Cited by 278Stress Responses and CortisolAdrenal Hormones and DisordersNeuropeptides and Animal Physiology

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Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress

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Shanks, N, Larocque, S, Meaney, MJ·1995·The Journal of Neuroscience

DOI 10.1523/jneurosci.15-01-00376.1995PMC PMC6578303

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Abstract

The long-term consequences of neonatal endotoxin exposure on hypothalamic-pituitary-adrenal axis (HPA) function were assessed in adult female and male Long-Evans rats. At 3 and 5 d of age, pups were administered endotoxin (Salmonella enteritidis, 0.05 mg/kg, i.p.) at a dose that provokes a rapid and sustained physiological response, but with no mortality. As adults, neonatally endotoxin-treated animals exhibited significantly greater adrenocorticotrophic hormone (ACTH) and corticosterone responses to restraint stress than controls. In addition, dexamethasone pretreatment was less effective in suppressing ACTH responses to restraint stress in endotoxin-treated animals than in controls, suggesting decreased negative-feedback sensitivity to glucocorticoids. Neonatal endotoxin treatment elevated resting-state median eminence levels of corticotropin-releasing hormone (CRH) and arginine vasopressin in adult male animals, and arginine vasopressin in both adult males and females. Neonatal exposure to endotoxin also increased CRH mRNA expression in the paraventricular nucleus of the hypothalamus of adult males, with no difference in females. Finally, glucocorticoid receptor density was reduced across a wide range of brain regions in the neonatal endotoxin-treated, adult animals. These data illustrate the interactive nature of immune and endocrine systems during development. It appears that endotoxin exposure during critical stages of development decreases glucocorticoid negative-feedback inhibition of ACTH secretagogue synthesis, thus increasing HPA responsiveness to stress. The implication of these findings is that exposure to gram-negative LPS in early life can alter the development of neural systems which govern endocrine responses to stress and may thereby predispose individuals to stress-related pathology.

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Research works printed but not linked: 5

Bhatnagar S, Shanks N, Meaney MJ (in press) Hypothalamic-pitui- tary-adrenal function in chronic, intermittently cold stressed handled and nonhandled rats. J Neuroendocrinol, in press.
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Authors: Shanks, N., Larocque, S., & Meaney, M.
Affiliations: Douglas Mental Health University Institute (CA)
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1995-01-01
Volume: 15
Issue: 1
Pages: 376-384
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.15-01-00376.1995
PMC: PMC6578303
OpenAlex: W2097726093
Cited by: 278
References: 66
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 16 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 18
FWCI: 3.56
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Pittsburgh
Medical Research Council Canada
Medical Center, University of Pittsburgh
Natural Sciences and Engineering Research Council of Canada
Medical Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: lipopolysaccharide, hypothalamic-pituitary-adrenal axis, stress responsivity, glucocorticoid negative feedback, ACTH, corticosterone, restraint stress, corticotropin-releasing factor, vasopressin, paraventricular nucleus, endocrine-immune interaction, developmental programming, sex differences, Long-Evans rats
MeSH terms: Adrenocorticotropic Hormone, Animals, Animals, Newborn, Arginine Vasopressin, Corticotropin-Releasing Hormone, Dexamethasone, Endotoxins, Female, Hypothalamo-Hypophyseal System, Male, Median Eminence, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Rats, Inbred Strains, Receptors, Glucocorticoid, Restraint, Physical, RNA, Messenger, Stress, Physiological, Transcortin, Rats

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Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress

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