Lifetime modulation of the pain system via neuroimmune and neuroendocrine interactions
Open accessAbstract
Chronic pain is a debilitating condition that still is challenging both clinicians and researchers. Despite intense research, it is still not clear why some individuals develop chronic pain while others do not or how to heal this disease. In this review, we argue for a multisystem approach to understand chronic pain. Pain is not only to be viewed simply as a result of aberrant neuronal activity but also as a result of adverse early-life experiences that impact an individual's endocrine, immune, and nervous systems and changes which in turn program the pain system. First, we give an overview of the ontogeny of the central nervous system, endocrine, and immune systems and their windows of vulnerability. Thereafter, we summarize human and animal findings from our laboratories and others that point to an important role of the endocrine and immune systems in modulating pain sensitivity. Taking "early-life history" into account, together with the past and current immunological and endocrine status of chronic pain patients, is a necessary step to understand chronic pain pathophysiology and assist clinicians in tailoring the best therapeutic approach.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activated mast cells may establish a self-sustaining positive feedback of neuroinflammation and autoimmunity.
“These activated mast cells may then go on to establish a self-sustaining positive feedback of neuroinflammation and autoimmunity70–72”
From Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome (2019) · cites this paper as [71]
In “Animal Studies Demonstrate Inflammation-Induced Pain Sensitivity” (page unavailable), the paper says mast cells release pro-inflammatory cytokines and that peripheral inflammation can lead to central neuroinflammation. It does not describe a self-sustaining feedback loop or link mast-cell activation to autoimmunity. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503 · see citing works
Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404 · see citing works
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works
Neutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,045 · see citing works
The period of susceptibility to the physiological effects of unilateral eye closure in kittens
Hubel, D. H., & Wiesel, T. N. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009022 · Cited by 3,030 · see citing works
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556 · see citing works
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Living with the Past: Evolution, Development, and Patterns of Disease
Gluckman, P. D., & Hanson, M. A. (2004) · Science · doi:10.1126/science.1095292 · Cited by 1,917 · see citing works
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843 · see citing works
The Ionic Channels in Excitable Membranes
Keynes, R. D. (1975) · Novartis Foundation symposium · doi:10.1002/9780470720134.ch11 · Cited by 1,671 · see citing works
Stoll, B. J. (2004) · JAMA · doi:10.1001/jama.292.19.2357 · Cited by 1,535 · see citing works
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519 · see citing works
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504 · see citing works
Altman, J. (1969) · The Journal of Comparative Neurology · doi:10.1002/cne.901370404 · Cited by 1,489 · see citing works
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,478 · see citing works
Different immune cells mediate mechanical pain hypersensitivity in male and female mice
Sorge, R. E., Mapplebeck, J. C. S., Rosen, S., Beggs, S., Taves, S., Alexander, J. K., Martin, L. J., Austin, J.-S., Sotocinal, S. G., Chen, D., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4053 · Cited by 1,442 · see citing works
Twenty years of research on cytokine-induced sickness behavior
Dantzer, R., & Kelley, K. W. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.09.006 · Cited by 1,420 · see citing works
Somatosensory cortical map changes following digit amputation in adult monkeys
Merzenich, M. M., Nelson, R. J., Stryker, M. P., Cynader, M. S., Schoppmann, A., & Zook, J. M. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902240408 · Cited by 1,326 · see citing works
Hensch, T. K. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144327 · Cited by 1,300 · see citing works
Childhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · see citing works
Neurogenesis in the Neocortex of Adult Primates
Gould, E., Reeves, A. J., Graziano, M. S. A., & Gross, C. G. (1999) · Science · doi:10.1126/science.286.5439.548 · Cited by 1,262 · see citing works
Innate immunity of the newborn: basic mechanisms and clinical correlates
Levy, O. (2007) · Nature reviews. Immunology · doi:10.1038/nri2075 · Cited by 1,227 · see citing works
Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987) · Science · doi:10.1126/science.2443979 · Cited by 1,151 · see citing works
Role of the Immune system in chronic pain
Marchand, F., Perretti, M., & McMahon, S. B. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1700 · Cited by 1,098 · see citing works
