 17
Mother-infant Interactions and the Development of Immunity from Conception through Weaning
Coe, C. L., & Lubach, G. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50027-7 · Cited by 18
Effects of inhibiting neonatal methamphetamine‐induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels
Grace, C. E., Schaefer, T. L., Graham, D. L., Skelton, M. R., Williams, M. T., & Vorhees, C. V. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.02.005 · Cited by 17
Socioeconomic Status, Inflammation, and Immune Function
Steptoe, A. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195394399.013.0013 · Cited by 16
Transgenerational Social Stress, Immune Factors, Hormones, and Social Behavior
Murgatroyd, C., Babb, J. A., Bradburn, S., Carini, L. M., Beamer, G., & Nephew, B. C. (2016) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2015.00149 · Cited by 17
Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells
Xiang, C., Chen, P., Zhang, Q., Li, Y., Pan, Y., Xie, W., Sun, J., & Liu, Z. (2021) · iScience · doi:10.1016/j.isci.2021.102849 · Cited by 15
Neonatal endotoxin exposure changes neuroendocrine, cardiovascular function and mortality during polymicrobial sepsis in adult rats.
Saia, R., Oliveira-Pelegrin, G. R., da Silva, M. E. N. B., Aguila, F. A., Antunes-Rodrigues, J., Rocha, M., & Cárnio, E. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.04.009 · Cited by 10
Pre and post-natal antigen exposure can program the stress axis of adult zebra finches: Evidence for environment matching
Merrill, L., & Grindstaff, J. L. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.013 · Cited by 14
Prophylactic Role for Complementary and Alternative Medicine in Perinatal Programming of Adult Health
Hodgson, D. M., Nakamura, T., & Walker, A. K. (2007) · Complementary Medicine Research · doi:10.1159/000100958 · Cited by 13
Sensitization of depressive-like behavior during repeated maternal separation is associated with more-rapid increase in core body temperature and reduced plasma cortisol levels
Yusko, B., Hawk, K., Schiml, P. A., Deak, T., & Hennessy, M. B. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.10.026 · Cited by 19
Plasticity of Neuroendocrine-Immune Interactions During Ontogeny: Role of Perinatal Programming in Pathogenesis of Inflammation and Stress- Related Diseases in Adults
Zakharova, L. (2008) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221409787003010 · Cited by 13
Pathogen burden and cortisol profiles over the day
Steptoe, A., Gylfe, Å., Shamaei‐Tousi, A., Bergström, S., & Henderson, B. E. (2009) · Epidemiology and Infection · doi:10.1017/s0950268809002738 · Cited by 11
Factors in Early-Life Programming of Reproductive Fitness
Sominsky, L., Fuller, E. A., & Hodgson, D. M. (2015) · Neuroendocrinology · doi:10.1159/000431378 · Cited by 12
Targets and tactics: The analysis of moment-to-moment decision making in animal combat
Pellis, S. M. (1997) · Aggressive Behavior · doi:10.1002/(sici)1098-2337(1997)23:2 · Cited by 54
Overcoming neonatal sickness: Sex-specific effects of sickness on physiology and social behavior
Sylvia, K. E., & Demas, G. E. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.07.002 · Cited by 11
Strain-dependent behavioral alterations induced by peripheral interleukin-1 challenge in neonatal mice
Tsuda, N., Tohmi, M., Mizuno, M., & Nawa, H. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.007 · Cited by 11
Prenatal expression of interleukin 1beta and interleukin 6 in the rat pituitary gland.
Moro, J., Carretero, J., Alonso, M., Martín, C., Gato, Á., & la Mano, A. D. (2008) · Cytokine · doi:10.1016/j.cyto.2008.08.005 · Cited by 14
LPS‐induced neonatal stress in mice affects the response profile to an inflammatory stimulus in an age and sex‐dependent manner
Barth, C., Luft, C., Funchal, G. A., de Oliveira, J. R., Porto, B. N., & Donadio, M. V. F. (2016) · Developmental Psychobiology · doi:10.1002/dev.21404 · Cited by 11

Authors: Shanks, N., Larocque, S., & Meaney, M.
Affiliations: Douglas Mental Health University Institute (CA)
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1995-01-01
Volume: 15
Issue: 1
Pages: 376-384
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.15-01-00376.1995
PMC: PMC6578303
OpenAlex: W2097726093
Cited by: 278
References: 66
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 16 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 18
FWCI: 3.56
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Pittsburgh
Medical Research Council Canada
Medical Center, University of Pittsburgh
Natural Sciences and Engineering Research Council of Canada
Medical Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: lipopolysaccharide, hypothalamic-pituitary-adrenal axis, stress responsivity, glucocorticoid negative feedback, ACTH, corticosterone, restraint stress, corticotropin-releasing factor, vasopressin, paraventricular nucleus, endocrine-immune interaction, developmental programming, sex differences, Long-Evans rats
MeSH terms: Adrenocorticotropic Hormone, Animals, Animals, Newborn, Arginine Vasopressin, Corticotropin-Releasing Hormone, Dexamethasone, Endotoxins, Female, Hypothalamo-Hypophyseal System, Male, Median Eminence, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Rats, Inbred Strains, Receptors, Glucocorticoid, Restraint, Physical, RNA, Messenger, Stress, Physiological, Transcortin, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks