Increased probability of GABA release during withdrawal from morphine

Brain Dopamine and Reward

Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968 · see citing works

Opioids excite dopamine neurons by hyperpolarization of local interneurons

Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637 · see citing works

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

Aghajanian, G. K. (1978) · Nature · doi:10.1038/276186a0 · Cited by 803 · see citing works

Local and diffuse synaptic actions of GABA in the hippocampus

Isaacson, J. S., Solis, J. M., & Nicoll, R. A. (1993) · Neuron · doi:10.1016/0896-6273(93)90308-e · Cited by 688 · see citing works

Two types of neurone in the rat ventral tegmental area and their synaptic inputs.

Johnson, S. W., & NORTH, R. A. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019136 · Cited by 672 · see citing works

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

Sharma, S. K., Klee, W. A., & Nirenberg, M. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.3092 · Cited by 671 · see citing works

Molecular Mechanisms of Drug Reinforcement and Addiction

Self, D. W., & Nestler, E. J. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.002335 · Cited by 565 · see citing works

Drug addiction: A model for the molecular basis of neural plasticity

Nestler, E. J., Hope, B. T., & Widnell, K. L. (1993) · Neuron · doi:10.1016/0896-6273(93)90213-b · Cited by 544 · see citing works

A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function

Terwilliger, R. Z., Beitner‐Johnson, D., Sevarino, K. A., Crain, S. M., & Nestler, E. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91111-d · Cited by 534 · see citing works

Intracranial self-administration of morphine into the ventral tegmental area in rats

Bozarth, M. A., & Wise, R. A. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90148-x · Cited by 503 · see citing works

Morphine-induced activation of A10 dopamine neurons in the rat

Gysling, K., & Wang, R. Y. (1983) · Brain Research · doi:10.1016/0006-8993(83)90913-7 · Cited by 493 · see citing works

Cyclic AMP Mediates a Presynaptic Form of LTP at Cerebellar Parallel Fiber Synapses

Salin, P. A., Malenka, R. C., & Nicoll, R. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80099-9 · Cited by 439 · see citing works

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

Rosenmund, C., Carr, D. W., Bergeson, S. E., Nilaver, G., Scott, J. D., & Westbrook, G. L. (1994) · Nature · doi:10.1038/368853a0 · Cited by 371 · see citing works

Enkephalin blocks inhibitory pathways in the vertebrate CNS

Nicoll, R. A., Alger, B. E., & Jahr, C. E. (1980) · Nature · doi:10.1038/287022a0 · Cited by 333 · see citing works

Enkephalin hyperpolarizes interneurones in the rat hippocampus.

Madison, D. V., & Nicoll, R. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017033 · Cited by 292 · see citing works

Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.

Duman, R. S., Tallman, J. F., & Nestler, E. J. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22179-6 · Cited by 282 · see citing works

Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input

Akaoka, H., & Aston‐Jones, G. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-12-03830.1991 · Cited by 266 · see citing works

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

Christie, M. J., Williams, J. T., & NORTH, R. A. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13048-4 · Cited by 264 · see citing works

Dopamine D1 receptors facilitate transmitter release

Cameron, D. L., & Williams, J. T. (1993) · Nature · doi:10.1038/366344a0 · Cited by 263 · see citing works

5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons

Johnson, S., Mercuri, N. B., & North, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-02000.1992 · Cited by 249 · see citing works

Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneurons.

Cohen, G. A., Doze, V., & Madison, D. (1992) · Neuron · doi:10.1016/0896-6273(92)90171-9 · Cited by 244 · see citing works

Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.

Nestler, E. J., & Tallman, J. F. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13123-4 · Cited by 235 · see citing works

A Common Mechanism Mediates Long-Term Changes in Synaptic Transmission after Chronic Cocaine and Morphine

Bonci, A., & Williams, J. T. (1996) · Neuron · doi:10.1016/s0896-6273(00)80082-3 · Cited by 228 · see citing works

Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome

Harris, G. C., & Aston‐Jones, G. (1994) · Nature · doi:10.1038/371155a0 · Cited by 214 · see citing works

Cocaine inhibits GABA release in the VTA through endogenous 5-HT

Cameron, D., & Williams, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06763.1994 · Cited by 188 · see citing works

Mechanisms of cellular adaptive sensitivity changes: applications to opioid tolerance and dependence.