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A., Fraser, K. A., Rosato, P. C., Filali-Mouhim, A., et al. (2016) · Nature · doi:10.1038/nature17655 · Cited by 1,072 · see citing works
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.020 · Cited by 1,065 · see citing works
Neonatal adaptive immunity comes of age
Adkins, B., Leclerc, C., & Marshall-Clarke, S. (2004) · Nature reviews. Immunology · doi:10.1038/nri1394 · Cited by 1,005 · see citing works
Cytokine-induced sickness behaviour: mechanisms and implications
Konsman, J. P., Parnet, P., & Dantzer, R. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02088-9 · Cited by 999 · see citing works
Owens, P. C., Smith, R., Brinsmead, M. W., Hall, C., Foureur, M. J., Hurt, D., Lovelock, M., Chan, E.-C., Cubis, J., & Lewin, T. J. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90603-5 · Cited by 958 · see citing works
Pathological pain and the neuroimmune interface
Grace, P. M., Hutchinson, M. R., Maier, S. F., & Watkins, L. R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3621 · Cited by 951 · see citing works
Prenatal stress, glucocorticoids and the programming of the brain
Welberg, L. A. M., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00601.x · Cited by 928 · see citing works
Prenatal Stress, Glucocorticoids and the Programming of the Brain
Welberg, L., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00601.x · Cited by 922 · see citing works
Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862 · see citing works
Interactions between the immune and nervous systems in pain
Ren, K., & Dubner, R. A. (2010) · Nature Medicine · doi:10.1038/nm.2234 · Cited by 817 · see citing works
Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768 · see citing works
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.015 · Cited by 756 · see citing works
Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity
Dantzer, R. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.040 · Cited by 743 · see citing works
Veehof, M. M., Trompetter, H. R., Bohlmeijer, E. T., & Schreurs, K. M. G. (2016) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2015.1098724 · Cited by 737 · see citing works
Hannibal, K. E., & Bishop, M. D. (2014) · Physical Therapy · doi:10.2522/ptj.20130597 · Cited by 729 · see citing works
Inflammation-associated depression: From serotonin to kynurenine
Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726 · see citing works
Predictive adaptive responses and human evolution
Gluckman, P. D., Hanson, M. A., & Spencer, H. G. (2005) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2005.08.001 · Cited by 713 · see citing works
Watkins, L. R., Maier, S. F., & Goehler, L. E. (1995) · Pain · doi:10.1016/0304-3959(95)00186-7 · Cited by 659 · see citing works
Do early‐life events permanently alter behavioral and hormonal responses to stressors?
Anisman, H., Zaharia, M. D., Meaney, M. J., & Merali, Z. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00025-2 · Cited by 654 · see citing works
Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue
Ferreira, S. H., Lorenzetti, B. B., Bristow, A. F., & Poole, S. (1988) · Nature · doi:10.1038/334698a0 · Cited by 624 · see citing works
Maternal and Fetal Hypothalamic‐Pituitary‐Adrenal Axes During Pregnancy and Postpartum
MASTORAKOS, G., & ILIAS, I. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.016 · Cited by 621 · see citing works
Robertson, D., & Irvine, D. R. F. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902820311 · Cited by 604 · see citing works
Doyle, S., & O'Neill, L. A. J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.010 · Cited by 594 · see citing works
Cunningham, C., Campion, S., Lunnon, K., Murray, C. L., Woods, J. F. C., Deacon, R. M. J., Rawlins, J. N. P., & Perry, V. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.024 · Cited by 584 · see citing works
Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress
Jankord, R., & Herman, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.012 · Cited by 578 · see citing works
Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat
Madden, J. J., Akil, H., Patrick, R. L., & Barchas, J. D. (1977) · Nature · doi:10.1038/265358a0 · Cited by 559 · see citing works
Dickenson, A. H., & Sullivan, A. F. (1987) · Pain · doi:10.1016/0304-3959(87)90023-6 · Cited by 544 · see citing works
Pain and Stress in a Systems Perspective: Reciprocal Neural, Endocrine, and Immune Interactions
Chapman, C. R., Tuckett, R. P., & Song, C. W. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.09.006 · Cited by 541 · see citing works
Cai, Z., Pan, Z.-L., Pang, Y., Evans, O. B., & Rhodes, P. G. (2000) · Pediatric Research · doi:10.1203/00006450-200001000-00013 · Cited by 507 · see citing works
Peripheral and Central Mechanisms of NGF‐induced Hyperalgesia
Lewin, G. R., Rueff, A., & Mendell, L. M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00581.x · Cited by 507 · see citing works
Characterization of cytokine-induced hyperalgesia
