The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Dopamine Depresses Excitatory and Inhibitory Synaptic Transmission by Distinct Mechanisms in the Nucleus Accumbens
Open accessAbstract
The release of dopamine (DA) in the nucleus accumbens (NAc) is thought to be critical for mediating natural rewards as well as for the reinforcing actions of drugs of abuse. DA and amphetamine depress both excitatory and inhibitory synaptic transmission in the NAc by a presynaptic D1-like DA receptor. However, the mechanisms of depression of excitatory and inhibitory synaptic transmission appear to be different. DA depressed the frequency of spontaneous miniature EPSCs, but the frequency of miniature IPSCs was depressed only when spontaneous release was made dependent on Ca 2+influx through voltage-dependent Ca 2+channels. Furthermore, the K+channel blocker Ba 2+attenuated the effects of DA on evoked IPSPs, but not on EPSPs. Thus, DA appears to depress inhibitory synaptic transmission in the NAc by reducing Ca 2+influx into the presynaptic terminal, but depresses excitatory transmission by a distinct mechanism that is independent of the entry of Ca 2+.
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Cites
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688
Dopamine action in the nucleus accumbens
DeFrance, J. F., Sikes, R. W., & Chronister, R. B. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.6.1568 · Cited by 66
Cited by
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action
Floresco, S. B. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115159 · Cited by 938
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
Wolf, M. E. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00090-7 · Cited by 934
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931
Self-citationInhibitory control of neostriatal projection neurons by GABAergic interneurons
Koós, T., & Tepper, J. M. (1999) · Nature Neuroscience · doi:10.1038/8138 · Cited by 849
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Williams, J. T., Christie, M. J., & Manzoni, O. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 848
Metadata
- Authors
- Nicola, S. M., & Malenka, R. C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-08-01
- Volume
- 17
- Issue
- 15
- Pages
- 5697-5710
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2114641211
- Cited by
- 185
- References
- 5
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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