Johnson, S. M., & Fleming, W. W. (1989) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00035-3 · Cited by 175 · see citing works

Paired‐pulse modulation of fast excitatory synaptic currents in microcultures of rat hippocampal neurons.

Mennerick, S. J., & Zorumski, C. F. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020948 · Cited by 171 · see citing works

Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.

Diana, M., Pistis, M., Muntoni, A. L., & Gessa, G. L. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24484-6 · Cited by 170 · see citing works

Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation

Wimpey, T. L., & Chavkin, C. (1991) · Neuron · doi:10.1016/0896-6273(91)90363-5 · Cited by 141 · see citing works

Morphine tolerance and dependence in the locus coeruleus: Single cell studies in brain slices

Andrade, R., VanderMaelen, C. P., & Aghajanian, G. K. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90461-2 · Cited by 139 · see citing works

Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats

Kogan, J. H., Nestler, E. J., & Aghajanian, G. K. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90261-2 · Cited by 128 · see citing works

Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus

Chavkin, C., & Goldstein, A. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.22.7253 · Cited by 128 · see citing works

Loss of opiate receptor activity in neuroblastoma X glioma NG108-15 hybrid cells after chronic opiate treatment. A multiple-step process.

Law, P., Hom, D. S., & Loh, H. H. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14943-2 · Cited by 126 · see citing works

Hyperpolarization by opioids acting on μ‐receptors of a sub‐population of rat periaqueductal gray neurones in vitro

Chieng, B. C. H., & Christie, M. J. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb16183.x · Cited by 125 · see citing works

Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: a useful model for the study of tolerance at mu opioid receptors.

Puttfarcken, P. S., Werling, L. L., & Cox, B. M. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13363-4 · Cited by 118 · see citing works

Regulation of Cyclic AMP by the μ‐Opioid Receptor in Human Neuroblastoma SH‐SY5Y Cells

Yu, V. C. K., Eiger, S. M., Duan, D. S., Lameh, J., & Sadée, W. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb03151.x · Cited by 101 · see citing works

Local Opioid Withdrawal in Rat Single Periaqueductal Gray NeuronsIn Vitro

Chieng, B. C. H., & Christie, M. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-22-07128.1996 · Cited by 75 · see citing works

Great Expectations

Maren, T. H. (1982) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.000245 · Cited by 52 · see citing works

Presynaptic inhibition of gamma-aminobutyric acidB-mediated synaptic current by adenosine recorded in vitro in midbrain dopamine neurons.

Wu, Y., Mercuri, N. B., & Johnson, S. W. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09507-2 · Cited by 47 · see citing works

A DEMONSTRATION OF NALOXONE‐PRECIPITATED OPIATE WITHDRAWAL ON SINGLE NEURONES IN THE MORPHINE‐TOLERANT/DEPENDENT RAT BRAIN

Fry, J. P., Herz, A., & Zieglgänsberger, W. (1980) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1980.tb14574.x · Cited by 46 · see citing works

Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus.

Wimpey, T. L., Opheim, K. E., & Chavkin, C. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20822-9 · Cited by 42 · see citing works

Mu-opioid receptor inhibition of calcium current: development of homologous tolerance in single SH-SY5Y cells after chronic exposure to morphine in vitro.

Kennedy, C., & Henderson, G. (1991) · PubMed · Cited by 38 · see citing works

Morphine withdrawal responses of rat locus coeruleus neurons are blocked by an excitatory amino‐acid antagonist

TUNG, C. ‐., Grenhoff, J., & Svensson, T. H. (1990) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1990.tb08888.x · Cited by 36 · see citing works

Chronic exposure to morphine does not induce dependence at the level of the calcium channel current in human SH-SY5Y cells

Kennedy, C., & Henderson, G. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90369-d · Cited by 25 · see citing works

Tolerance and dependence of dorsal horn neurones of the cat: The role of the opiate receptors of the substantia gelatinosa

Johnson, S. M., & Duggan, A. W. (1981) · Neuropharmacology · doi:10.1016/0028-3908(81)90093-9 · Cited by 25 · see citing works

Molecular basis of long-term plasticity underlying addiction

Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,857 · see citing works

Is there a common molecular pathway for addiction?

Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388 · see citing works

Cellular and Synaptic Adaptations Mediating Opioid Dependence

Williams, J. T., Christie, M. J., & Manzoni, O. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 852 · see citing works

Opioid receptors

Waldhoer, M., Bartlett, S. E., & Whistler, J. L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073940 · Cited by 740 · see citing works

Activation of VTA GABA Neurons Disrupts Reward Consumption

van Zessen, R., Phillips, J. L., Budygin, E. A., & Stuber, G. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.016 · Cited by 609 · see citing works

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works

Methamphetamine: An update on epidemiology, pharmacology, clinical phenomenology, and treatment literature

Courtney, K. E., & Ray, L. A. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.08.003 · Cited by 502 · see citing works

Guidelines for the psychosocially assisted pharmacological treatment of opioid dependence

Uchtenhagen, A. (2009) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-17408 · Cited by 487 · see citing works

Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

Christie, M. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.100 · Cited by 481 · see citing works

Endocannabinoids Mediate Presynaptic Inhibition of Glutamatergic Transmission in Rat Ventral Tegmental Area Dopamine Neurons through Activation of CB1 Receptors

Melis, M., Pistis, M., Perra, S., Muntoni, A. L., Pillolla, G., & Gessa, G. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4503-03.2004 · Cited by 478 · see citing works

Neurobiology of opioid addiction: Opponent process, hyperkatifeia, and negative reinforcement

Koob, G. F. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.023 · Cited by 477 · see citing works

Opioid dependence and addiction during opioid treatment of chronic pain

Ballantyne, J. C., & LaForge, S. K. (2007) · Pain · doi:10.1016/j.pain.2007.03.028 · Cited by 445 · see citing works

Historical review: molecular and cellular mechanisms of opiate and cocaine addiction

Nestler, E. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.005 · Cited by 425 · see citing works

Molecular Neurobiology of Addiction

Nestler, E. J. (2001) · American Journal on Addictions · doi:10.1080/105504901750532094 · Cited by 412 · see citing works

Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization

He, L., Fong, J. C., von Zastrow, M., & Whistler, J. L. (2002) · Cell · doi:10.1016/s0092-8674(02)00613-x · Cited by 340 · see citing works

Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location

Ford, C. P., Mark, G. P., & Williams, J. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4331-05.2006 · Cited by 339 · see citing works

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works

Acute and Chronic Ethanol Alter Glutamatergic Transmission in Rat Central Amygdala: an<i>In Vitro</i>and<i>In Vivo</i>Analysis

Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., & Siggins, G. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5077-03.2004 · Cited by 312 · see citing works

Increased GABA Release in the Central Amygdala of Ethanol-Dependent Rats

Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., & Siggins, G. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3004-04.2004 · Cited by 299 · see citing works

Endocytosis of the Mu Opioid Receptor Reduces Tolerance and a Cellular Hallmark of Opiate Withdrawal

Finn, A. K., & Whistler, J. L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00517-7 · Cited by 285 · see citing works

Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits

Chen, K., Baram, T., & Soltesz, I. (1999) · Nature Medicine · doi:10.1038/11330 · Cited by 337 · see citing works

The Dopamine Hypothesis of Drug Addiction: Hypodopaminergic State

Melis, M., Spiga, S., & Diana, M. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)63005-x · Cited by 271 · see citing works

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics

Trang, T., Al‐Hasani, R., Salvemini, D., Salter, M. W., Gutstein, H. B., & Cahill, C. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2711-15.2015 · Cited by 277 · see citing works

Hippocampal Long-Term Potentiation Is Reduced by Chronic Opiate Treatment and Can Be Restored by Re-Exposure to Opiates

Pu, L., Bao, G., Xu, N., Ma, L., & Pei, G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01914.2002 · Cited by 242 · see citing works

The endogenous opioid system: A common substrate in drug addiction

Trigo, J. M., Martín‐García, E., Berrendero, F., Robledo, P., & Maldonado, R. J. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.10.011 · Cited by 240 · see citing works

Separate GABA Afferents to Dopamine Neurons Mediate Acute Action of Opioids, Development of Tolerance, and Expression of Withdrawal

Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T., & Williams, J. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.030 · Cited by 237 · see citing works

Anhedonia and Substance Dependence: Clinical Correlates and Treatment Options

Hatzigiakoumis, D. S., Martinotti, G., Giannantonio, M. D., & Janiri, L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00010 · Cited by 238 · see citing works

The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence

Martini, L., & Whistler, J. L. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.10.004 · Cited by 234 · see citing works