Watkins, L. R., Wiertelak, E. P., Goehler, L. E., Smith, K. P., Martin, D., & Maier, S. F. (1994) · Brain Research · doi:10.1016/0006-8993(94)91566-0 · Cited by 502 · see citing works
Yoon, B. H., Romero, R. J., Kim, C. J., Jun, J. K., Gómez, R., Choi, J., & Syn, H. C. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90028-4 · Cited by 493 · see citing works
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
Meseguer, V., Alpizar, Y. A., Luis, E., Tajada, S., Denlinger, B., Fajardo, O., Manenschijn, J.-A., Fernández-Peña, C., Talavera, A., Kichko, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms4125 · Cited by 479 · see citing works
Puig, S., & Sorkin, L. S. (1996) · Pain · doi:10.1016/0304-3959(95)00121-2 · Cited by 473 · see citing works
Wigle, D. T., Arbuckle, T. E., Turner, M. C., Bérubé, A., Yang, Q., Liu, S., & Krewski, D. R. (2008) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937400801921320 · Cited by 467 · see citing works
Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults
Kollmann, T. R., Crabtree, J., Rein‐Weston, A., Blimkie, D., Thommai, F., Wang, X. Y., Lavoie, P. M., Furlong, J., Fortuno, E. S., Hajjar, A. M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901481 · Cited by 465 · see citing works
Neuroinflammation and comorbidity of pain and depression
Walker, A. K., Kavelaars, A., Heijnen, C. J., & Dantzer, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008144 · Cited by 460 · see citing works
Central control of thermogenesis in mammals
Morrison, S. F., Nakamura, K., & Madden, C. J. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2007.041848 · Cited by 424 · see citing works
Conti, B. (2004) · Frontiers in bioscience · doi:10.2741/1341 · Cited by 411 · see citing works
Kostović, I. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.5.536 · Cited by 408 · see citing works
Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
Metz, A. E., Yau, H.-J., Centeno, M. V., Apkarian, A. V., & Martina, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809897106 · Cited by 407 · see citing works
Urakubo, A., Jarskog, L. F., Lieberman, J. A., & Gilmore, J. H. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00032-3 · Cited by 405 · see citing works
Antenatal Glucocorticoids and Programming of the Developing CNS
Matthews, S. G. (2000) · Pediatric Research · doi:10.1203/00006450-200003000-00003 · Cited by 400 · see citing works
Adult-generated hippocampal and neocortical neurons in macaques have a transient existence
Gould, E., Vail, N. K., WAGERS, M. W., & Gross, C. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181354698 · Cited by 400 · see citing works
Towards a new developmental synthesis: adaptive developmental plasticity and human disease
Gluckman, P. D., Hanson, M. A., Bateson, P., Beedle, A. S., Law, C., Bhutta, Z. A., Anokhin, K. V., Bougneres, P. F., Chandak, G. R., Dasgupta, P. S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60234-8 · Cited by 400 · see citing works
The Pain of Being Sick: Implications of Immune-to-Brain Communication for Understanding Pain
Watkins, L. R., & Maier, S. F. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.29 · Cited by 388 · see citing works
Brydon, L., Harrison, N. A., Walker, C., Steptoe, A., & Critchley, H. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.007 · Cited by 381 · cited 1× · see citing works
“In several studies, the increased BOLD activity in these areas correlates with peripheral cytokine levels (210, 222, 226, 228, 229).”
BackgroundLevy, O., Zarember, K. A., Roy, R. M., Cywes, C., Godowski, P. J., & Wessels, M. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4627 · Cited by 375 · see citing works
Shanks, N., Windle, R. J., Perks, P. A., Harbuz, M. S., Jessop, D. S., Ingram, C. D., & Lightman, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090571897 · Cited by 374 · see citing works
DeLeo, J. A., Colburn, R. W., NICHOLS, M., & MALHOTRA, A. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.695 · Cited by 373 · see citing works
Immune regulation of central nervous system functions: from sickness responses to pathological pain
Watkins, L. R., & Maier, S. F. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01443.x · Cited by 367 · see citing works
Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
Sandiego, C. M., Gallezot, J.-D., Pittman, B., Nabulsi, N., Lim, K., Lin, S.-F., Matuskey, D., Lee, J.-Y., O’Connor, K. C., Huang, Y., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511003112 · Cited by 356 · see citing works
The later development of the brain and its vulnerability
Dobbing, J. (1982) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01805569 · Cited by 353 · see citing works
The neuroimmune basis of fatigue
Dantzer, R., Heijnen, C. J., Kavelaars, A., Laye, S., & Capuron, L. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.003 · Cited by 346 · see citing works
Neural Origins of Human Sickness in Interoceptive Responses to Inflammation
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., Dolan, R. J., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.007 · Cited by 345 · see citing works
