The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Lipid Rafts Mediate the Synaptic Localization of α-Synuclein
Open accessAbstract
α-Synuclein contributes to the pathogenesis of Parkinson's disease (PD), but its precise role in the disorder and its normal function remain poorly understood. Consistent with a presumed role in neurotransmitter release and its prominent deposition in the dystrophic neurites of PD, α-synuclein localizes almost exclusively to the nerve terminal. In brain extracts, however, α-synuclein behaves as a soluble, monomeric protein. Using a binding assay to characterize the association of α-synuclein with cell membranes, we find that α-synuclein binds saturably and with high affinity to characteristic intracellular structures that double label for components of lipid rafts. Biochemical analysis demonstrates the interaction of α-synuclein with detergent-resistant membranes and reveals a shift in electrophoretic mobility of the raft-associated protein. In addition, the A30P mutation associated with PD disrupts the interaction of α-synuclein with lipid rafts. Furthermore, we find that both the A30P mutation and raft disruption redistribute α-synuclein away from synapses, indicating an important role for raft association in the normal function of α-synuclein and its role in the pathogenesis of PD.
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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
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Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
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Cited by
Bendor, J. T., Logan, T. P., & Edwards, R. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.004 · Cited by 825
Self-citationSchulz-Schaeffer, W. J. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0711-0 · Cited by 627
Neuropathology, biochemistry, and biophysics of α‐synuclein aggregation
Uversky, V. N. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04764.x · Cited by 567
α-Synuclein Is Localized to Mitochondria-Associated ER Membranes
Guardia-Laguarta, C., Area-Gomez, E., Rüb, C., Liu, Y., Magrané, J., Becker, D., Voos, W., Schon, E. A., & Przedborski, S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2507-13.2014 · Cited by 515
α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis
Mehra, S., Sahay, S., & Maji, S. K. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.03.001 · Cited by 499
Metadata
- Authors
- Fortin, D. L., Troyer, M. D., Nakamura, K., Kubo, S.-I., Anthony, M. D., & Edwards, R. H.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-07-28
- Volume
- 24
- Issue
- 30
- Pages
- 6715-6723
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2129146981
- Cited by
- 518
- References
- 6
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fortin, D. L., Troyer, M. D., Nakamura, K., Kubo, S.-I., Anthony, M. D., & Edwards, R. H. (2004). Lipid Rafts Mediate the Synaptic Localization of α-Synuclein. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1594-04.2004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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