Nucleus Accumbens Medium Spiny Neurons Target Non-Dopaminergic Neurons in the Ventral Tegmental Area

Xia, Y., Driscoll, J. R., Wilbrecht, L., Margolis, E. B., Fields, H. L., & Hjelmstad, G. O. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1504-11.2011 · Cited by 218 · see citing works

Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors

Zweifel, L. S., Argilli, E., Bonci, A., & Palmiter, R. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.028 · Cited by 210 · see citing works

Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence

Liu, J. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00057-1 · Cited by 209 · see citing works

Regional and Cellular Mapping of cAMP Response Element-Mediated Transcription during Naltrexone-Precipitated Morphine Withdrawal

Shaw-Lutchman, T. Z., Barrot, M., Wallace, T. L., Gilden, L., Zachariou, V., Impey, S., Duman, R. S., Storm, D. R., & Nestler, E. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03663.2002 · Cited by 205 · see citing works

Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area

Laviolette, S. R., Gallegos, R. A., Henriksen, S. J., & van der Kooy, D. (2004) · Nature Neuroscience · doi:10.1038/nn1182 · Cited by 203 · see citing works

Identification of Rat Ventral Tegmental Area GABAergic Neurons

Margolis, E. B., Toy, B. C., Himmels, P., Morales, M., & Fields, H. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042365 · Cited by 202 · see citing works

Long-Lasting Potentiation of GABAergic Synapses in Dopamine Neurons after a Single<i>In Vivo</i>Ethanol Exposure

Melis, M., Camarini, R., Ungless, M. A., & Bonci, A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02074.2002 · Cited by 196 · see citing works

Opioid-Sensitive GABA Inputs from Rostromedial Tegmental Nucleus Synapse onto Midbrain Dopamine Neurons

Matsui, A., & Williams, J. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4570-11.2011 · Cited by 191 · see citing works

Inhibitory Inputs from Rostromedial Tegmental Neurons Regulate Spontaneous Activity of Midbrain Dopamine Cells and Their Responses to Drugs of Abuse

Lecca, S., Melis, M., Luchicchi, A., Muntoni, A. L., & Pistis, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.302 · Cited by 185 · see citing works

Neural correlates of the motivational and somatic components of naloxone‐precipitated morphine withdrawal

Frenois, F., Cador, M., Caillé, S., Stinus, L., & Moine, C. L. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02187.x · Cited by 179 · see citing works

Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices

Khirug, S., Huttu, K., Ludwig, A., Smirnov, S., Voipio, J., Rivera, C., Kaila, K., & Khiroug, L. S. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03886.x · Cited by 168 · see citing works

Regulation of Gene Expression by Chronic Morphine and Morphine Withdrawal in the Locus Ceruleus and Ventral Tegmental Area

McClung, C. A., Nestler, E. J., & Zachariou, V. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0062-05.2005 · Cited by 163 · see citing works

Deficits in dopamine D2 receptors and pre-synaptic dopamine in heroin dependence: commonalities and differences with other types of addiction

Martinez, D., Saccone, P., Liu, F., Slifstein, M., Orlowska, D., Grassetti, A., Cook, S., Broft, A., Heertum, R. V. V., & Comer, S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.024 · Cited by 153 · see citing works

Enhanced Opioid Efficacy in Opioid Dependence Is Caused by an Altered Signal Transduction Pathway

Ingram, S., Vaughan, C. W., Bagley, E. E., Connor, M. A., & Christie, M. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10269.1998 · Cited by 161 · see citing works

The tipsy terminal: presynaptic effects of ethanol.

Siggins, G., Roberto, M., & Nie, Z. (2005) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2005.01.006 · Cited by 167 · see citing works

Presynaptic Regulation of Glutamate Release in the Ventral Tegmental Area During Morphine Withdrawal

Manzoni, O. J., & Williams, J. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06629.1999 · Cited by 156 · see citing works

Molecular mechanisms of opiate and cocaine addiction

Nestler, E. J. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80094-3 · Cited by 149 · see citing works

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works

Suppression of the morphine‐induced rewarding effect in the rat with neuropathic pain: implication of the reduction in µ‐opioid receptor functions in the ventral tegmental area

Ozaki, S., Narita, M., Narita, M., Iino, M., Sugita, J., Matsumura, Y., & Suzuki, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01071.x · Cited by 142 · see citing works