Pandemic Influenza and Pregnant Women
Rasmussen, S. A., Jamieson, D. J., & Bresee, J. (2008) · Emerging infectious diseases · doi:10.3201/eid1401.070667 · Cited by 345 · see citing works
Welberg, L., Seckl, J. R., & Holmes, M. C. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00958.x · Cited by 344 · see citing works
The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factorsa
Levine, S. D. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39245.x · Cited by 343 · see citing works
Watkins, R. L., Martin, D., Ulrich, P. C., Tracey, K. J., & Maier, F. (1997) · Pain · doi:10.1016/s0304-3959(97)03369-1 · Cited by 341 · see citing works
Willer, J. C., Dehen, H., & Cambier, J. (1981) · Science · doi:10.1126/science.6261330 · Cited by 336 · see citing works
Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis
Beishuizen, A., & THIJS, L. G. (2003) · Journal of Endotoxin Research · doi:10.1179/096805103125001298 · Cited by 333 · see citing works
A Review of the Fetal Brain Cytokine Imbalance Hypothesis of Schizophrenia
Meyer, U., Feldon, J., & Yee, B. K. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn022 · Cited by 318 · see citing works
Reeve, A. J., Patel, S., Fox, A., Walker, K. M., & Urbán, L. (2000) · European Journal of Pain · doi:10.1053/eujp.2000.0177 · Cited by 313 · see citing works
Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W., & Siggins, G. R. (1983) · Science · doi:10.1126/science.6603658 · Cited by 309 · see citing works
Prenatal rubella, premorbid abnormalities, and adult schizophrenia
Brown, A. S., Cohen, P., Harkavy‐Friedman, J., Babulas, V. P., Malaspina, D., Gorman, J., & Susser, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01068-x · Cited by 298 · see citing works
Anatomical Brain Magnetic Resonance Imaging of Typically Developing Children and Adolescents
Gerber, A. J., Peterson, B. S., Giedd, J. N., Lalonde, F. M., Celano, M. J., White, S., Wallace, G. L., Lee, N., & Lenroot, R. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819f2715 · Cited by 298 · see citing works
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.020 · Cited by 289 · see citing works
Vachon-Presseau, É., Roy, M., Martel, M., Caron, E., Marin, M.-F., Chen, J., Albouy, G., Plante, I., Sullivan, M., Lupien, S., et al. (2013) · Brain : a journal of neurology · doi:10.1093/brain/aws371 · Cited by 285 · see citing works
Illness, Cytokines, and Depression
YIRMIYA, R., POLLAK, Y., MORAG, M., REICHENBERG, A., BARAK, O., AVITSUR, R., SHAVIT, Y., OVADIA, H., WEIDENFELD, J., MORAG, A., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05412.x · Cited by 284 · see citing works
Contribution of systemic inflammation to chronic neurodegeneration
Perry, V. H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0722-x · Cited by 283 · see citing works
Parada, C. A., Tambeli, C. H., Cunha, F. Q., et al. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00523-6 · Cited by 281 · see citing works
Shanks, N., Larocque, S., & Meaney, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00376.1995 · Cited by 278 · see citing works
Martich, G. D., Boujoukos, A. J., & Suffredini, A. F. (1993) · Immunobiology · doi:10.1016/s0171-2985(11)80353-0 · Cited by 275 · see citing works
The postnatal development of the hypothalamic–pituitary–adrenal axis in the mouse
Schmidt, M. V., Enthoven, L., van der Mark, M. H., Levine, S. D., de Kloet, E. R., & Oitzl, M. S. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00030-3 · Cited by 271 · see citing works
Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23802 · Cited by 268 · see citing works
Dickenson, A. H., & Sullivan, A. F. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90242-4 · Cited by 267 · see citing works
Inta, D., Alfonso, J., von Engelhardt, J., Kreuzberg, M. M., Meyer, A. H., van Hooft, J. A., & Monyer, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807059105 · Cited by 267 · see citing works
The Infancy of the Human Brain
Dehaene-Lambertz, G., & Spelke, E. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.026 · Cited by 264 · see citing works
Inflammation selectively enhances amygdala activity to socially threatening images
Inagaki, T. K., Muscatell, K. A., Irwin, M. R., Cole, S. W., & Eisenberger, N. I. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.090 · Cited by 264 · see citing works
In utero infection and adult schizophrenia
Brown, A. S., & Susser, E. (2002) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10004 · Cited by 261 · see citing works
Meyer, U., Feldon, J., Schedlowski, M., & Yee, B. K. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.11.003 · Cited by 260 · see citing works
Nosocomial Infections in a Newborn Intensive-Care Unit
Hemming, V. G., Overall, J. C., & Britt, M. R. (1976) · New England Journal of Medicine · doi:10.1056/nejm197606102942403 · Cited by 256 · see citing works
Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity
Olson, J. A., McDonald-Hyman, C. S., Jameson, S. C., & Hamilton, S. E. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.009 · Cited by 254 · see citing works
