State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation
Open accessAbstract
Object recognition memories (ORM) can incorporate new information upon reactivation. This update initially involves destabilization of the original memory, which is followed by restabilization of the upgraded engram through a reconsolidation process that requires gene expression and protein synthesis in the hippocampus. We found that when given in dorsal CA1 either immediately after training or 15 min before ORM reactivation in the presence of a novel object, the dopamine D1/D5 receptor antagonist SCH23390 did not affect ORM consolidation, expression or retention but impeded the amnesia caused by the post-retrieval administration of the mRNA synthesis inhibitor α-amanitin or the protein synthesis blocker anisomycin. This anti-amnesic effect was not observed when SCH23390 was given immediately after training and again 15 min before memory reactivation. Our results demonstrate that hippocampal D1/D5 receptors are not needed for formation, retrieval or post-retrieval restabilization of the ORM trace but are essential for its destabilization when reactivation occurs together with the incorporation of new information into the original memory. Importantly, they also suggest that reenactment of the animal's post-learning neurochemical milieu at the moment of memory reactivation can be a boundary condition for reconsolidation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Post-sample trial microinjections of the D1-R antagonist SCH23390 and D3-R agonist 7-OH-DPAT, but not the D2-R antagonist L-741.626, into the hippocampus impaired NOP when tested 1 hour later.
“Post-sample trial microinjections of the D1-R antagonist SCH23390 and D3-R agonist 7-OH-DPAT, but not D2-R antagonist L-741.626, into the hippocampus impaired NOP when tested 1 hour later”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rossato et al., 2015
Post-sample hippocampal infusions of SCH23390 had no effect on long-term NOP memory.
“post-sample hippocampal infusions of SCH23390 had no effect on long-term NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rossato et al., 2015
Pre-test infusions of SCH23390 into the dorsal hippocampal CA1 area showed no effects on long-term NOP memory.
“pre-test infusions of SCH23390 into the dorsal hippocampal CA1 area showed no effects on long-term NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rossato et al., 2015
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931 · see citing works
A single standard for memory: The case for reconsolidation
Nader, K., & Hardt, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2590 · Cited by 811 · see citing works
Dopamine controls persistence of long-term memory storage
Rossato, J. I., Bevilaqua, L. R. M., Izquierdo, I., Medina, J. H., & Cammarota, M. (2009) · Science · doi:10.1126/science.1172545 · Cited by 486 · see citing works
Self-citationMallet, N. P., Pogosyan, A. H., Sharott, A., Csicsvari, J., Bolam, J. P., Brown, P., & Magill, P. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0123-08.2008 · Cited by 459 · see citing works
Statedependent or "dissociated" learning produced with pentobarbital.
Overton, D. A. (1964) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0048023 · Cited by 432 · see citing works
Memory reconsolidation: an update
Nader, K., & Einarsson, E. Ö. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05443.x · Cited by 356 · see citing works
Morris, R. G. M., Inglis, J., Ainge, J. A., Olverman, H. J., Tulloch, J., Dudai, Y., & Kelly, P. A. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.012 · Cited by 342 · see citing works
Inagaki, H. K., Ben-Tabou de-Leon, S., Wong, A. M., Jagadish, S., Ishimoto, H., Barnea, G., Kitamoto, T., Axel, R., & Anderson, D. J. (2012) · Cell · doi:10.1016/j.cell.2011.12.022 · Cited by 325 · see citing works
Prediction Error Governs Pharmacologically Induced Amnesia for Learned Fear
Sevenster, D., Beckers, T., & Kindt, M. (2013) · Science · doi:10.1126/science.1231357 · Cited by 305 · see citing works
Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation
Wang, S., Alvares, L. D. O., & Nader, K. (2009) · Nature Neuroscience · doi:10.1038/nn.2350 · Cited by 305 · see citing works
Gasbarri, A., Verney, C., Innocenzi, R., Campana, E., & Pacitti, C. (1994) · Brain Research · doi:10.1016/0006-8993(94)90512-6 · Cited by 302 · see citing works
Taste memory: The role of protein synthesis in gustatory cortex
