Ventral Tegmental Dopamine Dysregulation Prevents Appetitive Memory Destabilization
Open accessAbstract
Through the process of reconsolidation, memories can be updated to maintain their relevance. To reconsolidate, a memory must first be destabilized in a process that we have hypothesized is initiated by a prediction error signal. Here we demonstrate that dysregulation of ventral tegmental area (VTA) signaling, which is thought to mediate prediction errors, prevented the destabilization of an appetitive goal-tracking memory in rats. We additionally show that intra-VTA infusion of either the competitive NMDA antagonist AP5 or the noncompetitive NMDA antagonist MK-801 does not selectively disrupt reconsolidation, indicating that the VTA may not be an important neural locus of reconsolidation-related neural plasticity.
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The same reactivation procedure led to extinction for a weakly-trained appetitive pavlovian memory and reconsolidation for a strongly-trained pavlovian memory.
“while the same reactivation procedure led to extinction for a weakly-trained appetitive pavlovian memory and reconsolidation for a strongly-trained pavlovian memory (Reichelt and Lee, 2013).”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Reichelt and Lee, 2013
The Discussion reports that excessive stimulus reexposure relative to training strength disrupted extinction rather than reconsolidation, and that the present study’s conditions engaged reconsolidation. It does not state that the same reactivation procedure was tested with both weakly and strongly trained memories or produced the two outcomes claimed. (LLM, conf=0.82)
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“…between the expected and actual outcome following a CS presentation, is necessary to destabilise both appetitive and aversive memories in crabs (Kaczer et al., 2011; López et al., 2016), rats (Morris et al., 2006; Reichelt et al., 2013), and humans (Sevenster et al., 2013; Das et al., 2015).”
Background
- Authors
- Reichelt, A. C., Exton-McGuinness, M. T., & Lee, J. L. C.
- Affiliations
- University of Birmingham (GB)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-08-28
- Volume
- 33
- Issue
- 35
- Pages
- 14205-14210
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618505
- OpenAlex
- W2005863470
- Cited by
- 61
- References
- 2
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Leverhulme Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- ventral tegmental area, dopamine, memory reconsolidation, memory destabilization, prediction error, NMDA receptor antagonists, AP5, MK-801, neuroplasticity
- MeSH terms
- Animals, Appetitive Behavior, Goals, Male, Memory, Rats, Inbred Strains, Receptors, N-Methyl-D-Aspartate, Ventral Tegmental Area, Dopamine Antagonists, Excitatory Amino Acid Antagonists, Rats
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