Species comparison of anatomical and functional immune system development
Holsapple, M. P., West, L. J., & Landreth, K. S. (2003) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.10035 · Cited by 251 · see citing works
Implications of immune-to-brain communication for sickness and pain
Watkins, L. R., & Maier, S. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7710 · Cited by 250 · see citing works
Ventromedial Preoptic Prostaglandin E2 Activates Fever-Producing Autonomic Pathways
Scammell, T. E., Elmquist, J. K., Griffin, J. D., & Saper, C. B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06246.1996 · Cited by 249 · see citing works
Pang, Y., Cai, Z., & Rhodes, P. G. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00606-5 · Cited by 248 · see citing works
Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction
Seckl, J. R. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67002-2 · Cited by 245 · see citing works
Diaz, R., Brown, R. W., & Seckl, J. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02570.1998 · Cited by 240 · see citing works
Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines
Applequist, S. E. (2002) · International Immunology · doi:10.1093/intimm/dxf069 · Cited by 238 · see citing works
Long‐term sensory hyperinnervation following neonatal skin wounds
Reynolds, M. L., & Fitzgerald, M. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903580403 · Cited by 236 · see citing works
Maternal Exposure to Herpes Simplex Virus and Risk of Psychosis Among Adult Offspring
Buka, S. L., Cannon, T. D., Torrey, E. F., & Yolken, R. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.022 · Cited by 233 · see citing works
Konsman, J. P., Kelley, K. W., & Dantzer, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00368-6 · Cited by 232 · see citing works
Kluger, M. J., Kozak, W., Conn, C. A., Leon, L. R., & Soszyński, D. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08329.x · Cited by 231 · see citing works
Systematic review on intensive interdisciplinary pain treatment of children with chronic pain
Hechler, T., Kanstrup, M., Holley, A. L., Simons, L. E., Wicksell, R., Hirschfeld, G., & Zernikow, B. (2015) · Pediatrics · doi:10.1542/peds.2014-3319 · Cited by 230 · cited 2× · see citing works
“For diseases like chronic pain, with such wide individual variability in symptomatology and treatment efficacy (8, 9), not only should comorbid disease and stressful life events (i.”
BackgroundDirect Activation of Rat Spinal Dorsal Horn Neurons by Prostaglandin E2
Baba, H., Kohno, T., Moore, K. A., & Woolf, C. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01750.2001 · Cited by 228 · see citing works
Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment
Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B. J., Nemeroff, C. B., Berns, G. S., & Miller, A. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.033 · Cited by 222 · see citing works
Katsuura, G., Arimura, A., Köves, K., & Gottschall, P. E. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.1.e163 · Cited by 221 · see citing works
Synaptogenesis, heterochrony and epigenesis in the mammalian neocortex
Bourgeois, J. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb18340.x · Cited by 216 · see citing works
Hannestad, J. O., Gallezot, J., Schafbauer, T., Lim, K., Kloczynski, T., Morris, E. D., Carson, R. E., Ding, Y., & Cosgrove, K. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.055 · Cited by 213 · see citing works
Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin
Maier, S. F., Wiertelak, E. P., Martin, D., & Watkins, L. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)91446-y · Cited by 210 · see citing works
Toll-like receptor 4-mediated activation of murine mast cells
McCurdy, J. D., Lin, T.-J., & Marshall, J. S. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.977 · Cited by 210 · see citing works
Rosenberger, C. M., Scott, M. G., Gold, M. R., Hancock, R. E. W., & Finlay, B. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5894 · Cited by 209 · see citing works
Brain inflammation is induced by co-morbidities and risk factors for stroke
Drake, C., Boutin, H., Jones, M. S., Dénes, Á., McColl, B. W., Selvarajah, J. R., Hulme, S., Georgiou, R. F., Hinz, R., Gerhard, A., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.008 · Cited by 205 · see citing works
Byrne, M., Agerbo, E., Bennedsen, B. E., Eaton, W. W., & Mortensen, P. B. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.07.018 · Cited by 201 · see citing works
Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐1 receptor antagonist
da Cunha, J. M., Cunha, F. Q., Poole, S., & Ferreira, S. H. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703434 · Cited by 198 · see citing works
Cutaneous hyperalgesia induced by peripheral injection of interleukin-1β in the rat
Fukuoka, H., Kawatani, M., Hisamitsu, T., & Takeshige, C. (1994) · Brain Research · doi:10.1016/0006-8993(94)90960-1 · Cited by 194 · see citing works
Neonatal immunity: how well has it grown up?
