Reconsolidation: maintaining memory relevance
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The retrieval of a memory places it into a plastic state, the result of which is that the memory can be disrupted or even enhanced by experimental treatment. This phenomenon has been conceptualised within a framework of memories being reactivated and then reconsolidated in repeated rounds of cellular processing. The reconsolidation phase has been seized upon as crucial for the understanding of memory stability and, more recently, as a potential therapeutic target in the treatment of disorders such as post-traumatic stress and drug addiction. However, little is known about the reactivation process, or what might be the adaptive function of retrieval-induced plasticity. Reconsolidation has long been proposed to mediate memory updating, but only recently has this hypothesis been supported experimentally. Here, the adaptive function of memory reconsolidation is explored in more detail, with a strong emphasis on its role in updating memories to maintain their relevance.
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Whether or not a memory trace is destabilized may, at least partly, depend on whether there is something to be learned, i.e. whether novel or conflicting information requires an update.
“Whether or not a memory trace is destabilized may, at least partly, depend on whether there is something to be learned, i.e. whether novel or conflicting information requires an update [56,96,98,131,132], highlighting a potential evolutionary function of reconsolidation mechanisms [86,133].”
From Multiple memory systems, multiple time points: How science can inform treatment to control the expression of unwanted emotional memories (2018) · cites this paper as [133]
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- Authors
- Lee, J. L. C.
- Affiliations
- University of Birmingham (GB)
- Corresponding author
- Lee, Jonathan L.C.
- ORCID
- Lee, Jonathan L.C.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 32
- Issue
- 8
- Pages
- 413-420
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC3650827
- OpenAlex
- W2029548206
- Cited by
- 516
- References
- 72
- Citations by year
- 2026: 10 · 2025: 24 · 2024: 18 · 2023: 19 · 2022: 28 · 2021: 25 · 2020: 40 · 2019: 27 · 2018: 41 · 2017: 39 · 2016: 38 · 2015: 38 · 2014: 35 · 2013: 43 · 2012: 36
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- memory reconsolidation, memory retrieval, memory updating, memory stability, memory reactivation, post-traumatic stress disorder, drug addiction
- MeSH terms
- Animals, Avoidance Learning, Conditioning, Classical, Extinction, Psychological, Humans, Memory, Neuronal Plasticity, Taste
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