Noradrenaline Triggers GABAAInhibition of Bed Nucleus of the Stria Terminalis Neurons Projecting to the Ventral Tegmental Area

Dumont, É. C., & Williams, J. T. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0425-04.2004 · Cited by 137 · see citing works

Patch-clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: Glycerol replacement of NaCl protects CNS neurons

Ye, J. H., Zhang, J., Xiao, C., & Kong, J. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.06.006 · Cited by 136 · see citing works

Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking

Heinsbroek, J. A., Neuhofer, D., Griffin, W. C., Siegel, G. S., Bobadilla, A., Kupchik, Y. M., & Kalivas, P. W. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2659-16.2016 · Cited by 129 · see citing works

Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal

Diana, M., Muntoni, A. L., Pistis, M., Melis, M., & Gessa, G. L. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00488.x · Cited by 132 · see citing works

It’s MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system

Chartoff, E. H., & Connery, H. S. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00116 · Cited by 128 · see citing works

Direct Evidence for the Involvement of the Mesolimbic κ-Opioid System in the Morphine-Induced Rewarding Effect Under an Inflammatory Pain-Like State

Narita, M., Kishimoto, Y., Ise, Y., Yajima, Y., Misawa, K., & Suzuki, T. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300527 · Cited by 128 · see citing works

Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction

Kokane, S. S., & Perrotti, L. I. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00074 · Cited by 123 · see citing works

Ethanol Facilitates Glutamatergic Transmission to Dopamine Neurons in the Ventral Tegmental Area

Xiao, C., Shao, X. M., Olive, M. F., Griffin, W. C., Li, K.-Y., Krnjević, K., Zhou, C., & Ye, J. H. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.99 · Cited by 129 · see citing works

Biased signaling by endogenous opioid peptides

Gomes, I., Sierra, S., Lueptow, L. M., Gupta, A., Gouty, S., Margolis, E. B., Cox, B. M., & Devi, L. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000712117 · Cited by 127 · see citing works

A Specific Limbic Circuit Underlies Opiate Withdrawal Memories

Frenois, F., Stinus, L., Blasi, F. D., Cador, M., & Moine, C. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3090-04.2005 · Cited by 117 · see citing works

Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine NeuronsPreprint

Mazei‐Robison, M. S., & Nestler, E. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012070 · Cited by 113 · see citing works

Acute Opioid Receptor Desensitization And Tolerance: Is There A Link?

Borgland, S. L. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03418.x · Cited by 115 · see citing works

Increased Opioid Inhibition of GABA Release in Nucleus Accumbens during Morphine Withdrawal

Chieng, B. C. H., & Williams, J. T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-07033.1998 · Cited by 112 · see citing works

Differential Regulation of Neurotrophin andtrkReceptor mRNAs in Catecholaminergic Nuclei during Chronic Opiate Treatment and Withdrawal

Numan, S., Lane-Ladd, S. B., Zhang, L., Lundgren, K. H., Russell, D., Seroogy, K. B., & Nestler, E. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10700.1998 · Cited by 111 · see citing works

Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway

Jolas, T., Nestler, E. J., & Aghajanian, G. K. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00436-4 · Cited by 110 · see citing works

The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release

Nagai, T., Yamada, K., Yoshimura, M., Ishikawa, K., Miyamoto, Y., Hashimoto, K., Noda, Y., Nitta, A., & Nabeshima, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306587101 · Cited by 110 · see citing works

Neuroimmune regulation of GABAergic neurons within the ventral tegmental area during withdrawal from chronic morphine

Taylor, A. M. W., Castonguay, A., Ghogha, A., Vayssiere, P., Pradhan, A. A. A., Xue, L., Mehrabani, S., Wu, J., Levitt, P., Olmstead, M. C., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.221 · Cited by 109 · see citing works

Presynaptic dopamine D2‐like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones

Koga, E., & Momiyama, T. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-2-00163.x · Cited by 107 · see citing works

Direct Bidirectional μ-Opioid Control of Midbrain Dopamine Neurons

Margolis, E. B., Hjelmstad, G. O., Fujita, W., & Fields, H. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2144-14.2014 · Cited by 104 · see citing works

The Role of Opioid Receptor Internalization and ??-Arrestins in the Development of Opioid Tolerance