Marshall-Clarke, S., Reen, D. J., Tasker, L., & Hassan, J. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01548-0 · Cited by 189 · see citing works
Low-dose endotoxemia and human neuropsychological functions
Krabbe, K. S., Reichenberg, A., Yirmiya, R., Smed, A., Pedersen, B. K., & Bruunsgaard, H. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.04.010 · Cited by 189 · see citing works
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi
Li, Y., Oosting, M., Deelen, P., Ricaño-Ponce, I., Smeekens, S. P., Jaeger, M., Matzaraki, V., Swertz, M. A., Xavier, R. J., Franke, L., et al. (2016) · Nature Medicine · doi:10.1038/nm.4139 · Cited by 189 · see citing works
Stress-related synaptic plasticity in the hypothalamus
Bains, J. S., Cusulin, J. I. W., & Inoue, W. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3881 · Cited by 186 · see citing works
Fortier, M., Joober, R., Luheshi, G., & Boksa, P. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2003.10.001 · Cited by 186 · see citing works
A neurocomputational account of how inflammation enhances sensitivity to punishments versus rewards
Harrison, N. A., Voon, V., Cercignani, M., Cooper, E. A., Pessiglione, M., & Critchley, H. D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.018 · Cited by 185 · see citing works
Cowan, W. M. (1979) · Scientific American · doi:10.1038/scientificamerican0979-112 · Cited by 184 · see citing works
Endogenous retroviruses and schizophrenia
Yolken, R. H. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00037-5 · Cited by 182 · see citing works
Mast cells on the mind: new insights and opportunities
Silver, R., & Curley, J. P. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.001 · Cited by 178 · see citing works
Hypoxia‐ischaemia model in the 7‐day‐old rat: possibilities and shortcomings
Hagberg, H., Bona, E., Gilland, E., & Puka‐Sundvall, M. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb18353.x · Cited by 173 · see citing works
Asnis, G. M., & Garza, R. D. L. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000210099.36500.fe · Cited by 170 · see citing works
Urban, J. F., Fayer, R., Chen, S. J., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.263 · Cited by 167 · see citing works
Taylor, S. M., & Bryson, Y. J. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.3.1493 · Cited by 166 · see citing works
Garcia, A. M., Fadel, S. A., Cao, S., & Sarzotti‐Kelsoe, M. (2000) · Immunologic Research · doi:10.1385/ir:22:2-3:177 · Cited by 165 · see citing works
Kovács, K., Kiss, J. Z., & Makara, G. B. (2008) · Neuroendocrinology · doi:10.1159/000124650 · Cited by 164 · see citing works
Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia
Püntener, U., Booth, S. G., Perry, V. H., & Teeling, J. L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-146 · Cited by 163 · see citing works
Blüml, S., Wisnowski, J. L., Nelson, M. D., Paquette, L. B., Gilles, F. H., Kinney, H. C., & Panigrahy, A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs283 · Cited by 155 · see citing works
Human responses to bacterial endotoxin.
Burrell, R. E. (1994) · PubMed · Cited by 154 · see citing works
Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood
Wit, D. D., Tonon, S., Olislagers, V., Goriely, S., Boutriaux, M., Goldman, M., & Willems, F. (2003) · Journal of Autoimmunity · doi:10.1016/j.jaut.2003.08.003 · Cited by 152 · see citing works
Beggs, S., Torsney, C., Drew, L., & Fitzgerald, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02185.x · Cited by 152 · see citing works
Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms
Pearce, B. D. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000956 · Cited by 152 · see citing works
Individuality and Variation of Personal Regulomes in Primary Human T Cells
Qu, K., Zaba, L. C., Giresi, P. G., Li, R., Longmire, M. R., Kim, Y. H., Greenleaf, W. J., & Chang, H. Y. (2015) · Cell Systems · doi:10.1016/j.cels.2015.06.003 · Cited by 151 · see citing works
Walker, A. K., Nakamura, T., Byrne, R. J., Naicker, S., Tynan, R. J., Hunter, M., & Hodgson, D. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.010 · Cited by 150 · see citing works
Belderbos, M. E., van Bleek, G. M., Levy, O., et al. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.07.003 · Cited by 150 · see citing works
Malmberg, A. B., & Yaksh, T. L. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13315.x · Cited by 146 · see citing works
Maternal contact inhibits pituitary‐adrenal stress responses in preweanling rats
Stanton, M. E., Wallstrom, J., & Levine, S. D. (1987) · Developmental Psychobiology · doi:10.1002/dev.420200204 · Cited by 146 · see citing works
Glucocorticoid Feedback Inhibition of Adrenocorticotropic Hormone Secretagogue Release
Sapolsky, R. M., Armanini, M. P., Packan, D. R., Sutton, S. W., & Plotsky, P. M. (2008) · Neuroendocrinology · doi:10.1159/000125357 · Cited by 145 · see citing works
