Cited by 516Memory and Neural MechanismsMemory Processes and InfluencesSleep and Wakefulness Research

Reconsolidation: maintaining memory relevance

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Lee, Jonathan L.C.·2009·Trends in Neurosciences

Abstract

The retrieval of a memory places it into a plastic state, the result of which is that the memory can be disrupted or even enhanced by experimental treatment. This phenomenon has been conceptualised within a framework of memories being reactivated and then reconsolidated in repeated rounds of cellular processing. The reconsolidation phase has been seized upon as crucial for the understanding of memory stability and, more recently, as a potential therapeutic target in the treatment of disorders such as post-traumatic stress and drug addiction. However, little is known about the reactivation process, or what might be the adaptive function of retrieval-induced plasticity. Reconsolidation has long been proposed to mediate memory updating, but only recently has this hypothesis been supported experimentally. Here, the adaptive function of memory reconsolidation is explored in more detail, with a strong emphasis on its role in updating memories to maintain their relevance.

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Authors
Lee, J. L. C.
Affiliations
University of Birmingham (GB)
Corresponding author
Lee, Jonathan L.C.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2009-08
Volume
32
Issue
8
Pages
413-420
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2029548206
Cited by
516
References
72
Citations by year
2026: 10 · 2025: 24 · 2024: 18 · 2023: 19 · 2022: 28 · 2021: 25 · 2020: 40 · 2019: 27 · 2018: 41 · 2017: 39 · 2016: 38 · 2015: 38 · 2014: 35 · 2013: 43 · 2012: 36
FWCI
2.29
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
memory reconsolidation, memory retrieval, memory updating, memory stability, memory reactivation, post-traumatic stress disorder, drug addiction
MeSH terms
Animals, Avoidance Learning, Conditioning, Classical, Extinction, Psychological, Humans, Memory, Neuronal Plasticity, Taste

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