Zuo, Z. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000160588.32007.ad · Cited by 103 · see citing works

Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens

Manzoni, O. J., & Bockaert, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00723-3 · Cited by 103 · see citing works

Presynaptic Glycine Receptors on GABAergic Terminals Facilitate Discharge of Dopaminergic Neurons in Ventral Tegmental Area

Ye, J.-H., Wang, F., Krnjević, K., Wang, W., Xiong, Z., & Zhang, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2016-04.2004 · Cited by 100 · see citing works

Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal

Kaufling, J., & Aston‐Jones, G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0715-15.2015 · Cited by 89 · see citing works

cAMP-Mediated Mechanisms for Pain Sensitization during Opioid Withdrawal

Bie, B., Peng, Y., Zhang, Y., & Pan, Z. Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5010-04.2005 · Cited by 92 · see citing works

Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence

Kim, J. A., Bartlett, S. E., Li, H., Nielsen, C. K., Chang, A. M., Kharazia, V., Waldhoer, M., Ou, C. J., Taylor, S., Ferwerda, M., et al. (2008) · Current Biology · doi:10.1016/j.cub.2007.12.057 · Cited by 92 · see citing works

Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid

Luca, M. A. D., Bimpisidis, Z., Melis, M., Marti, M., Caboni, P., Valentini, V., Margiani, G., Pintori, N., Polis, I. Y., Marsicano, G., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.041 · Cited by 88 · see citing works

Drug Dependence as a Disorder of Neural Plasticity: Focus on Dopamine and Glutamate

Pulvirenti, L., & Diana, M. (2001) · Reviews in the Neurosciences · doi:10.1515/revneuro.2001.12.2.141 · Cited by 87 · see citing works

Morphine withdrawal‐induced morphological changes in the nucleus accumbens

Spiga, S., Puddu, M. C., Pisano, M., & Diana, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04416.x · Cited by 86 · see citing works

Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro

Hack, S. P., Vaughan, C. W., & Christie, M. J. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00205-3 · Cited by 85 · see citing works

L-Type Calcium Channels Mediate a Slow Excitatory Synaptic Transmission in Rat Midbrain Dopaminergic Neurons

Bonci, A., Grillner, P., Mercuri, N. B., & Bernardi, G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06693.1998 · Cited by 85 · see citing works

Differential Desensitization of Responses Mediated by Presynaptic and Postsynaptic A1Adenosine Receptors

Wetherington, J. P., & Lambert, N. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01248.2002 · Cited by 85 · see citing works

The Endocannabinoid System Tonically Regulates Inhibitory Transmission and Depresses the Effect of Ethanol in Central Amygdala

Roberto, M., Cruz, M. T., Bajo, M., Siggins, G. R., Parsons, L. H., & Schweitzer, P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.70 · Cited by 84 · see citing works

An Opiate Cocktail that Reduces Morphine Tolerance and Dependence

Li, H., & Whistler, J. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.052 · Cited by 84 · see citing works

Histamine regulates activities of neurons in the ventrolateral preoptic nucleus

Liu, Y.-W., Li, J., & Ye, J.-H. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.193904 · Cited by 81 · see citing works

A Possible Mechanism Underlying the Effectiveness of Acupuncture in the Treatment of Drug Addiction

Yang, C. H., Lee, B. H., & Sohn, S. H. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem081 · Cited by 81 · see citing works

Discovery of endogenous opioid systems: what it has meant for the clinician's understanding of pain and its treatment

Ballantyne, J. C., & Sullivan, M. D. (2017) · Pain · doi:10.1097/j.pain.0000000000001043 · Cited by 79 · see citing works

Regulation of Lateral Hypothalamic Orexin Activity by Local GABAergic Neurons

Ferrari, L. L., Park, D., Zhu, L., Palmer, M. R., Broadhurst, R. Y., & Arrigoni, E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1925-17.2017 · Cited by 79 · see citing works

Local Opiate Withdrawal in Locus Coeruleus Neurons In Vitro

Ivanov, A., & Aston‐Jones, G. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2388 · Cited by 74 · see citing works

Augmented Accumbal Serotonin Levels Decrease the Preference for a Morphine Associated Environment During Withdrawal

Harris, G. C. M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00184-6 · Cited by 75 · see citing works

Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis

Fuentealba, J. A., Forray, M. I., & Gysling, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750741.x · Cited by 74 · see citing works