Intracerebroventricular injection of interleukin-1β induces hyperalgesia in rats
Oka, T., Aou, S., & Hori, T. (1993) · Brain Research · doi:10.1016/0006-8993(93)90060-z · Cited by 142 · see citing works
Long-Term Alterations in Neuroimmune Responses after Neonatal Exposure to Lipopolysaccharide
Lomax, L. B., Mouihate, A., Ellis, S. L., & Pittman, Q. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1077-04.2004 · Cited by 142 · see citing works
Serious bacterial infections in newborn infants in developing countries
Osrin, D., Vergnano, S., & Costello, A. M. D. L. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200406000-00008 · Cited by 141 · see citing works
Sung, C., Wen, Z., Chang, W., Ho, S., Tsai, S., Chang, Y., & Wong, C. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.068 · Cited by 134 · see citing works
Prenatal development of rat primary afferent fibers: II. Central projections
Mirnics, K., & Koerher, H. R. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903550409 · Cited by 132 · see citing works
The role of the ventral striatum in inflammatory-induced approach toward support figures
Inagaki, T. K., Muscatell, K. A., Irwin, M. R., Moieni, M., Dutcher, J. M., Jevtic, I., Breen, E. C., & Eisenberger, N. I. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.10.006 · Cited by 132 · see citing works
Buß, C., Entringer, S., & Wadhwa, P. D. (2012) · Science Signaling · doi:10.1126/scisignal.2003406 · Cited by 131 · see citing works
Chronic Low-Grade Inflammation in Metabolic Disorders: Relevance for Behavioral Symptoms
Lasselin, J., & Capuron, L. (2014) · NeuroImmunoModulation · doi:10.1159/000356535 · Cited by 129 · see citing works
Hathway, G. J., Koch, S. C., Low, L. A., & Fitzgerald, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.168013 · Cited by 126 · see citing works
Fetal Origins of Stress‐Related Adult Disease
Kajantie, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.026 · Cited by 125 · see citing works
Yang, Y., Cheng, Z., Tang, H., Jiao, H., Sun, X., Cui, Q., Luo, F., Pan, H., Ma, C., & Li, B. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw121 · Cited by 124 · see citing works
del Rey, A., Yau, H., Randolf, A., Centeno, M. V., Wildmann, J., Martina, M., Besedovsky, H. O., & Apkarian, A. V. (2011) · Pain · doi:10.1016/j.pain.2011.09.013 · Cited by 118 · see citing works
Blackburn-Munro, G. (2004) · Current Pain and Headache Reports · doi:10.1007/s11916-004-0025-9 · Cited by 117 · see citing works
Engler, H., Benson, S., Wegner, A., Spreitzer, I., Schedlowski, M., & Elsenbruch, S. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.013 · Cited by 114 · see citing works
Rusanen, M., Ngandu, T., Laatikainen, T. K., Tuomilehto, J., Soininen, H. S., & Kivipelto, M. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310050011 · Cited by 113 · see citing works
Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans
Hannestad, J., Subramanyam, K., DellaGioia, N., Planeta-Wilson, B., Weinzimmer, D., Pittman, B., & Carson, R. E. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.097014 · Cited by 113 · see citing works
Brunson, K. L., Avishai-Eliner, S., Hatalski, C. G., & Baram, T. Z. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000942 · Cited by 112 · see citing works
Fetal programming by maternal stress: Insights from a conflict perspective
Giudice, M. D. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.014 · Cited by 112 · see citing works
Spencer, S. J., Martin, S. M., Mouihate, A., & Pittman, Q. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301004 · Cited by 110 · see citing works
Ellis, S. L., Mouihate, A., & Pittman, Q. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-3569fje · Cited by 110 · see citing works
The formalin test: a dose–response analysis at three developmental stages
Teng, C. J., & Abbott, F. V. (1998) · Pain · doi:10.1016/s0304-3959(98)00065-7 · Cited by 110 · see citing works
Programming and reproductive functioning
Davies, M. J., & Norman, R. J. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00691-4 · Cited by 110 · see citing works
Ghaffari‐Tabrizi‐Wizsy, N., Bauer, B., Villunger, A., Baier-Bitterlich, G., Altman, A., Utermann, G., Überall, F., & Baier, G. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199901)29:01 · Cited by 108 · see citing works
Wegner, A., Elsenbruch, S., Maluck, J., Grigoleit, J., Engler, H., Jäger, M., Spreitzer, I., Schedlowski, M., & Benson, S. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.001 · Cited by 106 · see citing works
Levy, O. (2005) · Journal of Endotoxin Research · doi:10.1179/096805105x37376 · Cited by 106 · see citing works
Lasselin, J., Elsenbruch, S., Lekander, M., Axelsson, J., Karshikoff, B., Grigoleit, J., Engler, H., Schedlowski, M., & Benson, S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.01.003 · Cited by 106 · see citing works
Self-citationThe Association of Pain With Protein Inflammatory Biomarkers: A Review of the Literature