Rosenblum, K., Meiri, N., & Dudai, Y. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)91145-d · Cited by 288 · see citing works
Takahashi, Y. K., Roesch, M. R., Stalnaker, T. A., Haney, R. Z., Calu, D. J., Taylor, A. R., Burke, K. A., & Schoenbaum, G. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.005 · Cited by 284 · see citing works
Rossato, J. I., Bevilaqua, L. R. M., Myskiw, J. C., Medina, J. H., Izquierdo, I., & Cammarota, M. (2007) · Learning & Memory · doi:10.1101/lm.422607 · Cited by 282 · see citing works
Self-citationEnnaceur, A., Michalíková, S., Bradford, A., & Ahmed, S. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.006 · Cited by 195 · see citing works
Hansen, N., & Manahan‐Vaughan, D. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs362 · Cited by 185 · see citing works
Tzavara, E. T., Wade, M. R., & Nomikos, G. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09374.2003 · Cited by 151 · see citing works
Lavı́n, A., & Grace, A. A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00096-3 · Cited by 87 · see citing works
Young, C. E., & Yang, C. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1650-03.2004 · Cited by 78 · see citing works
Rossato, J. I., Radiske, A., Kohler, C. A., Gonzalez, C., Bevilaqua, L. R., Medina, J. H., & Cammarota, M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.012 · Cited by 75 · see citing works
Self-citationVentral Tegmental Dopamine Dysregulation Prevents Appetitive Memory Destabilization
Reichelt, A. C., Exton-McGuinness, M. T., & Lee, J. L. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1614-13.2013 · Cited by 61 · see citing works
Winters, B. D., Tucci, M. C., Jacklin, D. L., Reid, J. M., & Newsome, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2968-11.2011 · Cited by 61 · see citing works
Balderas, I., Rodríguez‐Ortiz, C. J., & Bermúdez‐Rattoni, F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.001 · Cited by 59 · see citing works
Balderas, I., Moreno‐Castilla, P., & Bermudez‐Rattoni, F. (2013) · Hippocampus · doi:10.1002/hipo.22143 · Cited by 46 · see citing works
Fitch, T. E., Sahr, R. N., Eastwood, B. J., Zhou, F., & Yang, C. R. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01210.2005 · Cited by 45 · see citing works
Reconsolidation may incorporate state-dependency into previously consolidated memoriesPreprint
Sierra, R. O., Cassini, L. F., Santana, F., Crestani, A. P., Duran, J. M., Haubrich, J., Alvares, L. D. O., & Quillfeldt, J. A. (2013) · Learning & Memory · doi:10.1101/lm.030023.112 · Cited by 40 · see citing works
Flint, R. W., Noble, L. J., & Ulmen, A. R. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.01.009 · Cited by 25 · see citing works
Effect of α-amanitin on brain RNA and protein synthesis and on retention of avoidance conditioning
Strocchi, P., Montanaro, N., & DallʼOlio, R. (1977) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(77)90181-2 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Merlo, E., Ratano, P., Ilioi, E. C., Robbins, M. A. L. S., Everitt, B. J., & Milton, A. L. (2015) · eneuro · doi:10.1523/eneuro.0024-14.2015 · Cited by 38 · see citing works
- Authors
- Rossato, J. I., Köhler, C. A., Radiske, A., Lima, R. H., Bevilaqua, L. R. M., & Cammarota, M.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 285
- Pages
- 194-199
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2073782538
- Cited by
- 48
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 6
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil)
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS, Brazil)
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Norte (FAPERN, Brazil)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil)
- Programa de Pós-Graduação em Gerontologia Biomédica of Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS, Brazil)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- dopamine D1/D5 receptors, memory reconsolidation, memory destabilization, object recognition memory, hippocampus, dorsal CA1, SCH 23390, alpha-amanitin, anisomycin, protein synthesis, memory consolidation, memory retrieval
- MeSH terms
- Memory Consolidation, Animals, Anisomycin, Benzazepines, Hippocampus, Male, Neuropsychological Tests, Protein Synthesis Inhibitors, Gene Expression, Rats, Wistar, Receptors, Dopamine D1, Dopamine Antagonists, Nucleic Acid Synthesis Inhibitors, Recognition, Psychology, Receptors, Dopamine D5, Alpha-Amanitin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