Opiates and plasticity

Dacher, M., & Nugent, F. S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.028 · Cited by 71 · see citing works

PKG and PKA Signaling in LTP at GABAergic Synapses

Nugent, F. S., Niehaus, J. L., & Kauer, J. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.5 · Cited by 73 · see citing works

Nociceptin/Orphanin FQ Blockade of Corticotropin-Releasing Factor-Induced Gamma-Aminobutyric Acid Release in Central Amygdala Is Enhanced After Chronic Ethanol Exposure

Cruz, M. T., Herman, M. A., Kallupi, M., & Roberto, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.032 · Cited by 72 · see citing works

In vivo modulation of ventral tegmental area dopamine and glutamate efflux by local GABAB receptors is altered after repeated amphetamine treatment

Giorgetti, M., Hotsenpiller, G., Froestl, W., & Wolf, M. E. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00510-3 · Cited by 72 · see citing works

Distinct Roles of Adenylyl Cyclases 1 and 8 in Opiate Dependence: Behavioral, Electrophysiological, and Molecular Studies

Zachariou, V., Liu, R., LaPlant, Q., Xiao, G., Renthal, W., Chan, G. C., Storm, D. R., Aghajanian, G., & Nestler, E. J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.021 · Cited by 70 · see citing works

Cocaine disinhibits dopamine neurons in the ventral tegmental area via use‐dependent blockade of GABA neuron voltage‐sensitive sodium channels

Steffensen, S. C., Taylor, S. R., Horton, M. L., Barber, E. N., Lyle, L. T., Stobbs, S. H., & Allison, D. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06479.x · Cited by 70 · see citing works

Alteration in Regulation of Serotonin Release in Rat Dorsal Raphe Nucleus after Prolonged Exposure to Morphine

Tao, R., Ma, Z., & Auerbach, S. B. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37608-6 · Cited by 70 · see citing works

Opioid-Induced GABA Potentiation after Chronic Morphine Attenuates the Rewarding Effects of Opioids in the Ventral Tegmental Area

Madhavan, A., Bonci, A., & Whistler, J. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3366-10.2010 · Cited by 69 · see citing works

Morphine withdrawal‐induced abnormalities in the VTA: confocal laser scanning microscopy

Spiga, S., Serra, G. P., Puddu, M. C., Foddai, M., & Diana, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02435.x · Cited by 69 · see citing works

Role of extracellular signal‐regulated kinase in the ventral tegmental area in the suppression of the morphine‐induced rewarding effect in mice with sciatic nerve ligation

Ozaki, S., Narita, M., Narita, M., Ozaki, M., Khotib, J., & Suzuki, T. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02272.x · Cited by 66 · see citing works

Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine

Collo, G., Cavalleri, L., & Spano, P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00259 · Cited by 66 · see citing works

Ghrelin Increases GABAergic Transmission and Interacts with Ethanol Actions in the Rat Central Nucleus of the Amygdala

Cruz, M. T., Herman, M. A., Cote, D. M., Ryabinin, A. E., & Roberto, M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.190 · Cited by 66 · see citing works

How to design an opioid drug that causes reduced tolerance and dependence

Berger, A. C., & Whistler, J. L. (2010) · Annals of Neurology · doi:10.1002/ana.22002 · Cited by 65 · see citing works

Increased probability of GABA release during withdrawal from morphine. J Neurosci 17:796–803

Bonci, A., & Williams, J. T. (1997)

Presynaptic Inhibition of GABAB-Mediated Synaptic Potentials in the Ventral Tegmental Area during Morphine Withdrawal

Shoji, Y., Delfs, J. M., & Williams, J. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02347.1999 · Cited by 65 · see citing works

Increased Opioid Inhibition of GABA Release in Nucleus Accumbens during Morphine Withdrawal

Chieng, B. C. H., & Williams, J. T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-07033.1998 · Cited by 112 · see citing works

μ-Opioid Receptor Endocytosis Prevents Adaptations in Ventral Tegmental Area GABA Transmission Induced during Naloxone-Precipitated Morphine Withdrawal

Madhavan, A., He, L., Stuber, G. D., Bonci, A., & Whistler, J. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4634-09.2010 · Cited by 45 · see citing works

Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP

Bajo, M., Madamba, S. G., Roberto, M., & Siggins, G. R. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00045 · Cited by 29 · see citing works