DeVon, H. A., Piano, M. R., Rosenfeld, A. G., & Hoppensteadt, D. A. (2014) · Nursing Research · doi:10.1097/nnr.0000000000000013 · Cited by 101 · see citing works
Asa, S. L., Kovács, K., László, F. A., Domokos, I., & EZRIN, C. (2008) · Neuroendocrinology · doi:10.1159/000124545 · Cited by 99 · see citing works
Noorlander, C. W., Graan, P. N. E. D., Middeldorp, J., van Beers, J. J. B. C., & Visser, G. H. A. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21162 · Cited by 98 · see citing works
Yoon, S.-Y., Patel, D. R., & Dougherty, P. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.024 · Cited by 98 · see citing works
Systemic Inflammation Decreases Pain Threshold in Humans In Vivo
de Goeij, M., van Eijk, L. T., Vanelderen, P., Wilder‐Smith, O. H. G., Vissers, K. C. P., van der Hoeven, J. G., Kox, M., Scheffer, G. J., & Pickkers, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084159 · Cited by 96 · see citing works
Citalopram reduces endotoxin-induced fatigue
Hannestad, J., DellaGioia, N., Ortiz, N., Pittman, B., & Bhagwagar, Z. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.013 · Cited by 95 · see citing works
Modality and sex differences in pain sensitivity during human endotoxemia
Karshikoff, B., Lekander, M., Soop, A., Lindstedt, F., Ingvar, M., Kosek, E., Höglund, C. O., & Axelsson, J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.014 · Cited by 95 · see citing works
Self-citationAnalysis of Neonatal T Cell and Antigen Presenting Cell Functions
Trivedi, H. N., HayGlass, K. T., Gangur, V., et al. (1997) · Human Immunology · doi:10.1016/s0198-8859(97)00202-4 · Cited by 94 · see citing works
Hains, L. E., Loram, L. C., Weiseler, J. L., Frank, M. G., Bloss, E. B., Sholar, P. W., Taylor, F. R., Harrison, J. A., Martin, T. J., Eisenach, J. C., et al. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.01.271 · Cited by 94 · see citing works
Kullmann, J. S., Grigoleit, J.-S., Lichte, P., Kobbe, P., Rosenberger, C., Banner, C., Wolf, O. T., Engler, H., Oberbeck, R., Elsenbruch, S., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22063 · Cited by 93 · cited 1× · see citing works
“To maintain the same level of performance during peripheral inflammatory activity, regions of the PFC appear to be required (224, 225)—areas implicated in pain regulation and processing of affective components of pain.”
BackgroundWhy sickness hurts: A central mechanism for pain induced by peripheral inflammation.
Karshikoff, B., Jensen, K., Kosek, E., Kalpouzos, G., Soop, A., Ingvar, M., Höglund, C. O., Lekander, M., & Axelsson, J. (2016) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2016.04.001 · Cited by 93 · see citing works
Self-citationFreshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation
Adkins, B., & Hamilton, K. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.11.3448 · Cited by 91 · see citing works
Hodgson, D. M., Knott, B., & Walker, F. R. (2001) · Pediatric Research · doi:10.1203/00006450-200112000-00020 · Cited by 89 · see citing works
Kwan, M., Metayer, C., Crouse, V., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj336 · Cited by 89 · see citing works
Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment
Raison, C. L., & Miller, A. H. (2013) · Modern Trends in Psychiatry · doi:10.1159/000343966 · Cited by 88 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [218]Engler H Benson S Wegner A Spreitzer I Schedlowski M Elsenbruch S Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms. Brain Behav Immun (2016) 52: 18– 26. 10.1016/j.bbi.2015.08.013 26291403 · DOI
Cited by
Sorted by citations
Neuroimmune modulation of pain across the developmental spectrum
Karshikoff, B., Tadros, M. A., Mackey, S., & Zouikr, I. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.010 · Cited by 21 · see citing works
Self-citationMorris, M. C., Cooney, K. E., Sedghamiz, H., Abreu, M., Collado, F., Balbin, E. G., Craddock, T. J. A., Klimas, N. G., Broderick, G., & Fletcher, M. A. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.03.002 · Cited by 14 · see citing works
- Authors
- Zouikr, I., & Karshikoff, B.
- Affiliations
- RIKEN (JP)
- Stockholm University (SE)
- Corresponding author
- Zouikr, Ihssane
- ORCID
- Karshikoff, Bianka
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2017-03-13
- Volume
- 8
- Pages
- 276-276
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC5347117
- OpenAlex
- W2596201282
- Cited by
- 45
- References
- 276
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 1 · 2017: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16F16726)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- chronic pain, neuroimmune interactions, neuroendocrine interaction, early life experience, pain sensitivity, immune system development, endocrine system development, window of vulnerability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review